Tldc2 (TBC/LysM-associated domain containing 2)

Gene: Tldc2 (TBC/LysM-associated domain containing 2) Ictidomys tridecemlineatus

Analyze

Symbol:

Tldc2

Name:

TBC/LysM-associated domain containing 2

RGD ID:

12676596

Description:

INVOLVED IN negative regulation of cellular response to oxidative stress (ortholog); ASSOCIATED WITH Aicardi-Goutieres syndrome (ortholog); Aicardi-Goutieres Syndrome 5 (ortholog); Chilblain Lupus 2 (ortholog); FOUND IN nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

TBC/LysM-associated domain containing 2, transcript variant X1; TBC/LysM-associated domain containing 2, transcript variant X2; TLD domain-containing protein 2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	174,509,374 - 174,519,623 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936561	4,230,257 - 4,241,425 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936561	4,229,945 - 4,241,425 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Aicardi-Goutieres syndrome (ISO)

Aicardi-Goutieres Syndrome 5 (ISO)

Chilblain Lupus 2 (ISO)

focal epilepsy (ISO)

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of cellular response to oxidative stress (IEA,ISO)

response to oxidative stress (IEA)

Cellular Component

nucleus (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Tldc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	174,509,374 - 174,519,623 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936561	4,230,257 - 4,241,425 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936561	4,229,945 - 4,241,425 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TLDC2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	36,876,121 - 36,894,235 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	36,876,121 - 36,894,235 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	35,504,524 - 35,522,638 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	34,937,984 - 34,956,046 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	20	32,212,079 - 32,230,180 (+)	NCBI		Celera
Cytogenetic Map	20	q11.23	NCBI
HuRef	20	32,240,663 - 32,258,356 (+)	NCBI		HuRef
CHM1_1	20	35,406,122 - 35,424,192 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	38,597,382 - 38,618,601 (+)	NCBI		T2T-CHM13v2.0

Tldc2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	156,918,542 - 156,938,868 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	156,928,975 - 156,938,402 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	157,076,627 - 157,096,948 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	157,087,055 - 157,096,482 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	156,912,791 - 156,922,217 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	156,779,835 - 156,787,922 (+)	NCBI		MGSCv36	mm8
Celera	2	163,020,296 - 163,029,764 (+)	NCBI		Celera
Cytogenetic Map	2	H1	NCBI
cM Map	2	77.99	NCBI

Tldc2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	166,162,315 - 166,178,881 (+)	NCBI		GRCr8
mRatBN7.2	3	145,742,381 - 145,758,847 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	145,743,619 - 145,758,741 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	3	153,195,295 - 153,208,118 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	153,197,644 - 153,207,816 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	158,506,894 - 158,519,839 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	147,675,172 - 147,687,339 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	144,452,720 - 144,465,559 (+)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

Tldc2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	24,781,806 - 24,793,625 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	24,781,476 - 24,795,112 (-)	NCBI	ChiLan1.0	ChiLan1.0

TLDC2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	42,612,137 - 42,626,703 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	42,605,235 - 42,618,976 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	33,204,182 - 33,221,160 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	34,321,315 - 34,342,670 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	34,321,315 - 34,342,664 (+)	Ensembl	panpan1.1		panPan2

TLDC2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	25,602,002 - 25,623,273 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	25,610,851 - 25,623,803 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	25,245,688 - 25,268,284 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	26,297,990 - 26,320,648 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	26,308,277 - 26,321,178 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	25,575,548 - 25,598,308 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	25,676,015 - 25,698,821 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	26,165,476 - 26,188,297 (+)	NCBI		UU_Cfam_GSD_1.0

TLDC2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	40,109,210 - 40,120,399 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	40,105,500 - 40,118,743 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	45,548,275 - 45,557,678 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TLDC2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	57,629,205 - 57,640,736 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	57,627,764 - 57,640,177 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	417,260 - 431,726 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tldc2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624842	2,626,897 - 2,668,822 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624842	2,649,943 - 2,668,957 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005329860	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013360549	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010003700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000000596 ⟹ ENSSTOP00000000542

