INSL6 (insulin like 6) - Rat Genome Database

Name: INSL6
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: INSL6 (insulin like 6) Chlorocebus sabaeus

Analyze

Symbol:

INSL6

Name:

insulin like 6

RGD ID:

18601462

Description:

ENCODES a protein that exhibits hormone activity (inferred); INVOLVED IN apoptotic process (ortholog); ectopic germ cell programmed cell death (ortholog); fertilization (ortholog); ASSOCIATED WITH Acute Lymphoblastic Leukemia, with Lymphomatous Features (ortholog); acute myeloid leukemia (ortholog); adrenocortical carcinoma (ortholog); FOUND IN extracellular region (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

insulin-like peptide INSL6

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	INSL6 (insulin like 6)	NCBI	Ortholog
Mus musculus (house mouse):	Insl6 (insulin-like 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Insl6 (insulin-like 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Insl6 (insulin like 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	INSL6 (insulin like 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	INSL6 (insulin like 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Insl6 (insulin like 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	INSL6 (insulin like 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Insl6 (insulin like 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	74,345,243 - 74,372,778 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	74,346,706 - 74,372,729 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	62,743,906 - 62,770,088 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Lymphoblastic Leukemia, with Lymphomatous Features (ISO)

acute myeloid leukemia (ISO)

adrenocortical carcinoma (ISO)

Budd-Chiari syndrome (ISO)

chromosome 9p deletion syndrome (ISO)

chronic myelogenous leukemia, BCR-ABL1 positive (ISO)

chronic myeloid leukemia (ISO)

familial erythrocytosis 1 (ISO)

genetic disease (ISO)

hereditary breast ovarian cancer syndrome (ISO)

Hereditary Neoplastic Syndromes (ISO)

myelofibrosis (ISO)

myeloid neoplasm (ISO)

polycythemia (ISO)

polycythemia vera (ISO)

primary ovarian insufficiency (ISO)

Splenomegaly (ISO)

Thrombocythemia 3 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic process (ISO)

ectopic germ cell programmed cell death (ISO)

fertilization (ISO)

flagellated sperm motility (ISO)

male gonad development (ISO)

negative regulation of apoptotic process (ISO)

negative regulation of developmental process (ISO)

negative regulation of reproductive process (ISO)

signal transduction (IEA)

spermatid development (ISO)

spermatogenesis (ISO)

Cellular Component

extracellular region (IEA)

Molecular Function

hormone activity (IEA)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

INSL6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	74,345,243 - 74,372,778 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	74,346,706 - 74,372,729 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	62,743,906 - 62,770,088 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

INSL6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	4,991,976 - 5,185,639 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	5,123,880 - 5,185,647 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	5,163,868 - 5,185,639 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	5,153,863 - 5,175,618 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	5,153,864 - 5,175,618	NCBI
Celera	9	5,089,480 - 5,111,235 (-)	NCBI		Celera
Cytogenetic Map	9	p24.1	NCBI
HuRef	9	5,119,294 - 5,141,049 (-)	NCBI		HuRef
CHM1_1	9	5,164,034 - 5,185,789 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	4,992,955 - 5,190,714 (-)	NCBI		T2T-CHM13v2.0

Insl6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	29,298,754 - 29,302,718 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	29,298,744 - 29,302,756 (-)	Ensembl		GRCm39 Ensembl
GRCm38	19	29,321,354 - 29,325,318 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	29,321,344 - 29,325,356 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	29,395,844 - 29,399,808 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	29,387,351 - 29,391,315 (-)	NCBI		MGSCv36	mm8
Celera	19	30,097,916 - 30,101,880 (-)	NCBI		Celera
Cytogenetic Map	19	C1	NCBI
cM Map	19	23.82	NCBI

Insl6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	236,483,530 - 236,487,065 (-)	NCBI		GRCr8
mRatBN7.2	1	227,069,958 - 227,073,493 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	227,069,958 - 227,073,493 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	235,471,624 - 235,475,151 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	242,401,288 - 242,404,815 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	235,218,731 - 235,222,261 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	247,473,292 - 247,476,827 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	247,473,292 - 247,476,827 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	254,721,416 - 254,724,951 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	232,990,534 - 232,994,069 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	233,154,556 - 233,158,092 (-)	NCBI
Celera	1	224,221,875 - 224,225,410 (-)	NCBI		Celera
Cytogenetic Map	1	q52	NCBI

