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Gene: Ndufaf5 (NADH:ubiquinone oxidoreductase complex assembly factor 5) Heterocephalus glaber

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Symbol:

Ndufaf5

Name:

NADH:ubiquinone oxidoreductase complex assembly factor 5

RGD ID:

18913927

Description:

ENCODES a protein that exhibits methyltransferase activity (inferred); S-adenosylmethionine-dependent methyltransferase activity (inferred); INVOLVED IN methylation (inferred); mitochondrial respiratory chain complex I assembly (inferred); ASSOCIATED WITH genetic disease (ortholog); Leber plus disease (ortholog); Leigh disease (ortholog); FOUND IN matrix side of mitochondrial inner membrane (inferred); mitochondrion (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

arginine-hydroxylase NDUFAF5, mitochondrial; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex assembly factor 5

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624741	14,778,109 - 14,823,893 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624741	14,778,126 - 14,824,079 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ndufaf5	Naked Mole-Rat	genetic disease		ISO	RGD:1603963	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:25326635\|PMID:25356970\|PMID:25741868\|PMID:27817865\|PMID:28492532\|PMID:29261183\|PMID:29581464\|PMID:30473481\|PMID:30581749\|PMID:34177781\|PMID:34797029
Ndufaf5	Naked Mole-Rat	Leber plus disease		ISO	RGD:1603963	8554872	ClinVar Annotator: match by term: Leber plus disease	ClinVar	PMID:25741868
Ndufaf5	Naked Mole-Rat	Leigh disease		ISO	RGD:1603963	8554872	ClinVar Annotator: match by term: Leigh syndrome \| ClinVar Annotator: match by term: Leigh's disease more ...	ClinVar	PMID:16199547\|PMID:17576681\|PMID:25326635\|PMID:25356970\|PMID:25741868\|PMID:26275793\|PMID:27817865\|PMID:28492532\|PMID:29261183\|PMID:29581464\|PMID:30473481\|PMID:30581749\|PMID:32005694\|PMID:32348839\|PMID:32918965\|PMID:34177781\|PMID:34797029\|PMID:35094435\|PMID:9536098
Ndufaf5	Naked Mole-Rat	mitochondrial complex I deficiency		ISO	RGD:1603963	8554872	ClinVar Annotator: match by term: MITOCHONDRIAL NADH DEHYDROGENASE COMPONENT OF COMPLEX I, DEFICIENCY OF \| more ...	ClinVar	PMID:18940309\|PMID:21607760\|PMID:23536703\|PMID:25326635\|PMID:25356970\|PMID:25741868\|PMID:26467025\|PMID:27817865\|PMID:28492532\|PMID:29261183\|PMID:29581464\|PMID:30473481\|PMID:30581749\|PMID:34177781\|PMID:34797029
Ndufaf5	Naked Mole-Rat	nuclear type mitochondrial complex I deficiency 1		ISO	RGD:1603963	8554872	ClinVar Annotator: match by term: Mitochondrial complex I deficiency, nuclear type 1	ClinVar	PMID:25741868\|PMID:27817865\|PMID:28492532\|PMID:29261183\|PMID:30473481\|PMID:30581749\|PMID:34797029
Ndufaf5	Naked Mole-Rat	nuclear type mitochondrial complex I deficiency 16		ISO	RGD:1603963	8554872	ClinVar Annotator: match by term: MITOCHONDRIAL COMPLEX I DEFICIENCY, NUCLEAR TYPE 16 \| ClinVar Annotator: more ...	ClinVar	PMID:16199547\|PMID:17576681\|PMID:18940309\|PMID:19542079\|PMID:21607760\|PMID:23536703\|PMID:25326635\|PMID:25356970\|PMID:25741868\|PMID:26275793\|PMID:26467025\|PMID:27817865\|PMID:28454995\|PMID:28492532\|PMID:29261183\|PMID:29581464\|PMID:30473481\|PMID:30581749\|PMID:31130284\|PMID:32005694\|PMID:32348839\|PMID:32918965\|PMID:34177781\|PMID:34645488\|PMID:34732400\|PMID:34797029\|PMID:34964562\|PMID:35379322\|PMID:9536098
Ndufaf5	Naked Mole-Rat	Subacute Necrotizing Encephalopathy of Leigh, Infantile		ISO	RGD:1603963	8554872	ClinVar Annotator: match by term: Leigh's necrotizing encephalopathy \| ClinVar Annotator: match by term: Necrotizing more ...	ClinVar	PMID:17576681\|PMID:25326635\|PMID:25356970\|PMID:25741868\|PMID:26275793\|PMID:27817865\|PMID:28492532\|PMID:29261183\|PMID:29581464\|PMID:30473481\|PMID:30581749\|PMID:32005694\|PMID:32348839\|PMID:32918965\|PMID:34177781\|PMID:34797029\|PMID:9536098

