Elp3 (elongator acetyltransferase complex subunit 3)

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Gene: Elp3 (elongator acetyltransferase complex subunit 3) Rattus norvegicus

Analyze

Symbol:

Elp3

Name:

elongator acetyltransferase complex subunit 3

RGD ID:

2324506

Description:

Predicted to enable acetyltransferase activity and phosphorylase kinase regulator activity. Predicted to be involved in several processes, including nervous system development; positive regulation of cell migration; and tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation. Predicted to be located in cytosol and nucleolus. Predicted to be part of elongator holoenzyme complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human ELP3 (elongator acetyltransferase complex subunit 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; thioacetamide.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

elongation protein 3 homolog; elongation protein 3 homolog (S. cerevisiae); elongator complex protein 3; LOC100362548; rCG52086-like

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	15	39,754,635 - 39,816,482 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	39,754,632 - 39,816,445 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	15	48,942,866 - 49,005,074 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	48,942,871 - 49,005,058 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	52,682,548 - 52,744,186 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	44,958,714 - 45,020,426 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	15	39,428,188 - 39,489,987 (-)	NCBI		Celera
Cytogenetic Map	15	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amyotrophic lateral sclerosis (ISO)

Animal Disease Models (ISO)

autosomal dominant nocturnal frontal lobe epilepsy (ISO)

benign familial infantile seizures 6 (ISO)

Breast Neoplasms (ISO)

genetic disease (ISO)

Neoplasm Invasiveness (ISO)

Neoplasm Metastasis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (ISO)

acrolein (ISO)

alpha-pinene (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

caffeine (ISO)

copper(II) sulfate (ISO)

dibutyl phthalate (ISO)

disodium selenite (ISO)

doxorubicin (ISO)

fenthion (ISO)

folic acid (ISO)

ivermectin (ISO)

lead(0) (ISO)

lead(2+) (ISO)

methidathion (ISO)

nickel atom (ISO)

ozone (ISO)

paracetamol (ISO)

thioacetamide (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

central nervous system development (ISO)

neuron migration (ISO)

positive regulation of cell migration (ISO)

regulation of transcription by RNA polymerase II (ISO)

tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation (IBA)

tRNA wobble uridine modification (ISO)

Cellular Component

cytoplasm (IBA,ISO)

cytosol (ISO)

elongator holoenzyme complex (IBA,ISO)

nucleolus (ISO)

nucleus (IBA)

Molecular Function

4 iron, 4 sulfur cluster binding (IEA)

acetyltransferase activity (ISO)

metal ion binding (IEA)

phosphorylase kinase regulator activity (ISO)

protein binding (ISO)

tRNA binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11714725	PMID:11818576	PMID:19185337	PMID:22854966	PMID:31505169

Genomics

Comparative Map Data

Elp3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	15	39,754,635 - 39,816,482 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	39,754,632 - 39,816,445 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	15	48,942,866 - 49,005,074 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	48,942,871 - 49,005,058 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	52,682,548 - 52,744,186 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	44,958,714 - 45,020,426 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	15	39,428,188 - 39,489,987 (-)	NCBI		Celera
Cytogenetic Map	15	p11	NCBI

ELP3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	28,090,232 - 28,191,153 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	8	28,089,673 - 28,191,156 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	27,947,749 - 28,048,670 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	28,006,645 - 28,104,585 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	28,006,644 - 28,104,585	NCBI
Celera	8	26,910,426 - 27,008,547 (+)	NCBI		Celera
Cytogenetic Map	8	p21.1	NCBI
HuRef	8	26,496,034 - 26,593,992 (+)	NCBI		HuRef
CHM1_1	8	28,152,676 - 28,250,744 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	28,368,442 - 28,469,343 (+)	NCBI		T2T-CHM13v2.0

Elp3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	65,767,895 - 65,830,561 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	65,767,898 - 65,830,524 (-)	Ensembl		GRCm39 Ensembl
GRCm38	14	65,530,446 - 65,593,112 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	65,530,449 - 65,593,075 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	66,149,293 - 66,211,847 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	64,484,566 - 64,547,120 (-)	NCBI		MGSCv36	mm8
Celera	14	63,281,822 - 63,344,421 (-)	NCBI		Celera
Cytogenetic Map	14	D1	NCBI

Elp3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	50,565,583 - 50,637,294 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	50,565,496 - 50,635,226 (+)	NCBI	ChiLan1.0	ChiLan1.0

