GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1) - Rat Genome Database

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Gene: GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1) Chlorocebus sabaeus
Analyze
Symbol: GRINA
Name: glutamate ionotropic receptor NMDA type subunit associated protein 1
RGD ID: 18527068
Description: ENCODES a protein that exhibits transmembrane transporter binding (ortholog); INVOLVED IN endoplasmic reticulum calcium ion homeostasis (ortholog); negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (ortholog); ASSOCIATED WITH Brown-Vialetto-Van Laere syndrome 2 (ortholog); epidermolysis bullosa simplex with muscular dystrophy (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum (inferred); Golgi apparatus (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein lifeguard 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18138,199,642 - 138,202,989 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8138,200,792 - 138,202,453 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660391,670,935 - 1,674,284 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
GRINA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18138,199,642 - 138,202,989 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8138,200,792 - 138,202,453 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660391,670,935 - 1,674,284 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
GRINA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388143,990,056 - 143,993,415 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8143,990,056 - 143,993,415 (+)EnsemblGRCh38hg38GRCh38
GRCh378145,064,224 - 145,067,583 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368145,136,214 - 145,139,571 (+)NCBINCBI36Build 36hg18NCBI36
Cytogenetic Map8q24.3NCBI
HuRef8140,305,288 - 140,323,781 (+)NCBIHuRef
CHM1_18145,104,475 - 145,107,832 (+)NCBICHM1_1
T2T-CHM13v2.08145,150,254 - 145,153,613 (+)NCBIT2T-CHM13v2.0
Grina
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391576,130,917 - 76,134,109 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1576,130,964 - 76,134,104 (+)EnsemblGRCm39 Ensembl
GRCm381576,246,717 - 76,249,909 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1576,246,764 - 76,249,904 (+)EnsemblGRCm38mm10GRCm38
MGSCv371576,077,237 - 76,080,334 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361576,074,062 - 76,077,159 (+)NCBIMGSCv36mm8
Celera1577,746,755 - 77,749,852 (+)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1535.59NCBI
Grina
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87109,842,870 - 109,846,048 (+)NCBIGRCr8
mRatBN7.27107,962,194 - 107,965,372 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7107,962,207 - 107,965,366 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7109,705,794 - 109,708,972 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07111,929,476 - 111,932,654 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07111,887,957 - 111,891,135 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07117,304,742 - 117,307,916 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7117,304,742 - 117,307,916 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07117,290,445 - 117,293,621 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47114,277,208 - 114,280,339 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17114,311,439 - 114,314,569 (+)NCBI
Celera7104,314,740 - 104,317,914 (+)NCBICelera
Cytogenetic Map7q34NCBI
Grina
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554542,658,490 - 2,660,021 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554542,657,374 - 2,660,591 (+)NCBIChiLan1.0ChiLan1.0
GRINA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27161,479,190 - 161,483,099 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18137,009,368 - 137,012,765 (+)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl8143,749,331 - 143,752,071 (+)Ensemblpanpan1.1panPan2
GRINA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11337,512,129 - 37,514,303 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1337,512,217 - 37,514,257 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1337,475,101 - 37,478,196 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01337,987,687 - 37,990,781 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11337,659,794 - 37,662,885 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01337,787,997 - 37,791,086 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01338,264,550 - 38,267,645 (+)NCBIUU_Cfam_GSD_1.0
Grina
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303754,364 - 757,621 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364708,180,468 - 8,183,694 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRINA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4682,835 - 686,116 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14682,823 - 686,144 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Grina
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473512,821,243 - 12,822,787 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473512,820,678 - 12,823,920 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 20 60
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_008001870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000006901   ⟹   ENSCSAP00000005097
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl8138,200,792 - 138,202,453 (+)Ensembl
RefSeq Acc Id: XM_008001870   ⟹   XP_008000061
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.18138,199,642 - 138,202,989 (+)NCBI
Vero_WHO_p1.0NW_0236660391,670,935 - 1,674,284 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008000061 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000005097
  ENSCSAP00000005097.1
Reference Protein Sequences
RefSeq Acc Id: XP_008000061   ⟸   XM_008001870
- UniProtKB: A0A0D9R908 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000005097   ⟸   ENSCSAT00000006901


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000008836 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000006901.1 UniProtKB/TrEMBL
InterPro Bax_inhibitor_1-related UniProtKB/TrEMBL
KEGG Report csab:103237596 UniProtKB/TrEMBL
NCBI Gene GRINA ENTREZGENE
PANTHER PROTEIN LIFEGUARD 1 UniProtKB/TrEMBL
  PTHR23291 UniProtKB/TrEMBL
Pfam Bax1-I UniProtKB/TrEMBL
UniProt A0A0D9R908 ENTREZGENE, UniProtKB/TrEMBL