FARSB (phenylalanyl-tRNA synthetase subunit beta)

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Gene: FARSB (phenylalanyl-tRNA synthetase subunit beta) Chlorocebus sabaeus

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Symbol:

FARSB

Name:

phenylalanyl-tRNA synthetase subunit beta

RGD ID:

18678367

Description:

ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); ATP binding (inferred); magnesium ion binding (inferred); INVOLVED IN phenylalanyl-tRNA aminoacylation (inferred); protein heterotetramerization (inferred); translation (inferred); PARTICIPATES IN phenylketonuria pathway; tyrosinemia type II pathway; tyrosinemia type III pathway; ASSOCIATED WITH Aneurysm (ortholog); genetic disease (ortholog); INTERSTITIAL LUNG AND LIVER DISEASE (ortholog); FOUND IN cytoplasm (inferred); phenylalanine-tRNA ligase complex (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

phenylalanine--tRNA ligase beta subunit; phenylalanyl-tRNA synthetase beta subunit

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	108,492,463 - 108,568,226 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	108,492,652 - 108,568,293 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	90,804,343 - 90,888,983 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Aneurysm (ISO)

genetic disease (ISO)

INTERSTITIAL LUNG AND LIVER DISEASE (ISO)

interstitial lung disease (ISO)

liver cirrhosis (ISO)

Neurodevelopmental Disorders (ISO)

Rajab Interstitial Lung Disease with Brain Calcifications (ISO)

Rajab Interstitial Lung Disease with Brain Calcifications 1 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

phenylalanyl-tRNA aminoacylation (IEA)

protein heterotetramerization (IEA)

translation (IEA)

Cellular Component

cytoplasm (IEA)

phenylalanine-tRNA ligase complex (IEA)

Molecular Function

aminoacyl-tRNA ligase activity (IEA)

ATP binding (IEA)

magnesium ion binding (IEA)

metal ion binding (IEA)

phenylalanine-tRNA ligase activity (IEA)

protein binding (ISO)

RNA binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

phenylketonuria pathway (ISO)

tyrosinemia type II pathway (ISO)

tyrosinemia type III pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

FARSB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	108,492,463 - 108,568,226 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	108,492,652 - 108,568,293 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	90,804,343 - 90,888,983 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

FARSB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	222,566,899 - 222,656,092 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	222,566,899 - 222,656,092 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	223,431,618 - 223,520,811 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	223,144,406 - 223,229,071 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	223,260,760 - 223,346,310	NCBI
Celera	2	217,204,356 - 217,288,733 (-)	NCBI		Celera
Cytogenetic Map	2	q36.1	NCBI
HuRef	2	215,289,904 - 215,374,144 (-)	NCBI		HuRef
CHM1_1	2	223,442,666 - 223,527,209 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	223,052,236 - 223,141,156 (-)	NCBI		T2T-CHM13v2.0

Farsb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	78,394,593 - 78,465,530 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	78,394,612 - 78,465,534 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	78,417,958 - 78,488,897 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	78,417,975 - 78,488,897 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	78,421,411 - 78,485,421 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	78,307,983 - 78,371,993 (-)	NCBI		MGSCv36	mm8
Celera	1	78,895,232 - 78,957,096 (-)	NCBI		Celera
Cytogenetic Map	1	C4	NCBI
cM Map	1	40.44	NCBI

Farsb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	87,336,321 - 87,395,546 (-)	NCBI		GRCr8
mRatBN7.2	9	79,887,852 - 79,947,082 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	79,887,842 - 79,947,045 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	88,317,637 - 88,376,818 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	93,430,056 - 93,490,053 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	91,829,079 - 91,888,260 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	84,324,456 - 84,383,674 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	84,324,442 - 84,383,687 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	84,083,341 - 84,142,523 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	77,806,573 - 77,865,757 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	77,989,996 - 78,049,176 (-)	NCBI
Celera	9	77,396,205 - 77,455,355 (-)	NCBI		Celera
Cytogenetic Map	9	q33	NCBI

