DYRK4 (dual specificity tyrosine phosphorylation regulated kinase 4) - Rat Genome Database

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Gene: DYRK4 (dual specificity tyrosine phosphorylation regulated kinase 4) Chlorocebus sabaeus
Analyze
Symbol: DYRK4
Name: dual specificity tyrosine phosphorylation regulated kinase 4
RGD ID: 18656694
Description: ENCODES a protein that exhibits ATP binding (inferred); protein serine/threonine kinase activity (inferred); protein serine/threonine/tyrosine kinase activity (inferred); ASSOCIATED WITH episodic ataxia type 1 (ortholog); genetic disease (ortholog); Hyperphosphatemic Familial Tumoral Calcinosis 1 (ortholog); FOUND IN cytoplasm (inferred); cytoskeleton (inferred); intracellular membrane-bounded organelle (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dual specificity tyrosine-phosphorylation-regulated kinase 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1114,578,646 - 4,634,328 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl114,609,589 - 4,634,205 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660633,607,585 - 3,630,137 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DYRK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1114,578,646 - 4,634,328 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl114,609,589 - 4,634,205 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660633,607,585 - 3,630,137 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
DYRK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38124,562,208 - 4,613,875 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl124,562,208 - 4,615,302 (+)EnsemblGRCh38hg38GRCh38
GRCh37124,671,374 - 4,723,041 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36124,569,505 - 4,593,302 (+)NCBINCBI36Build 36hg18NCBI36
Build 34124,569,504 - 4,593,301NCBI
Celera126,321,281 - 6,345,070 (+)NCBICelera
Cytogenetic Map12p13.32NCBI
HuRef124,555,938 - 4,579,734 (+)NCBIHuRef
CHM1_1124,698,866 - 4,722,653 (+)NCBICHM1_1
T2T-CHM13v2.0124,568,995 - 4,620,692 (+)NCBIT2T-CHM13v2.0
Dyrk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396126,852,983 - 126,899,039 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6126,852,983 - 126,898,802 (-)EnsemblGRCm39 Ensembl
GRCm386126,876,020 - 126,922,083 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6126,876,020 - 126,921,839 (-)EnsemblGRCm38mm10GRCm38
MGSCv376126,826,217 - 126,871,857 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366126,841,818 - 126,873,130 (-)NCBIMGSCv36mm8
Celera6128,553,852 - 128,596,185 (-)NCBICelera
Cytogenetic Map6F3NCBI
cM Map661.92NCBI
Dyrk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84161,401,580 - 161,443,816 (-)NCBIGRCr8
mRatBN7.24159,715,658 - 159,757,660 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4159,715,417 - 159,757,627 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.04159,426,447 - 159,467,973 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4159,427,340 - 159,467,955 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04232,145,820 - 232,185,943 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44163,265,261 - 163,292,524 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14163,510,196 - 163,566,789 (-)NCBI
Celera4148,430,998 - 148,473,543 (-)NCBICelera
Cytogenetic Map4q42NCBI
Dyrk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554132,363,882 - 2,410,720 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554132,359,480 - 2,410,395 (+)NCBIChiLan1.0ChiLan1.0
DYRK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21010,112,330 - 10,164,120 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11210,109,088 - 10,160,878 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0124,681,395 - 4,733,134 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1124,604,239 - 4,653,764 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl124,604,241 - 4,653,762 (+)Ensemblpanpan1.1panPan2
DYRK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12740,239,151 - 40,301,806 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2740,251,779 - 40,301,791 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha276,380,203 - 6,443,250 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02740,594,207 - 40,657,249 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2740,606,830 - 40,657,453 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12740,483,299 - 40,546,328 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02740,508,254 - 40,571,279 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0275,790,805 - 5,853,828 (+)NCBIUU_Cfam_GSD_1.0
Dyrk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945104,413,773 - 104,465,671 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366064,718,533 - 4,769,524 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366064,740,227 - 4,769,734 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DYRK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl565,812,243 - 65,870,092 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1565,815,063 - 65,877,804 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2568,022,180 - 68,048,292 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Dyrk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248601,674,136 - 1,683,350 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 23 17 50
Below cutoff 13 3 10

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007967278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007967279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007967280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007967281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007967282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007967283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007967284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007967285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007967288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007967289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007967290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007967291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007967292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007967293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007967294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007967295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007967296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000009099   ⟹   ENSCSAP00000007228
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl114,609,589 - 4,634,205 (+)Ensembl
RefSeq Acc Id: XM_007967279   ⟹   XP_007965470
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1114,584,248 - 4,634,328 (+)NCBI
Vero_WHO_p1.0NW_0236660633,607,585 - 3,630,137 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007967294   ⟹   XP_007965485
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1114,617,977 - 4,634,328 (+)NCBI
Vero_WHO_p1.0NW_0236660633,607,585 - 3,625,275 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007965470 (Get FASTA)   NCBI Sequence Viewer  
  XP_007965485 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000007228.1
Reference Protein Sequences
RefSeq Acc Id: XP_007965470   ⟸   XM_007967279
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RF39 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007965485   ⟸   XM_007967294
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCSAP00000007228   ⟸   ENSCSAT00000009099


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000011051 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000009099.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.10.30 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro DYRK UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene DYRK4 ENTREZGENE
PANTHER DUAL SPECIFICITY PROTEIN KINASE UniProtKB/TrEMBL
  DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A0D9RF39 ENTREZGENE, UniProtKB/TrEMBL