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Gene: ELP3 (elongator acetyltransferase complex subunit 3) Chlorocebus sabaeus

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Symbol:

ELP3

Name:

elongator acetyltransferase complex subunit 3

RGD ID:

18718369

Description:

ENCODES a protein that exhibits 4 iron, 4 sulfur cluster binding (inferred); acetyltransferase activity (inferred); acyltransferase activity (inferred); INVOLVED IN central nervous system development (inferred); neuron migration (inferred); positive regulation of cell migration (inferred); ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); Animal Disease Models (ortholog); autosomal dominant nocturnal frontal lobe epilepsy (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); elongator holoenzyme complex (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

elongator complex protein 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	26,190,992 - 26,291,085 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	26,190,944 - 26,292,890 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	15,840,056 - 15,945,485 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amyotrophic lateral sclerosis (ISO)

Animal Disease Models (ISO)

autosomal dominant nocturnal frontal lobe epilepsy (ISO)

benign familial infantile seizures 6 (ISO)

Breast Neoplasms (ISO)

Neoplasm Invasiveness (ISO)

Neoplasm Metastasis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

central nervous system development (IEA)

neuron migration (IEA)

positive regulation of cell migration (IEA)

regulation of transcription by RNA polymerase II (IEA)

tRNA processing (IEA)

tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation (IEA)

tRNA wobble uridine modification (IEA)

Cellular Component

cytoplasm (IEA)

cytosol (IEA)

elongator holoenzyme complex (IEA)

nucleolus (IEA)

nucleus (IEA)

Molecular Function

4 iron, 4 sulfur cluster binding (IEA)

acetyltransferase activity (IEA)

acyltransferase activity (IEA)

acyltransferase activity, transferring groups other than amino-acyl groups (IEA)

iron-sulfur cluster binding (IEA)

metal ion binding (IEA)

phosphorylase kinase regulator activity (IEA)

protein binding (ISO)

tRNA binding (IEA)

tRNA uridine(34) acetyltransferase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

ELP3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	26,190,992 - 26,291,085 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	26,190,944 - 26,292,890 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	15,840,056 - 15,945,485 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

ELP3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	28,090,232 - 28,191,153 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	28,089,673 - 28,191,156 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	27,947,749 - 28,048,670 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	28,006,645 - 28,104,585 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	28,006,644 - 28,104,585	NCBI
Celera	8	26,910,426 - 27,008,547 (+)	NCBI		Celera
Cytogenetic Map	8	p21.1	NCBI
HuRef	8	26,496,034 - 26,593,992 (+)	NCBI		HuRef
CHM1_1	8	28,152,676 - 28,250,744 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	28,368,442 - 28,469,343 (+)	NCBI		T2T-CHM13v2.0

Elp3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	65,767,895 - 65,830,561 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	65,767,898 - 65,830,524 (-)	Ensembl		GRCm39 Ensembl
GRCm38	14	65,530,446 - 65,593,112 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	65,530,449 - 65,593,075 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	66,149,293 - 66,211,847 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	64,484,566 - 64,547,120 (-)	NCBI		MGSCv36	mm8
Celera	14	63,281,822 - 63,344,421 (-)	NCBI		Celera
Cytogenetic Map	14	D1	NCBI
cM Map	14	34.33	NCBI

Elp3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	43,930,234 - 43,992,065 (-)	NCBI		GRCr8
mRatBN7.2	15	39,754,635 - 39,816,482 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	39,754,632 - 39,816,445 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	15	48,942,866 - 49,005,074 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	48,942,871 - 49,005,058 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	52,682,548 - 52,744,186 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	44,958,714 - 45,020,426 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	15	39,428,188 - 39,489,987 (-)	NCBI		Celera
Cytogenetic Map	15	p12	NCBI

Elp3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	50,565,583 - 50,637,294 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	50,565,496 - 50,635,226 (+)	NCBI	ChiLan1.0	ChiLan1.0

ELP3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	46,630,472 - 46,730,550 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	22,344,817 - 22,444,914 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	27,370,360 - 27,470,169 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	24,570,410 - 24,669,941 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	24,570,410 - 24,669,941 (+)	Ensembl	panpan1.1		panPan2

