ARHGEF39 (Rho guanine nucleotide exchange factor 39) - Rat Genome Database

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Gene: ARHGEF39 (Rho guanine nucleotide exchange factor 39) Chlorocebus sabaeus
Analyze
Symbol: ARHGEF39
Name: Rho guanine nucleotide exchange factor 39
RGD ID: 18709584
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN positive regulation of cell migration (inferred); ASSOCIATED WITH acromesomelic dysplasia, Maroteaux type (ortholog); anauxetic dysplasia (ortholog); autosomal recessive distal hereditary motor neuronopathy 2 (ortholog); FOUND IN plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11244,937,488 - 44,941,708 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1244,937,923 - 44,944,842 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603842,042,641 - 42,047,396 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ARHGEF39Green Monkeyacromesomelic dysplasia, Maroteaux type  ISOARHGEF39 (Homo sapiens)8554872ClinVar Annotator: match by term: Acromesomelic dysplasia 1 and Maroteaux typeClinVarPMID:28492532
ARHGEF39Green Monkeyanauxetic dysplasia  ISOARHGEF39 (Homo sapiens)8554872ClinVar Annotator: match by term: Anauxetic dysplasiaClinVarPMID:28492532
ARHGEF39Green Monkeyautosomal recessive distal hereditary motor neuronopathy 2  ISOARHGEF39 (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal recessive distal spinal muscular atrophy 2ClinVarPMID:28492532
ARHGEF39Green Monkeydistal arthrogryposis type 1A  ISOARHGEF39 (Homo sapiens)8554872ClinVar Annotator: match by term: Arthrogryposis more ...ClinVarPMID:28492532
ARHGEF39Green Monkeyfrontotemporal dementia and/or amyotrophic lateral sclerosis 6  ISOARHGEF39 (Homo sapiens)8554872ClinVar Annotator: match by term: Frontotemporal dementia and/or amyotrophic lateral sclerosis 6ClinVarPMID:28492532
ARHGEF39Green Monkeygalactosemia  ISOARHGEF39 (Homo sapiens)8554872ClinVar Annotator: match by term: Deficiency of UDPglucose-hexose-1-phosphate uridylyltransferaseClinVarPMID:28492532
ARHGEF39Green Monkeyhyperphosphatasia with impaired intellectual development syndrome 2  ISOARHGEF39 (Homo sapiens)8554872ClinVar Annotator: match by term: GLYCOSYLPHOSPHATIDYLINOSITOL BIOSYNTHESIS DEFECT 6ClinVarPMID:22683086 more ...
ARHGEF39Green Monkeyparaplegia  ISOARHGEF39 (Homo sapiens)8554872ClinVar Annotator: match by term: Spastic paraplegiaClinVarPMID:23332916 more ...
ARHGEF39Green Monkeyprimary ciliary dyskinesia  ISOARHGEF39 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary ciliary dyskinesiaClinVarPMID:28492532
1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ARHGEF39Green Monkeyhepatocellular carcinoma  ISOARHGEF39 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:28284560


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ARHGEF39Green Monkeypositive regulation of cell migration involved_inIEAUniProtKB:Q8N4T4 and ensembl:ENSP00000367638150520179 EnsemblGO_REF:0000107
ARHGEF39Green Monkeypositive regulation of cell migration involved_inIEAPANTHER:PTN000517494150520179 TreeGrafterGO_REF:0000118

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ARHGEF39Green Monkeyplasma membrane located_inIEAUniProtKB:Q8N4T4 and ensembl:ENSP00000367638150520179 EnsemblGO_REF:0000107
ARHGEF39Green Monkeyplasma membrane located_inIEAPANTHER:PTN000517494150520179 TreeGrafterGO_REF:0000118

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ARHGEF39Green Monkeyguanyl-nucleotide exchange factor activity enablesIEAInterPro:IPR000219150520179 InterProGO_REF:0000002
ARHGEF39Green Monkeyprotein binding enablesISOUniProtKB:Q2T9J09068941 PMID:33961781IntActPMID:33961781
ARHGEF39Green Monkeyprotein binding enablesISOUniProtKB:Q13137 and UniProtKB:Q96CG39068941 PMID:25416956 and PMID:31515488IntActPMID:25416956 and PMID:31515488

