FAM89B (family with sequence similarity 89 member B)

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Gene: FAM89B (family with sequence similarity 89 member B) Chlorocebus sabaeus

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Symbol:

FAM89B

Name:

family with sequence similarity 89 member B

RGD ID:

18724473

Description:

ENCODES a protein that exhibits transcription corepressor binding (inferred); INVOLVED IN establishment of cell polarity (inferred); negative regulation of SMAD protein signal transduction (inferred); negative regulation of transforming growth factor beta receptor signaling pathway (inferred); ASSOCIATED WITH Aicardi-Goutieres Syndrome 3 (ortholog); Bardet-Biedl syndrome (ortholog); glycogen storage disease V (ortholog); FOUND IN cytoplasm (inferred); lamellipodium (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

leucine repeat adapter protein 25; protein FAM89B

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	8,666,812 - 8,669,128 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	8,667,370 - 8,668,320 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	105,961,493 - 105,963,608 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Aicardi-Goutieres Syndrome 3 (ISO)

Bardet-Biedl syndrome (ISO)

glycogen storage disease V (ISO)

high grade glioma (ISO)

intellectual disability (ISO)

Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular Malformations (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

establishment of cell polarity (IEA)

negative regulation of SMAD protein signal transduction (IEA)

negative regulation of transforming growth factor beta receptor signaling pathway (IEA)

positive regulation of cell migration (IEA)

Cellular Component

cytoplasm (IEA)

lamellipodium (IEA)

Molecular Function

protein binding (ISO)

transcription corepressor binding (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

FAM89B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	8,666,812 - 8,669,128 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	8,667,370 - 8,668,320 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	105,961,493 - 105,963,608 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

FAM89B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	65,572,538 - 65,574,190 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	65,572,349 - 65,574,198 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	65,340,009 - 65,341,661 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	65,096,396 - 65,098,245 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	11	62,666,209 - 62,668,103 (+)	NCBI		Celera
Cytogenetic Map	11	q13.1	NCBI
HuRef	11	61,666,853 - 61,668,702 (+)	NCBI		HuRef
CHM1_1	11	65,223,718 - 65,225,567 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	65,566,770 - 65,568,422 (+)	NCBI		T2T-CHM13v2.0

Fam89b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	5,778,115 - 5,779,694 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	5,778,115 - 5,779,681 (-)	Ensembl		GRCm39 Ensembl
GRCm38	19	5,728,087 - 5,729,666 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	5,728,087 - 5,729,653 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	5,728,087 - 5,729,666 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	5,728,087 - 5,729,648 (-)	NCBI		MGSCv36	mm8
Celera	19	5,598,137 - 5,599,716 (-)	NCBI		Celera
Cytogenetic Map	19	A	NCBI
cM Map	19	4.34	NCBI

Fam89b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	212,445,101 - 212,447,164 (-)	NCBI		GRCr8
mRatBN7.2	1	203,015,772 - 203,017,890 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	203,015,773 - 203,017,367 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	211,368,457 - 211,370,012 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	218,461,171 - 218,462,726 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	211,152,215 - 211,153,770 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	221,085,894 - 221,087,449 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	221,085,895 - 221,087,449 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	228,018,857 - 228,020,412 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	208,355,217 - 208,356,772 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	208,508,670 - 208,510,225 (-)	NCBI
Celera	1	200,551,352 - 200,552,907 (-)	NCBI		Celera
Cytogenetic Map	1	q43	NCBI

Fam89b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	19,691,352 - 19,692,377 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	19,690,806 - 19,693,575 (-)	NCBI	ChiLan1.0	ChiLan1.0

FAM89B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	66,800,413 - 66,803,922 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	67,843,169 - 67,846,678 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	60,931,592 - 60,933,317 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	64,267,223 - 64,268,500 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

FAM89B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	51,632,509 - 51,634,218 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	51,632,781 - 51,634,034 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	50,240,894 - 50,242,439 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	52,669,633 - 52,671,178 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	52,669,665 - 52,671,260 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	51,769,554 - 51,771,099 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	51,343,584 - 51,345,129 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	52,133,952 - 52,135,497 (-)	NCBI		UU_Cfam_GSD_1.0

FAM89B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	6,681,490 - 6,682,511 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	6,680,832 - 6,682,506 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	5,886,705 - 5,905,831 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Fam89b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624767	20,822,860 - 20,824,571 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624767	20,822,975 - 20,824,952 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

hemolymphoid system	mesenchyme	mesoderm
7	7	7

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007986315	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000005888 ⟹ ENSCSAP00000004102

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	1	8,667,370 - 8,668,320 (-)	Ensembl

RefSeq Acc Id:

XM_007986315 ⟹ XP_007984506

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	1	8,666,812 - 8,669,128 (-)	NCBI
Vero_WHO_p1.0	NW_023666038	105,961,493 - 105,963,608 (-)	NCBI

