Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Sema4b | Mouse | 17beta-estradiol | decreases expression | ISO | SEMA4B (Homo sapiens) | 6480464 | Estradiol results in decreased expression of SEMA4B mRNA | CTD | PMID:24758408 | Sema4b | Mouse | 17beta-estradiol | multiple interactions | ISO | SEMA4B (Homo sapiens) | 6480464 | EGF protein inhibits the reaction [Estradiol results in decreased expression of SEMA4B mRNA] | CTD | PMID:24758408 | Sema4b | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Sema4b (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SEMA4B mRNA | CTD | PMID:22298810 | Sema4b | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of SEMA4B mRNA | CTD | PMID:21570461 | Sema4b | Mouse | 2-methylcholine | affects expression | ISO | SEMA4B (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of SEMA4B mRNA | CTD | PMID:21179406 | Sema4b | Mouse | 3,4-methylenedioxymethamphetamine | decreases expression | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of SEMA4B mRNA | CTD | PMID:26251327 | Sema4b | Mouse | 4,4'-sulfonyldiphenol | decreases methylation | ISO | SEMA4B (Homo sapiens) | 6480464 | bisphenol S results in decreased methylation of SEMA4B gene | CTD | PMID:31601247 | Sema4b | Mouse | 6-propyl-2-thiouracil | affects expression | ISO | Sema4b (Rattus norvegicus) | 6480464 | Propylthiouracil affects the expression of SEMA4B mRNA | CTD | PMID:24780913 | Sema4b | Mouse | 6-propyl-2-thiouracil | decreases expression | ISO | Sema4b (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of SEMA4B mRNA | CTD | PMID:30047161 and PMID:36843608 | Sema4b | Mouse | acetazolamide | increases expression | EXP | | 6480464 | Acetazolamide results in increased expression of SEMA4B mRNA | CTD | PMID:19274763 | Sema4b | Mouse | all-trans-retinoic acid | increases expression | ISO | SEMA4B (Homo sapiens) | 6480464 | Tretinoin results in increased expression of SEMA4B mRNA | CTD | PMID:33167477 | Sema4b | Mouse | alpha-Zearalanol | multiple interactions | ISO | Sema4b (Rattus norvegicus) | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in increased expression of SEMA4B mRNA | CTD | PMID:35163327 | Sema4b | Mouse | amitrole | decreases expression | ISO | Sema4b (Rattus norvegicus) | 6480464 | Amitrole results in decreased expression of SEMA4B mRNA | CTD | PMID:30047161 | Sema4b | Mouse | antirheumatic drug | decreases expression | ISO | SEMA4B (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of SEMA4B mRNA | CTD | PMID:24449571 | Sema4b | Mouse | arsane | affects methylation | ISO | SEMA4B (Homo sapiens) | 6480464 | Arsenic affects the methylation of SEMA4B gene | CTD | PMID:25304211 | Sema4b | Mouse | arsenic atom | affects methylation | ISO | SEMA4B (Homo sapiens) | 6480464 | Arsenic affects the methylation of SEMA4B gene | CTD | PMID:25304211 | Sema4b | Mouse | azoxystrobin | decreases expression | ISO | SEMA4B (Homo sapiens) | 6480464 | azoxystrobin results in decreased expression of SEMA4B mRNA | CTD | PMID:33512557 | Sema4b | Mouse | benzo[a]pyrene | affects methylation | ISO | SEMA4B (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of SEMA4B 5' UTR and Benzo(a)pyrene affects the methylation of SEMA4B promoter | CTD | PMID:27901495 | Sema4b | Mouse | beta-lapachone | increases expression | ISO | SEMA4B (Homo sapiens) | 6480464 | beta-lapachone results in increased expression of SEMA4B mRNA | CTD | PMID:38218311 | Sema4b | Mouse | bisphenol A | increases expression | ISO | Sema4b (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of SEMA4B mRNA | CTD | PMID:25181051 and PMID:34947998 | Sema4b | Mouse | bisphenol A | increases expression | ISO | SEMA4B (Homo sapiens) | 6480464 | bisphenol A results in increased expression of SEMA4B mRNA | CTD | PMID:33670352 | Sema4b | Mouse | butan-1-ol | multiple interactions | ISO | SEMA4B (Homo sapiens) | 6480464 | [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of SEMA4B mRNA | CTD | PMID:29432896 | Sema4b | Mouse | butanal | decreases expression | ISO | SEMA4B (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of SEMA4B mRNA | CTD | PMID:26079696 | Sema4b | Mouse | cadmium dichloride | increases expression | ISO | SEMA4B (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of SEMA4B mRNA | CTD | PMID:38382870 | Sema4b | Mouse | caffeine | increases phosphorylation | ISO | SEMA4B (Homo sapiens) | 6480464 | Caffeine results in increased phosphorylation of SEMA4B protein | CTD | PMID:35688186 | Sema4b | Mouse | calcitriol | increases expression | ISO | SEMA4B (Homo sapiens) | 6480464 | Calcitriol results in increased expression of SEMA4B mRNA | CTD | PMID:16002434 and PMID:26485663 | Sema4b | Mouse | carbon nanotube | increases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25620056 | Sema4b | Mouse | CGP 52608 | multiple interactions | ISO | SEMA4B (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to SEMA4B gene] | CTD | PMID:28238834 | Sema4b | Mouse | chlorpyrifos | increases expression | EXP | | 6480464 | Chlorpyrifos results in increased expression of SEMA4B mRNA | CTD | PMID:20350560 and PMID:37019170 | Sema4b | Mouse | cocaine | increases expression | ISO | Sema4b (Rattus norvegicus) | 6480464 | Cocaine results in increased expression of SEMA4B mRNA | CTD | PMID:15691709 | Sema4b | Mouse | Cuprizon | affects expression | ISO | Sema4b (Rattus norvegicus) | 6480464 | Cuprizone affects the expression of SEMA4B mRNA | CTD | PMID:26577399 | Sema4b | Mouse | cyclosporin A | decreases expression | ISO | SEMA4B (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of SEMA4B mRNA | CTD | PMID:20106945 | Sema4b | Mouse | deguelin | decreases expression | ISO | SEMA4B (Homo sapiens) | 6480464 | deguelin results in decreased expression of SEMA4B mRNA | CTD | PMID:33512557 | Sema4b | Mouse | diclofenac | increases expression | EXP | | 6480464 | Diclofenac results in increased expression of SEMA4B mRNA | CTD | PMID:26934552 | Sema4b | Mouse | dioxygen | increases expression | ISO | SEMA4B (Homo sapiens) | 6480464 | Oxygen deficiency results in increased expression of SEMA4B mRNA | CTD | PMID:26516004 | Sema4b | Mouse | doxorubicin | decreases expression | ISO | SEMA4B (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of SEMA4B mRNA | CTD | PMID:29803840 | Sema4b | Mouse | ethanol | increases expression | EXP | | 6480464 | Ethanol results in increased expression of SEMA4B mRNA | CTD | PMID:30319688 | Sema4b | Mouse | fenpyroximate | decreases expression | ISO | SEMA4B (Homo sapiens) | 6480464 | fenpyroximate results in decreased expression of SEMA4B mRNA | CTD | PMID:33512557 | Sema4b | Mouse | fenthion | decreases expression | EXP | | 6480464 | Fenthion results in decreased expression of SEMA4B mRNA | CTD | PMID:34813904 | Sema4b | Mouse | glycidol | decreases expression | ISO | Sema4b (Rattus norvegicus) | 6480464 | glycidol results in decreased expression of SEMA4B mRNA | CTD | PMID:24915197 | Sema4b | Mouse | iron dichloride | decreases expression | ISO | SEMA4B (Homo sapiens) | 6480464 | ferrous chloride results in decreased expression of SEMA4B mRNA | CTD | PMID:35984750 | Sema4b | Mouse | ivermectin | decreases expression | ISO | SEMA4B (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of SEMA4B protein | CTD | PMID:32959892 | Sema4b | Mouse | methidathion | decreases expression | EXP | | 6480464 | methidathion results in decreased expression of SEMA4B mRNA | CTD | PMID:34813904 | Sema4b | Mouse | methimazole | decreases expression | ISO | Sema4b (Rattus norvegicus) | 6480464 | Methimazole results in decreased expression of SEMA4B mRNA | CTD | PMID:30047161 | Sema4b | Mouse | oxaliplatin | multiple interactions | ISO | Sema4b (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of SEMA4B mRNA | CTD | PMID:25729387 | Sema4b | Mouse | ozone | multiple interactions | ISO | SEMA4B (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of SEMA4B mRNA | CTD | PMID:35430440 | Sema4b | Mouse | paracetamol | decreases expression | ISO | SEMA4B (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of SEMA4B mRNA | CTD | PMID:21420995 and PMID:29067470 | Sema4b | Mouse | perfluorohexanesulfonic acid | decreases expression | EXP | | 6480464 | perfluorohexanesulfonic acid results in decreased expression of SEMA4B mRNA | CTD | PMID:37995155 | Sema4b | Mouse | perfluorononanoic acid | decreases expression | ISO | SEMA4B (Homo sapiens) | 6480464 | perfluoro-n-nonanoic acid results in decreased expression of SEMA4B mRNA | CTD | PMID:32588087 | Sema4b | Mouse | perfluorooctanoic acid | multiple interactions | ISO | Sema4b (Rattus norvegicus) | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in increased expression of SEMA4B mRNA | CTD | PMID:35163327 | Sema4b | Mouse | picoxystrobin | decreases expression | ISO | SEMA4B (Homo sapiens) | 6480464 | picoxystrobin results in decreased expression of SEMA4B mRNA | CTD | PMID:33512557 | Sema4b | Mouse | progesterone | affects expression | EXP | | 6480464 | Progesterone affects the