NR2E3 (nuclear receptor subfamily 2 group E member 3) - Rat Genome Database

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Gene: NR2E3 (nuclear receptor subfamily 2 group E member 3) Chlorocebus sabaeus
Analyze
Symbol: NR2E3
Name: nuclear receptor subfamily 2 group E member 3
RGD ID: 18767171
Description: ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN cell population proliferation (inferred); eye photoreceptor cell development (inferred); negative regulation of cell population proliferation (inferred); PARTICIPATES IN retinitis pigmentosa pathway; ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); cone-rod dystrophy (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); transcription regulator complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: photoreceptor-specific nuclear receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12611,648,675 - 11,655,408 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2611,648,758 - 11,654,850 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048129,915,839 - 129,922,267 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 18 of 18 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NR2E3Green MonkeyBloom syndrome  ISONR2E3 (Homo sapiens)8554872ClinVar Annotator: match by term: Bloom syndromeClinVarPMID:28492532
NR2E3Green Monkeycolorectal cancer  ISONR2E3 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial colorectal cancerClinVarPMID:28492532
NR2E3Green Monkeycone-rod dystrophy  ISONR2E3 (Homo sapiens)8554872ClinVar Annotator: match by term: Cone-rod dystrophyClinVarPMID:10655056 more ...
NR2E3Green Monkeyenhanced S-cone syndrome  ISONR2E3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10655056 more ...
NR2E3Green MonkeyEye Abnormalities  ISONR2E3 (Homo sapiens)8554872ClinVar Annotator: match by term: Abnormality of the eyeClinVarPMID:19006237 more ...
NR2E3Green Monkeyfundus dystrophy  ISONR2E3 (Homo sapiens)8554872ClinVar Annotator: match by term: Retinal dystrophyClinVarPMID:10655056 more ...
NR2E3Green Monkeygenetic disease  ISONR2E3 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:10655056 more ...
NR2E3Green MonkeyLeber congenital amaurosis  ISONR2E3 (Homo sapiens)8554872ClinVar Annotator: match by term: Leber congenital amaurosisClinVarPMID:10655056 more ...
NR2E3Green Monkeyocular albinism 1  ISONR2E3 (Homo sapiens)8554872ClinVar Annotator: match by term: Ocular albinismClinVarPMID:10655056 more ...
NR2E3Green Monkeyoptic atrophy  ISONR2E3 (Homo sapiens)8554872ClinVar Annotator: match by term: Optic atrophyClinVarPMID:17564971 more ...
NR2E3Green Monkeyretinitis pigmentosa  ISONR2E3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10655056 more ...
NR2E3Green Monkeyretinitis pigmentosa  ISONR2E3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10655056 more ...
NR2E3Green Monkeyretinitis pigmentosa  ISONR2E3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10655056 more ...
NR2E3Green Monkeyretinitis pigmentosa  ISONR2E3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10655056 more ...
NR2E3Green Monkeyretinitis pigmentosa  ISONR2E3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10655056 more ...
NR2E3Green Monkeyretinitis pigmentosa 37  ISONR2E3 (Homo sapiens)8554872ClinVar Annotator: match by term: Retinitis pigmentosa 37ClinVarPMID:10655056 more ...
NR2E3Green MonkeyTay-Sachs disease  ISONR2E3 (Homo sapiens)8554872ClinVar Annotator: match by term: Tay-Sachs diseaseClinVarPMID:1833974 more ...
NR2E3Green MonkeyVision Disorders  ISONR2E3 (Homo sapiens)8554872ClinVar Annotator: match by term: Visual impairmentClinVarPMID:10655056 more ...
1 to 18 of 18 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NR2E3Green Monkeyenhanced S-cone syndrome  ISONR2E3 (Homo sapiens)7240710 OMIM 
NR2E3Green Monkeyretinitis pigmentosa 37  ISONR2E3 (Homo sapiens)7240710 OMIM 