Sequence:

show sequence

CACTCTCTGCTCTCCCTGACGCCCTGAGATGAGTTGAACTTGTTTCTGCTCAGTTTCTCGTCAG
GATGCGGGAGTAGGTAGAGGACTATGTGATGCACCTTTTCTAAGGAAGAGGTGATAGCCTTTTC
AAAGGTAGCAGCCAGAGGGGTGGACCCTAGCCTTGTGTCTGGCAGCACATCTGCAGTTTCTCCG
CCATGCGGTGCCCATTCCCCACCTGGAAGTGAGATTTTGGGTTCCAATCCCCTTGATAGATTCC
GCTCCTTTCCCTGAGCATCCTGACCCTATCAGCCTATTCCATCTCATGGCCACCCCAGGTACTC
AGCGACAGGAGTTTGTGGTGACCTCAGCGTCAGGTGGCACGTTAGGCACCAACTGTGGACTTGC
CAGTCTCCTGATTCCACTGTTAGGATCATTTTCCTTGGGAGGGTAATGGGCAGAACACAGTGTG
TGGGGGCGGGGCGCGGCGGGCAGACGGGGTAGCGAAAAGAACCGCGAAGAAACCACGCCTGCCC
CCTTCGGCCTTTTCCCCCCTCCGCCGCATTTTTCCATCTCCCCTTGAGTGAGTGGGTGCCCCGC
TGTCTTTTTCTCAGCTTTACGCGACGTGGTCCCACAGCCGTTGCCTTTTTAAGAGAGGCCCGGC
CCATGCGGAGGGGGTGGGGCAGAGGCGGAGTCTGAGGAGCTGGGGAAGGAACAAAGCGCGGCCT
GCGGGCGGCGGCTGGGCTCCGGCGGGGCCGCGGGGTGCGGGGCCTGCGGGCAGCGTCCTGGGCG
GAGTGTTGGGGAGAAGGAGGTGGCATCGCCGTCGGTGGCCATGAACGGGCTGCCCTCGGCAGAG
GCGCCGGGCGGGGCAAGCTGCGCCTTGGCCGGGCTCCCACCGCTGCCGCGCGGCCTCAGCGGCC
TCCTTAATGCGAGCGGGGGCTCGTGGCGGGAGCTGGAGCGCGTCTACAGCCAGCGCAGCCGCAT
CCACGACGAGCTGAGCCGCGCCGCCCGCGCACCGGACGGGCCCCGCCACGCCGCCGGCGCCGCC
AACGCGGGACCCGCAGTCGGCCCGCGTCGTCCTGTCAACCTCGACTCGGCGCTGGCCGCGCTGC
GCAAGGAGATGGTGGGGCTGCGGCAGTTGGACATGTCCCTGTTGTGCCAGCTGTGGGGCCTGTA
TGAGTCAATCCAGGACTACAAACACCTGTGTCAAGACCTGAGCTTCTGTCAGGACCTGTCATCC
TCCCTCCATTCGGACAGCTCCTACCCACCGGATGCGGGCCTGTCTGACGATGAGGAGCCTCCCG
ATGCCAGCCTGCCTCCTGACCCGCCACCCCTCACTGTGCCCCAGACGCACAATGCCCGTGACCA
GTGGCTGCAGGATGCCTTCCACATCAGCCTCTGAAGAGCTGGGGGGCAGGGGGCACGCACCCAT
GCAAAAGGCTCAGAAACTCCCCCTCTGGCAAGCCCTCAGACTGCGGAGCCTGCGCCTTCCCCCA
TACCACCTCACCTCACAGGAGGGCCAGGCATGTATTCCTCAGAGGCGAAACTGCCAAACCCTTT
CTCTTGTCTTGGGTTGACTGGCACTGGGGCGGGTACCTAGGGTACAGCCTCTGCCCATGGTACT
GGGCCTCCACTTCTTCCACATGTGTGCACCCCCAGCTTGGCCAACCCTCAGCCTTGCAGTGGGG
CCCGAAGAAGCATCTTCCCCTCCCATTGGCATCTCTGGGATTGGGATGAGTGCCTCGCTCCCAT
CTCCTCCTCACCTTTTGTTGCTATCGGCAGCTGCTGGCTCAGGGGCATCCCACCTCCGGGCTCT
GGGTTCCTCTGCCCTGGAAGGGCTCCAGGACCCGTCCCAATACCCACCCATGGCCAGGAGGGCC
AAGGCCCCGTGCTGGATATTTAAATTTAGGGGCCGGCCTCCAGGGCGCGTAGATAAATAAATAC
TCTCAGCGTCGTTGTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007984506	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000004102
	ENSCSAP00000004102.1

RefSeq Acc Id:	XP_007984506 ⟸ XM_007986315
- UniProtKB:	A0A0D9R663 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000004102 ⟸ ENSCSAT00000005888

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000007846	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000005888.1	UniProtKB/TrEMBL
InterPro	LURA1/LRA25	UniProtKB/TrEMBL
KEGG Report	csab:103228705	UniProtKB/TrEMBL
NCBI Gene	FAM89B	ENTREZGENE
PANTHER	LEUCINE REPEAT ADAPTER PROTEIN 25	UniProtKB/TrEMBL
	LEUCINE REPEAT ADAPTER PROTEIN 25	UniProtKB/TrEMBL
Pfam	LURAP	UniProtKB/TrEMBL
UniProt	A0A0D9R663	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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