SEC24A (SEC24 homolog A, COPII coat complex component) - Rat Genome Database

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Gene: SEC24A (SEC24 homolog A, COPII coat complex component) Chlorocebus sabaeus
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Symbol: SEC24A
Name: SEC24 homolog A, COPII coat complex component
RGD ID: 18664112
Description: ENCODES a protein that exhibits SNARE binding (inferred); zinc ion binding (inferred); INVOLVED IN cholesterol homeostasis (ortholog); positive regulation of protein secretion (ortholog); regulation of cholesterol transport (ortholog); ASSOCIATED WITH familial adenomatous polyposis 1 (ortholog); Hereditary Neoplastic Syndromes (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN COPII vesicle coat (inferred); cytoplasmic vesicle (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC103244555; LOC103244556; protein transport protein Sec24A-like
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12337,448,344 - 37,501,745 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603440,396,807 - 40,476,728 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SEC24A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12337,448,344 - 37,501,745 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603440,396,807 - 40,476,728 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SEC24A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385134,648,382 - 134,727,909 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5134,648,785 - 134,727,909 (+)EnsemblGRCh38hg38GRCh38
GRCh375133,984,475 - 134,063,599 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365134,012,378 - 134,091,500 (+)NCBINCBI36Build 36hg18NCBI36
Build 345134,012,709 - 134,091,398NCBI
Celera5130,110,657 - 130,189,971 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5129,170,647 - 129,249,607 (+)NCBIHuRef
CHM1_15133,417,069 - 133,496,225 (+)NCBICHM1_1
T2T-CHM13v2.05135,172,809 - 135,253,535 (+)NCBIT2T-CHM13v2.0
Sec24a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391151,583,090 - 51,649,172 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1151,583,091 - 51,654,461 (-)EnsemblGRCm39 Ensembl
GRCm381151,692,263 - 51,757,161 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1151,692,264 - 51,763,634 (-)EnsemblGRCm38mm10GRCm38
MGSCv371151,505,765 - 51,570,336 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361151,538,243 - 51,600,008 (-)NCBIMGSCv36mm8
Celera1156,259,252 - 56,323,967 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.28NCBI
Sec24a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81036,450,043 - 36,525,303 (-)NCBIGRCr8
mRatBN7.21035,946,901 - 36,024,353 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1035,947,031 - 36,024,353 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1040,642,849 - 40,718,575 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01040,132,834 - 40,208,555 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01035,636,547 - 35,712,284 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01037,138,539 - 37,215,899 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1037,139,806 - 37,215,899 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01036,911,427 - 36,988,825 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01034,817,549 - 34,826,602 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41037,208,603 - 37,283,895 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11037,215,390 - 37,284,473 (-)NCBI
Celera1035,304,430 - 35,379,024 (-)NCBICelera
Cytogenetic Map10q22NCBI
Sec24a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554085,803,455 - 5,848,093 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554085,803,438 - 5,850,879 (+)NCBIChiLan1.0ChiLan1.0
SEC24A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24129,945,473 - 130,023,324 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15128,085,052 - 128,162,886 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05130,050,625 - 130,128,212 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15136,197,495 - 136,273,158 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5136,197,746 - 136,273,158 (+)Ensemblpanpan1.1panPan2
SEC24A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11122,749,633 - 22,813,045 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1122,750,046 - 22,810,199 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1121,499,013 - 21,562,145 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01123,555,714 - 23,619,270 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1123,555,703 - 23,619,248 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11122,254,959 - 22,318,573 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01122,121,201 - 22,184,878 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01122,763,524 - 22,826,917 (+)NCBIUU_Cfam_GSD_1.0
Sec24a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213113,607,154 - 113,686,258 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936647612,976 - 688,552 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936647612,640 - 689,963 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SEC24A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2136,883,854 - 136,952,178 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12136,833,399 - 136,952,181 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22142,447,631 - 142,565,796 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sec24a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473337,620,211 - 37,693,636 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473337,620,326 - 37,693,753 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_008014472   ⟹   XP_008012663
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12337,448,360 - 37,499,171 (+)NCBI
Vero_WHO_p1.0NW_02366603440,430,531 - 40,476,728 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008014473   ⟹   XP_008012664
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12337,448,344 - 37,499,054 (+)NCBI
Vero_WHO_p1.0NW_02366603440,430,692 - 40,476,728 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038007722   ⟹   XP_037863650
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603440,396,807 - 40,476,728 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008012663 (Get FASTA)   NCBI Sequence Viewer  
  XP_008012664 (Get FASTA)   NCBI Sequence Viewer  
  XP_037863650 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000009627.1
RefSeq Acc Id: XP_008012664   ⟸   XM_008014473
- Peptide Label: isoform X2
RefSeq Acc Id: XP_008012663   ⟸   XM_008014472
- Peptide Label: isoform X2
RefSeq Acc Id: XP_037863650   ⟸   XM_038007722
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RLY8 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000013554 UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000011560.1 UniProtKB/TrEMBL
Gene3D-CATH beta-sandwich domain of Sec23/24 UniProtKB/TrEMBL
  Sec23/Sec24 helical domain UniProtKB/TrEMBL
  Severin UniProtKB/TrEMBL
  von Willebrand factor, type A domain UniProtKB/TrEMBL
  Zn-finger domain of Sec23/24 UniProtKB/TrEMBL
InterPro ADF-H/Gelsolin-like_dom_sf UniProtKB/TrEMBL
  Gelsolin-like_dom UniProtKB/TrEMBL
  Gelsolin-like_dom_sf UniProtKB/TrEMBL
  Sec23/24_helical_dom UniProtKB/TrEMBL
  Sec23/24_helical_dom_sf UniProtKB/TrEMBL
  Sec23/24_trunk_dom UniProtKB/TrEMBL
  Sec23_24_beta_S UniProtKB/TrEMBL
  SEC23_SEC24_subfamily UniProtKB/TrEMBL
  Sec24-like_trunk_dom UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
  Znf_Sec23_Sec24 UniProtKB/TrEMBL
  Znf_Sec23_Sec24_sf UniProtKB/TrEMBL
NCBI Gene LOC103244556 ENTREZGENE
PANTHER PROTEIN TRANSPORT PROTEIN SEC24A UniProtKB/TrEMBL
  SEC24-RELATED PROTEIN UniProtKB/TrEMBL
Pfam Gelsolin UniProtKB/TrEMBL
  Sec23_BS UniProtKB/TrEMBL
  Sec23_helical UniProtKB/TrEMBL
  Sec23_trunk UniProtKB/TrEMBL
  zf-Sec23_Sec24 UniProtKB/TrEMBL
Superfamily-SCOP beta-sandwich domain of Sec23/24 UniProtKB/TrEMBL
  C-terminal, gelsolin-like domain of Sec23/24 UniProtKB/TrEMBL
  Helical domain of Sec23/24 UniProtKB/TrEMBL
  vWA-like UniProtKB/TrEMBL
  Zn-finger domain of Sec23/24 UniProtKB/TrEMBL
UniProt A0A0D9RLY8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-08 SEC24A  SEC24 homolog A, COPII coat complex component  LOC103244556  protein transport protein Sec24A  Symbol and/or name change 5135510 APPROVED
2020-12-03 LOC103244556  protein transport protein Sec24A  LOC103244555  protein transport protein Sec24A-like  Data merged from RGD:18763935 737654 PROVISIONAL