Nkx2-8 (NK2 homeobox 8) - Rat Genome Database

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Gene: Nkx2-8 (NK2 homeobox 8) Rattus norvegicus
Analyze
Symbol: Nkx2-8
Name: NK2 homeobox 8
RGD ID: 1310629
Description: Enables sequence-specific DNA binding activity. Predicted to be involved in cell differentiation; positive regulation of transcription by RNA polymerase II; and transcription by RNA polymerase II. Predicted to act upstream of or within axonogenesis; lung development; and negative regulation of epithelial cell proliferation. Predicted to be active in nucleus. Orthologous to human NKX2-8 (NK2 homeobox 8); INTERACTS WITH bisphenol A; Cuprizon; 17beta-estradiol (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: homeobox protein Nkx-2.8; LOC299061; NK2 transcription factor related, locus 9; NK2 transcription factor related, locus 9 (Drosophila); Nkx2-9
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8679,821,342 - 79,823,045 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl679,821,342 - 79,823,045 (-)EnsemblGRCr8
mRatBN7.2674,086,274 - 74,087,977 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl674,086,274 - 74,087,977 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx674,482,683 - 74,484,386 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0674,789,074 - 74,790,777 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0674,216,539 - 74,218,242 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0677,506,882 - 77,508,585 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl677,506,882 - 77,508,585 (-)Ensemblrn6Rnor6.0
Rnor_5.0687,033,998 - 87,035,701 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4677,007,954 - 77,009,657 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera672,893,390 - 72,895,093 (-)NCBICelera
RGSC_v3.1677,011,215 - 77,012,752 (-)NCBI
Cytogenetic Map6q23NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Regulation of alpha-fetoprotein expression by Nkx2.8. Kajiyama Y, etal., Mol Cell Biol 2002 Sep;22(17):6122-30.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:9446603   PMID:16267219   PMID:17079460   PMID:30361391  


