SHE (Src homology 2 domain containing E) - Rat Genome Database

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Gene: SHE (Src homology 2 domain containing E) Chlorocebus sabaeus
Analyze
Symbol: SHE
Name: Src homology 2 domain containing E
RGD ID: 18602726
Description: ENCODES a protein that exhibits phosphotyrosine residue binding (inferred); ASSOCIATED WITH Charcot-Marie-Tooth disease type 2 (ortholog); dyschromatosis symmetrica hereditaria (ortholog); gastrointestinal stromal tumor (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: SH2 domain-containing adapter protein E
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1209,324,123 - 9,358,509 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl209,324,296 - 9,345,730 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660388,667,267 - 8,687,637 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SHE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1209,324,123 - 9,358,509 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl209,324,296 - 9,345,730 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660388,667,267 - 8,687,637 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SHE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381154,469,637 - 154,502,412 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1154,469,772 - 154,502,412 (-)EnsemblGRCh38hg38GRCh38
GRCh371154,451,957 - 154,474,888 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361152,718,581 - 152,741,213 (-)NCBINCBI36Build 36hg18NCBI36
Celera1127,523,605 - 127,546,174 (-)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1125,815,602 - 125,838,171 (-)NCBIHuRef
CHM1_11155,848,282 - 155,870,854 (-)NCBICHM1_1
T2T-CHM13v2.01153,606,788 - 153,639,550 (-)NCBIT2T-CHM13v2.0
She
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39389,738,667 - 89,766,149 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl389,738,677 - 89,766,141 (+)EnsemblGRCm39 Ensembl
GRCm38389,831,370 - 89,858,846 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl389,831,370 - 89,858,834 (+)EnsemblGRCm38mm10GRCm38
MGSCv37389,635,292 - 89,662,768 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36389,917,297 - 89,944,763 (+)NCBIMGSCv36mm8
Celera389,868,234 - 89,895,712 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.19NCBI
She
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82177,559,636 - 177,585,485 (+)NCBIGRCr8
mRatBN7.22175,262,431 - 175,287,807 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2175,262,442 - 175,286,669 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.02189,169,691 - 189,194,934 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2189,169,877 - 189,191,000 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02208,592,786 - 208,617,919 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42182,042,669 - 182,064,466 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2169,204,593 - 169,229,820 (+)NCBICelera
Cytogenetic Map2q34NCBI
She
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955545991,593 - 1,011,080 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955545989,390 - 1,011,100 (-)NCBIChiLan1.0ChiLan1.0
SHE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2195,331,716 - 95,357,939 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1195,066,789 - 95,093,264 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01129,834,422 - 129,857,317 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11133,446,410 - 133,469,580 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1133,446,417 - 133,469,841 (-)Ensemblpanpan1.1panPan2
SHE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1742,853,116 - 42,869,293 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl742,853,083 - 42,867,858 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha742,343,497 - 42,359,635 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0742,722,822 - 42,738,945 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl742,722,522 - 42,738,815 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1742,502,025 - 42,518,147 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0742,555,865 - 42,571,972 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0742,839,504 - 42,855,643 (+)NCBIUU_Cfam_GSD_1.0
She
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505825,064,648 - 25,079,577 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365804,095,234 - 4,109,964 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365804,095,218 - 4,109,961 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SHE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl495,284,607 - 95,308,099 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1495,284,275 - 95,308,109 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24104,110,648 - 104,131,181 (+)NCBISscrofa10.2Sscrofa10.2susScr3
She
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248852,886,584 - 2,904,953 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 36 17 60
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000016579   ⟹   ENSCSAP00000016084
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl209,324,296 - 9,345,730 (+)Ensembl
RefSeq Acc Id: XM_007976968   ⟹   XP_007975159
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1209,324,127 - 9,344,425 (+)NCBI
Vero_WHO_p1.0NW_0236660388,667,267 - 8,687,637 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007975159 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000016084
  ENSCSAP00000016084.1
Reference Protein Sequences
RefSeq Acc Id: XP_007975159   ⟸   XM_007976968
- UniProtKB: A0A0D9S5E5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000016084   ⟸   ENSCSAT00000016579


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000001949 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000016579.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
InterPro SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SHE_SH2 UniProtKB/TrEMBL
KEGG Report csab:103223921 UniProtKB/TrEMBL
NCBI Gene SHE ENTREZGENE
PANTHER HEAVYWEIGHT, ISOFORM A UniProtKB/TrEMBL
  PTHR15127:SF29 UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
Superfamily-SCOP SSF55550 UniProtKB/TrEMBL
UniProt A0A0D9S5E5 ENTREZGENE, UniProtKB/TrEMBL