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Gene: CFHR5 (complement factor H related 5) Chlorocebus sabaeus

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Symbol:

CFHR5

Name:

complement factor H related 5

RGD ID:

18545271

Description:

ENCODES a protein that exhibits complement component C3b binding (inferred); identical protein binding (inferred); protein heterodimerization activity (inferred); INVOLVED IN complement activation (inferred); cytolysis by host of symbiont cells (inferred); ASSOCIATED WITH atypical hemolytic-uremic syndrome (ortholog); C3 Glomerulopathy 3 (ortholog); cholestasis (ortholog); FOUND IN extracellular space (inferred); protein-containing complex (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

complement factor H-related protein 5

RGD Orthologs

Human

Bonobo

Dog

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	32,411,268 - 32,440,499 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	32,410,158 - 32,439,961 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	33,318,099 - 33,347,846 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
CFHR5	Green Monkey	atypical hemolytic-uremic syndrome		ISO	CFHR5 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome	ClinVar	PMID:16299065 more ...
CFHR5	Green Monkey	C3 Glomerulopathy 3		ISO	CFHR5 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:16299065 more ...
CFHR5	Green Monkey	chronic kidney disease		ISO	CFHR5 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Chronic kidney disease	ClinVar	PMID:17000000 more ...
CFHR5	Green Monkey	gastrointestinal stromal tumor		ISO	CFHR5 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Gastrointestinal stromal tumor	ClinVar	PMID:28492532
CFHR5	Green Monkey	genetic disease		ISO	CFHR5 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:17000000 more ...
CFHR5	Green Monkey	kidney disease		ISO	CFHR5 (Homo sapiens)	8554872	ClinVar Annotator: match by term: renal disease	ClinVar	PMID:19365580 more ...
CFHR5	Green Monkey	membranoproliferative glomerulonephritis		ISO	CFHR5 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Mesangiocapillary glomerulonephritis and type II	ClinVar	PMID:25741868 and PMID:28492532
CFHR5	Green Monkey	parathyroid carcinoma		ISO	CFHR5 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Parathyroid carcinoma	ClinVar	PMID:28492532
CFHR5	Green Monkey	retinitis pigmentosa 12		ISO	CFHR5 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Retinitis pigmentosa 12	ClinVar	PMID:10508521 more ...

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
CFHR5	Green Monkey	cholestasis		ISO	CFHR5 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:27989131

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
CFHR5	Green Monkey	C3 Glomerulopathy 3		ISO	CFHR5 (Homo sapiens)	7240710		OMIM

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
CFHR5	Green Monkey	complement activation	involved_in	IEA	PANTHER:PTN000763576	150520179		TreeGrafter	GO_REF:0000118
CFHR5	Green Monkey	cytolysis by host of symbiont cells	involved_in	IEA	UniProtKB:Q9BXR6 and ensembl:ENSP00000256785	150520179		Ensembl	GO_REF:0000107

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
CFHR5	Green Monkey	extracellular space	located_in	IEA	PANTHER:PTN000763576	150520179		TreeGrafter	GO_REF:0000118
CFHR5	Green Monkey	protein-containing complex	part_of	IEA	UniProtKB:Q9BXR6 and ensembl:ENSP00000256785	150520179		Ensembl	GO_REF:0000107

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
CFHR5	Green Monkey	complement component C3b binding	enables	IEA	PANTHER:PTN000763576	150520179		TreeGrafter	GO_REF:0000118
CFHR5	Green Monkey	identical protein binding	enables	IEA	UniProtKB:Q9BXR6 and ensembl:ENSP00000256785	150520179		Ensembl	GO_REF:0000107
CFHR5	Green Monkey	protein binding	enables	ISO	UniProtKB:P02741	9068941	PMID:28533443	IntAct	PMID:28533443
CFHR5	Green Monkey	protein binding	enables	ISO	UniProtKB:Q03591	9068941	PMID:23728178	IntAct	PMID:23728178
CFHR5	Green Monkey	protein binding	enables	ISO	UniProtKB:O43889-2 and UniProtKB:Q96BA8	9068941	PMID:25910212	IntAct	PMID:25910212
CFHR5	Green Monkey	protein binding	enables	ISO	UniProtKB:P01027 and UniProtKB:Q03591	9068941	PMID:23487775	UniProt	PMID:23487775
CFHR5	Green Monkey	protein binding	enables	ISO	UniProtKB:O00559 more ...	9068941	PMID:32296183	IntAct	PMID:32296183
CFHR5	Green Monkey	protein heterodimerization activity	enables	IEA	UniProtKB:Q9BXR6 and ensembl:ENSP00000256785	150520179		Ensembl	GO_REF:0000107