ELP3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	29,415,229 - 29,507,159 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	29,415,924 - 29,507,098 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	30,065,152 - 30,157,019 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	29,607,769 - 29,699,772 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	29,607,769 - 29,699,705 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	29,533,972 - 29,625,916 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	29,418,481 - 29,510,434 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	29,584,694 - 29,676,660 (-)	NCBI		UU_Cfam_GSD_1.0

Elp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	7,571,232 - 7,652,484 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936675	933,676 - 1,016,242 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936675	933,698 - 1,014,919 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ELP3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	11,832,962 - 11,940,070 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	11,832,947 - 11,940,080 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	13,066,325 - 13,075,039 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Elp3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624758	22,837,374 - 22,903,714 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624758	22,838,077 - 22,904,627 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in ELP3
2727 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007962016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007962017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037983645	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037983646	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037983647	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000014026 ⟹ ENSCSAP00000012007

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	8	26,190,944 - 26,292,890 (+)	Ensembl

RefSeq Acc Id:

XM_007962016 ⟹ XP_007960207

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	8	26,190,992 - 26,291,085 (+)	NCBI
Vero_WHO_p1.0	NW_023666052	15,841,092 - 15,945,263 (-)	NCBI

Sequence:

show sequence

GACAGGCGGGGTTGCTTTGTGGCTGTGAGCTTTCCCCGAGGTCTGAGTTTGTGGCTGCATTTTT
ATACCTGGTGGTTCTGCTACGGCGGCGCAGAAATGAGGCAGAAGCGGAAAGGAGATCTCAGCCC
TGCTGAGCTGATGATGCTGACTATAGGAGATGTTATTAAACAACTGATTGAAGCCCACGAGCAG
GGGAAAGACATCGATCTAAATAAGGTGAAAACCAAGACAGCCGCCAAATATGGCCTTTCTGCCC
AGCCCCGGCTGGTGGATATCATTGCTGCCGTCCCTCCTCAATATCGCAAGGTCTTGATTCCCAA
GTTAAAGGCGAAACCCATCAGAACTGCCAGTGGGATTGCTGTTGTGGCTGTGATGTGCAAACCC
CACAGATGTCCACACATCAGTTTTACAGGAAATATATGTGTATACTGCCCTGGTGGACCTGATT
CCGATTTTGAGTATTCCACCCAGTCTTACACTGGCTATGAGCCAACCTCCATGAGAGCTATCCG
TGCCAGATATGACCCTTTCCTACAGACAAGACACCGAATAGAGCAGTTAAAACAACTTGGTCAT
AGTGTGGATAAAGTGGAGTTTATTGTGATGGGTGGAACGTTTATGGCCCTTCCAGAAGAATACA
GAGATTATTTTATTCGAAATTTACATGATGCCTTATCAGGACATACTTCCAACAATATTTACGA
GGCAGTCAAGTATTCTGAGAGAAGCCTCACAAAGTGTATTGGAATTACTATAGAGACCAGACCA
GATTACTGCATGAAGCGGCATTTAAGTGACATGTTGACCTATGGCTGCACAAGGCTGGAGATTG
GGGTGCAGAGCGTTTATGAAGATGTGGCTAGAGACACCAACAGGGGCCACACTGTGAAGGCAGT
GTGTGAGTCATTTCACCTGGCCAAAGATTCCGGTTTCAAAGTGGTGGCCCATATGATGCCTGAC
CTGCCAAATGTGGGACTAGAAAGAGACATTGAACAGTTCACAGAGTTTTTTGAGAACCCTGCTT
TTCGTCCCGATGGTCTGAAACTCTATCCTACCCTGGTGATTCGTGGGACCGGGCTTTATGAGCT
TTGGAAATCAGGAAGATATAAGAGTTACTCTCCTAGTGACCTGGTCGAATTGGTGGCTCGGATC
CTAGCCCTCGTGCCTCCATGGACTCGAGTGTACCGAGTGCAGAGGGATATTCCAATGCCTTTAG
TCAGCTCAGGAGTAGAGCATGGTAACCTGAGAGAGCTGGCACTTGCAAGAATGAAAGACCTCGG
AATACAGTGTCGAGATGTGAGAACCAGAGAAGTTGGAATCCAAGAAATTCATCACAAAGTACGG
CCATACCAGGTTGAACTGGTTAGGAGAGATTATGTTGCAAATGGTGGCTGGGAAACATTCTTGT
CATATGAAGACCCAGATCAAGACATTTTGATTGGCCTCCTACGATTACGCAAGTGTTCAGAAGA
AACTTTCCGTTTCGAATTGGGTGGAGGTGTCTCCATAGTACGAGAGCTGCATGTGTATGGAAGT
GTGGTCCCTGTGAGCAGCCGGGATCCTACCAAATTTCAGCATCAGGGATTTGGCATGCTGCTGA
TGGAGGAAGCAGAAAGAATAGCTAGAGAAGAACATGGATCTGGGAAAATCGCTGTGATATCAGG
GGTCGGCACCAGGAATTATTATAGAAAGATCGGCTACAGATTACAAGGCCCGTACATGGTGAAG
ATGCTGAAATAATGGCCACACCAGTCCACCTTTCTGCAGTATCCTCCCTGGCAGAACACGGAGA
ATCAGGATTTCTTAAATACTCAACAGAGAGGCTGAGCAGAGCAAATAGGGGACTTCACCCTCAT
CCCGCAGCTGCAGAGACTGGAAAGCTGCAGAGACCTTCAAGGCCACGGCTGGTCATCTGCTGAC
CACACCCCAGATCCGTCCTCTCCTGTGTGCACCTAAAAAAAATCATTTGCATTTTTGAGGCTTA
AATCGTCTATCCAGTTTCTAAATTTTGCATGCGGCCTGCAGGTGGCCTATTTTGACTCAGACGG
TGACAAAAGCAAATTAACTCATTTGGACACCATAACTCATGAAATAAAACTGATTGTCATTTGA
GGAGCAAA