Biological Process
1 to 9 of 9 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NR2E3Green Monkeycell population proliferation acts_upstream_ofIEAUniProtKB:Q9QXZ7 and ensembl:ENSMUSP00000034831150520179 EnsemblGO_REF:0000107
NR2E3Green Monkeyeye photoreceptor cell development acts_upstream_of_or_withinIEAUniProtKB:Q9QXZ7 and ensembl:ENSMUSP00000034831150520179 EnsemblGO_REF:0000107
NR2E3Green Monkeynegative regulation of cell population proliferation acts_upstream_of_or_withinIEAUniProtKB:Q9QXZ7 and ensembl:ENSMUSP00000034831150520179 EnsemblGO_REF:0000107
NR2E3Green Monkeynegative regulation of transcription by RNA polymerase II acts_upstream_of_or_withinIEAUniProtKB:Q9QXZ7 and ensembl:ENSMUSP00000034831150520179 EnsemblGO_REF:0000107
NR2E3Green Monkeypositive regulation of gene expression acts_upstream_of_or_withinIEAUniProtKB:Q9QXZ7 and ensembl:ENSMUSP00000034831150520179 EnsemblGO_REF:0000107
NR2E3Green Monkeypositive regulation of transcription by RNA polymerase II involved_inIEAUniProtKB:Q9Y5X4 and ensembl:ENSP00000482504150520179 EnsemblGO_REF:0000107
NR2E3Green Monkeypositive regulation of transcription by RNA polymerase II acts_upstream_of_or_withinIEAUniProtKB:Q9QXZ7 and ensembl:ENSMUSP00000034831150520179 EnsemblGO_REF:0000107
NR2E3Green Monkeyregulation of DNA-templated transcription involved_inIEAInterPro:IPR001628 and InterPro:IPR013088150520179 InterProGO_REF:0000002
NR2E3Green Monkeyretina development in camera-type eye acts_upstream_of_or_withinIEAUniProtKB:Q9QXZ7 and ensembl:ENSMUSP00000034831150520179 EnsemblGO_REF:0000107
1 to 9 of 9 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NR2E3Green Monkeynucleoplasm located_inIEAARBA:ARBA00026290150520179 UniProtGO_REF:0000117
NR2E3Green Monkeynucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043
NR2E3Green Monkeynucleus located_inIEAUniProtKB:Q9QXZ7 and ensembl:ENSMUSP00000034831150520179 EnsemblGO_REF:0000107
NR2E3Green Monkeynucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044
NR2E3Green Monkeytranscription regulator complex part_ofIEAUniProtKB:Q9QXZ7 and ensembl:ENSMUSP00000034831150520179 EnsemblGO_REF:0000107

Molecular Function
1 to 13 of 13 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NR2E3Green MonkeyDNA binding enablesIEAUniProtKB-KW:KW-0238150520179 UniProtGO_REF:0000043
NR2E3Green MonkeyDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAUniProtKB:Q9Y5X4 and ensembl:ENSP00000482504150520179 EnsemblGO_REF:0000107
NR2E3Green MonkeyDNA-binding transcription factor activity enablesIEAInterPro:IPR001628150520179 InterProGO_REF:0000002
NR2E3Green MonkeyDNA-binding transcription factor activity enablesIEAUniProtKB:Q9QXZ7 and ensembl:ENSMUSP00000034831150520179 EnsemblGO_REF:0000107
NR2E3Green Monkeymetal ion binding enablesIEAUniProtKB-KW:KW-0479150520179 UniProtGO_REF:0000043
NR2E3Green Monkeyprotein binding enablesISOUniProtKB:P619649068941 PMID:32296183IntActPMID:32296183
NR2E3Green Monkeyprotein binding enablesISOPR:O547519068941 PMID:15689355MGIPMID:15689355
NR2E3Green Monkeyprotein binding enablesISOUniProtKB:Q8C8Y59068941 PMID:28900001UniProtPMID:28900001
NR2E3Green MonkeyRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIEAUniProtKB:Q9Y5X4 and ensembl:ENSP00000482504150520179 EnsemblGO_REF:0000107
NR2E3Green Monkeysequence-specific DNA binding enablesIEAInterPro:IPR001628150520179 InterProGO_REF:0000002
NR2E3Green Monkeysequence-specific DNA binding enablesIEAUniProtKB:Q9Y5X4 and ensembl:ENSP00000482504150520179 EnsemblGO_REF:0000107
NR2E3Green Monkeyzinc ion binding enablesIEAInterPro:IPR001628 and InterPro:IPR013088150520179 InterProGO_REF:0000002
NR2E3Green Monkeyzinc ion binding enablesIEAUniProtKB-KW:KW-0863150520179 UniProtGO_REF:0000043
1 to 13 of 13 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NR2E3Green Monkeyretinitis pigmentosa pathway   ISONR2E3 (Homo sapiens)9068941 RGDPMID:23701314 and REF_RGD_ID:8547535
PMID:22301074   PMID:30032202  



