Irs4 (insulin receptor substrate 4) - Rat Genome Database

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Gene: Irs4 (insulin receptor substrate 4) Heterocephalus glaber
Analyze
Symbol: Irs4
Name: insulin receptor substrate 4
RGD ID: 18904429
Description: ENCODES a protein that exhibits protein domain specific binding (ortholog); INVOLVED IN insulin receptor signaling pathway (inferred); signal transduction (inferred); PARTICIPATES IN insulin signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); autosomal hemophilia A (ortholog); basal cell carcinoma (ortholog); FOUND IN protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248037,477,142 - 7,480,930 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248037,476,840 - 7,493,109 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Irs4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248037,477,142 - 7,480,930 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248037,476,840 - 7,493,109 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
IRS4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X108,719,946 - 108,736,563 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX108,719,946 - 108,736,563 (-)EnsemblGRCh38hg38GRCh38
GRCh37X107,963,176 - 107,979,793 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X107,862,368 - 107,866,307 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X107,781,856 - 107,785,784NCBI
CeleraX108,447,146 - 108,451,026 (-)NCBICelera
Cytogenetic MapXq22.3NCBI
HuRefX97,599,533 - 97,603,519 (-)NCBIHuRef
CHM1_1X107,886,615 - 107,890,495 (-)NCBICHM1_1
T2T-CHM13v2.0X107,157,529 - 107,174,147 (-)NCBIT2T-CHM13v2.0
Irs4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X140,493,994 - 140,508,213 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX140,493,994 - 140,508,259 (-)EnsemblGRCm39 Ensembl
GRCm38X141,710,998 - 141,725,217 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX141,710,998 - 141,725,263 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X138,145,541 - 138,159,760 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X136,957,366 - 136,971,585 (-)NCBIMGSCv36mm8
CeleraX125,711,653 - 125,725,766 (-)NCBICelera
Cytogenetic MapXF2NCBI
cM MapX62.43NCBI
Irs4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X110,132,490 - 110,148,473 (-)NCBIGRCr8
mRatBN7.2X105,344,020 - 105,360,004 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_UtxX107,461,148 - 107,477,141 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X110,960,343 - 110,976,334 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X108,532,305 - 108,548,287 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X113,003,824 - 113,018,088 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X111,457,261 - 111,471,505 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X36,881,414 - 36,885,105 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX104,754,830 - 104,768,446 (-)NCBICelera
Cytogenetic MapXq33NCBI
Irs4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554907,135,969 - 7,139,802 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554907,135,969 - 7,139,802 (+)NCBIChiLan1.0ChiLan1.0
IRS4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X108,201,449 - 108,218,978 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X108,205,053 - 108,222,582 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X97,818,895 - 97,835,986 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X108,202,208 - 108,205,984 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX108,202,208 - 108,205,821 (-)Ensemblpanpan1.1panPan2
IRS4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X82,275,642 - 82,292,398 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX82,276,187 - 82,292,375 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX68,396,271 - 68,412,952 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X83,925,400 - 83,942,146 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX83,925,941 - 83,942,143 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X81,384,480 - 81,401,164 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X83,096,771 - 83,113,520 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X82,887,838 - 82,904,529 (-)NCBIUU_Cfam_GSD_1.0
Irs4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X81,530,456 - 81,546,933 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364996,111,487 - 6,115,272 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364996,111,422 - 6,127,487 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRS4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX89,204,355 - 89,221,085 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X89,204,348 - 89,221,463 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X104,771,354 - 104,773,557 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IRS4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X96,589,292 - 96,605,715 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX96,601,944 - 96,605,699 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606521,705,865 - 21,722,358 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000003807   ⟹   ENSHGLP00000003752
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248037,477,142 - 7,480,930 (+)Ensembl
RefSeq Acc Id: XM_004861447   ⟹   XP_004861504
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248037,476,840 - 7,493,109 (+)NCBI
RefSeq Acc Id: XM_021241607   ⟹   XP_021097266
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248037,476,840 - 7,493,109 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004861504 (Get FASTA)   NCBI Sequence Viewer  
  XP_021097266 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021097266   ⟸   XM_021241607
- Peptide Label: isoform X2
- UniProtKB: A0AAX6RKR7 (UniProtKB/TrEMBL),   G5BZE0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004861504   ⟸   XM_004861447
- Peptide Label: isoform X1
- UniProtKB: A0AAX6PX10 (UniProtKB/TrEMBL),   G5BZE0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000003752   ⟸   ENSHGLT00000003807


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000002760 Ensembl
Gene3D-CATH Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) UniProtKB/TrEMBL
InterPro IRS UniProtKB/TrEMBL
  IRS_PTB UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
NCBI Gene Irs4 ENTREZGENE
PANTHER INSULIN RECEPTOR SUBSTRATE UniProtKB/TrEMBL
  INSULIN RECEPTOR SUBSTRATE 4 UniProtKB/TrEMBL
Pfam IRS UniProtKB/TrEMBL
PRINTS INSULINRSI UniProtKB/TrEMBL
PROSITE IRS_PTB UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
SMART IRS UniProtKB/TrEMBL
  PTBI UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
UniProt A0AAX6PX10 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6RKR7 ENTREZGENE, UniProtKB/TrEMBL
  G5BZE0 ENTREZGENE, UniProtKB/TrEMBL