ELP3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	8	24,570,410 - 24,669,941 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	24,570,410 - 24,669,941 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	8	27,370,360 - 27,470,169 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

ELP3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	29,415,229 - 29,507,159 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	29,415,924 - 29,507,098 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	30,065,152 - 30,157,019 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	29,607,769 - 29,699,772 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	29,607,769 - 29,699,705 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	29,533,972 - 29,625,916 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	29,418,481 - 29,510,434 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	29,584,694 - 29,676,660 (-)	NCBI		UU_Cfam_GSD_1.0

Elp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	7,571,232 - 7,652,484 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936675	933,676 - 1,016,242 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936675	933,698 - 1,014,919 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ELP3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	11,832,962 - 11,940,070 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	11,832,947 - 11,940,080 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	13,066,325 - 13,075,039 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ELP3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	26,190,992 - 26,291,085 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	26,190,944 - 26,292,890 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	15,840,056 - 15,945,485 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Elp3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624758	22,837,374 - 22,903,714 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624758	22,838,077 - 22,904,627 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Elp3
123 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	48
Count of miRNA genes:	47
Interacting mature miRNAs:	48
Transcripts:	ENSRNOT00000019262
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
731170	Pur3	Proteinuria QTL 3	2.3	0.0005	urine protein amount (VT:0005160)	urine protein excretion rate (CMO:0000759)	15	1	41686771	Rat
1641887	Alcrsp14	Alcohol response QTL 14			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	15	1	42356671	Rat
2298549	Neuinf12	Neuroinflammation QTL 12	3.5		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	15	1	55302115	Rat
10401805	Kidm51	Kidney mass QTL 51			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	15	306329	45306329	Rat
738017	Hcas7	Hepatocarcinoma susceptibility QTL 7	2.91		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	15	2266368	46921453	Rat
1582251	Gluco24	Glucose level QTL 24	3.2	0.0008	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	15	5530756	50530756	Rat
631273	Lecl2	Lens clarity QTL 2		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	15	10596089	55596089	Rat
2300167	Bmd63	Bone mineral density QTL 63	5.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
2300173	Bmd62	Bone mineral density QTL 62	12.8	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
2293688	Bss29	Bone structure and strength QTL 29	5.31	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	15	11111142	56111142	Rat
2317750	Glom26	Glomerulus QTL 26	4.3		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	15	12496141	65205939	Rat
61424	Scl1	Serum cholesterol level QTL 1	7.7	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	15	16725528	80672115	Rat
1331729	Rf42	Renal function QTL 42	3.071		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	15	17362897	73690657	Rat
2324620	Coatc3	Coat color QTL 3			coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	15	19856566	46187442	Rat
10054130	Srcrt8	Stress Responsive Cort QTL 8	2.18	0.0085	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	15	22117933	67117933	Rat
1578646	Bmd18	Bone mineral density QTL 18	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	15	22806240	98288169	Rat
1578647	Bmd17	Bone mineral density QTL 17	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	15	22806240	98288169	Rat
1578660	Bss19	Bone structure and strength QTL 19	4.3		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	15	22806240	98288169	Rat
1582214	Stl21	Serum triglyceride level QTL 21	3.1	0.022	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	15	28030665	82262678	Rat
1582227	Gluco30	Glucose level QTL 30	3.6	0.0003	blood glucose amount (VT:0000188)	absolute change in blood glucose level area under curve (CMO:0002034)	15	28030665	82262678	Rat
1582228	Epfw3	Epididymal fat weight QTL 3	4.1	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	28030665	82262678	Rat
1582242	Gluco28	Glucose level QTL 28	3.3	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	15	28030665	82262678	Rat
1582244	Bw79	Body weight QTL 79	4	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	28030665	82262678	Rat
2293691	Bmd37	Bone mineral density QTL 37	6.6	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	15	33611058	71477291	Rat
2293686	Bmd36	Bone mineral density QTL 36	7.4	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	15	33611058	71477291	Rat
1598828	Glom14	Glomerulus QTL 14	2.5		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	15	34054139	79054139	Rat

