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Gene: Dcaf11 (DDB1 and CUL4 associated factor 11) Heterocephalus glaber

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Symbol:

Dcaf11

Name:

DDB1 and CUL4 associated factor 11

RGD ID:

18905889

Description:

INVOLVED IN cognition (inferred); exploration behavior (inferred); gene expression (inferred); ASSOCIATED WITH Brain-Lung-Thyroid Syndrome (ortholog); lysinuric protein intolerance (ortholog); Specific Granule Deficiency (ortholog); FOUND IN Cul4-RING E3 ubiquitin ligase complex (inferred); nucleoplasm (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

DDB1- and CUL4-associated factor 11; WD repeat-containing protein 23

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624820	8,407,596 - 8,415,295 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624820	8,407,597 - 8,415,301 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dcaf11	Naked Mole-Rat	Brain-Lung-Thyroid Syndrome		ISO	DCAF11 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Brain-lung-thyroid syndrome	ClinVar	PMID:25741868
Dcaf11	Naked Mole-Rat	lysinuric protein intolerance		ISO	DCAF11 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Lysinuric protein intolerance	ClinVar	PMID:28492532
Dcaf11	Naked Mole-Rat	Specific Granule Deficiency		ISO	DCAF11 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Specific granule deficiency	ClinVar	PMID:28492532

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dcaf11	Naked Mole-Rat	cognition	acts_upstream_of_or_within	IEA	UniProtKB:Q91VU6 and ensembl:ENSMUSP00000114211	150520179		Ensembl	GO_REF:0000107
Dcaf11	Naked Mole-Rat	exploration behavior	acts_upstream_of_or_within	IEA	UniProtKB:Q91VU6 and ensembl:ENSMUSP00000114211	150520179		Ensembl	GO_REF:0000107
Dcaf11	Naked Mole-Rat	gene expression	acts_upstream_of_or_within	IEA	UniProtKB:Q91VU6 and ensembl:ENSMUSP00000114211	150520179		Ensembl	GO_REF:0000107
Dcaf11	Naked Mole-Rat	memory	acts_upstream_of_or_within	IEA	UniProtKB:Q91VU6 and ensembl:ENSMUSP00000114211	150520179		Ensembl	GO_REF:0000107
Dcaf11	Naked Mole-Rat	proteasome-mediated ubiquitin-dependent protein catabolic process	involved_in	IEA	PANTHER:PTN000457310	150520179		TreeGrafter	GO_REF:0000118
Dcaf11	Naked Mole-Rat	protein stabilization	acts_upstream_of_or_within	IEA	UniProtKB:Q91VU6 and ensembl:ENSMUSP00000114211	150520179		Ensembl	GO_REF:0000107
Dcaf11	Naked Mole-Rat	protein ubiquitination	involved_in	IEA	UniPathway:UPA00143	150520179		UniProt	GO_REF:0000041
Dcaf11	Naked Mole-Rat	respiratory system process	acts_upstream_of_or_within	IEA	UniProtKB:Q91VU6 and ensembl:ENSMUSP00000114211	150520179		Ensembl	GO_REF:0000107
Dcaf11	Naked Mole-Rat	response to oxidative stress	acts_upstream_of_or_within	IEA	UniProtKB:Q91VU6 and ensembl:ENSMUSP00000114211	150520179		Ensembl	GO_REF:0000107

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dcaf11	Naked Mole-Rat	Cul4-RING E3 ubiquitin ligase complex	part_of	IEA	PANTHER:PTN000457310	150520179		TreeGrafter	GO_REF:0000118
Dcaf11	Naked Mole-Rat	Cul4-RING E3 ubiquitin ligase complex	part_of	IEA	UniProtKB:Q8TEB1 and ensembl:ENSP00000415556	150520179		Ensembl	GO_REF:0000107
Dcaf11	Naked Mole-Rat	nucleoplasm	located_in	IEA	UniProtKB:Q8TEB1 and ensembl:ENSP00000415556	150520179		Ensembl	GO_REF:0000107

