UACA (uveal autoantigen with coiled-coil domains and ankyrin repeats) - Rat Genome Database

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Gene: UACA (uveal autoantigen with coiled-coil domains and ankyrin repeats) Chlorocebus sabaeus
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Symbol: UACA
Name: uveal autoantigen with coiled-coil domains and ankyrin repeats
RGD ID: 18601468
Description: ENCODES a protein that exhibits transcription regulator inhibitor activity (ortholog); INVOLVED IN intrinsic apoptotic signaling pathway in response to DNA damage (ortholog); intrinsic apoptotic signaling pathway in response to oxidative stress (ortholog); negative regulation of canonical NF-kappaB signal transduction (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); COVID-19 (ortholog); FOUND IN apoptosome (ortholog); cytoplasm (ortholog); membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12612,693,208 - 12,792,900 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2612,749,774 - 12,795,279 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048128,693,327 - 128,794,723 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
UACA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12612,693,208 - 12,792,900 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2612,749,774 - 12,795,279 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048128,693,327 - 128,794,723 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
UACA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381570,654,554 - 70,778,903 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1570,654,554 - 70,763,558 (-)EnsemblGRCh38hg38GRCh38
GRCh371570,946,893 - 71,055,897 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361568,733,947 - 68,842,904 (-)NCBINCBI36Build 36hg18NCBI36
Build 341568,733,947 - 68,842,904NCBI
Celera1547,837,778 - 47,946,745 (-)NCBICelera
Cytogenetic Map15q23NCBI
HuRef1547,782,261 - 47,891,072 (-)NCBIHuRef
CHM1_11571,065,499 - 71,174,066 (-)NCBICHM1_1
T2T-CHM13v2.01568,477,439 - 68,601,842 (-)NCBIT2T-CHM13v2.0
Uaca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39960,700,488 - 60,787,713 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl960,701,824 - 60,787,652 (+)EnsemblGRCm39 Ensembl
GRCm38960,793,206 - 60,880,431 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl960,794,542 - 60,880,370 (+)EnsemblGRCm38mm10GRCm38
MGSCv37960,642,355 - 60,728,177 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36960,592,554 - 60,678,376 (+)NCBIMGSCv36mm8
Celera958,019,203 - 58,105,030 (+)NCBICelera
Cytogenetic Map9BNCBI
cM Map932.93NCBI
Uaca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8870,155,059 - 70,243,416 (+)NCBIGRCr8
mRatBN7.2861,259,415 - 61,347,789 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl861,259,477 - 61,347,789 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx866,767,563 - 66,855,994 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0865,040,137 - 65,128,563 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0862,909,993 - 62,998,417 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0865,686,586 - 65,774,940 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl865,686,648 - 65,774,989 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0865,436,288 - 65,524,224 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4864,730,633 - 65,118,809 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera860,685,577 - 60,772,913 (+)NCBICelera
Cytogenetic Map8q24NCBI
Uaca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554506,122,439 - 6,197,177 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554506,122,271 - 6,195,345 (+)NCBIChiLan1.0ChiLan1.0
UACA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21659,923,133 - 60,025,189 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11564,087,081 - 64,189,178 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01549,607,308 - 49,711,188 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11568,375,908 - 68,477,574 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1568,375,939 - 68,477,395 (-)Ensemblpanpan1.1panPan2
UACA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13034,376,072 - 34,467,278 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3034,376,077 - 34,467,206 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3034,309,793 - 34,355,595 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03034,575,880 - 34,668,746 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3034,577,484 - 34,668,705 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13034,500,752 - 34,546,442 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03034,562,448 - 34,607,964 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03034,813,893 - 34,859,690 (-)NCBIUU_Cfam_GSD_1.0
Uaca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640112,364,382 - 112,464,821 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647130,211,588 - 30,363,992 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647130,213,742 - 30,312,873 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UACA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1168,350,557 - 168,453,344 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11168,353,655 - 168,453,175 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21186,635,724 - 186,735,061 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Uaca
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247813,106,608 - 3,191,870 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247813,106,658 - 3,189,325 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 18 34 34 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000011761   ⟹   ENSCSAP00000009824
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2612,749,774 - 12,795,279 (+)Ensembl
RefSeq Acc Id: XM_008016059   ⟹   XP_008014250
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12612,693,208 - 12,792,726 (+)NCBI
Vero_WHO_p1.0NW_023666048128,695,099 - 128,794,723 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008016060   ⟹   XP_008014251
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12612,749,382 - 12,792,728 (+)NCBI
Vero_WHO_p1.0NW_023666048128,693,327 - 128,738,465 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008016061   ⟹   XP_008014252
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12612,749,913 - 12,792,900 (+)NCBI
Vero_WHO_p1.0NW_023666048128,693,327 - 128,737,955 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038010103   ⟹   XP_037866031
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666048128,693,327 - 128,778,050 (-)NCBI
RefSeq Acc Id: XM_038010104   ⟹   XP_037866032
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666048128,695,099 - 128,794,591 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008014250 (Get FASTA)   NCBI Sequence Viewer  
  XP_008014251 (Get FASTA)   NCBI Sequence Viewer  
  XP_008014252 (Get FASTA)   NCBI Sequence Viewer  
  XP_037866031 (Get FASTA)   NCBI Sequence Viewer  
  XP_037866032 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000009824.1
RefSeq Acc Id: XP_008014250   ⟸   XM_008016059
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RMI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008014251   ⟸   XM_008016060
- Peptide Label: isoform X3
- UniProtKB: A0A0D9RMI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008014252   ⟸   XM_008016061
- Peptide Label: isoform X4
- UniProtKB: A0A0D9RMI5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000009824   ⟸   ENSCSAT00000011761
RefSeq Acc Id: XP_037866031   ⟸   XM_038010103
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RMI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037866032   ⟸   XM_038010104
- Peptide Label: isoform X5
- UniProtKB: A0A0D9RMI5 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000013665 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000011761.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  T_SNARE_dom UniProtKB/TrEMBL
NCBI Gene UACA ENTREZGENE
PANTHER ANKYCORBIN UniProtKB/TrEMBL
  UVEAL AUTOANTIGEN WITH COILED-COIL DOMAINS AND ANKYRIN REPEATS UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  T_SNARE UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/TrEMBL
UniProt A0A0D9RMI5 ENTREZGENE, UniProtKB/TrEMBL