Farsb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955453	11,176,432 - 11,240,780 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955453	11,176,481 - 11,237,243 (+)	NCBI	ChiLan1.0	ChiLan1.0

FARSB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	125,186,179 - 125,414,446 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	125,201,208 - 125,429,414 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	109,813,000 - 109,897,159 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	228,394,238 - 228,478,345 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	228,394,238 - 228,478,345 (-)	Ensembl	panpan1.1		panPan2

FARSB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	28,647,114 - 28,716,193 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	37	28,647,115 - 28,716,198 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	37	29,483,532 - 29,552,756 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	37	28,671,627 - 28,741,798 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	37	28,583,297 - 28,652,114 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	37	28,515,013 - 28,583,765 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	37	28,533,289 - 28,602,513 (-)	NCBI		UU_Cfam_GSD_1.0

Farsb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	178,181,689 - 178,261,741 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936569	4,523,046 - 4,604,560 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936569	4,524,525 - 4,604,539 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FARSB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	15	124,472,236 - 124,555,042 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	137,963,814 - 137,984,032 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Farsb
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624823	2,559,756 - 2,627,606 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624823	2,559,757 - 2,627,606 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007966441	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000005847 ⟹ ENSCSAP00000004065

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	10	108,492,652 - 108,568,293 (-)	Ensembl

RefSeq Acc Id:

XM_007966441 ⟹ XP_007964632

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	10	108,492,463 - 108,568,226 (-)	NCBI
Vero_WHO_p1.0	NW_023666040	90,804,343 - 90,888,983 (+)	NCBI

Sequence:

show sequence

GCCGCGCAGGCGCAGTGAGTTCGACTCGCCATGCCGACTGTCAGCGTGAAGCGTGATCTGCTCT
TCCAAGCCCTGGGCCGCACCTACACTGACGAAGAATTTGACGAACTATGTTTTGAATTTGGTCT
GGAACTTGATGAAATTACATCTGAGAAGGAAATAATAAGTAAAGAACAAGGTAATGTAAAGGCA
GCAGGAGCCTCTGATGTTGTTCTTTACAAAATTGACGTCCCTGCCAATAGATATGATCTCCTGT
GTCTGGAAGGATTGGTTCGAGGACTTCAGGTCTTCAAAGAAAGGATAAAGGCTCCAGTGTATAA
ACGGGTAATGCCTGATGGAAAAATCCAGAAATTGATTATCACAGAAGAGACAGCTAAGATACGT
CCTTTTGCGGTAGCAGCAGTTCTCCGTAATATAAAGTTTACTAAAGATCGATACGATAGCTTCA
TTGAACTTCAGGAAAAATTACATCAGAATATTTGCAGGAAAAGAGCATTGGTTGCTATTGGCAC
CCATGATTTGGACACTTTGTCAGGCCCATTTACTTATACTGCAAAGCGTCCTTCAGATATTAAA
TTCAAGCCTCTAAATAAGACCAAGGAGTATACAGCCTGTGAACTGATGAACATATACAAGACTG
ATAATCACCTTAAACATTATTTACATATCATTGAAAACAAACCCCTGTATCCAGTTATCTATGA
TAGCAATGGTGTCGTCCTTTCAATGCCTCCCATCATCAATGGGGATCATTCCAGAATAACAGTA
AATACTAGAAATATTTTTATTGAATGCACTGGAACTGACTTTACTAAGGCAAAAATAGTTCTTG
ATATTATTGTCACCATGTTCAGTGAATACTGTGAGAATCAATTTACGGTCGAAGCTGCTGAGGT
GGTTTTTCCTAATGGAAAATCATATACCTTTCCAGAATTAGCTTACCGAAAGGAGATGGTGAGA
GCTGACCTCATTAACAAAAAAGTTGGAATCAGAGAAACTCCAGAAAATCTTGCCAAACTTCTGA
CAAGGATGTATTTAAAATCAGAAGTCATAGGTGACGGGAATCAGATTGAGATTGAAATCCCTCC
AACCAGAGCTGACATTATCCATGCATGTGATATTGTAGAAGATGCAGCTATTGCTTATGGATAT
AACAACATTCAGATGACTCTCCCGAAAACTTACACCATAGCTAATCAATTTCCTCTTAATAAGC
TCACTGAACTTCTCAGATATGACATGGCAGCTGCTGGCTTCACTGAAGTGCTTACCTTTGCCCT
GTGCTCCCAAGAAGATATAGCTGATAAACTCGGTCTGGATATCTCTGCAACAAAGGCGGTCCAC
ATAAGTAATCCTAAAACAGCTGAATTTCAGGTGGCACGCACTACCCTTCTTCCTGGCCTCCTGA
AGACCATAGCAGCAAATCGTAAGATGCCCCTTCCTCTGAAACTGTTTGAAATCTCCGACATTGT
AATAAAAGATTCTAATACAGATGTAGGCGCAAAAAACTACCGGCATCTCTGCGCTGTTTATTAC
AACAAGAATCCTGGGTTTGAGATCATTCATGGGCTGCTGGACAGAATTATGCAGTTGCTCGATG
TGCCTCCTGGTGAAGACAAGGGAGGATATGTGATCAAAGCATCGGAAGGGCCTGCTTTCTTCCC
CGGGCGATGTGCAGAGATCTTTGCCAGGGGTCAAAGTGTTGGGAAACTTGGGGTCCTTCATCCT
GACGTTATCACCAAGTTTGAGCTGACGATGCCCTGCTCCTCGCTAGAAATCAATATTGGACCCT
TTTTGTGAAGACTGGTCTCTGTGGTGTGATTCTCTTCCCAAGTATCCTTTTCTCCTCCCCTAGT
GTCCTTTAGTCTTCCTCCACAGGGAACGTCTATTTGGGCTTTAATGTTTAATAAAGTAGAAAGC
ACTGTCTGGCTGTGTGGGTAGAGACCACCCTTTCCCTGCATTAGACCAGCTTGTGCCATATACG
AATGT

