CREB3 (cAMP responsive element binding protein 3)

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Gene: CREB3 (cAMP responsive element binding protein 3) Chlorocebus sabaeus

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Symbol:

CREB3

Name:

cAMP responsive element binding protein 3

RGD ID:

18714507

Description:

ENCODES a protein that exhibits cAMP response element binding protein binding (ortholog); CCR1 chemokine receptor binding (ortholog); chromatin binding (ortholog); INVOLVED IN cytoplasmic sequestering of transcription factor (ortholog); DNA-templated transcription (ortholog); establishment of viral latency (ortholog); PARTICIPATES IN endoplasmic reticulum stress - the unfolded protein response pathway; ASSOCIATED WITH acromesomelic dysplasia, Maroteaux type (ortholog); anauxetic dysplasia (ortholog); autosomal recessive distal hereditary motor neuronopathy 2 (ortholog); FOUND IN cytoplasm (ortholog); Golgi apparatus (ortholog); Golgi membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cyclic AMP-responsive element-binding protein 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	44,865,409 - 44,870,074 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	44,865,682 - 44,869,621 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	41,968,965 - 41,973,616 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acromesomelic dysplasia, Maroteaux type (ISO)

anauxetic dysplasia (ISO)

autosomal recessive distal hereditary motor neuronopathy 2 (ISO)

breast ductal carcinoma (ISO)

distal arthrogryposis type 1A (ISO)

frontotemporal dementia and/or amyotrophic lateral sclerosis 6 (ISO)

galactosemia (ISO)

hyperphosphatasia with impaired intellectual development syndrome 2 (ISO)

invasive ductal carcinoma (ISO)

paraplegia (ISO)

primary ciliary dyskinesia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cytoplasmic sequestering of transcription factor (ISO)

DNA-templated transcription (ISO)

endoplasmic reticulum unfolded protein response (IEA)

establishment of viral latency (ISO)

induction of positive chemotaxis (ISO)

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (IEA)

positive regulation of calcium ion transport (ISO)

positive regulation of cell migration (ISO)

positive regulation of deacetylase activity (ISO)

positive regulation of defense response to virus by host (ISO)

positive regulation of DNA-templated transcription (ISO)

positive regulation of monocyte chemotaxis (IEA)

positive regulation of transcription by RNA polymerase II (IEA)

regulation of apoptotic process (ISO)

regulation of cell growth (ISO)

regulation of cell population proliferation (ISO)

regulation of DNA-templated transcription (IEA)

regulation of transcription by RNA polymerase II (IEA)

release from viral latency (ISO)

response to endoplasmic reticulum stress (ISO)

response to unfolded protein (IEA)

Cellular Component

cytoplasm (ISO)

cytosol (IEA)

endoplasmic reticulum (IEA)

endoplasmic reticulum membrane (IEA)

Golgi apparatus (ISO)

Golgi membrane (ISO)

membrane (ISO)

neuronal cell body (ISO)

nuclear body (ISO)

nucleus (IEA)

RNA polymerase II transcription regulator complex (IEA)

Molecular Function

cAMP response element binding protein binding (ISO)

CCR1 chemokine receptor binding (ISO)

chromatin binding (ISO)

DNA binding (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (IEA)

DNA-binding transcription factor activity (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IEA)

identical protein binding (IEA)

protein binding (ISO)

protein homodimerization activity (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IEA)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (ISO)

sequence-specific DNA binding (ISO)

sequence-specific double-stranded DNA binding (IEA)

transcription coregulator binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

endoplasmic reticulum stress - the unfolded protein response pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

CREB3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	44,865,409 - 44,870,074 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	44,865,682 - 44,869,621 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	41,968,965 - 41,973,616 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

CREB3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	35,732,666 - 35,736,999 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	35,732,598 - 35,736,999 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	35,732,663 - 35,736,996 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	35,722,317 - 35,727,005 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	35,722,316 - 35,727,004	NCBI
Celera	9	35,665,867 - 35,670,555 (+)	NCBI		Celera
Cytogenetic Map	9	p13.3	NCBI
HuRef	9	35,687,941 - 35,692,625 (+)	NCBI		HuRef
CHM1_1	9	35,732,720 - 35,737,408 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	35,753,346 - 35,757,679 (+)	NCBI		T2T-CHM13v2.0