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Dcaf11	Naked Mole-Rat	protein binding	enables	ISO	UniProtKB:Q8XB62	9068941	PMID:27018634	AgBase	PMID:27018634
Dcaf11	Naked Mole-Rat	protein binding	enables	ISO	UniProtKB:O95994 more ...	9068941	PMID:32296183	IntAct	PMID:32296183
Dcaf11	Naked Mole-Rat	protein binding	enables	ISO	UniProtKB:P12504	9068941	PMID:22190034	IntAct	PMID:22190034
Dcaf11	Naked Mole-Rat	protein binding	enables	ISO	UniProtKB:Q13619 more ...	9068941	PMID:16949367	UniProt	PMID:16949367
Dcaf11	Naked Mole-Rat	protein binding	enables	ISO	UniProtKB:Q16531	9068941	PMID:19109893 more ...	IntAct	PMID:19109893 more ...

PMID:21993625	PMID:22301074	PMID:30032202

Dcaf11
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624820	8,407,596 - 8,415,295 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624820	8,407,597 - 8,415,301 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

DCAF11
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	24,114,777 - 24,125,242 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	24,114,195 - 24,125,242 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	24,583,986 - 24,594,451 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	23,653,861 - 23,664,291 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	23,653,860 - 23,664,290	NCBI
Celera	14	4,448,376 - 4,458,921 (+)	NCBI		Celera
Cytogenetic Map	14	q12	NCBI
HuRef	14	4,699,126 - 4,709,671 (+)	NCBI		HuRef
CHM1_1	14	24,582,565 - 24,593,110 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	18,313,090 - 18,323,554 (+)	NCBI		T2T-CHM13v2.0

Dcaf11
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	55,796,557 - 55,807,522 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	55,797,463 - 55,807,522 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	55,559,125 - 55,570,065 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	55,560,006 - 55,570,065 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	56,178,869 - 56,188,902 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	54,514,103 - 54,524,136 (+)	NCBI		MGSCv36	mm8
Celera	14	53,364,886 - 53,374,919 (+)	NCBI		Celera
Cytogenetic Map	14	C3	NCBI
cM Map	14	28.19	NCBI

Dcaf11
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	33,015,370 - 33,027,407 (+)	NCBI		GRCr8
mRatBN7.2	15	29,046,744 - 29,057,450 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	29,046,826 - 29,057,669 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	30,892,505 - 30,903,150 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	32,039,711 - 32,050,356 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	30,282,055 - 30,292,700 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	34,233,840 - 34,244,512 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	34,234,193 - 34,244,504 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	38,124,048 - 38,134,707 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	33,691,576 - 33,701,328 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	33,707,275 - 33,717,025 (+)	NCBI
Celera	15	28,622,724 - 28,633,369 (+)	NCBI		Celera
Cytogenetic Map	15	p13	NCBI

Dcaf11
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	36,272,184 - 36,279,872 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	36,272,184 - 36,279,985 (-)	NCBI	ChiLan1.0	ChiLan1.0

DCAF11
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	25,465,976 - 25,478,412 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	24,682,468 - 24,694,904 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	4,890,956 - 4,900,296 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	23,015,525 - 23,024,650 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	23,015,680 - 23,024,650 (+)	Ensembl	panpan1.1		panPan2

DCAF11
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	4,115,756 - 4,124,329 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	4,116,912 - 4,123,596 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	4,037,424 - 4,045,984 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	4,226,332 - 4,234,902 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	4,226,712 - 4,234,912 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	3,916,964 - 3,925,526 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	3,978,716 - 3,987,276 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	4,240,837 - 4,249,445 (+)	NCBI		UU_Cfam_GSD_1.0

Dcaf11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	35,966,258 - 35,974,161 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936722	414,831 - 422,694 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936722	414,830 - 422,722 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DCAF11
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	75,168,992 - 75,180,953 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	75,169,701 - 75,181,137 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	80,442,389 - 80,452,269 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DCAF11
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	1,100,974 - 1,110,283 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	1,101,653 - 1,111,965 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666036	12,782,646 - 12,792,028 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_004864133	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_004864135	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021243859	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021243860	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001182317	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_002389112	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AHKG01080464	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GEBF01004968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JH168072	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSHGLT00000004401 ⟹ ENSHGLP00000004341

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624820	8,407,596 - 8,415,295 (-)	Ensembl

RefSeq Acc Id:

XM_004864133 ⟹ XP_004864190

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624820	8,407,597 - 8,415,301 (-)	NCBI

RefSeq Acc Id:

XM_004864135 ⟹ XP_004864192

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624820	8,407,597 - 8,415,301 (-)	NCBI

RefSeq Acc Id:

XM_021243859 ⟹ XP_021099518

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624820	8,407,597 - 8,414,804 (-)	NCBI

RefSeq Acc Id:

XM_021243860 ⟹ XP_021099519

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624820	8,407,597 - 8,414,803 (-)	NCBI

RefSeq Acc Id:

XR_001182317

Type:

NON-CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624820	8,408,435 - 8,415,301 (-)	NCBI

RefSeq Acc Id:

XR_002389112

Type:

NON-CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624820	8,408,547 - 8,415,301 (-)	NCBI


Protein RefSeqs	XP_004864190	(Get FASTA)	NCBI Sequence Viewer
	XP_004864192	(Get FASTA)	NCBI Sequence Viewer
	XP_021099518	(Get FASTA)	NCBI Sequence Viewer
	XP_021099519	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EHB03408	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSHGLP00000004341
GenBank Protein	JAN98664	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_004864192 ⟸ XM_004864135
- Peptide Label:	isoform X2
- UniProtKB:	G5B298 (UniProtKB/TrEMBL), A0AAX6Q300 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_004864190 ⟸ XM_004864133
- Peptide Label:	isoform X1
- UniProtKB:	A0A0P6J7Q1 (UniProtKB/TrEMBL), G5B298 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_021099518 ⟸ XM_021243859
- Peptide Label:	isoform X1
- UniProtKB:	A0A0P6J7Q1 (UniProtKB/TrEMBL), G5B298 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_021099519 ⟸ XM_021243860
- Peptide Label:	isoform X2
- UniProtKB:	G5B298 (UniProtKB/TrEMBL), A0AAX6Q300 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSHGLP00000004341 ⟸ ENSHGLT00000004401

Database	Acc Id	Source(s)
Ensembl Genes	ENSHGLG00000003175	Ensembl, ENTREZGENE
Ensembl Transcript	ENSHGLT00000004401	ENTREZGENE
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
InterPro	DCAF	UniProtKB/TrEMBL
	DCAF11/LEC14B	UniProtKB/TrEMBL
	G-protein_beta_WD-40_rep	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom_sf	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
KEGG Report	hgl:101704427	UniProtKB/TrEMBL
NCBI Gene	Dcaf11	ENTREZGENE
PANTHER	DDB1- AND CUL4-ASSOCIATED FACTOR 11	UniProtKB/TrEMBL
	DDB1- AND CUL4-ASSOCIATED FACTOR 11	UniProtKB/TrEMBL
Pfam	WD40	UniProtKB/TrEMBL
PIRSF	WD_repeat_p23	UniProtKB/TrEMBL
PRINTS	GPROTEINBRPT	UniProtKB/TrEMBL
PROSITE	WD_REPEATS_2	UniProtKB/TrEMBL
	WD_REPEATS_REGION	UniProtKB/TrEMBL
SMART	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50978	UniProtKB/TrEMBL
UniProt	A0A0P6J7Q1	ENTREZGENE, UniProtKB/TrEMBL
	A0AAX6Q300	ENTREZGENE, UniProtKB/TrEMBL
	G5B298	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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Imported Disease Annotations - ClinVar