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ndufaf5	Naked Mole-Rat	nuclear type mitochondrial complex I deficiency 16		ISO	RGD:1603963	7240710		OMIM

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ndufaf5	Naked Mole-Rat	methylation	involved_in	IEA	UniProtKB-KW:KW-0489	150520179		UniProt	GO_REF:0000043
Ndufaf5	Naked Mole-Rat	mitochondrial respiratory chain complex I assembly	involved_in	IEA	UniProtKB:Q5TEU4\|ensembl:ENSP00000367346	150520179		Ensembl	GO_REF:0000107
Ndufaf5	Naked Mole-Rat	mitochondrial respiratory chain complex I assembly	involved_in	IEA	PANTHER:PTN000318003	150520179		TreeGrafter	GO_REF:0000118

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ndufaf5	Naked Mole-Rat	matrix side of mitochondrial inner membrane	located_in	IEA	UniProtKB:Q5TEU4\|ensembl:ENSP00000367346	150520179		Ensembl	GO_REF:0000107
Ndufaf5	Naked Mole-Rat	mitochondrion	located_in	IEA	UniProtKB:Q5TEU4\|ensembl:ENSP00000367346	150520179		Ensembl	GO_REF:0000107
Ndufaf5	Naked Mole-Rat	mitochondrion	located_in	IEA	PANTHER:PTN000318003	150520179		TreeGrafter	GO_REF:0000118

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ndufaf5	Naked Mole-Rat	methyltransferase activity	enables	IEA	UniProtKB-KW:KW-0489	150520179		UniProt	GO_REF:0000043
Ndufaf5	Naked Mole-Rat	protein binding	enables	ISO	UniProtKB:O75251	9068941	PMID:27226634	UniProt	PMID:27226634
Ndufaf5	Naked Mole-Rat	protein binding	enables	ISO	UniProtKB:A1L188	9068941	PMID:27499296, PMID:28514442, PMID:33961781	UniProt	PMID:27499296\|PMID:28514442\|PMID:33961781
Ndufaf5	Naked Mole-Rat	protein binding	enables	ISO	UniProtKB:Q96I23	9068941	PMID:35614220	UniProt	PMID:35614220
Ndufaf5	Naked Mole-Rat	S-adenosylmethionine-dependent methyltransferase activity	enables	IEA	InterPro:IPR013216	150520179		InterPro	GO_REF:0000002

PMID:22301074	PMID:30032202

Ndufaf5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624741	14,778,109 - 14,823,893 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624741	14,778,126 - 14,824,079 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

NDUFAF5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	13,785,028 - 13,821,580 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	13,785,007 - 13,821,580 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	13,765,674 - 13,802,226 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	13,713,682 - 13,745,874 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	20	13,835,718 - 13,869,123 (+)	NCBI		Celera
Cytogenetic Map	20	p12.1	NCBI
HuRef	20	13,720,309 - 13,753,711 (+)	NCBI		HuRef
CHM1_1	20	13,765,617 - 13,799,023 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	13,828,747 - 13,865,323 (+)	NCBI		T2T-CHM13v2.0

Ndufaf5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	140,012,504 - 140,047,172 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	140,012,569 - 140,045,609 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	140,170,584 - 140,218,965 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	140,170,649 - 140,203,689 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	139,996,382 - 140,030,988 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	139,862,471 - 139,895,073 (+)	NCBI		MGSCv36	mm8
Celera	2	141,356,217 - 141,391,065 (+)	NCBI		Celera
Cytogenetic Map	2	F3	NCBI
cM Map	2	69.2	NCBI

