TMEM129 (transmembrane protein 129, E3 ubiquitin ligase) - Rat Genome Database

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Gene: TMEM129 (transmembrane protein 129, E3 ubiquitin ligase) Chlorocebus sabaeus
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Symbol: TMEM129
Name: transmembrane protein 129, E3 ubiquitin ligase
RGD ID: 18778977
Description: ENCODES a protein that exhibits ubiquitin protein ligase activity (inferred); INVOLVED IN ERAD pathway (inferred); protein polyubiquitination (inferred); protein ubiquitination (inferred); ASSOCIATED WITH cherubism (ortholog); FOUND IN endoplasmic reticulum (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 ubiquitin-protein ligase TM129; transmembrane protein 129
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12747,045,579 - 47,050,641 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2747,045,427 - 47,051,327 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660513,422,266 - 3,427,234 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
cherubism  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TMEM129
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12747,045,579 - 47,050,641 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2747,045,427 - 47,051,327 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660513,422,266 - 3,427,234 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
TMEM129
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3841,715,952 - 1,721,323 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl41,715,952 - 1,721,358 (-)EnsemblGRCh38hg38GRCh38
GRCh3741,717,679 - 1,723,050 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3641,687,477 - 1,692,882 (-)NCBINCBI36Build 36hg18NCBI36
Celera41,628,728 - 1,634,133 (-)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef41,660,571 - 1,665,977 (-)NCBIHuRef
CHM1_141,715,638 - 1,721,039 (-)NCBICHM1_1
T2T-CHM13v2.041,713,779 - 1,719,151 (-)NCBIT2T-CHM13v2.0
Tmem129
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39533,810,560 - 33,815,321 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl533,810,560 - 33,815,760 (-)EnsemblGRCm39 Ensembl
GRCm38533,653,216 - 33,657,977 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl533,653,216 - 33,658,416 (-)EnsemblGRCm38mm10GRCm38
MGSCv37533,995,865 - 34,000,481 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36533,970,073 - 33,974,689 (-)NCBIMGSCv36mm8
Celera531,129,332 - 31,133,948 (-)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.83NCBI
Tmem129
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81481,289,852 - 81,295,416 (+)NCBIGRCr8
mRatBN7.21477,065,391 - 77,070,871 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1477,065,841 - 77,070,865 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1481,518,138 - 81,523,175 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01482,758,738 - 82,763,775 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01479,204,038 - 79,209,075 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01482,350,734 - 82,356,084 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1482,350,734 - 82,356,078 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01483,039,741 - 83,045,469 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41482,761,553 - 82,766,583 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1475,989,391 - 75,994,419 (+)NCBICelera
Cytogenetic Map14q21NCBI
Tmem129
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955514968,763 - 972,918 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955514968,763 - 972,918 (-)NCBIChiLan1.0ChiLan1.0
TMEM129
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v232,044,648 - 2,049,840 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan141,979,836 - 1,984,747 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v041,853,126 - 1,858,461 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.141,767,517 - 1,772,643 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl41,767,517 - 1,772,643 (-)Ensemblpanpan1.1panPan2
TMEM129
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1362,381,240 - 62,386,381 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl362,381,411 - 62,385,349 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha364,898,957 - 64,904,102 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0362,856,654 - 62,861,787 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl362,856,660 - 62,861,787 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1362,350,156 - 62,355,301 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0362,553,675 - 62,558,821 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0362,912,915 - 62,918,061 (+)NCBIUU_Cfam_GSD_1.0
Tmem129
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528567,964,220 - 67,968,975 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647721,665,275 - 21,670,668 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647721,665,955 - 21,670,667 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM129
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8819,764 - 826,192 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18819,762 - 826,233 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28306,726 - 312,619 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Tmem129
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475525,694,026 - 25,699,489 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475525,694,391 - 25,699,294 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TMEM129
96 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000013730   ⟹   ENSCSAP00000011720
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2747,045,427 - 47,051,327 (+)Ensembl
RefSeq Acc Id: XM_008018150   ⟹   XP_008016341
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12747,045,579 - 47,050,641 (+)NCBI
Vero_WHO_p1.0NW_0236660513,422,266 - 3,427,234 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008018151   ⟹   XP_008016342
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12747,045,579 - 47,050,641 (+)NCBI
Vero_WHO_p1.0NW_0236660513,422,266 - 3,427,234 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008016341 (Get FASTA)   NCBI Sequence Viewer  
  XP_008016342 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000011720
  ENSCSAP00000011720.1
RefSeq Acc Id: XP_008016341   ⟸   XM_008018150
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RSY1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008016342   ⟸   XM_008018151
- Peptide Label: isoform X2
Ensembl Acc Id: ENSCSAP00000011720   ⟸   ENSCSAT00000013730


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000015634 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000013730.1 UniProtKB/TrEMBL
InterPro TM129 UniProtKB/TrEMBL
KEGG Report csab:103246481 UniProtKB/TrEMBL
NCBI Gene TMEM129 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE TM129 UniProtKB/TrEMBL
  PTHR31322 UniProtKB/TrEMBL
Pfam Tmpp129 UniProtKB/TrEMBL
UniProt A0A0D9RSY1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-03-25 TMEM129  transmembrane protein 129, E3 ubiquitin ligase  TMEM129  transmembrane protein 129  Symbol and/or name change 5135510 APPROVED