PKP2 (plakophilin 2) - Rat Genome Database

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Gene: PKP2 (plakophilin 2) Chlorocebus sabaeus
Analyze
Symbol: PKP2
Name: plakophilin 2
RGD ID: 18746798
Description: ENCODES a protein that exhibits alpha-catenin binding (inferred); DNA binding (inferred); intermediate filament binding (inferred); INVOLVED IN adherens junction maintenance (ortholog); cardiac muscle cell action potential (ortholog); cell-cell adhesion (ortholog); ASSOCIATED WITH arrhythmogenic right ventricular cardiomyopathy (ortholog); arrhythmogenic right ventricular dysplasia 1 (ortholog); arrhythmogenic right ventricular dysplasia 9 (ortholog); FOUND IN adherens junction (ortholog); intercalated disc (ortholog); intermediate filament (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: plakophilin-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11132,225,743 - 32,333,951 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1132,225,600 - 32,333,615 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660692,557,970 - 2,670,195 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
PKP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11132,225,743 - 32,333,951 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1132,225,600 - 32,333,615 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660692,557,970 - 2,670,195 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
PKP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381232,790,755 - 32,896,777 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1232,790,745 - 32,896,798 (-)EnsemblGRCh38hg38GRCh38
GRCh371232,943,689 - 33,049,711 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361232,834,947 - 32,941,047 (-)NCBINCBI36Build 36hg18NCBI36
Build 341232,834,953 - 32,940,993NCBI
Celera1212,764,378 - 12,870,162 (-)NCBICelera
Cytogenetic Map12p11.21NCBI
HuRef1232,696,154 - 32,802,035 (-)NCBIHuRef
CHM1_11232,910,199 - 33,015,916 (-)NCBICHM1_1
T2T-CHM13v2.01232,667,065 - 32,772,770 (-)NCBIT2T-CHM13v2.0
Pkp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391616,031,209 - 16,090,576 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1616,031,182 - 16,090,576 (+)EnsemblGRCm39 Ensembl
GRCm381616,213,345 - 16,272,712 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1616,213,318 - 16,272,712 (+)EnsemblGRCm38mm10GRCm38
MGSCv371616,213,438 - 16,272,805 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361616,126,923 - 16,186,290 (+)NCBIMGSCv36mm8
Celera1616,784,266 - 16,843,631 (+)NCBICelera
Cytogenetic Map16A2NCBI
cM Map1610.09NCBI
Pkp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81198,165,974 - 98,231,916 (-)NCBIGRCr8
mRatBN7.21184,661,783 - 84,727,730 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1184,661,783 - 84,727,730 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1193,393,755 - 93,459,584 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01186,054,906 - 86,120,731 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01185,108,508 - 85,174,333 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,912,163 - 88,972,213 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01191,966,047 - 92,031,277 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,553,493 - 86,584,425 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,497,846 - 86,625,018 (+)NCBI
Celera1183,407,295 - 83,471,505 (-)NCBICelera
Cytogenetic Map11q23NCBI
Pkp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555052,878,081 - 2,958,404 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555052,878,001 - 2,959,299 (+)NCBIChiLan1.0ChiLan1.0
PKP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21063,850,924 - 63,957,419 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11263,847,328 - 63,953,815 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01253,322,227 - 53,428,747 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11255,925,514 - 56,030,996 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1255,925,174 - 56,030,998 (+)Ensemblpanpan1.1panPan2
PKP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12716,023,186 - 16,109,978 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2716,023,224 - 16,109,603 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2730,317,043 - 30,404,388 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02716,202,157 - 16,290,541 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2716,185,310 - 16,290,531 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12716,015,227 - 16,100,629 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02716,043,378 - 16,131,741 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02730,463,876 - 30,551,090 (-)NCBIUU_Cfam_GSD_1.0
Pkp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494576,625,035 - 76,699,086 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366073,458,073 - 3,532,543 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366073,458,406 - 3,530,066 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PKP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl541,424,845 - 41,508,868 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1541,424,687 - 41,509,590 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2544,676,288 - 44,708,684 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pkp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247783,261,390 - 3,342,850 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247783,261,446 - 3,344,204 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007968132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCSAT00000005405   ⟹   ENSCSAP00000003627
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1132,225,600 - 32,333,615 (-)Ensembl
RefSeq Acc Id: XM_007968132   ⟹   XP_007966323
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11132,225,743 - 32,333,951 (-)NCBI
Vero_WHO_p1.0NW_0236660692,557,970 - 2,670,195 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007966323 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000003627.1
RefSeq Acc Id: XP_007966323   ⟸   XM_007968132
- UniProtKB: A0A0D9R4T8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000003627   ⟸   ENSCSAT00000005405


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000007363 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000005405.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Armadillo UniProtKB/TrEMBL
  Plakophilin/d_Catenin UniProtKB/TrEMBL
KEGG Report csab:103218840 UniProtKB/TrEMBL
NCBI Gene PKP2 ENTREZGENE
PANTHER PLAKOPHILIN-2 UniProtKB/TrEMBL
  PTHR10372 UniProtKB/TrEMBL
Pfam Arm UniProtKB/TrEMBL
PROSITE ARM_REPEAT UniProtKB/TrEMBL
SMART ARM UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
UniProt A0A0D9R4T8 ENTREZGENE, UniProtKB/TrEMBL