Ndufaf5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	147,961,612 - 147,991,128 (+)	NCBI		GRCr8
mRatBN7.2	3	127,507,931 - 127,537,477 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	127,507,941 - 127,537,477 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	131,371,136 - 131,400,649 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	139,955,232 - 139,984,745 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	137,658,373 - 137,687,888 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	133,232,412 - 133,261,932 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	133,232,432 - 133,261,973 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	139,688,300 - 139,717,717 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	128,353,866 - 128,384,213 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	128,259,473 - 128,289,786 (+)	NCBI
Celera	3	126,154,809 - 126,184,287 (+)	NCBI		Celera
Cytogenetic Map	3	q41	NCBI

Ndufaf5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	23,221,084 - 23,262,073 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955415	23,221,084 - 23,263,548 (+)	NCBI	ChiLan1.0	ChiLan1.0

NDUFAF5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	14,679,233 - 14,715,055 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	14,675,994 - 14,724,032 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	13,751,315 - 13,788,024 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	13,735,768 - 13,769,147 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	13,735,798 - 13,768,671 (+)	Ensembl	panpan1.1		panPan2

NDUFAF5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	8,810,682 - 8,873,212 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	8,837,253 - 8,873,176 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	8,621,611 - 8,684,816 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	9,249,725 - 9,285,751 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	9,247,744 - 9,285,708 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	8,822,205 - 8,885,310 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	8,918,663 - 8,981,572 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	9,267,158 - 9,330,256 (-)	NCBI		UU_Cfam_GSD_1.0

Ndufaf5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	157,563,024 - 157,593,648 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936485	5,992,668 - 6,025,467 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936485	5,994,388 - 6,025,042 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NDUFAF5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	22,480,340 - 22,511,180 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	22,480,344 - 22,508,804 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	25,160,198 - 25,188,788 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NDUFAF5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	42,670,613 - 42,706,341 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	42,670,421 - 42,711,024 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	2,946,890 - 2,982,616 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_004840835	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021255085	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_002393484	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AHKG01019302	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AHKG01019303	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AHKG01019304	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AHKG01019305	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GEBF01000443	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSHGLT00000017602 ⟹ ENSHGLP00000017428

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624741	14,778,109 - 14,823,893 (+)	Ensembl

RefSeq Acc Id:

XM_004840835 ⟹ XP_004840892

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624741	14,778,126 - 14,824,079 (+)	NCBI

RefSeq Acc Id:

XM_021255085 ⟹ XP_021110744

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624741	14,778,126 - 14,824,079 (+)	NCBI

RefSeq Acc Id:

XR_002393484

Type:

NON-CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624741	14,778,126 - 14,823,646 (+)	NCBI


Protein RefSeqs	XP_004840892	(Get FASTA)	NCBI Sequence Viewer
	XP_021110744	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSHGLP00000017428
GenBank Protein	JAO03190	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_021110744 ⟸ XM_021255085
- Peptide Label:	isoform X1
- UniProtKB:	A0AAX6SQA8 (UniProtKB/TrEMBL), G5ALV2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_004840892 ⟸ XM_004840835
- Peptide Label:	isoform X2
- UniProtKB:	A0A0N8EUW5 (UniProtKB/TrEMBL), G5ALV2 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSHGLP00000017428 ⟸ ENSHGLT00000017602

Database	Acc Id	Source(s)
Ensembl Genes	ENSHGLG00000012482	Ensembl, ENTREZGENE
Ensembl Transcript	ENSHGLT00000017602	ENTREZGENE
Gene3D-CATH	3.40.50.150	UniProtKB/TrEMBL
InterPro	Malonyl-ACP_OMT	UniProtKB/TrEMBL
	Methyltransf_11	UniProtKB/TrEMBL
	SAM-dependent_MTases	UniProtKB/TrEMBL
KEGG Report	hgl:101704983	UniProtKB/TrEMBL
NCBI Gene	Ndufaf5	ENTREZGENE
PANTHER	ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL	UniProtKB/TrEMBL
	UNCHARACTERIZED	UniProtKB/TrEMBL
Pfam	Methyltransf_11	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53335	UniProtKB/TrEMBL
UniProt	A0A0N8EUW5	ENTREZGENE, UniProtKB/TrEMBL
	A0AAX6SQA8	ENTREZGENE, UniProtKB/TrEMBL
	G5ALV2	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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