SEMA4B (semaphorin 4B) - Rat Genome Database

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Gene: SEMA4B (semaphorin 4B) Chlorocebus sabaeus
Analyze
Symbol: SEMA4B
Name: semaphorin 4B
RGD ID: 18718119
Description: ENCODES a protein that exhibits chemorepellent activity (inferred); semaphorin receptor binding (inferred); INVOLVED IN axon guidance (inferred); cell differentiation (inferred); negative chemotaxis (inferred); ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); D-2-hydroxyglutaric aciduria 2 (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: semaphorin-4B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1298,733,647 - 8,776,618 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl298,749,015 - 8,775,621 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605937,953,982 - 37,981,988 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SEMA4B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1298,733,647 - 8,776,618 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl298,749,015 - 8,775,621 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605937,953,982 - 37,981,988 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SEMA4B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381590,184,920 - 90,229,661 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1590,160,604 - 90,229,679 (+)EnsemblGRCh38hg38GRCh38
GRCh371590,728,152 - 90,772,893 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361588,529,156 - 88,573,896 (+)NCBINCBI36Build 36hg18NCBI36
Build 341588,545,565 - 88,573,894NCBI
Celera1567,132,562 - 67,177,271 (+)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1566,840,233 - 66,884,886 (+)NCBIHuRef
CHM1_11590,570,020 - 90,614,740 (+)NCBICHM1_1
T2T-CHM13v2.01587,940,946 - 87,985,668 (+)NCBIT2T-CHM13v2.0
Sema4b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39779,836,618 - 79,876,394 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl779,836,589 - 79,876,275 (+)EnsemblGRCm39 Ensembl
GRCm38780,186,870 - 80,226,646 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl780,186,841 - 80,226,527 (+)EnsemblGRCm38mm10GRCm38
MGSCv37787,331,727 - 87,371,410 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36780,072,038 - 80,099,907 (+)NCBIMGSCv36mm8
Celera777,588,064 - 77,627,863 (+)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.51NCBI
Sema4b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,545,727 - 143,587,037 (+)NCBIGRCr8
mRatBN7.21134,136,646 - 134,177,777 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,149,536 - 134,177,775 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1142,058,363 - 142,086,508 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01149,227,763 - 149,255,908 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01142,145,557 - 142,173,801 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01141,986,145 - 142,014,400 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1141,986,145 - 142,014,398 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01142,941,088 - 142,968,795 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41136,001,219 - 136,031,302 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11136,079,624 - 136,109,702 (+)NCBI
Celera1126,209,674 - 126,237,909 (+)NCBICelera
Cytogenetic Map1q31NCBI
Sema4b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541615,108,175 - 15,130,746 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541615,107,258 - 15,143,338 (-)NCBIChiLan1.0ChiLan1.0
SEMA4B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21679,733,117 - 79,777,995 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11583,432,586 - 83,477,430 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01568,873,927 - 68,918,792 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11588,076,399 - 88,120,729 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1588,076,399 - 88,120,729 (+)Ensemblpanpan1.1panPan2
SEMA4B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,159,233 - 53,184,102 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,121,775 - 53,184,118 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha355,751,921 - 55,822,246 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0353,575,541 - 53,600,478 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,575,536 - 53,600,127 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1353,050,291 - 53,120,581 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0353,306,792 - 53,331,717 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0353,647,261 - 53,672,192 (+)NCBIUU_Cfam_GSD_1.0
Sema4b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640130,371,613 - 130,410,098 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648315,937,398 - 15,961,911 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648315,937,132 - 15,963,170 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SEMA4B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl755,753,097 - 55,793,980 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1755,752,854 - 55,793,982 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sema4b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476817,185,161 - 17,207,666 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476817,170,732 - 17,208,601 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SEMA4B
1086 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000015199   ⟹   ENSCSAP00000013145
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl298,749,015 - 8,775,621 (+)Ensembl
RefSeq Acc Id: XM_037987685   ⟹   XP_037843613
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605937,953,982 - 37,981,988 (-)NCBI
RefSeq Acc Id: XM_037987686   ⟹   XP_037843614
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605937,953,982 - 37,966,460 (-)NCBI
Protein Sequences
Protein RefSeqs XP_037843613 (Get FASTA)   NCBI Sequence Viewer  
  XP_037843614 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000013145.1
Ensembl Acc Id: ENSCSAP00000013145   ⟸   ENSCSAT00000015199
RefSeq Acc Id: XP_037843613   ⟸   XM_037987685
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RX06 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037843614   ⟸   XM_037987686
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000017114 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000015199.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
  ligand-binding face of the semaphorins, domain 2 UniProtKB/TrEMBL
InterPro Plexin_repeat UniProtKB/TrEMBL
  PSI UniProtKB/TrEMBL
  Semap_dom UniProtKB/TrEMBL
  Semap_dom_sf UniProtKB/TrEMBL
  Semaphorin UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
NCBI Gene SEMA4B ENTREZGENE
PANTHER PTHR11036 UniProtKB/TrEMBL
  SEMAPHORIN-4B UniProtKB/TrEMBL
Pfam PSI UniProtKB/TrEMBL
  Sema UniProtKB/TrEMBL
PROSITE SEMA UniProtKB/TrEMBL
SMART PSI UniProtKB/TrEMBL
  Sema UniProtKB/TrEMBL
Superfamily-SCOP Plexin repeat UniProtKB/TrEMBL
  SSF101912 UniProtKB/TrEMBL
UniProt A0A0D9RX06 ENTREZGENE, UniProtKB/TrEMBL