CFHR5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	32,411,268 - 32,440,499 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	32,410,158 - 32,439,961 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	33,318,099 - 33,347,846 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

CFHR5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	196,975,034 - 197,009,678 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	196,975,010 - 197,009,678 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	196,946,686 - 196,978,808 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	195,213,327 - 195,245,429 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	193,678,364 - 193,710,461	NCBI
Celera	1	170,072,138 - 170,104,273 (+)	NCBI		Celera
Cytogenetic Map	1	q31.3	NCBI
HuRef	1	168,103,962 - 168,136,037 (+)	NCBI		HuRef
CHM1_1	1	198,368,946 - 198,401,079 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	196,236,842 - 196,271,501 (+)	NCBI		T2T-CHM13v2.0

CFHR5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	52,396,896 - 52,430,608 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	52,346,267 - 52,379,975 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	172,541,948 - 172,574,591 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	176,876,635 - 176,908,723 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	176,876,635 - 176,908,723 (+)	Ensembl	panpan1.1		panPan2

CFHR5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	5,723,819 - 5,752,881 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	5,724,129 - 5,752,816 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	5,351,490 - 5,381,962 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	5,418,471 - 5,448,938 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	5,418,422 - 5,448,895 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	5,353,202 - 5,383,610 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	5,454,174 - 5,484,601 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	5,487,344 - 5,517,817 (-)	NCBI		UU_Cfam_GSD_1.0

Variants in CFHR5
666 total Variants

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
20	18	18	20	20	18	16


RefSeq Transcripts	XM_007989080	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000023	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000011668 ⟹ ENSCSAP00000009734

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	25	32,410,158 - 32,439,961 (-)	Ensembl

RefSeq Acc Id:

XM_007989080 ⟹ XP_007987271

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	25	32,411,268 - 32,440,499 (-)	NCBI
Vero_WHO_p1.0	NW_023666055	33,318,099 - 33,347,846 (-)	NCBI

Sequence:

show sequence

ATACCAAGACCCTCCCAAAGCCATTCTCAAAGTCCCACCTGAACAAAATGATTTTGAATTATAATTTTGTGCCTTTAAACATTTCAGGAAACGTTACTTGGCAAAAATTATTCTTGATTAGACCTTTT
ATAGTTTATGAAATATTAAAACTGTTAAGAAGGTACCTAATTATTAGTGCCAGTTTTAAAAGAAATTTACGACTACAAAAGTGATGTTGTATTAAGATGAGGAGTGATGACTTGCACTTGCTTGCCTT
TTGAAACAGCTGAACTCTTGGCTAGAAAAAAAGAAAAAAAAAAAAAGGCAGGGGGGAGCTTCCTGTCTCCTCTAAACAGTTATTTCTGATTATTCCAAACTCAGAGACTCGGTGACTACAACAAGGAA
ATTGAACAGCAGTTATTTTGCGCAAATAAACATTACATAATGAGTTGAGAACATTTTTGTGAAAACACTGATTAGACACTATTTGCTTATTTCACACAACCCTCCATGAACTTTGATATTTTCCACAA
AGGGATTTACTAAAGTAGCTTCCCATTAGTATACTGAAATACAAAGTCATGTTCATAACTGTTAATTTAAAGTAACACCACCATCACTGGAGTACTTTTAGTTATATGTGATTGGGACTACCAAGCAT
GTTGCTCTTATTCAGTGTAATCCTAATCTCATGGGTATCCACTGTTGGGGGAGAAGCAACACTTTGTGATTTTCCAAAAATACGCCATGGATTTCTGTATGATGAAGAAAATTATAAGCCATTTTCCC
AAGTTCCTATAGGGGAAGTTTTCTATTACTCCTGTGAATATAATTTTGTGTCTCCGTCAAAATCCTTTTGGACTCGCATAACATGCACAGAAGAAGGATGGTCACCAACACCAAAGTGTCTCAGAATG
TGTTCCTTTCCTTTTGTAAGAAATGGTCATTCTGAATCTTCAGGACAAATACATCTGGAAGGTGATACTGTACAAATTGTTTGCAACAGAGGATACAGCCTTCAAAACAAGGAGAAAAGCATTTCATG
TGTAGAACGGGGCTGGTCCACTCCTCCCAAATGCAGCTTCACTAAAGAAGAATGTCATGTTCCAATTTTAGAAGCAAATGTAGATGCTAAGCCAGAAAAAGAAAGCTACGAAGTTGGAGATGTGTTGA
AATTCTCCTGCAGAAAAAATCTTACAAGAGTTGGACCAGATTCAGTTCAATGTTACCAATTCGGGTGGTCACCCAACTTTCCGACATGTAAAGGACGAGTACAGTCGTGTGGTCCACCTCCTCAGCTC
TCCAATGGTGAAGTTAAGGAGATAAGAAAAGAGGAATATGGACACAATGAAGTAGTAGAATATTATTGCAATCGTAATTTTATAATAAAAGGACCTAAGAAAATACAATGTGTGGATGGAAAATGGAC
AACTTTACCCACTTGTGTTGAGCAAGTGAAAACATGTGGATATATACCTGAACTTCAGTATGGTTATGTTCAGCAGTCTGTCCCTCCCTATCAACATGGAGTTTCAGTGGAGGTGAATTGCAGAAATG
AATATACAATGATTGGAAATAACGAGATTACCTGTATTGATGGACTATGGACAGAGCTTCCTATGTGTGTTGCAACACACCAACTTAAGAGGTGCAAAATATCAGGAGTTAATATAAAAATGTTATTC
AGGTCATCTGGGAATGAATTTAATCATAATGCTAGAATACGTTACAGATGTTTAGACATCCTTGGATACAGGCACTCAGTCTGCATAGACGGGAAATGGATTCCTGAACTAGACTGCACAGAAAAAAA
GGAACAATTCTGCCCACCGCCACCTCAGATACCTAATGCTCAGAATATGACAACCACAGTGAATTATCAGGATGGAGAAAAAGTAGCTGTTCTCTGTAAAGAAAACTATCTACTTCCAGAAGCAAAAG
AAATTGTATGTAAAAATGGACGATGGCAATCATTACCACACTGTGTTGAGTCTACAGCATATTGTGGGCCCCCTCCATCTATTAACAATGGCGATATCACCTCATTCCCATTATCAGTGTATCCTCCA
TGGTCAACAGTGACATACCGTTGCCAGTCCTTCTATGAACTCCAGGGCTCTGTAACTGTAACATGCAGAAACAAACAGTGGTCAGAACCACCAAGATGCCTAGATCCATGTGTGATATCTGAAGAAAA
CATGAACAAAAATAACCTACAGTTAAGATGGAGAAACAATAAAAAACTTTACGTAAAAACAGGGGATGCTGTTGAATTTCAGTGTAAATTCCTATATAAAGCAAAGATATCATCACCATCATTTCGAG
CAATCTGTCAAGAAGGGAAATTTGAATATCCCATATGTGAAAGAAGCGAGCTTAATTTTCCTGAATAAATTCTTAAAACATACATCTATGCTAAAAGTA

hide sequence


Protein RefSeqs	XP_007987271	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000009734.1

RefSeq Acc Id:	XP_007987271 ⟸ XM_007989080
- UniProtKB:	A0A0D9RM95 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000009734 ⟸ ENSCSAT00000011668

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000013575	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000011668.1	UniProtKB/TrEMBL
Gene3D-CATH	Complement Module, domain 1	UniProtKB/TrEMBL
InterPro	ComplSys_Reg/VirEntry_Med	UniProtKB/TrEMBL
	Sushi/SCR/CCP_sf	UniProtKB/TrEMBL
	Sushi_SCR_CCP_dom	UniProtKB/TrEMBL
KEGG Report	csab:103230380	UniProtKB/TrEMBL
NCBI Gene	CFHR5	ENTREZGENE
PANTHER	COMPLEMENT FACTOR H-RELATED	UniProtKB/TrEMBL
	COMPLEMENT FACTOR H-RELATED PROTEIN 5	UniProtKB/TrEMBL
Pfam	Sushi	UniProtKB/TrEMBL
PROSITE	SUSHI	UniProtKB/TrEMBL
SMART	CCP	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57535	UniProtKB/TrEMBL
UniProt	A0A0D9RM95	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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