Markers in Region

D15Rat132

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	39,813,850 - 39,814,006 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	49,002,485 - 49,002,640	NCBI	Rnor6.0
Rnor_5.0	15	52,741,599 - 52,741,754	UniSTS	Rnor5.0
RGSC_v3.4	15	45,017,852 - 45,018,008	RGD	RGSC3.4
RGSC_v3.4	15	45,017,853 - 45,018,008	UniSTS	RGSC3.4
RGSC_v3.1	15	45,033,552 - 45,033,708	RGD
Celera	15	39,487,393 - 39,487,548	UniSTS
FHH x ACI Map	15	46.36	RGD
FHH x ACI Map	15	46.36	UniSTS

RH129518

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	39,788,330 - 39,789,035 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	48,976,592 - 48,977,296	NCBI	Rnor6.0
Rnor_5.0	15	52,715,706 - 52,716,410	UniSTS	Rnor5.0
RGSC_v3.4	15	44,992,338 - 44,993,042	UniSTS	RGSC3.4
Celera	15	39,461,917 - 39,462,621	UniSTS
RH 3.4 Map	15	307.4	UniSTS
Cytogenetic Map	8	q24	UniSTS
Cytogenetic Map	15	p12	UniSTS

RH130163

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	39,754,684 - 39,754,897 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	48,942,916 - 48,943,128	NCBI	Rnor6.0
Rnor_5.0	15	52,682,598 - 52,682,810	UniSTS	Rnor5.0
RGSC_v3.4	15	44,958,365 - 44,958,577	UniSTS	RGSC3.4
Celera	15	39,428,238 - 39,428,450	UniSTS
RH 3.4 Map	15	305.9	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_002728290	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_003751505	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_003752819	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_003752820	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474023	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000270	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000019262 ⟹ ENSRNOP00000019262

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	39,754,638 - 39,816,445 (-)	Ensembl
Rnor_6.0 Ensembl	15	48,942,871 - 49,005,058 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000098117 ⟹ ENSRNOP00000085832

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	39,754,632 - 39,814,369 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000104506 ⟹ ENSRNOP00000085019

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	39,754,632 - 39,814,369 (-)	Ensembl

RefSeq Acc Id:

XM_002728290 ⟹ XP_002728336

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	39,754,635 - 39,816,482 (-)	NCBI
Rnor_6.0	15	48,942,866 - 49,005,064 (-)	NCBI
Rnor_5.0	15	52,682,548 - 52,744,186 (-)	NCBI
RGSC_v3.4	15	44,958,714 - 45,020,426 (-)	RGD

Sequence:

show sequence

GTCGCGGCGTGCTTTACGGCTGCCAAGTTTCTCCGCCGTCTGAACCTCGATAACGAGGTGCCAC
CCTACTACGCCAGCGCAGAGATGAAGCAAAAGAGGAAAGGGGATCTCAGCCCGGCTGAGCTGAT
GATGCTGACTATAGGAGACGTGATCAAGCAGCTGGTTGAAGCTCATGAACAAGGCAAGGACGTC
GATCTAAATAAGCTGAAAACCAAAACAGCTTCCAAGTATGGCCTGTCGTCCCAGCCTCGCCTGG
TGGATATCATTGCTGCAGTCCCTCCTCACTATCGAAAGATCTTGATTCCCAAGCTAAAGGCAAA
GCCCATCAGGACTGCCAGTGGGATTGCTGTTGTGGCTGTGATGTGCAAACCCCACAGATGTCCA
CACATCAGTTTTACAGGGAATATATGTGTATACTGCCCTGGAGGACCTGACTCAGATTTTGAGT
ACTCAACCCAGTCTTACACGGGCTATGAGCCAACTTCCATGCGAGCTATCCGTGCTAGATACGA
CCCTTATCTGCAGACAAGACACCGGATAGAGCAGCTAAAGCAGCTTGGCCACAGTGTGGATAAG
GTGGAGTTCATCGTGATGGGCGGAACGTTCATGGCCCTTCCGGAGGAATACAGAGATTATTTTA
TCCGAAATTTACACGATGCTTTATCAGGACATACTTCAAACAATATTTACGAGGCAATCAAGTA
TTCCGAGAGAAGCCTCACAAAGTGCATAGGGATTACCATTGAGACCAGACCTGATTACTGCATG
AAGCGGCACCTAAGTGACATGTTGACTTACGGCTGCACAAGGCTGGAGATTGGAGTGCAGAGTG
TCTATGAAGATGTGGCCAGAGATACCAACAGGGGCCACACCGTGAAGGCAGTATGTGAATCATT
CCACCTGGCCAAAGATTCTGGGTTCAAAGTGGTGGCGCACATGATGCCTGACCTGCCGAATGTG
GGACTAGAGAGAGACATTGAGCAGTTTATAGAATTTTTTGAGAACCCTGCTTTTCGTCCTGATG
GTTTGAAGCTCTACCCTACCCTGGTGATCCGTGGAACTGGTCTGTATGAGCTGTGGAAATCAGG
GAGATACAGGAGCTATTCTCCCAGTGATCTGATTGAGTTGGTGGCTCGGATCCTAGCCCTCGTG
CCCCCTTGGACTCGTGTGTACCGAGTGCAGAGAGACATTCCAATGCCCCTCGTCAGCTCAGGAG
TAGACCATGGCAACCTTCGAGAGCTGGCATTTGCAAGAATGAAAGATCTTGGGATACAGTGCCG
AGATGTGAGAACCAGGGAGGTTGGAATCCAAGAAATTCATCACAGAGTGCGGCCGTACCAGGTT
GAGTTGGTACGGAGAGATTATGTTGCCAATGGCGGCTGGGAGACCTTCCTTTCCTACGAAGATC
CCGATCAGGACATTCTAATTGGCCTCCTAAGGCTACGGAAATGCTCTGAGGAAACCTTCCGATT
TGAACTGGGTGGAGGCGTTTCCATAGTCCGAGAGCTACATGTGTATGGAAGTGTGGTCCCTGTG
AGCAGCCGGGACCCCACTAAATTTCAGCATCAGGGGTTCGGCATGCTGCTGATGGAAGAAGCAG
AAAGAATCGCTCTGGAAGAGCACGGGTCTGGGAAAATCGCAGTTATATCAGGAGTCGGCACAAG
AAATTACTACCGAAAGATGGGCTACAGATTGCAAGGCCCGTACATGGTAAAGATGCTAAAATAA
GACCACTACAGTCTACCTTCATGCAGCGTCCTCTGACTAAATTCAGGTGGGGTCTCCTGAATAC
GCAGCGGAGGCTGAGAGGTAAATGGTCTGCACGCCCCTGGACAGTACTCTGCCCTCCCCTGCGG
CTGCCACTCACAACTCTGACCCCTGTGACAGAGGCCAAATTCACCCTCTTTATGTGTCCGTGGA
GCCACTTCTGGTTTTGAGGCTTAAAGGATTTTAAATTCTGCATGAAGGCTGCAGGTGACCCATT
TGGGCTCAGATGCTATGTGACCAGAGCAAATCAACTCCTTAGGCCATCATCACTTGTGATTGTC
ATCTGAGGGGCAGGCTCGGGAGAAGATTAGTTATATATCCACAGACAAAAGCCGGACTGTAGCG
CAGACAAGCTGTCAGACGTGACTCTCTGCCCTTTAACCACGTGCACATTCACCCAGAGACGGAG
AAGATGAGCTTTGCAGTGGGAGTCTCCGTGGCCCTGCCATGTCTTGAAATGGCCGTGTTTGGGG
AAGGAAGAGCTATGGTAGTGGGTAGTGTTAAGCTTGATGCCGGCTGTCTCACCTGCCCTGAGCC
AGGCCTCTCAGAGCCTTTCCTTTGTCTCATATCTGTGAAAGTCTGTGCGTCCATACCCCTGACA
CCTGCAGGGCAGTGTGCACTATCTCATGTGTGCTGGGCTAGCTTGTGCCAGCCAGTTCATCTGT
CCTGCGCATCACGGTCCAGGGTGCATGGCTAGAGCCTCATGGCCCTGGTCAGGACTAGTCCATC
CTCAGACACGTCTCTGCATGTTAATTCTGTGAGGTTGGTAGTGGTGATGGTGCTGCATGAAGAA
GGTAGGAGTTAGGCTAGTGTGTGAAAGTGGGCCTGTCTGAGCATGGAGGGACAGTGGGCTTTTC
AGAGGCTTCTTCACCATCCAGCTTGTCCACTGAGGAGACCAGGCTCTGAGACAGCCTGCCTCGC
CTGGGCATCTGTCATTTCCAGCAGTGTTTAGTGAAAGCTGTTCTCTAAAAGGTCTGAAAAATAA
AGTGTTTGGCACAAAAGAA

hide sequence

RefSeq Acc Id:

XM_003751505 ⟹ XP_003751553

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	39,754,635 - 39,816,436 (-)	NCBI
Rnor_6.0	15	48,942,866 - 49,005,074 (-)	NCBI
Rnor_5.0	15	52,682,548 - 52,744,186 (-)	NCBI

Sequence:

show sequence

TTTCACGACAGTCGCGGCGTGCTTTACGGCTGCCAAGTTTCTCCGCCGTCTGAACCTCGATAAC
GAGGTGCCACCCTACTACGCCAGCGCAGAGATGAAGCAAAAGAGGAAAGGTGCAAAAAACGCGG
GACAAGGGCACAAGGGAGGCGGTGGATGCTCTGAGATCACAGGGGATCTCAGCCCGGCTGAGCT
GATGATGCTGACTATAGGAGACGTGATCAAGCAGCTGGTTGAAGCTCATGAACAAGGCAAGGAC
GTCGATCTAAATAAGCTGAAAACCAAAACAGCTTCCAAGTATGGCCTGTCGTCCCAGCCTCGCC
TGGTGGATATCATTGCTGCAGTCCCTCCTCACTATCGAAAGATCTTGATTCCCAAGCTAAAGGC
AAAGCCCATCAGGACTGCCAGTGGGATTGCTGTTGTGGCTGTGATGTGCAAACCCCACAGATGT
CCACACATCAGTTTTACAGGGAATATATGTGTATACTGCCCTGGAGGACCTGACTCAGATTTTG
AGTACTCAACCCAGTCTTACACGGGCTATGAGCCAACTTCCATGCGAGCTATCCGTGCTAGATA
CGACCCTTATCTGCAGACAAGACACCGGATAGAGCAGCTAAAGCAGCTTGGCCACAGTGTGGAT
AAGGTGGAGTTCATCGTGATGGGCGGAACGTTCATGGCCCTTCCGGAGGAATACAGAGATTATT
TTATCCGAAATTTACACGATGCTTTATCAGGACATACTTCAAACAATATTTACGAGGCAATCAA
GTATTCCGAGAGAAGCCTCACAAAGTGCATAGGGATTACCATTGAGACCAGACCTGATTACTGC
ATGAAGCGGCACCTAAGTGACATGTTGACTTACGGCTGCACAAGGCTGGAGATTGGAGTGCAGA
GTGTCTATGAAGATGTGGCCAGAGATACCAACAGGGGCCACACCGTGAAGGCAGTATGTGAATC
ATTCCACCTGGCCAAAGATTCTGGGTTCAAAGTGGTGGCGCACATGATGCCTGACCTGCCGAAT
GTGGGACTAGAGAGAGACATTGAGCAGTTTATAGAATTTTTTGAGAACCCTGCTTTTCGTCCTG
ATGGTTTGAAGCTCTACCCTACCCTGGTGATCCGTGGAACTGGTCTGTATGAGCTGTGGAAATC
AGGGAGATACAGGAGCTATTCTCCCAGTGATCTGATTGAGTTGGTGGCTCGGATCCTAGCCCTC
GTGCCCCCTTGGACTCGTGTGTACCGAGTGCAGAGAGACATTCCAATGCCCCTCGTCAGCTCAG
GAGTAGACCATGGCAACCTTCGAGAGCTGGCATTTGCAAGAATGAAAGATCTTGGGATACAGTG
CCGAGATGTGAGAACCAGGGAGGTTGGAATCCAAGAAATTCATCACAGAGTGCGGCCGTACCAG
GTTGAGTTGGTACGGAGAGATTATGTTGCCAATGGCGGCTGGGAGACCTTCCTTTCCTACGAAG
ATCCCGATCAGGACATTCTAATTGGCCTCCTAAGGCTACGGAAATGCTCTGAGGAAACCTTCCG
ATTTGAACTGGGTGGAGGCGTTTCCATAGTCCGAGAGCTACATGTGTATGGAAGTGTGGTCCCT
GTGAGCAGCCGGGACCCCACTAAATTTCAGCATCAGGGGTTCGGCATGCTGCTGATGGAAGAAG
CAGAAAGAATCGCTCTGGAAGAGCACGGGTCTGGGAAAATCGCAGTTATATCAGGAGTCGGCAC
AAGAAATTACTACCGAAAGATGGGCTACAGATTGCAAGGCCCGTACATGGTAAAGATGCTAAAA
TAAGACCACTACAGTCTACCTTCATGCAGCGTCCTCTGACTAAATTCAGGTGGGGTCTCCTGAA
TACGCAGCGGAGGCTGAGAGGTAAATGGTCTGCACGCCCCTGGACAGTACTCTGCCCTCCCCTG
CGGCTGCCACTCACAACTCTGACCCCTGTGACAGAGGCCAAATTCACCCTCTTTATGTGTCCGT
GGAGCCACTTCTGGTTTTGAGGCTTAAAGGATTTTAAATTCTGCATGAAGGCTGCAGGTGACCC
ATTTGGGCTCAGATGCTATGTGACCAGAGCAAATCAACTCCTTAGGCCATCATCACTTGTGATT
GTCATCTGAGGGGCAGGCTCGGGAGAAGATTAGTTATATATCCACAGACAAAAGCCGGACTGTA
GCGCAGACAAGCTGTCAGACGTGACTCTCTGCCCTTTAACCACGTGCACATTCACCCAGAGACG
GAGAAGATGAGCTTTGCAGTGGGAGTCTCCGTGGCCCTGCCATGTCTTGAAATGGCCGTGTTTG
GGGAAGGAAGAGCTATGGTAGTGGGTAGTGTTAAGCTTGATGCCGGCTGTCTCACCTGCCCTGA
GCCAGGCCTCTCAGAGCCTTTCCTTTGTCTCATATCTGTGAAAGTCTGTGCGTCCATACCCCTG
ACACCTGCAGGGCAGTGTGCACTATCTCATGTGTGCTGGGCTAGCTTGTGCCAGCCAGTTCATC
TGTCCTGCGCATCACGGTCCAGGGTGCATGGCTAGAGCCTCATGGCCCTGGTCAGGACTAGTCC
ATCCTCAGACACGTCTCTGCATGTTAATTCTGTGAGGTTGGTAGTGGTGATGGTGCTGCATGAA
GAAGGTAGGAGTTAGGCTAGTGTGTGAAAGTGGGCCTGTCTGAGCATGGAGGGACAGTGGGCTT
TTCAGAGGCTTCTTCACCATCCAGCTTGTCCACTGAGGAGACCAGGCTCTGAGACAGCCTGCCT
CGCCTGGGCATCTGTCATTTCCAGCAGTGTTTAGTGAAAGCTGTTCTCTAAAAGGTCTGAAAAA
TAAAGTGTTTGGCACAAAAGAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_002728336	(Get FASTA)	NCBI Sequence Viewer
	XP_003751553	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL85359	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	XP_002728336 ⟸ XM_002728290
- Peptide Label:	isoform X2
- UniProtKB:	D4ACM1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKQKRKGDLSPAELMMLTIGDVIKQLVEAHEQGKDVDLNKLKTKTASKYGLSSQPRLVDIIAAV PPHYRKILIPKLKAKPIRTASGIAVVAVMCKPHRCPHISFTGNICVYCPGGPDSDFEYSTQSYT GYEPTSMRAIRARYDPYLQTRHRIEQLKQLGHSVDKVEFIVMGGTFMALPEEYRDYFIRNLHDA LSGHTSNNIYEAIKYSERSLTKCIGITIETRPDYCMKRHLSDMLTYGCTRLEIGVQSVYEDVAR DTNRGHTVKAVCESFHLAKDSGFKVVAHMMPDLPNVGLERDIEQFIEFFENPAFRPDGLKLYPT LVIRGTGLYELWKSGRYRSYSPSDLIELVARILALVPPWTRVYRVQRDIPMPLVSSGVDHGNLR ELAFARMKDLGIQCRDVRTREVGIQEIHHRVRPYQVELVRRDYVANGGWETFLSYEDPDQDILI GLLRLRKCSEETFRFELGGGVSIVRELHVYGSVVPVSSRDPTKFQHQGFGMLLMEEAERIALEE HGSGKIAVISGVGTRNYYRKMGYRLQGPYMVKMLK hide sequence