Creb3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	43,562,658 - 43,567,061 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	43,562,332 - 43,567,060 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	43,562,658 - 43,567,061 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	43,562,332 - 43,567,060 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	43,575,506 - 43,579,932 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	43,583,769 - 43,587,967 (+)	NCBI		MGSCv36	mm8
Celera	4	43,596,627 - 43,601,049 (+)	NCBI		Celera
Cytogenetic Map	4	A5	NCBI
cM Map	4	23.05	NCBI

Creb3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	62,613,652 - 62,619,019 (+)	NCBI		GRCr8
mRatBN7.2	5	57,817,865 - 57,823,233 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	57,817,832 - 57,824,390 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	59,797,695 - 59,803,062 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	61,616,511 - 61,621,878 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	61,587,974 - 61,593,343 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	59,063,532 - 59,068,196 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	59,063,531 - 59,068,188 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	63,588,126 - 63,592,790 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	60,040,874 - 60,045,512 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	60,041,052 - 60,045,688 (+)	NCBI
Celera	5	56,398,438 - 56,403,076 (+)	NCBI		Celera
Cytogenetic Map	5	q22	NCBI

Creb3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955472	564,493 - 568,491 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955472	564,227 - 568,708 (-)	NCBI	ChiLan1.0	ChiLan1.0

CREB3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	88,851,453 - 88,855,944 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	88,855,363 - 88,862,231 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	35,583,351 - 35,587,870 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	36,385,867 - 36,390,540 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	36,385,867 - 36,390,540 (+)	Ensembl	panpan1.1		panPan2

CREB3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	52,260,340 - 52,265,085 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	52,260,420 - 52,266,515 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	50,827,661 - 50,832,639 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	53,325,030 - 53,330,008 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	53,325,322 - 53,330,008 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	51,869,576 - 51,874,554 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	51,853,091 - 51,858,072 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	52,555,244 - 52,560,222 (+)	NCBI		UU_Cfam_GSD_1.0

Creb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	167,179,510 - 167,183,384 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936524	3,727,098 - 3,730,975 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936524	3,727,104 - 3,730,962 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CREB3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	236,450,573 - 236,456,375 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	236,450,573 - 236,456,381 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	264,175,788 - 264,181,569 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Creb3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624868	5,056,691 - 5,060,669 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624868	5,056,415 - 5,061,234 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007968777	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000008640 ⟹ ENSCSAP00000006782

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	12	44,865,682 - 44,869,621 (-)	Ensembl

RefSeq Acc Id:

XM_007968777 ⟹ XP_007966968

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	12	44,865,409 - 44,870,074 (-)	NCBI
Vero_WHO_p1.0	NW_023666038	41,968,965 - 41,973,616 (-)	NCBI

Sequence:

show sequence

GGAAGCGAGGGTGCGGCGCAATCCGGAGAGAACGCCAAGACGACGCCCGAGTTCCCTTTCAGGC
CAGAACTCTTCCTTTTTCTAGCTTGGGGGAGAAGGCGGAGCCGGAGCCCCGGAACCCCCGCCCT
CGGGGTGCGAGGCGGCAGCAGGGCCGTCCCCTACATTTGCATAGCCCCTGGGACGTGGCGCGGC
ACCCAGGCCTCTTCTCAGTTGGAGGGAACTCCAAGTCCCACAGTGCCACGGGGTGGGGTGCGTC
ACTTTCGCTGCGTTGGAGGCTGAGGAGAATTGAGCCTGGGAGGCGGGTCCGGAGAGGGCTACGG
AAAGCCCCTGGCGGGGAAGCCCGGCCGTAGAGGGACAGTGGATAGGTGCTCGAGGCCTGCAGCT
GGCCTGGGGCTCGTGTCTGGGCTTTGGACGTTGGGGCCCGGTGGCCCACCCTTTCCGTAGTTGT
CCCAAATGGAGCTGGAATTGGACGCTGGTGACCAAGACCTGCTGGGCTTCCTGCTAGAGGAAAG
TGGAGATTTGGGGACGGCGCCCGATGAGTCCGTGAGGGCCCCGCTGGACTGGGAGCTGCCGCTT
TCTGAGGTACCGAGCGACTGGGAGGTAGATGATTTGCTGAGCTCCCTGCTGAGTCCCCCAGCGT
CGTCGTTGAACGTTCTCAGCAACTCCAACCCCTGCCTTGTCCACCATGACCACACCTACTCCCT
CCCACGGGAACCTGTCTCTATGGATCTAGAGAGTGAGAGCTGTAGAAAAGAGGGGACCCAGATG
ACTCCACAGCATATGGAGGAGCTGGCAGAGCAGGAGATTGCTAGGCTGGTACTGACAGATGAGG
AGAAGAGTCTATTGGAGAAGGAGGGGCTTATTCTGCCTGAGACACTTCCTCTCACTAAGATGGA
GGAACAAATTCTGAAACGTGTGCGGAGGAAGATCCGAAATAAAAGATCTGCTCAAGAGAGCCGC
AGGAAAAAGAAGGTGTATGTTGGGGGTTTAGAGAGCAGGGTCTTGAAATACACAGCCCAGAATA
TGGAGCTTCAGAACAAAGTACAGCTTCTTGAGGAACAGAATTTGTCCCTTATACATCAACTGAG
GAAACTCCAGGCCATGGTGATTGAGATATCAAACAAAACGAGCAGTAGCAGCACCTGCATCTTG
GTCCTACTAGTCTCCTTCTGCCTCCTCCTTGTACCTGCTATGTACTCCTCTGACACAAGGGGGA
GCCTGCCAGCTGAGCATGGAGTGTTGTCCCGCCAGCTTCGTGCCCTCCCCAGTGAGAACCCTTA
CCAGCTGGAGTTGCCTACCCTGCAGTCAGAGGTGCCAAAAGACAGCACACACCAGTGGCTGGAC
AGCTCAGACCACGTACTCCAGGCTCCTGGCAACTCTTCCTGCCTACTGTACTACATGCCTCAGG
CTCCCAGTGCAGAGCCTCCCCTGGAGTGGCCATTCCCTGACCTCTTCTCAGAGCCTCTCTGCCG
AGGTCCCATCTTCCCCCTGCAGGCAAATCTCACAAGGAAGGGGGGATGGCTTCCTACCGGTAGC
CCCTCTGTCATCTTGCAGAACAGATACTCAGGCTAGATATGAGGATATGTAGGGGGTCTCAGCA
AGAGCTTGTGGGGCTCCCCATCTGTGTCCAAATAAAAAGGGGTGGGCGAGGGCTGGCTGCAGCT
CCTATGCCCTATCAGGAGGACTGAGGGCTCAAACACACCACACTTACTGGCTTTCTGGGTCTTT
TATTTGTACCCATGTGTCTGTCACCCCATGAATGTACCCGGGGAAATCAACTGACCTCCCTGAA
CATTTCATGCAGTGAGGGAACGGGTGAGGAAAGAAATAAATAAGTGATTCTAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007966968	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000006782.1

RefSeq Acc Id:	XP_007966968 ⟸ XM_007968777
- UniProtKB:	A0A0D9RDU3 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000006782 ⟸ ENSCSAT00000008640

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000010554	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000008640.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.5.170	UniProtKB/TrEMBL
InterPro	bZIP	UniProtKB/TrEMBL
	bZIP_sf	UniProtKB/TrEMBL
	CREB_ATF_subfamily	UniProtKB/TrEMBL
KEGG Report	csab:103219209	UniProtKB/TrEMBL
NCBI Gene	CREB3	ENTREZGENE
PANTHER	AGAP001464-PB	UniProtKB/TrEMBL
	PTHR45996:SF4	UniProtKB/TrEMBL
Pfam	bZIP_1	UniProtKB/TrEMBL
PROSITE	BZIP	UniProtKB/TrEMBL
	BZIP_BASIC	UniProtKB/TrEMBL
SMART	BRLZ	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57959	UniProtKB/TrEMBL
UniProt	A0A0D9RDU3	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

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Imported Disease Annotations - ClinVar

RGD Manual Annotations