LMBRD1 (LMBR1 domain containing 1)

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Gene: LMBRD1 (LMBR1 domain containing 1) Chlorocebus sabaeus

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Symbol:

LMBRD1

Name:

LMBR1 domain containing 1

RGD ID:

18603043

Description:

ENCODES a protein that exhibits AP-2 adaptor complex binding (inferred); clathrin heavy chain binding (inferred); cobalamin binding (inferred); INVOLVED IN clathrin-dependent endocytosis (inferred); gastrulation (inferred); insulin receptor internalization (inferred); ASSOCIATED WITH Donnai-Barrow syndrome (ortholog); genetic disease (ortholog); inherited metabolic disorder (ortholog); FOUND IN clathrin-coated endocytic vesicle (inferred); clathrin-coated vesicle (inferred); endoplasmic reticulum membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

lysosomal cobalamin transport escort protein LMBD1; probable lysosomal cobalamin transporter

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	5,169,347 - 5,295,565 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	5,169,478 - 5,295,127 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666058	11,191,408 - 11,317,423 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Donnai-Barrow syndrome (ISO)

genetic disease (ISO)

inherited metabolic disorder (ISO)

methylmalonic aciduria and homocystinuria type cblC (ISO)

methylmalonic aciduria and homocystinuria type cblF (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

clathrin-dependent endocytosis (IEA)

gastrulation (IEA)

insulin receptor internalization (IEA)

protein localization to lysosome (IEA)

Cellular Component

clathrin-coated endocytic vesicle (IEA)

clathrin-coated vesicle (IEA)

endoplasmic reticulum membrane (IEA)

intracellular membrane-bounded organelle (IEA)

lysosomal membrane (IEA)

lysosome (IEA)

membrane (IEA)

plasma membrane (IEA)

Molecular Function

AP-2 adaptor complex binding (IEA)

clathrin heavy chain binding (IEA)

cobalamin binding (IEA)

insulin receptor binding (IEA)

protein binding (ISO)

protein transporter activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

LMBRD1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	5,169,347 - 5,295,565 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	5,169,478 - 5,295,127 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666058	11,191,408 - 11,317,423 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

LMBRD1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	69,674,010 - 69,797,010 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	69,672,757 - 69,867,236 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	70,383,902 - 70,506,902 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	70,442,470 - 70,563,609 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	70,442,470 - 70,563,609	NCBI
Celera	6	70,774,043 - 70,895,462 (-)	NCBI		Celera
Cytogenetic Map	6	q13	NCBI
HuRef	6	67,576,549 - 67,697,877 (-)	NCBI		HuRef
CHM1_1	6	70,551,896 - 70,673,235 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	70,854,076 - 70,977,089 (-)	NCBI		T2T-CHM13v2.0

Lmbrd1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	24,716,073 - 24,805,382 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	24,717,711 - 24,805,382 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	24,676,992 - 24,766,301 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	24,678,630 - 24,766,301 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	24,685,383 - 24,823,146 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	24,540,892 - 24,709,881 (+)	NCBI		MGSCv36	mm8
Celera	1	24,508,667 - 24,599,013 (+)	NCBI		Celera
Cytogenetic Map	1	A5	NCBI
cM Map	1	10.18	NCBI

Lmbrd1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	34,592,723 - 34,674,425 (+)	NCBI		GRCr8
mRatBN7.2	9	27,096,387 - 27,178,095 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	27,096,297 - 27,178,090 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	35,615,276 - 35,695,823 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	40,727,383 - 40,803,693 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	39,043,329 - 39,123,873 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	30,939,555 - 31,038,381 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	30,939,555 - 31,038,379 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	29,762,573 - 29,854,653 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	23,426,569 - 23,511,388 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	23,438,200 - 23,512,800 (+)	NCBI
Celera	9	24,630,912 - 24,711,848 (+)	NCBI		Celera
Cytogenetic Map	9	q21	NCBI