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Protein Sequences


Protein RefSeqs	XP_007964632	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000004065
	ENSCSAP00000004065.1

RefSeq Acc Id:	XP_007964632 ⟸ XM_007966441
- UniProtKB:	A0A0D9R626 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000004065 ⟸ ENSCSAT00000005847

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000007806	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000005847.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.56.10	UniProtKB/TrEMBL
	3.50.40.10	UniProtKB/TrEMBL
InterPro	aa-tRNA-synth_II/BPL/LPL	UniProtKB/TrEMBL
	B3/B4_tRNA-bd	UniProtKB/TrEMBL
	DNA-bd_dom_put_sf	UniProtKB/TrEMBL
	Phe-tRNA-ligase_IIc_bsu	UniProtKB/TrEMBL
	Phe-tRNA-synth_IIc_bsu_arc	UniProtKB/TrEMBL
	Phe-tRNA_synthase_B3/B4	UniProtKB/TrEMBL
	PheRS_beta_core	UniProtKB/TrEMBL
	PhetRS_B1	UniProtKB/TrEMBL
	tRNA_synthase_B5-dom	UniProtKB/TrEMBL
KEGG Report	csab:103217940	UniProtKB/TrEMBL
NCBI Gene	FARSB	ENTREZGENE
PANTHER	PHENYLALANINE--TRNA LIGASE BETA SUBUNIT	UniProtKB/TrEMBL
	PTHR10947	UniProtKB/TrEMBL
Pfam	B3_4	UniProtKB/TrEMBL
	PF03484	UniProtKB/TrEMBL
	PhetRS_B1	UniProtKB/TrEMBL
	tRNA_synthFbeta	UniProtKB/TrEMBL
PROSITE	PS51483	UniProtKB/TrEMBL
SMART	B3_4	UniProtKB/TrEMBL
	SM00874	UniProtKB/TrEMBL
Superfamily-SCOP	PheT/TilS domain	UniProtKB/TrEMBL
	SSF46955	UniProtKB/TrEMBL
	SSF55681	UniProtKB/TrEMBL
UniProt	A0A0D9R626	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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