hide sequence

RefSeq Acc Id:

XM_037983645 ⟹ XP_037839573

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666052	15,840,056 - 15,945,485 (-)	NCBI

RefSeq Acc Id:

XM_037983646 ⟹ XP_037839574

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666052	15,840,056 - 15,945,107 (-)	NCBI

RefSeq Acc Id:

XM_037983647 ⟹ XP_037839575

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666052	15,840,056 - 15,945,290 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_007960207	(Get FASTA)	NCBI Sequence Viewer
	XP_037839573	(Get FASTA)	NCBI Sequence Viewer
	XP_037839574	(Get FASTA)	NCBI Sequence Viewer
	XP_037839575	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000012007
	ENSCSAP00000012007.1

RefSeq Acc Id:	XP_007960207 ⟸ XM_007962016
- Peptide Label:	isoform X2
- UniProtKB:	A0A0D9RTR8 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000012007 ⟸ ENSCSAT00000014026

RefSeq Acc Id:	XP_037839573 ⟸ XM_037983645
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_037839575 ⟸ XM_037983647
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_037839574 ⟸ XM_037983646
- Peptide Label:	isoform X3

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000015927	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000014026.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.630.30	UniProtKB/TrEMBL
InterPro	Acyl_CoA_acyltransferase	UniProtKB/TrEMBL
	ELP3	UniProtKB/TrEMBL
	ELP3-like	UniProtKB/TrEMBL
	Elp3/MiaB/NifB	UniProtKB/TrEMBL
	GNAT_dom	UniProtKB/TrEMBL
	Radical_SAM_C	UniProtKB/TrEMBL
	rSAM	UniProtKB/TrEMBL
KEGG Report	csab:103215536	UniProtKB/TrEMBL
NCBI Gene	ELP3	ENTREZGENE
PANTHER	PTHR11135	UniProtKB/TrEMBL
	PTHR11135:SF0	UniProtKB/TrEMBL
Pfam	Radical_SAM	UniProtKB/TrEMBL
	Radical_SAM_C	UniProtKB/TrEMBL
PIRSF	Hist_AcTrfase_ELP3	UniProtKB/TrEMBL
PROSITE	GNAT	UniProtKB/TrEMBL
	RADICAL_SAM	UniProtKB/TrEMBL
SMART	Elp3	UniProtKB/TrEMBL
Superfamily-SCOP	Radical SAM enzymes	UniProtKB/TrEMBL
	SSF55729	UniProtKB/TrEMBL
UniProt	A0A0D9RTR8	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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