Lmbrd1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955488	4,772,504 - 4,879,423 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955488	4,774,835 - 4,879,401 (-)	NCBI	ChiLan1.0	ChiLan1.0

LMBRD1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	89,668,577 - 89,790,911 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	87,594,087 - 87,716,444 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	67,515,861 - 67,638,039 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	70,814,770 - 70,937,082 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	70,814,770 - 70,937,116 (-)	Ensembl	panpan1.1		panPan2

LMBRD1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	32,274,056 - 32,383,737 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	32,274,412 - 32,383,578 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	32,132,969 - 32,242,646 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	32,815,725 - 32,925,418 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	32,814,082 - 32,925,264 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	32,332,828 - 32,442,060 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	32,385,294 - 32,494,836 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	32,498,019 - 32,607,811 (-)	NCBI		UU_Cfam_GSD_1.0

Lmbrd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	67,532,246 - 67,635,247 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936618	1,689,646 - 1,792,802 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936618	1,694,886 - 1,792,586 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LMBRD1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	49,868,613 - 49,977,965 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	49,869,184 - 49,977,984 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	56,034,683 - 56,143,017 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Lmbrd1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624753	27,283,871 - 27,375,897 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624753	27,283,570 - 27,423,118 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008013601	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000026	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000011646 ⟹ ENSCSAP00000009713

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	17	5,169,478 - 5,295,127 (+)	Ensembl

RefSeq Acc Id:

XM_008013601 ⟹ XP_008011792

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	17	5,169,347 - 5,295,565 (+)	NCBI
Vero_WHO_p1.0	NW_023666058	11,191,408 - 11,317,423 (+)	NCBI

Sequence:

show sequence

TCAGCGGGCGCGGAAGCCAGCGCGGGCAGCGTGGTGACGTCACTGCGTCCGGACGCGCCCCGCC
CCTGAGCAGTCCTTGCTGCCCCGCCTCCACCCTGCTCGCCGCCAGGGGACGCTAGTGGGTCGAG
TCTCCTTGGCAACCACTTGCTCCTCCTCCTCCGCCCTTTTAACCTTTAGGGTGCGCGGGTGCAG
TGTACCTCGCGCTCTCTCCCTTTTCCCCCTCCCCTTTCCCCACCCCTGGCGCTCTGGTCGGTCT
GGACCGGAAGCGAAGATGGCGACTCCTGGCGCGGCCTCGGCGGAGCTGGTGATCGGCTGGTGTA
TTTTCGGCCTCTTACTACTGGCTATTTTGGCATTCTGCTGGATATATGTTCGTAAATACCAAAG
TCGGCGGGAAAGTGAAGTTGTCTCCACCATAACAGCAATTTTTTCTCTAGCAATTGCACTTATC
ACATCAGCACTTCTACCAGTGGATATATTTTTGGTTTCTTACATGAAAAATCAAAATGGTACAT
TTAAGGACTGGGCTAATGCTAATGTCAGCAGACAGATTGAGGACACTGTATTATATGGTTACTA
TACTTTATATTCTGTTATATTGTTCTGTGTGTTCTTCTGGATCCCTTTTGTCTACTTCTATTAT
GAAGAAAAGGATGATGATGATACTAGTAAATGTACTCAAATTAAAACGGCACTCAAGTATACTT
TGGGATTTGTTGTGATTTGTGCACTGCTTCTTTTAGTTGGTGCCTTTGTTCCATTGAATGTTCC
CAATAACAAAAATTCTACAGAGTGGGAAAAAGTGAAGTTCCTATTTGAAGAACTTGGAAGTAGT
CATGGTTTAGCTGCGTTGTCATTTTCTATCAGTTCTCTGACCTTGATCGGAATGTTGGCAGCTA
TAACTTACACAGCCTATGGCATGTCTGCGTTACCTTTAAATCTGATAAAAGGCACTAGAAGCGC
TGCTTATGAACGTTTAGAAAACACTGAAGACATTGAAGAAGTAGAACAACACATTCAAACGATT
AAATCAAAAAGCAAAGATGGTCGACCTTTGCCAGCAAGGGATAAACGCGCCTTAAAACAGTTTG
AAGAAAGGTTACGAACACTTAAGAAGAGAGAGAGGCATTTAGAATTCATTGAAAACAGCTGGTG
GACAAAATTTTGTGGCGCTCTGCGTCCCCTGAAGATCATCTGGGGAATATTTTTCATCTTAGTT
GCATTACTGTTTGTAATCTCTCTCTTCTTGTCAAATTTAGATAAAGCTCTTCATTCAGCTGGAA
TAGATTCTGGTTTCATAATTTTTGGAGCAAACCTGAGTAATCCACTGAATATGCTTTTGCCTTT
ACTACAAACAGTTTTCCCTCTTGATTATATTCTTATAACAATTATTATTATGTACTTTATTTTT
ACTTCAATGGCAGGAATTCGAAATATTGGCATATGGTTCTTTTGGATTAGATTATATAAAATCA
GAAGAGGTAGAACCAGGCCCCAAGCACTCCTTTTTCTCTGCATGATACTTCTGCTTATTGTCCT
TCACACTAGCTATATGATTTATAGTCTTGCTCCCCAATATGTTATGTATGGAAGCCAAAATTAC
TTAATAGAGACTAATGTAACTTCTGATAACCATAAAGGCAATTCAACCCTTTCTGTGCCAAAGA
GATGTGATGCAGATGCTCCTGAAGATCAGTGTACTGTTACCCGGACATACCTATTCCTTCACAA
GTTCTGGTTCTTCAGTGCTGCTTACTATTTTGGTAACTGGGCCTTTCTTGGGGTATTCTTGATT
GGATTAATTGTATCCTGTTGTAAAGGGAAGAAATCGGTTATTGAAGGAGTAGACGAAGATTCAG
ACATAAGTGATGATGAGCCCTCTGTTTATTCTGTTTGACAGCCTTCTCTGTCTTAAAGGTTTTA
TAACGCTGACTGAATATCTGTTATGCATTTTTAAAGTGTTAGACTGACATTAGGATGAGCTAAC
TAGCTTTCATCAAAAATGGGAGCATGGCTATAAAACAACTATATTTTATTATATGTTTTCAGAA
GTAACATTGTATCATAGATTAACATTTTAAATTACCATAATAATGCTATGTAAATACAAAACTA
CTGGCTTTGTGAAGGAATGTTTGTGCAAAATTTTTTCCTCTAATGTATAATAGTGTTTAATTAA
AAATCTTCCAGAATTAATATTCCCTTTTGTCACTTTTTAAAAACATAATACATCATTTATATCT
GTGCCTTAGGTTCTCCAGAGTGATGTGGAATTTTAAAGTGTCTCTCTCTGATTGCCTCCAAATA
AAATTTACAATATAGCTGATGAATGTTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008011792	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000009713
	ENSCSAP00000009713.1

RefSeq Acc Id:	XP_008011792 ⟸ XM_008013601
- UniProtKB:	A0A0D9RM74 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000009713 ⟸ ENSCSAT00000011646

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000013548	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000011646.1	UniProtKB/TrEMBL
InterPro	LMBD1_LysCbl_Transport	UniProtKB/TrEMBL
	LMBR1-like_membr_prot	UniProtKB/TrEMBL
KEGG Report	csab:103243937	UniProtKB/TrEMBL
NCBI Gene	LMBRD1	ENTREZGENE
PANTHER	LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1	UniProtKB/TrEMBL
	LYSOSOMAL COBALAMIN TRANSPORTER-RELATED	UniProtKB/TrEMBL
Pfam	LMBR1	UniProtKB/TrEMBL
UniProt	A0A0D9RM74	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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