expression of SEMA4B mRNA | CTD | PMID:17251523 | Sema4b | Mouse | pyrimidifen | decreases expression | ISO | SEMA4B (Homo sapiens) | 6480464 | pyrimidifen results in decreased expression of SEMA4B mRNA | CTD | PMID:33512557 | Sema4b | Mouse | raloxifene | decreases expression | ISO | SEMA4B (Homo sapiens) | 6480464 | Raloxifene Hydrochloride results in decreased expression of SEMA4B mRNA | CTD | PMID:19429434 | Sema4b | Mouse | senecionine | decreases expression | EXP | | 6480464 | senecionine results in decreased expression of SEMA4B protein | CTD | PMID:35357534 | Sema4b | Mouse | silicon dioxide | decreases expression | ISO | SEMA4B (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of SEMA4B mRNA | CTD | PMID:25895662 | Sema4b | Mouse | sodium arsenite | multiple interactions | ISO | SEMA4B (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of and affects the splicing of SEMA4B mRNA | CTD | PMID:25879800 | Sema4b | Mouse | sodium arsenite | decreases expression | ISO | SEMA4B (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of SEMA4B mRNA | CTD | PMID:38568856 | Sema4b | Mouse | sulfadimethoxine | decreases expression | ISO | Sema4b (Rattus norvegicus) | 6480464 | Sulfadimethoxine results in decreased expression of SEMA4B mRNA | CTD | PMID:30047161 | Sema4b | Mouse | tamoxifen | decreases expression | ISO | SEMA4B (Homo sapiens) | 6480464 | Tamoxifen results in decreased expression of SEMA4B mRNA | CTD | PMID:19429434 | Sema4b | Mouse | tebufenpyrad | decreases expression | ISO | SEMA4B (Homo sapiens) | 6480464 | 4-chloro-N-((4-(1 and 1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide results in decreased expression of SEMA4B mRNA | CTD | PMID:33512557 | Sema4b | Mouse | temozolomide | decreases expression | ISO | SEMA4B (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of SEMA4B mRNA | CTD | PMID:31758290 | Sema4b | Mouse | thiram | decreases expression | ISO | SEMA4B (Homo sapiens) | 6480464 | Thiram results in decreased expression of SEMA4B mRNA | CTD | PMID:38568856 | Sema4b | Mouse | titanium dioxide | decreases expression | EXP | | 6480464 | titanium dioxide results in decreased expression of SEMA4B mRNA | CTD | PMID:29264374 | Sema4b | Mouse | titanium dioxide | decreases methylation | EXP | | 6480464 | titanium dioxide results in decreased methylation of SEMA4B gene and titanium dioxide results in decreased methylation of SEMA4B promoter | CTD | PMID:35295148 | Sema4b | Mouse | topotecan | decreases expression | ISO | Sema4b (Rattus norvegicus) | 6480464 | Topotecan results in decreased expression of SEMA4B mRNA | CTD | PMID:25729387 | Sema4b | Mouse | topotecan | multiple interactions | ISO | Sema4b (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of SEMA4B mRNA | CTD | PMID:25729387 | Sema4b | Mouse | trichloroethene | increases expression | ISO | Sema4b (Rattus norvegicus) | 6480464 | Trichloroethylene results in increased expression of SEMA4B mRNA | CTD | PMID:33387578 | Sema4b | Mouse | triphenyl phosphate | affects expression | ISO | SEMA4B (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of SEMA4B mRNA | CTD | PMID:37042841 | Sema4b | Mouse | tris(2-butoxyethyl) phosphate | affects expression | ISO | SEMA4B (Homo sapiens) | 6480464 | tris(2-butoxyethyl) phosphate affects the expression of SEMA4B mRNA | CTD | PMID:29024780 | Sema4b | Mouse | trovafloxacin | increases expression | EXP | | 6480464 | trovafloxacin results in increased expression of SEMA4B mRNA | CTD | PMID:35537566 | Sema4b | Mouse | tungsten | decreases expression | EXP | | 6480464 | Tungsten results in decreased expression of SEMA4B mRNA | CTD | PMID:30912803 | Sema4b | Mouse | urethane | increases expression | ISO | SEMA4B (Homo sapiens) | 6480464 | Urethane results in increased expression of SEMA4B mRNA | CTD | PMID:28818685 | Sema4b | Mouse | vinclozolin | increases expression | ISO | Sema4b (Rattus norvegicus) | 6480464 | vinclozolin results in increased expression of SEMA4B mRNA | CTD | PMID:23869203 | Sema4b | Mouse | vinclozolin | decreases methylation | ISO | Sema4b (Rattus norvegicus) | 6480464 | vinclozolin results in decreased methylation of SEMA4B gene | CTD | PMID:31079544 | Sema4b | Mouse | zinc atom | multiple interactions | ISO | SEMA4B (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of SEMA4B mRNA | CTD | PMID:18593933 | Sema4b | Mouse | zinc(0) | multiple interactions | ISO | SEMA4B (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of SEMA4B mRNA | CTD | PMID:18593933 | |