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Gene: PCLAF (PCNA clamp associated factor) Chlorocebus sabaeus

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Symbol:

PCLAF

Name:

PCNA clamp associated factor

RGD ID:

18638083

Description:

ENCODES a protein that exhibits chromatin binding (inferred); molecular adaptor activity (inferred); INVOLVED IN centrosome cycle (inferred); DNA damage response (inferred); DNA repair (inferred); ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); hepatocellular carcinoma (ortholog); FOUND IN centrosome (inferred); cytoplasm (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

KIAA0101; PCNA-associated factor

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	19,140,901 - 19,155,488 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	19,140,843 - 19,155,730 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	122,242,653 - 122,259,245 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

colorectal cancer (ISO)

hepatocellular carcinoma (ISO)

nemaline myopathy 6 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

centrosome cycle (IEA)

DNA damage response (IEA)

DNA repair (IEA)

DNA replication (IEA)

regulation of cell cycle (IEA)

response to UV (IEA)

translesion synthesis (IEA)

Cellular Component

centrosome (IEA)

cytoplasm (IEA)

nucleus (IEA)

perinuclear region of cytoplasm (IEA)

Molecular Function

chromatin binding (IEA)

molecular adaptor activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

PCLAF
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	19,140,901 - 19,155,488 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	19,140,843 - 19,155,730 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	122,242,653 - 122,259,245 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

PCLAF
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	64,364,304 - 64,387,687 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	64,364,304 - 64,387,687 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	64,656,503 - 64,679,886 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	62,444,246 - 62,460,755 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	62,444,265 - 62,460,682	NCBI
Celera	15	41,535,211 - 41,551,717 (-)	NCBI		Celera
Cytogenetic Map	15	q22.31	NCBI
HuRef	15	41,481,234 - 41,497,634 (-)	NCBI		HuRef
CHM1_1	15	64,776,716 - 64,793,092 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	62,173,847 - 62,197,108 (-)	NCBI		T2T-CHM13v2.0

Pclaf
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	65,797,605 - 65,810,833 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	65,797,519 - 65,810,548 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	65,890,323 - 65,903,551 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	65,890,237 - 65,903,266 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	65,738,130 - 65,751,358 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	65,688,329 - 65,701,557 (+)	NCBI		MGSCv36	mm8
Celera	9	63,128,991 - 63,142,582 (+)	NCBI		Celera
Cytogenetic Map	9	C	NCBI
cM Map	9	35.58	NCBI

Pclaf
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	75,311,028 - 75,328,108 (+)	NCBI		GRCr8
mRatBN7.2	8	66,420,606 - 66,432,994 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	66,420,587 - 66,432,994 (+)	Ensembl		mRatBN7.2 Ensembl
mRatBN7.2 Ensembl	8	108,560,971 - 108,561,319 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	71,934,016 - 71,945,871 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	70,207,082 - 70,218,937 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	68,076,256 - 68,088,146 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	71,514,281 - 71,526,182 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	71,514,281 - 71,526,182 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	71,186,712 - 71,198,728 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	70,159,283 - 70,172,116 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	70,178,336 - 70,191,170 (+)	NCBI
Celera	8	65,810,620 - 65,822,516 (+)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

Pclaf
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955450	11,072,786 - 11,082,687 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955450	11,072,778 - 11,082,687 (+)	NCBI	ChiLan1.0	ChiLan1.0

PCLAF
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	53,617,214 - 53,633,472 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	57,788,668 - 57,803,694 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	43,311,115 - 43,331,979 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	61,602,830 - 61,617,303 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	61,602,830 - 61,617,303 (-)	Ensembl	panpan1.1		panPan2

PCLAF
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	28,832,388 - 28,846,824 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	28,751,144 - 28,765,515 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	29,008,166 - 29,022,548 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	29,011,296 - 29,022,547 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	28,942,687 - 28,957,061 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	29,004,629 - 29,018,932 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	29,244,130 - 29,258,484 (-)	NCBI		UU_Cfam_GSD_1.0

Pclaf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	106,949,408 - 106,959,958 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	24,797,393 - 24,808,227 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	24,797,291 - 24,812,196 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PCLAF
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	107,659,509 - 107,670,954 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	107,659,509 - 107,669,477 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	118,495,370 - 118,506,630 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Pclaf
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624781	8,195,451 - 8,206,187 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624781	8,195,256 - 8,207,357 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in PCLAF
213 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
54	36	20	36	36	38	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008016296	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008016298	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008016299	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008016300	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038008836	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000010586 ⟹ ENSCSAP00000008677