RefSeq Acc Id:	XP_003751553 ⟸ XM_003751505
- Peptide Label:	isoform X1
- UniProtKB:	D4ACM1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKQKRKGAKNAGQGHKGGGGCSEITGDLSPAELMMLTIGDVIKQLVEAHEQGKDVDLNKLKTKT ASKYGLSSQPRLVDIIAAVPPHYRKILIPKLKAKPIRTASGIAVVAVMCKPHRCPHISFTGNIC VYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPYLQTRHRIEQLKQLGHSVDKVEFIVMGGT FMALPEEYRDYFIRNLHDALSGHTSNNIYEAIKYSERSLTKCIGITIETRPDYCMKRHLSDMLT YGCTRLEIGVQSVYEDVARDTNRGHTVKAVCESFHLAKDSGFKVVAHMMPDLPNVGLERDIEQF IEFFENPAFRPDGLKLYPTLVIRGTGLYELWKSGRYRSYSPSDLIELVARILALVPPWTRVYRV QRDIPMPLVSSGVDHGNLRELAFARMKDLGIQCRDVRTREVGIQEIHHRVRPYQVELVRRDYVA NGGWETFLSYEDPDQDILIGLLRLRKCSEETFRFELGGGVSIVRELHVYGSVVPVSSRDPTKFQ HQGFGMLLMEEAERIALEEHGSGKIAVISGVGTRNYYRKMGYRLQGPYMVKMLK hide sequence

