DIRAS1 (DIRAS family GTPase 1) - Rat Genome Database

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Gene: DIRAS1 (DIRAS family GTPase 1) Sus scrofa
Analyze
Symbol: DIRAS1
Name: DIRAS family GTPase 1
RGD ID: 14169265
Description: ENCODES a protein that exhibits mitogen-activated protein kinase binding (ortholog); INVOLVED IN positive regulation of MAP kinase activity (ortholog); ASSOCIATED WITH early myoclonic encephalopathy (ortholog); Neurodevelopmental Disorders (ortholog); progressive myoclonus epilepsy 9 (ortholog); FOUND IN plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: GTP-binding protein Di-Ras1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl275,908,509 - 75,929,151 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1275,921,145 - 75,927,231 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2276,433,513 - 76,439,218 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,ISO)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DIRAS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl275,908,509 - 75,929,151 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1275,921,145 - 75,927,231 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2276,433,513 - 76,439,218 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DIRAS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38192,714,567 - 2,721,372 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl192,714,567 - 2,721,372 (-)EnsemblGRCh38hg38GRCh38
GRCh37192,714,565 - 2,721,370 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36192,665,565 - 2,672,369 (-)NCBINCBI36Build 36hg18NCBI36
Build 34192,665,564 - 2,672,369NCBI
Celera192,650,904 - 2,657,729 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef192,484,453 - 2,491,186 (-)NCBIHuRef
CHM1_1192,714,145 - 2,720,965 (-)NCBICHM1_1
T2T-CHM13v2.0192,689,849 - 2,696,659 (-)NCBIT2T-CHM13v2.0
Diras1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,855,423 - 80,862,038 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,855,423 - 80,861,496 (-)EnsemblGRCm39 Ensembl
GRCm381081,019,589 - 81,025,835 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,019,589 - 81,025,662 (-)EnsemblGRCm38mm10GRCm38
MGSCv371080,482,335 - 80,488,122 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,422,719 - 80,428,506 (-)NCBIMGSCv36mm8
Celera1082,039,688 - 82,045,475 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Diras1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,338,660 - 9,343,524 (+)NCBIGRCr8
mRatBN7.278,687,964 - 8,692,828 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,687,942 - 8,693,831 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,572,446 - 11,577,301 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,447,941 - 13,452,796 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,314,453 - 11,319,308 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,556,192 - 11,561,056 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,556,192 - 11,561,056 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,723,556 - 11,728,420 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,171,727 - 10,176,591 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,174,785 - 10,175,421 (+)NCBI
Celera76,875,230 - 6,880,094 (+)NCBICelera
Cytogenetic Map7q11NCBI
Diras1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554955,004,548 - 5,005,144 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554955,002,803 - 5,005,203 (-)NCBIChiLan1.0ChiLan1.0
DIRAS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2207,108,885 - 7,115,747 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1196,340,786 - 6,347,646 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0191,738,941 - 1,745,786 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1192,697,756 - 2,702,656 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl192,700,396 - 2,700,992 (-)Ensemblpanpan1.1panPan2
DIRAS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12056,469,283 - 56,477,314 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2056,474,105 - 56,474,701 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2056,265,522 - 56,273,545 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02057,202,556 - 57,210,586 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2057,207,381 - 57,207,977 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12056,255,599 - 56,263,614 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02056,740,475 - 56,748,499 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02056,940,863 - 56,948,888 (+)NCBIUU_Cfam_GSD_1.0
Diras1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118216,251,871 - 216,261,808 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365881,572,400 - 1,590,779 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365881,572,975 - 1,575,971 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC103233654
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.162,491,978 - 2,494,791 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl62,493,475 - 2,494,071 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660816,107,528 - 6,112,512 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Diras1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248285,809,660 - 5,816,819 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248285,808,355 - 5,816,865 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DIRAS1
89 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
ectoderm
endocrine system
mesenchyme
nervous system
renal system
reproductive system
2 23 3 3 23 2 3

Sequence


Ensembl Acc Id: ENSSSCT00000049381   ⟹   ENSSSCP00000045129
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl275,908,509 - 75,925,763 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000066768   ⟹   ENSSSCP00000074099
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl275,921,175 - 75,929,151 (+)Ensembl
RefSeq Acc Id: XM_021084177   ⟹   XP_020939836
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1275,921,145 - 75,927,231 (+)NCBI
Sequence:
RefSeq Acc Id: XP_020939836   ⟸   XM_021084177
- UniProtKB: A0A4X1VTH5 (UniProtKB/TrEMBL),   A0A5G2R9W2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000045129   ⟸   ENSSSCT00000049381
Ensembl Acc Id: ENSSSCP00000074099   ⟸   ENSSSCT00000066768


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000038013 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015068828 UniProtKB/TrEMBL
  ENSSSCG00025012602 UniProtKB/TrEMBL
  ENSSSCG00030007664 UniProtKB/TrEMBL
  ENSSSCG00035032420 UniProtKB/TrEMBL
  ENSSSCG00040029115 UniProtKB/TrEMBL
  ENSSSCG00045008748 UniProtKB/TrEMBL
  ENSSSCG00050053668 UniProtKB/TrEMBL
  ENSSSCG00055016928 UniProtKB/TrEMBL
  ENSSSCG00060026147 UniProtKB/TrEMBL
  ENSSSCG00065056379 UniProtKB/TrEMBL
  ENSSSCG00070026469 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000049381.3 UniProtKB/TrEMBL
  ENSSSCT00000066768 ENTREZGENE
  ENSSSCT00000066768.2 UniProtKB/TrEMBL
  ENSSSCT00015092184.1 UniProtKB/TrEMBL
  ENSSSCT00015092405.1 UniProtKB/TrEMBL
  ENSSSCT00025016668.1 UniProtKB/TrEMBL
  ENSSSCT00030010275.1 UniProtKB/TrEMBL
  ENSSSCT00035042923.1 UniProtKB/TrEMBL
  ENSSSCT00035042931.1 UniProtKB/TrEMBL
  ENSSSCT00040039121.1 UniProtKB/TrEMBL
  ENSSSCT00045014779.1 UniProtKB/TrEMBL
  ENSSSCT00045014805.1 UniProtKB/TrEMBL
  ENSSSCT00050073111.1 UniProtKB/TrEMBL
  ENSSSCT00055033365.1 UniProtKB/TrEMBL
  ENSSSCT00055033437.1 UniProtKB/TrEMBL
  ENSSSCT00060035408.1 UniProtKB/TrEMBL
  ENSSSCT00065077152.1 UniProtKB/TrEMBL
  ENSSSCT00065077161.1 UniProtKB/TrEMBL
  ENSSSCT00070053047.1 UniProtKB/TrEMBL
  ENSSSCT00070053049.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
  Small_GTPase_Ras-type UniProtKB/TrEMBL
  ZIP UniProtKB/TrEMBL
NCBI Gene DIRAS1 ENTREZGENE
PANTHER GTP-BINDING PROTEIN DI-RAS1 UniProtKB/TrEMBL
  PTHR24070 UniProtKB/TrEMBL
Pfam Ras UniProtKB/TrEMBL
  Zip UniProtKB/TrEMBL
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
SMART RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A287AMJ2_PIG UniProtKB/TrEMBL
  A0A4X1VS72_PIG UniProtKB/TrEMBL
  A0A4X1VTH5 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2R9W2 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:87312 ENTREZGENE