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936561	4,230,257 - 4,241,425 (-)	Ensembl

RefSeq Acc Id:

XM_005329860 ⟹ XP_005329917

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	174,509,374 - 174,519,623 (+)	NCBI
SpeTri2.0	NW_004936561	4,229,945 - 4,241,425 (-)	NCBI

Sequence:

show sequence

ATGCAAGGTCTCCGCTGGCGTTACACGAGGCTGCCCAGCCAGATGGAGGACACCATGTCTGGGG
AGGAGGGTGAGGAGGAGGAAGAGGAAGAGGAGACAGCCCCAGCCCCAGCTCCTGCCCCTACCCC
CGAAGACCCCGTGGAGCCCCAGCTGACAGAAGCCAGCCAGGTGCTCGGTGCCTCGGAGATCAGG
CAGCTTAGCCTCCACCTCCCCGCACGAGTCACCGGCCACCCCTGGAGTCTCGTTTTCTGTACGT
CGAGGGACGGCTTTAGTCTGCGGAGCCTGTACCGGCAGATGGAAGGCCACAGTGGGCCAGTGCT
GCTGCTCCTGAGGGACCAGGATGGGCAGATGTTTGGCGCCTTCTCCTCCTCAGCCCTTCGACTC
AGCAAGGGCTTCTACGGCACAGGCGAGACCTTCCTCTTCTCCTTCTCCCCACAGCTGAAGGTCT
TTAAGTGGACAGGAAGCAACTCTTTCTTTGTGAAAGGAGACTTGGATTCCCTGATGATGGGCAG
TGGCAGCGGCCAGTTTGGGCTATGGTTAGACGGAGACCTGTATCACGGGGGAAGCCACCCCTGC
GCGACCTTCAACAATGAGGTGCTGGCCCGGCGCGAGCAGTTCTGCATCAAGGAGCTGGAGGCCT
GGGTTCTGAGCTGATGCCCTGTGCCAGCAGCTTCCTGGGCCACAGGGACTCAGACCTGCTCATG
GACGCTGTCCAGGTCTTCCTCACATGGGGCAGCCCCTTCTGAAACTAGGATGACATACTCATGT
TGACTCTGGCTGTTGGACAGCCTCCTTATGGCTTGAGGACAGACAGGTAGGGGGGCAGACACTG
TTCTGCATAAGTGATCTGAATATGTGAAAGACACACCTTACCCAAGAAGCAGAGTACCTCATGA
AAATTATTGTTATAGGAATTCAACAGTGAATACATGTTTATTGGAGAAAACCCAGAAGACACAG
AAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005329917	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000000542.2
GenBank Protein	KAG3263221	(Get FASTA)	NCBI Sequence Viewer
	KAG3263222	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005329917 ⟸ XM_005329860

- UniProtKB:

I3LWZ9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MQGLRWRYTRLPSQMEDTMSGEEGEEEEEEEETAPAPAPAPTPEDPVEPQLTEASQVLGASEIR
QLSLHLPARVTGHPWSLVFCTSRDGFSLRSLYRQMEGHSGPVLLLLRDQDGQMFGAFSSSALRL
SKGFYGTGETFLFSFSPQLKVFKWTGSNSFFVKGDLDSLMMGSGSGQFGLWLDGDLYHGGSHPC
ATFNNEVLARREQFCIKELEAWVLS

hide sequence

RefSeq Acc Id:

ENSSTOP00000000542 ⟸ ENSSTOT00000000596

Protein Domains

TLDc

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000000597	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000000596.2	UniProtKB/TrEMBL
InterPro	TLDc_dom	UniProtKB/TrEMBL
NCBI Gene	Tldc2	ENTREZGENE
PANTHER	NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED	UniProtKB/TrEMBL
	TLD DOMAIN-CONTAINING PROTEIN 2	UniProtKB/TrEMBL
Pfam	TLD	UniProtKB/TrEMBL
PROSITE	TLDC	UniProtKB/TrEMBL
SMART	TLDc	UniProtKB/TrEMBL
UniProt	I3LWZ9	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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