Insl6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955434	9,349,142 - 9,355,739 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955434	9,349,033 - 9,355,817 (-)	NCBI	ChiLan1.0	ChiLan1.0

INSL6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	119,362,748 - 119,434,904 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	119,368,695 - 119,390,561 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	5,007,158 - 5,029,056 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	5,192,023 - 5,213,827 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	5,192,023 - 5,213,827 (-)	Ensembl	panpan1.1		panPan2

INSL6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	93,457,854 - 93,474,777 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	93,459,945 - 93,474,793 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	93,866,056 - 93,882,980 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	94,011,512 - 94,028,434 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	94,011,678 - 94,028,449 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	93,643,885 - 93,660,812 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	93,368,454 - 93,385,388 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	94,132,819 - 94,149,742 (-)	NCBI		UU_Cfam_GSD_1.0

Insl6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	141,095,258 - 141,105,131 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936503	67,933 - 78,496 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

INSL6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	216,792,787 - 216,823,479 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	216,792,785 - 216,820,197 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	242,534,691 - 242,561,841 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Insl6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624736	9,838,781 - 9,848,514 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
14	7	17	21	21	10	3

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007969340	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000006921 ⟹ ENSCSAP00000005115

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	12	74,346,706 - 74,372,729 (+)	Ensembl

RefSeq Acc Id:

XM_007969340 ⟹ XP_007967531

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	12	74,345,243 - 74,372,778 (+)	NCBI
Vero_WHO_p1.0	NW_023666038	62,743,906 - 62,770,088 (+)	NCBI

Sequence:

show sequence

ATTTCTTCTTTTTTATCTTTTATATATCTACTATAGGTTTTGCCTTGTGGGCTTACATTTTTTA
CATTTTGCCACTATAGTGGGCTTACATTCATCTCAGTATGATTAATATTTTCCTTTCTCAAAAA
CTTTACCTGATAAAGTTCTGACTAGGACTCATGGCCCACTATAGTTCGGACATAAGTTGTTTTT
CAAGGAAGGTGATTAAATTTTACTAATCTATATCAACCATTTAAAAAATCCAATGGGCAGTTAA
TTTAACAGCATTCATGGATGCCACTGGGAAGCAAGGAAAAGATGGGGAAACGGAAAACGAAGAA
AAAGACAGAGTCAGAAGACAGAAAATAAAGGGAGAAAAAAATAAAATTGTATAGGGAAATGGTA
AGATCACTGATAAGCTGGCACCTGTAGCTTCAGCATCCTGAAGCTTATTCCTGAGACAGCCCCC
GAATGCCCTCTTGTGGCTGATAGTACATCCTTCCACGCCAACACACTAATAACGCAGAACTTCA
TTTAAAATGATAAAGCTACCTATGCCGATTGTGCTTCGCTTCCATGCCCCTTCCCTACTGAGCA
AAATTATCTCACCTAAATGAGCATTTCATGCCGCATGCTGTTATTCTTACAAGGCAAATCCTCT
AGGGGTCCCTGTCACAAGTTAATTTGGTAACAGATAATCCTCTATGTTCTCTAACCGAAAGAAC
CAGATTTCTATCCCAGGTACCTCAAGACAGCATCCCTACTTCTTTTTTCCGGAGATTGAGGCTA
AGGCCTATGCCTCCCTGTGAACCAGTAGGATTTTTCTGAAGAAGCTTTGAACCTGACTAAACGC
ACATGCCTATATGCAACACACAAACGTTTCACCACATATTTGATTGCCAGCTAAATGCTAGCCC
CCGGAGTACAGTGGAAAGCAAGAACAGACGCAGGCCCTGCCTTCATGAAGCGGGGGTCTCAGGA
AAGAGGTCACACGCCCACAAATGGAAACAGGTCGATTAACACCGTGAAAGAGATGAGAGGGGGT
TTCTGTGAGGGAGACGAAGCTTCATTAACAACCCGGCAAACAAGAACGGGAAACGCAATCCAGG
TGGAGGGAGCAACACCTTTTAACGTACGTTATCAGGTCACAGGGGTCCTATGCTCTCTCGCTTA
GTGAGGAATCTCCCACTGGGGAACGAAAGAAAAATGAATCAAACCGGAGGGTGGCGGCGTAGTG
AGGGGATTTTGGCTTTCATTTTAGGAGCCAGGGCCTGCTACCTTCGACCACCTGAGACCCCTGG
GAGGGCGGGAAAGCCTCGGCGCCGCCAGCGCGCGCCTTCCCTTGTCGTTCGCGCGAGGCCCCCA
CGCGCTCGGAATTCCGCAGGGTTTGTGCGCGCGGCTCGGCCTGGCGCAGGCGCAGAGAGGGAGC
AGGGTCAGGCCGACCGCCATTGCACAACGCGGAGGACTCGCCTGCGGTCACAGGAATGCCGAGG
CTCTTCCGCTTGTGCATGCTGTGGCTTGGACTCTTGCTGGTTCGGTTTTCCCGTGAACTGAGCG
ACATCAGCAGTGCCAGGAAGCTGTGCGGCAGGTACTTGGTGAAAGAAATAGAAAAACTCTGCGG
CCATGCCAACTGGAGCCAGTTCCATTTCGAGGAGGAAACCCCTTTCCCACGGTTGATTGCACAG
GCCTCGGAAAAGGTCGAAGCCTTCAGCCCCTACCAGTTCGAAAGCCCGCAAACCGCTTTCCCGG
CCCGGGGAAGAGGCACAAACCCAGTGTCTACTTCTGCCTCTTGGGAAGAAGCAGTAAACAATTG
GGAAATGCAGTCACTACCTGAGTATCAGGATAAAAAGGCATATTCACCCCTTGATAAGGAAAGA
GAATTTTCTTCATCACATAATATCAATCTATATATTCATGAGAATGAAAAATTTAAGAAGAAAA
GTAGAAACAAAATTAAAACCTTAAGCAATTTGTTTTGGGGGAATCATCCCCAAAGAAAACGCAG
AGGATATTCAGAAAAGTGTTGTCTTACAGGATGTACAAAAGAAGAACTTAGCATTGCATGTCTT
CCATATATTGATTTTAAAAGGTTAAAGGAAAAAAAATCATCACTTGTAACTAAGATATACTAAC
CATTATAGAAATTTTTCTAACCTAATAAAAGCTTAATACATTTAT

hide sequence

Protein Sequences


Protein RefSeqs	XP_007967531	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000005115
	ENSCSAP00000005115.1

RefSeq Acc Id:	XP_007967531 ⟸ XM_007969340
- UniProtKB:	A0A0D9R926 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000005115 ⟸ ENSCSAT00000006921

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000008855	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000006921.1	UniProtKB/TrEMBL
Gene3D-CATH	Insulin-like	UniProtKB/TrEMBL
InterPro	Insulin-like	UniProtKB/TrEMBL
	Insulin-like_pep_6	UniProtKB/TrEMBL
	Insulin-like_sf	UniProtKB/TrEMBL
	Insulin_CS	UniProtKB/TrEMBL
	Repro_Hormone_Insulin-like	UniProtKB/TrEMBL
KEGG Report	csab:103219491	UniProtKB/TrEMBL
NCBI Gene	INSL6	ENTREZGENE
PANTHER	PTHR12004:SF1	UniProtKB/TrEMBL
	RELAXIN	UniProtKB/TrEMBL
Pfam	Insulin	UniProtKB/TrEMBL
PIRSF	Insulin-like_peptide_6	UniProtKB/TrEMBL
PROSITE	INSULIN	UniProtKB/TrEMBL
SMART	IlGF	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56994	UniProtKB/TrEMBL
UniProt	A0A0D9R926	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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