Genomics

Comparative Map Data
Nkx2-8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8679,821,342 - 79,823,045 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl679,821,342 - 79,823,045 (-)EnsemblGRCr8
mRatBN7.2674,086,274 - 74,087,977 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl674,086,274 - 74,087,977 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx674,482,683 - 74,484,386 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0674,789,074 - 74,790,777 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0674,216,539 - 74,218,242 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0677,506,882 - 77,508,585 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl677,506,882 - 77,508,585 (-)Ensemblrn6Rnor6.0
Rnor_5.0687,033,998 - 87,035,701 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4677,007,954 - 77,009,657 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera672,893,390 - 72,895,093 (-)NCBICelera
RGSC_v3.1677,011,215 - 77,012,752 (-)NCBI
Cytogenetic Map6q23NCBI
NKX2-8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381436,580,004 - 36,582,614 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1436,580,004 - 36,582,614 (-)Ensemblhg38GRCh38
GRCh371437,049,209 - 37,051,819 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361436,118,967 - 36,121,537 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341436,118,967 - 36,121,537NCBI
Celera1416,912,759 - 16,915,329 (-)NCBICelera
Cytogenetic Map14q13.3NCBI
HuRef1417,163,843 - 17,166,413 (-)NCBIHuRef
CHM1_11437,048,339 - 37,050,909 (-)NCBICHM1_1
T2T-CHM13v2.01430,769,341 - 30,771,951 (-)NCBIT2T-CHM13v2.0
Nkx2-9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391256,658,174 - 56,660,354 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1256,658,174 - 56,660,069 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381256,611,389 - 56,613,569 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1256,611,389 - 56,613,284 (-)Ensemblmm10GRCm38
MGSCv371257,712,380 - 57,714,271 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361257,529,411 - 57,531,296 (-)NCBIMGSCv36mm8
Celera1257,768,666 - 57,770,465 (-)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1224.47NCBI
Nkx2-8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540924,529,594 - 24,530,998 (+)Ensembl
ChiLan1.0NW_00495540924,529,414 - 24,531,293 (+)NCBIChiLan1.0ChiLan1.0
NKX2-8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21537,893,148 - 37,896,290 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11437,109,648 - 37,112,786 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01417,332,188 - 17,335,036 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11435,693,746 - 35,696,346 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1435,693,746 - 35,696,339 (-)EnsemblpanPan2panpan1.1
NKX2-8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1815,149,318 - 15,151,884 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl815,149,308 - 15,151,661 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha814,949,217 - 14,951,088 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0815,261,532 - 15,263,403 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl815,261,531 - 15,263,691 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1814,959,436 - 14,961,305 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0815,026,476 - 15,028,341 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0815,316,460 - 15,318,331 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nkx2-8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864047,074,257 - 47,076,109 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649410,580,445 - 10,581,798 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649410,580,445 - 10,581,798 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NKX2-8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl763,423,403 - 63,426,514 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1763,418,149 - 63,425,651 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2768,331,180 - 68,339,061 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NKX2-8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12413,379,287 - 13,382,596 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2413,379,687 - 13,381,185 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660532,378,023 - 2,380,654 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nkx2-8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624838228,153 - 229,728 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624838227,941 - 234,431 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Nkx2-8
6 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:99
Count of miRNA genes:79
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000011562
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)64451097489510974Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
4889933Bss88Bone structure and strength QTL 883.8tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)65368492198684921Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)64095756485957564Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)64515378690153786Rat
5684992Bmd83Bone mineral density QTL 824.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)65368492198684921Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)66345744194939581Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)64604735391047353Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)66303731995934232Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63902865986867923Rat
5684963Bss99Bone structure and strength QTL 993.1tibia area (VT:1000281)tibia area measurement (CMO:0001382)65368492198684921Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)64016318385163183Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)66345744194939581Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
3 1 28 3 16 1 3 6 3 25 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000011562   ⟹   ENSRNOP00000011591
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl679,821,342 - 79,823,045 (-)Ensembl
mRatBN7.2 Ensembl674,086,274 - 74,087,977 (-)Ensembl
Rnor_6.0 Ensembl677,506,882 - 77,508,585 (-)Ensembl
RefSeq Acc Id: NM_001106732   ⟹   NP_001100202
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8679,821,342 - 79,823,045 (-)NCBI
mRatBN7.2674,086,274 - 74,087,977 (-)NCBI
Rnor_6.0677,506,882 - 77,508,585 (-)NCBI
Rnor_5.0687,033,998 - 87,035,701 (-)NCBI
RGSC_v3.4677,007,954 - 77,009,657 (-)RGD
Celera672,893,390 - 72,895,093 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100202 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM03444 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000011591
  ENSRNOP00000011591.3
RefSeq Acc Id: NP_001100202   ⟸   NM_001106732
- UniProtKB: D4A7B5 (UniProtKB/TrEMBL),   A6HBN9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011591   ⟸   ENSRNOT00000011562
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A7B5-F1-model_v2 AlphaFold D4A7B5 1-234 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310629 AgrOrtholog
BioCyc Gene G2FUF-37428 BioCyc
Ensembl Genes ENSRNOG00000022970 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011562 ENTREZGENE
  ENSRNOT00000011562.5 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_NK-like UniProtKB/TrEMBL
  Homeobox_region UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
KEGG Report rno:299061 UniProtKB/TrEMBL
NCBI Gene 299061 ENTREZGENE
PANTHER HOMEOBOX PROTEIN NKX UniProtKB/TrEMBL
  HOMEOBOX PROTEIN NKX-2.8 UniProtKB/TrEMBL
Pfam Homeobox UniProtKB/TrEMBL
PhenoGen Nkx2-8 PhenoGen
PRINTS HOMEOBOX UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022970 RatGTEx
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
UniProt A6HBN9 ENTREZGENE, UniProtKB/TrEMBL
  D4A7B5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-26 Nkx2-8  NK2 homeobox 8  Nkx2-9  NK2 transcription factor related, locus 9 (Drosophila)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Nkx2-9  NK2 transcription factor related, locus 9 (Drosophila)   Nkx2-9_predicted  NK2 transcription factor related, locus 9 (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Nkx2-9_predicted  NK2 transcription factor related, locus 9 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED