Tldc2 (TBC/LysM-associated domain containing 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Tldc2 (TBC/LysM-associated domain containing 2) Heterocephalus glaber
Analyze
Symbol: Tldc2
Name: TBC/LysM-associated domain containing 2
RGD ID: 18905438
Description: INVOLVED IN negative regulation of cellular response to oxidative stress (ortholog); ASSOCIATED WITH Aicardi-Goutieres syndrome (ortholog); Aicardi-Goutieres Syndrome 5 (ortholog); Chilblain Lupus 2 (ortholog); FOUND IN nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: TLD domain-containing protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248422,626,897 - 2,668,822 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248422,649,943 - 2,668,957 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IEA)

References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Tldc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248422,626,897 - 2,668,822 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248422,649,943 - 2,668,957 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TLDC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382036,876,121 - 36,894,235 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2036,876,121 - 36,894,235 (+)EnsemblGRCh38hg38GRCh38
GRCh372035,504,524 - 35,522,638 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362034,937,984 - 34,956,046 (+)NCBINCBI36Build 36hg18NCBI36
Celera2032,212,079 - 32,230,180 (+)NCBICelera
Cytogenetic Map20q11.23NCBI
HuRef2032,240,663 - 32,258,356 (+)NCBIHuRef
CHM1_12035,406,122 - 35,424,192 (+)NCBICHM1_1
T2T-CHM13v2.02038,597,382 - 38,618,601 (+)NCBIT2T-CHM13v2.0
Tldc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392156,918,542 - 156,938,868 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2156,928,975 - 156,938,402 (+)EnsemblGRCm39 Ensembl
GRCm382157,076,627 - 157,096,948 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2157,087,055 - 157,096,482 (+)EnsemblGRCm38mm10GRCm38
MGSCv372156,912,791 - 156,922,217 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362156,779,835 - 156,787,922 (+)NCBIMGSCv36mm8
Celera2163,020,296 - 163,029,764 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map277.99NCBI
Tldc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83166,162,315 - 166,178,881 (+)NCBIGRCr8
mRatBN7.23145,742,381 - 145,758,847 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3145,743,619 - 145,758,741 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.03153,195,295 - 153,208,118 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3153,197,644 - 153,207,816 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03158,506,894 - 158,519,839 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43147,675,172 - 147,687,339 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3144,452,720 - 144,465,559 (+)NCBICelera
Cytogenetic Map3q42NCBI
Tldc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542224,781,806 - 24,793,625 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542224,781,476 - 24,795,112 (-)NCBIChiLan1.0ChiLan1.0
TLDC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22142,612,137 - 42,626,703 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12042,605,235 - 42,618,976 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02033,204,182 - 33,221,160 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12034,321,315 - 34,342,670 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2034,321,315 - 34,342,664 (+)Ensemblpanpan1.1panPan2
TLDC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12425,602,002 - 25,623,273 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2425,610,851 - 25,623,803 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2425,245,688 - 25,268,284 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02426,297,990 - 26,320,648 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2426,308,277 - 26,321,178 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12425,575,548 - 25,598,308 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02425,676,015 - 25,698,821 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02426,165,476 - 26,188,297 (+)NCBIUU_Cfam_GSD_1.0
Tldc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640174,509,374 - 174,519,623 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365614,230,257 - 4,241,425 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365614,229,945 - 4,241,425 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLDC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1740,109,210 - 40,120,399 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11740,105,500 - 40,118,743 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21745,548,275 - 45,557,678 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TLDC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1257,629,205 - 57,640,736 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl257,627,764 - 57,640,177 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666054417,260 - 431,726 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000012997   ⟹   ENSHGLP00000012860
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248422,626,897 - 2,668,822 (-)Ensembl
RefSeq Acc Id: XM_004867810   ⟹   XP_004867867
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248422,649,943 - 2,662,340 (-)NCBI
RefSeq Acc Id: XM_004867812   ⟹   XP_004867869
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248422,649,943 - 2,662,334 (-)NCBI
RefSeq Acc Id: XM_021246839   ⟹   XP_021102498
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248422,649,943 - 2,668,957 (-)NCBI
RefSeq Acc Id: XM_021246840   ⟹   XP_021102499
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248422,649,943 - 2,662,943 (-)NCBI
RefSeq Acc Id: XM_021246841   ⟹   XP_021102500
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248422,649,943 - 2,668,951 (-)NCBI
RefSeq Acc Id: XM_021246842   ⟹   XP_021102501
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248422,649,943 - 2,662,943 (-)NCBI
RefSeq Acc Id: XM_021246843   ⟹   XP_021102502
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248422,649,943 - 2,668,949 (-)NCBI
RefSeq Acc Id: XM_021246844   ⟹   XP_021102503
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248422,649,943 - 2,668,256 (-)NCBI
RefSeq Acc Id: XP_021102498   ⟸   XM_021246839
- Peptide Label: isoform X1
- UniProtKB: A0AAX6S0H1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021102500   ⟸   XM_021246841
- Peptide Label: isoform X3
- UniProtKB: G5B829 (UniProtKB/TrEMBL),   A0AAX6S2E2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021102502   ⟸   XM_021246843
- Peptide Label: isoform X5
- UniProtKB: G5B829 (UniProtKB/TrEMBL),   A0AAX6S3D0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021102503   ⟸   XM_021246844
- Peptide Label: isoform X6
- UniProtKB: G5B829 (UniProtKB/TrEMBL),   A0AAX6Q8N0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021102501   ⟸   XM_021246842
- Peptide Label: isoform X4
- UniProtKB: G5B829 (UniProtKB/TrEMBL),   A0AAX6S186 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021102499   ⟸   XM_021246840
- Peptide Label: isoform X2
- UniProtKB: G5B829 (UniProtKB/TrEMBL),   A0AAX6S0Y5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004867867   ⟸   XM_004867810
- Peptide Label: isoform X6
- UniProtKB: G5B829 (UniProtKB/TrEMBL),   A0AAX6Q8N0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004867869   ⟸   XM_004867812
- Peptide Label: isoform X6
- UniProtKB: G5B829 (UniProtKB/TrEMBL),   A0AAX6Q8N0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000012860   ⟸   ENSHGLT00000012997


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000009192 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000012997 ENTREZGENE
InterPro TLDc_dom UniProtKB/TrEMBL
NCBI Gene Tldc2 ENTREZGENE
PANTHER NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED UniProtKB/TrEMBL
  TLD DOMAIN-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
Pfam TLD UniProtKB/TrEMBL
PROSITE TLDC UniProtKB/TrEMBL
SMART TLDc UniProtKB/TrEMBL
UniProt A0AAX6Q8N0 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6S0H1 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6S0Y5 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6S186 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6S2E2 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6S3D0 ENTREZGENE, UniProtKB/TrEMBL
  G5B829 ENTREZGENE, UniProtKB/TrEMBL