NR2E3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12611,648,675 - 11,655,408 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2611,648,758 - 11,654,850 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048129,915,839 - 129,922,267 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
NR2E3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381571,810,554 - 71,818,253 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1571,792,638 - 71,818,259 (+)EnsemblGRCh38hg38GRCh38
GRCh371572,102,894 - 72,110,594 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361569,889,948 - 69,897,654 (+)NCBINCBI36Build 36hg18NCBI36
Build 341569,889,947 - 69,894,324NCBI
Celera1548,989,266 - 48,996,967 (+)NCBICelera
Cytogenetic Map15q23NCBI
HuRef1548,933,359 - 48,941,065 (+)NCBIHuRef
CHM1_11572,221,027 - 72,228,738 (+)NCBICHM1_1
T2T-CHM13v2.01569,629,504 - 69,637,203 (+)NCBIT2T-CHM13v2.0
Nr2e3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39959,850,054 - 59,868,117 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl959,850,054 - 59,867,942 (-)EnsemblGRCm39 Ensembl
GRCm38959,942,771 - 59,960,834 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl959,942,771 - 59,960,659 (-)EnsemblGRCm38mm10GRCm38
MGSCv37959,790,578 - 59,797,886 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36959,740,777 - 59,748,085 (-)NCBIMGSCv36mm8
Celera957,170,930 - 57,178,240 (-)NCBICelera
Cytogenetic Map9BNCBI
cM Map932.35NCBI
Nr2e3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8869,261,343 - 69,269,081 (-)NCBIGRCr8
mRatBN7.2860,365,581 - 60,373,383 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl860,366,124 - 60,373,163 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0864,797,518 - 64,801,587 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl864,797,518 - 64,800,467 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0864,555,324 - 64,557,833 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera859,807,339 - 59,816,089 (-)NCBICelera
Cytogenetic Map8q24NCBI
Nr2e3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554505,281,707 - 5,286,260 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554505,281,707 - 5,286,260 (-)NCBIChiLan1.0ChiLan1.0
NR2E3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21661,068,810 - 61,081,380 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11565,233,083 - 65,253,404 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01550,759,707 - 50,767,703 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11569,525,351 - 69,533,008 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1569,525,351 - 69,533,034 (+)Ensemblpanpan1.1panPan2
NR2E3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13035,375,181 - 35,382,398 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3035,309,120 - 35,318,785 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03035,578,487 - 35,588,153 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3035,582,048 - 35,588,151 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13035,529,407 - 35,539,055 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03035,561,018 - 35,567,025 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03035,811,616 - 35,821,244 (+)NCBIUU_Cfam_GSD_1.0
Nr2e3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640113,381,409 - 113,387,591 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647131,229,564 - 31,235,654 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647131,229,322 - 31,236,093 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR2E3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1169,360,729 - 169,366,087 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11169,358,662 - 169,373,175 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21187,978,045 - 187,993,204 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Nr2e3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247812,202,614 - 2,207,782 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247812,201,656 - 2,210,495 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in NR2E3
120 total Variants



ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
58 25 17 33 33 42 9



Ensembl Acc Id: ENSCSAT00000011798   ⟹   ENSCSAP00000009859
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2611,648,758 - 11,654,850 (-)Ensembl
RefSeq Acc Id: XM_008016045   ⟹   XP_008014236
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12611,648,675 - 11,654,343 (-)NCBI
Vero_WHO_p1.0NW_023666048129,916,597 - 129,922,267 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008016047   ⟹   XP_008014238
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12611,648,675 - 11,655,408 (-)NCBI
Vero_WHO_p1.0NW_023666048129,915,839 - 129,922,267 (+)NCBI
Sequence:
Protein RefSeqs XP_008014236 (Get FASTA)   NCBI Sequence Viewer  
  XP_008014238 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000009859
  ENSCSAP00000009859.1
RefSeq Acc Id: XP_008014238   ⟸   XM_008016047
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RMM0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008014236   ⟸   XM_008016045
- Peptide Label: isoform X1
Ensembl Acc Id: ENSCSAP00000009859   ⟸   ENSCSAT00000011798



1 to 25 of 25 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCSAG00000013721 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000011798.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/TrEMBL
InterPro NHR-like_dom_sf UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/TrEMBL
  Nuclear_hormone_rcpt_NR2 UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/TrEMBL
NCBI Gene NR2E3 ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/TrEMBL
  zf-C4 UniProtKB/TrEMBL
PRINTS COUPTNFACTOR UniProtKB/TrEMBL
  STRDHORMONER UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/TrEMBL
SMART HOLI UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
  SSF48508 UniProtKB/TrEMBL
UniProt A0A0D9RMM0 ENTREZGENE, UniProtKB/TrEMBL
1 to 25 of 25 rows