Nkx2-8 (NK2 homeobox 8) - Rat Genome Database

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Gene: Nkx2-8 (NK2 homeobox 8) Heterocephalus glaber
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Symbol: Nkx2-8
Name: NK2 homeobox 8
RGD ID: 18910598
Description: ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN axonogenesis (ortholog); DNA-templated transcription (ortholog); epithelial cell proliferation (ortholog); ASSOCIATED WITH Brain-Lung-Thyroid Syndrome (ortholog); choreatic disease (ortholog); spina bifida (ortholog); FOUND IN nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Homeobox protein Nkx-2.8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624838228,153 - 229,728 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624838227,941 - 234,431 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Nkx2-8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624838228,153 - 229,728 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624838227,941 - 234,431 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
NKX2-8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381436,580,004 - 36,582,614 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1436,580,004 - 36,582,614 (-)EnsemblGRCh38hg38GRCh38
GRCh371437,049,209 - 37,051,819 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361436,118,967 - 36,121,537 (-)NCBINCBI36Build 36hg18NCBI36
Build 341436,118,967 - 36,121,537NCBI
Celera1416,912,759 - 16,915,329 (-)NCBICelera
Cytogenetic Map14q13.3NCBI
HuRef1417,163,843 - 17,166,413 (-)NCBIHuRef
CHM1_11437,048,339 - 37,050,909 (-)NCBICHM1_1
T2T-CHM13v2.01430,769,341 - 30,771,951 (-)NCBIT2T-CHM13v2.0
Nkx2-9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391256,658,174 - 56,660,354 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1256,658,174 - 56,660,069 (-)EnsemblGRCm39 Ensembl
GRCm381256,611,389 - 56,613,569 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1256,611,389 - 56,613,284 (-)EnsemblGRCm38mm10GRCm38
MGSCv371257,712,380 - 57,714,271 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361257,529,411 - 57,531,296 (-)NCBIMGSCv36mm8
Celera1257,768,666 - 57,770,465 (-)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1224.47NCBI
Nkx2-8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8679,821,342 - 79,823,045 (-)NCBIGRCr8
mRatBN7.2674,086,274 - 74,087,977 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl674,086,274 - 74,087,977 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx674,482,683 - 74,484,386 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0674,789,074 - 74,790,777 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0674,216,539 - 74,218,242 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0677,506,882 - 77,508,585 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl677,506,882 - 77,508,585 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0687,033,998 - 87,035,701 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4677,007,954 - 77,009,657 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1677,011,215 - 77,012,752 (-)NCBI
Celera672,893,390 - 72,895,093 (-)NCBICelera
Cytogenetic Map6q23NCBI
Nkx2-8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540924,529,594 - 24,530,998 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540924,529,414 - 24,531,293 (+)NCBIChiLan1.0ChiLan1.0
NKX2-8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21537,893,148 - 37,896,290 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11437,109,648 - 37,112,786 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01417,332,188 - 17,335,036 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11435,693,746 - 35,696,346 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1435,693,746 - 35,696,339 (-)Ensemblpanpan1.1panPan2
NKX2-8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1815,149,318 - 15,151,884 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl815,149,308 - 15,151,661 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha814,949,217 - 14,951,088 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0815,261,532 - 15,263,403 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl815,261,531 - 15,263,691 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1814,959,436 - 14,961,305 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0815,026,476 - 15,028,341 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0815,316,460 - 15,318,331 (-)NCBIUU_Cfam_GSD_1.0
Nkx2-8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864047,074,257 - 47,076,109 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649410,580,445 - 10,581,798 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649410,580,445 - 10,581,798 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NKX2-8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl763,423,403 - 63,426,514 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1763,418,149 - 63,425,651 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2768,331,180 - 68,339,061 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NKX2-8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12413,379,287 - 13,382,596 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2413,379,687 - 13,381,185 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660532,378,023 - 2,380,654 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000002030   ⟹   ENSHGLP00000001984
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624838228,153 - 229,728 (+)Ensembl
RefSeq Acc Id: XM_004867545   ⟹   XP_004867602
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624838227,941 - 234,431 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004867602 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB15813 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000001984
RefSeq Acc Id: XP_004867602   ⟸   XM_004867545
- UniProtKB: A0AAX6Q878 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000001984   ⟸   ENSHGLT00000002030


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000001507 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000002030 ENTREZGENE
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro HD_metazoa UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_NK-like UniProtKB/TrEMBL
  Homeodomain-like_sf UniProtKB/TrEMBL
  IPR001356 UniProtKB/TrEMBL
NCBI Gene Nkx2-8 ENTREZGENE
PANTHER HOMEOBOX PROTEIN NKX UniProtKB/TrEMBL
  HOMEOBOX PROTEIN NKX-2.8 UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/TrEMBL
PRINTS HOMEOBOX UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain-like UniProtKB/TrEMBL
UniProt A0AAX6Q878 ENTREZGENE, UniProtKB/TrEMBL