RefSeq Acc Id:

ENSRNOP00000019262 ⟸ ENSRNOT00000019262

RefSeq Acc Id:

ENSRNOP00000085832 ⟸ ENSRNOT00000098117

RefSeq Acc Id:

ENSRNOP00000085019 ⟸ ENSRNOT00000104506

Protein Domains

N-acetyltransferase Radical SAM core

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4ACM1-F1-model_v2	AlphaFold	D4ACM1	1-547	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699789

Promoter ID:

EPDNEW_R10311

Type:

initiation region

Name:

Elp3_1

Description:

elongator acetyltransferase complex subunit 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	15	49,005,027 - 49,005,087	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2324506	AgrOrtholog
BioCyc Gene	G2FUF-13355	BioCyc
Ensembl Genes	ENSRNOG00000014291	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000019262	ENTREZGENE
	ENSRNOP00000019262.7	UniProtKB/TrEMBL
	ENSRNOP00000085019	ENTREZGENE
	ENSRNOP00000085019.1	UniProtKB/TrEMBL
	ENSRNOP00000085832.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000019262	ENTREZGENE
	ENSRNOT00000019262.8	UniProtKB/TrEMBL
	ENSRNOT00000098117.1	UniProtKB/TrEMBL
	ENSRNOT00000104506	ENTREZGENE
	ENSRNOT00000104506.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.630.30	UniProtKB/TrEMBL
InterPro	AcTrfase_GCN5-related	UniProtKB/TrEMBL
	Acyl_CoA_acyltransferase	UniProtKB/TrEMBL
	ELP3	UniProtKB/TrEMBL
	ELP3-like	UniProtKB/TrEMBL
	Elp3/MiaB/NifB	UniProtKB/TrEMBL
	Radical_SAM	UniProtKB/TrEMBL
	Radical_SAM_C	UniProtKB/TrEMBL
KEGG Report	rno:100362548	UniProtKB/TrEMBL
NCBI Gene	100362548	ENTREZGENE
PANTHER	PTHR11135	UniProtKB/TrEMBL
	PTHR11135:SF0	UniProtKB/TrEMBL
Pfam	Acetyltransf_1	UniProtKB/TrEMBL
	Radical_SAM	UniProtKB/TrEMBL
	Radical_SAM_C	UniProtKB/TrEMBL
PhenoGen	Elp3	PhenoGen
PIRSF	Hist_AcTrfase_ELP3	UniProtKB/TrEMBL
PROSITE	GNAT	UniProtKB/TrEMBL
	RADICAL_SAM	UniProtKB/TrEMBL
SMART	Elp3	UniProtKB/TrEMBL
Superfamily-SCOP	Acyl_CoA_acyltransferase	UniProtKB/TrEMBL
	Radical SAM enzymes	UniProtKB/TrEMBL
TIGRFAMs	ELP3	UniProtKB/TrEMBL
UniProt	A0A8I5ZZ89_RAT	UniProtKB/TrEMBL
	A0A8I6A114_RAT	UniProtKB/TrEMBL
	D4ACM1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-08-13	Elp3	elongator acetyltransferase complex subunit 3	LOC100362548	rCG52086-like	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-08-13	Elp3	elongator acetyltransferase complex subunit 3	Elp3	elongation protein 3 homolog (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-08-13	Elp3	elongation protein 3 homolog (S. cerevisiae)	Elp3	elongator acetyltransferase complex subunit 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-05-06	LOC100362548	rCG52086-like			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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