PMID:22301074   PMID:30032202  



ARHGEF39
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11244,937,488 - 44,941,708 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1244,937,923 - 44,944,842 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603842,042,641 - 42,047,396 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ARHGEF39
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38935,659,343 - 35,665,195 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl935,658,875 - 35,675,866 (-)EnsemblGRCh38hg38GRCh38
GRCh37935,659,340 - 35,665,192 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36935,649,341 - 35,655,278 (-)NCBINCBI36Build 36hg18NCBI36
Build 34935,648,873 - 35,655,189NCBI
Celera935,592,890 - 35,598,827 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef935,614,950 - 35,620,887 (-)NCBIHuRef
CHM1_1935,659,169 - 35,665,106 (-)NCBICHM1_1
T2T-CHM13v2.0935,679,995 - 35,685,847 (-)NCBIT2T-CHM13v2.0
Arhgef39
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39443,496,139 - 43,508,747 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl443,496,142 - 43,499,695 (-)EnsemblGRCm39 Ensembl
GRCm38443,496,139 - 43,508,747 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl443,496,142 - 43,499,695 (-)EnsemblGRCm38mm10GRCm38
MGSCv37443,509,014 - 43,512,532 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36443,517,242 - 43,520,730 (-)NCBIMGSCv36mm8
Celera443,530,162 - 43,533,680 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map423.04NCBI
Arhgef39
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8562,548,300 - 62,551,870 (-)NCBIGRCr8
mRatBN7.2557,752,509 - 57,756,079 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,752,509 - 57,756,109 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx559,732,391 - 59,735,965 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0561,551,204 - 61,554,778 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0561,522,655 - 61,526,213 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0558,998,209 - 59,001,779 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl558,995,249 - 59,001,800 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0563,522,803 - 63,526,373 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4559,977,497 - 59,979,258 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1559,976,596 - 59,979,421 (-)NCBI
Celera556,333,084 - 56,336,654 (-)NCBICelera
Cytogenetic Map5q22NCBI
Arhgef39
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955472633,405 - 640,305 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955472633,474 - 636,440 (+)NCBIChiLan1.0ChiLan1.0
ARHGEF39
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21188,920,738 - 88,928,473 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1988,926,669 - 88,934,538 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0935,510,876 - 35,517,299 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1936,313,296 - 36,319,732 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl936,313,296 - 36,319,732 (-)Ensemblpanpan1.1panPan2
ARHGEF39
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11152,191,170 - 52,200,769 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1152,196,462 - 52,200,778 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1150,765,489 - 50,768,556 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01153,256,556 - 53,265,956 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1153,261,492 - 53,271,849 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11151,807,441 - 51,810,506 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01151,790,921 - 51,793,983 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01152,493,055 - 52,496,124 (-)NCBIUU_Cfam_GSD_1.0
Arhgef39
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947167,110,767 - 167,126,613 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365243,660,454 - 3,663,696 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365243,660,364 - 3,663,664 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF39
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,383,925 - 236,387,667 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,383,684 - 236,387,705 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21264,108,957 - 264,120,992 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Arhgef39
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248685,126,781 - 5,130,320 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248685,126,041 - 5,130,696 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in ARHGEF39
46 total Variants



ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20



Ensembl Acc Id: ENSCSAT00000008484   ⟹   ENSCSAP00000006631
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1244,937,923 - 44,944,842 (+)Ensembl
RefSeq Acc Id: XM_007968814   ⟹   XP_007967005
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11244,937,490 - 44,941,708 (+)NCBI
Vero_WHO_p1.0NW_02366603842,042,641 - 42,046,556 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007968815   ⟹   XP_007967006
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11244,937,488 - 44,941,708 (+)NCBI
Vero_WHO_p1.0NW_02366603842,042,641 - 42,046,556 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007968816   ⟹   XP_007967007
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11244,937,493 - 44,941,708 (+)NCBI
Vero_WHO_p1.0NW_02366603842,042,641 - 42,047,396 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007968817   ⟹   XP_007967008
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11244,937,490 - 44,941,708 (+)NCBI
Vero_WHO_p1.0NW_02366603842,042,641 - 42,046,556 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007968818   ⟹   XP_007967009
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11244,937,491 - 44,941,708 (+)NCBI
Vero_WHO_p1.0NW_02366603842,042,641 - 42,046,556 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037998272   ⟹   XP_037854200
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603842,042,641 - 42,046,556 (+)NCBI
Protein RefSeqs XP_007967005 (Get FASTA)   NCBI Sequence Viewer  
  XP_007967006 (Get FASTA)   NCBI Sequence Viewer  
  XP_007967007 (Get FASTA)   NCBI Sequence Viewer  
  XP_007967008 (Get FASTA)   NCBI Sequence Viewer  
  XP_007967009 (Get FASTA)   NCBI Sequence Viewer  
  XP_037854200 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000006631
  ENSCSAP00000006631.1
RefSeq Acc Id: XP_007967006   ⟸   XM_007968815
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007967005   ⟸   XM_007968814
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007967008   ⟸   XM_007968817
- Peptide Label: isoform X3
RefSeq Acc Id: XP_007967009   ⟸   XM_007968818
- Peptide Label: isoform X4
RefSeq Acc Id: XP_007967007   ⟸   XM_007968816
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RDE2 (UniProtKB/TrEMBL)



1 to 21 of 21 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCSAG00000010393 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000008484.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro ARHGEF39 UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
NCBI Gene ARHGEF39 ENTREZGENE
PANTHER PTHR47056 UniProtKB/TrEMBL
  RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 39 UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
PROSITE DH_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
SMART RhoGEF UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF48065 UniProtKB/TrEMBL
UniProt A0A0D9RDE2 ENTREZGENE, UniProtKB/TrEMBL
1 to 21 of 21 rows