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	26	19,140,843 - 19,155,730 (+)	Ensembl

RefSeq Acc Id:

XM_008016298 ⟹ XP_008014489

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	26	19,140,966 - 19,155,488 (+)	NCBI
Vero_WHO_p1.0	NW_023666048	122,242,653 - 122,259,232 (-)	NCBI

Sequence:

show sequence

GGAGAGTCCTTGGAGCGCGCGGGAAAGAGACCAATATAAACTGTGGCGGGAGATTAGTTTTCGG
GTCCTTGTCCAGTGAAGCACCGTCGGTCGGCTGGGAAGTCAGTTCGTTCTCTCATCTTCTCTCG
TCTTGTTTGAACATGGTGCGGACTAAAGCAGACAGTGTTCCAGGCACTTACAGAAAAGTGGTGG
CTGCTCGAGCCCCTAGGAAGGTGCTTGGTTCTTCCACCTCTGCCACTAATTCGACACCAGTTTC
ATCGAGGAAAGAGAGTGTCCTTTGCAGCCTGATCACACAAATGATGAAAAAGAATAGAACTTTC
TCATTCATCTTTAAATAACGTCTCCTTGTTTACCCTGGTATTCTAGAATGTAAATTTACATAAA
TGTGTTTGTTCCAATTAGCTTTGTTGAACAGGCGTTTAATTAAGAAATTTAGGCTTAAATTTAG
ATGTTCAAAAGTAGTTGTGAAATTTGAGAATTTGTAAGACTAATTATGGTAACTTAGCTTAGTA
TTCAGTATAATGCATTGTTTGGTTTCTTGTACCAAATTAAGTGTCTTGTTCTTGCTAAAATCTA
GTCATTGCATTGTGTTCTAATTACAAGTATGTGGTATTTGAGATTTGCTTAAATTGTTGTACTG
CTGCCATTTTTATTGGTGTTTGATTATTGGAATGGTGCCATATTGTCACTCCTTCTATTTGCTT
TAAAAAGCAGAGTTAGACTTTTGCACATTAAAAAAAATTCAGTATTAATTAAATCTTACTTACT
CTA

hide sequence

RefSeq Acc Id:

XM_008016299 ⟹ XP_008014490

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	26	19,140,901 - 19,149,940 (+)	NCBI
Vero_WHO_p1.0	NW_023666048	122,249,974 - 122,259,234 (-)	NCBI

Sequence:

show sequence

TCACCATTGGGCATTGGCAATTGGTTCTGGGGGAACGGCGCGGAACCAATGGGAGCCGTGGCTC
CGGAGAGTCCTTGGAGCGCGCGGGAAAGAGACCAATATAAACTGTGGCGGGAGATTAGTTTTCG
GGTCCTTGTCCAGTGAAGCACCGTCGGTCGGCTGGGAAGTCAGTTCGTTCTCTCATCTTCTCTC
GTCTTGTTTGAACATGGTGCGGACTAAAGCAGACAGTGTTCCAGGCACTTACAGAAAAGTGGTG
GCTGCTCGAGCCCCTAGGAAGGTGCTTGGTTCTTCCACCTCTGCCACTAATTCGACACCAGTTT
CATCGAGGAAAGCTGAAAATAAATATGCAGGAGGGAATCCCGTTTGCGTGCGCCCAACTCCCAA
GTGGCAAAAAGGAATTGGAGAATTCTTTAGGTTGTGCTCTAAAGATTCTGAAAAAGAGAATCAG
ATTCCTGAAGAGGCAGGAAGCAGTGGCTTAGGAAAAGCAAAGAGAAACATGCCGGAAGCTACTG
CAGCCGAGACCACAAAGCCCTCCAACAGCGCCCTACAGCCTACAGCCAGTCTCCTTGTGGTCTT
GCTTGCCCTTCTACATCTCTACCATTAAGAGACAGGTCAAGAAACAGCTACAGTTCTCCAACTC
ATACTCTAAAACCGAATCCAAATGGTGCCTAGAAGTTCAGTGTGGCAAGGAAAAAAACCAGGTC
TTCATCAAATCTACTAATTTCACTCCTTATTTTATTAACAGAGAAACGCTTGAGAGTCTCAAAC
TGGACTGGTTTAAAGAGCATCTGAAGGATTGGACTAGATGATAAATGCCAATATTAAAACTGTT
GGAGTTTCATGTATAAGACAGAGGAGAAAGACAACATCAAAAATTAGTTAAAGAGATTATTAAG
CGTGGCTTAAGAAATATGGACACTTAAAACTCTATCTTGAAAAAAAACCTCTTTTTTGATAATA
ATAATTTCACTTTCATCTAGAGAAAAAGGATGAACTATGGAATGGAGATTCAGTTTTCATTTTA
GTTTGTTAAATCTGCAAGGCTGTAAAATGATTAGGTAGTATAAAAAGCTTCCATAATTCTATTT
ATTATATATGTACATTGGAAGAAACTACCAGATGTTACTATAAATATTCTCTGTATTGTT

hide sequence

RefSeq Acc Id:

XM_008016300 ⟹ XP_008014491

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	26	19,140,921 - 19,155,479 (+)	NCBI
Vero_WHO_p1.0	NW_023666048	122,242,653 - 122,259,245 (-)	NCBI

Sequence:

show sequence

TTGGTTCTGGGGGAACGGCGCGGAACCAATGGGAGCCGTGGCTCCGGAGAGTCCTTGGAGCGCG
CGGGAAAGAGACCAATATAAACTGTGGCGGGAGATTAGTTTTCGGGTCCTTGTCCAGTGAAGCA
CCGTCGGTCGGCTGGGAAGTCAGTTCGTTCTCTCATCTTCTCTCGTCTTGTTTGAACATGGTGC
GGACTAAAGCAGACAGTGTTCCAGGCACTTACAGAAAAGTGGTGGCTGCTCGAGCCCCTAGGAA
GGTGCTTGGTTCTTCCACCTCTGCCACTAATTCGACACCAGTTTCATCGAGGAAAGCTGAAAAT
AAATATGCAGGAGGGAATCCCGTTTGCGTGCGCCCAACTCCCAAGTGGCAAAAAGGAATTGGAG
AATTCTTTAGGTTGTGCTCTAAAGATTCTGAAAAAGAGAATCAGATTCCTGAAGAGGCAGGAAG
CAGTGGCTTAGGAAAAGCAAAGAGAAAAGAGTGTCCTTTGCAGCCTGATCACACAAATGATGAA
AAAGAATAGAACTTTCTCATTCATCTTTAAATAACGTCTCCTTGTTTACCCTGGTATTCTAGAA
TGTAAATTTACATAAATGTGTTTGTTCCAATTAGCTTTGTTGAACAGGCGTTTAATTAAGAAAT
TTAGGCTTAAATTTAGATGTTCAAAAGTAGTTGTGAAATTTGAGAATTTGTAAGACTAATTATG
GTAACTTAGCTTAGTATTCAGTATAATGCATTGTTTGGTTTCTTGTACCAAATTAAGTGTCTTG
TTCTTGCTAAAATCTAGTCATTGCATTGTGTTCTAATTACAAGTATGTGGTATTTGAGATTTGC
TTAAATTGTTGTACTGCTGCCATTTTTATTGGTGTTTGATTATTGGAATGGTGCCATATTGTCA
CTCCTTCTATTTGCTTTAAAAAGCAGAGTTAGACTTTTGCACATTAAAAAAAATTCAGTATTAA
TTAAATCTTA

hide sequence

RefSeq Acc Id:

XM_038008836 ⟹ XP_037864764

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666048	122,249,960 - 122,259,234 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_008014489	(Get FASTA)	NCBI Sequence Viewer
	XP_008014490	(Get FASTA)	NCBI Sequence Viewer
	XP_008014491	(Get FASTA)	NCBI Sequence Viewer
	XP_037864764	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000008677
	ENSCSAP00000008677.1

RefSeq Acc Id:	XP_008014490 ⟸ XM_008016299
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_008014491 ⟸ XM_008016300
- Peptide Label:	isoform X3
- UniProtKB:	A0A0D9RJ88 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_008014489 ⟸ XM_008016298
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_037864764 ⟸ XM_038008836
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSCSAP00000008677 ⟸ ENSCSAT00000010586

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000012494	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000010586.1	UniProtKB/TrEMBL
InterPro	PCNA-AF	UniProtKB/TrEMBL
	PCNA-AF_dom	UniProtKB/TrEMBL
NCBI Gene	PCLAF	ENTREZGENE
PANTHER	PCNA-ASSOCIATED FACTOR	UniProtKB/TrEMBL
	PTHR15679	UniProtKB/TrEMBL
Pfam	PAF	UniProtKB/TrEMBL
UniProt	A0A0D9RJ88	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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