GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1) Sus scrofa
Analyze
Symbol: GRINA
Name: glutamate ionotropic receptor NMDA type subunit associated protein 1
RGD ID: 14225251
Description: ENCODES a protein that exhibits protein kinase A regulatory subunit binding (inferred); transmembrane transporter binding (inferred); INVOLVED IN endoplasmic reticulum calcium ion homeostasis (ortholog); negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (ortholog); ASSOCIATED WITH Brown-Vialetto-Van Laere syndrome 2 (ortholog); epidermolysis bullosa simplex with muscular dystrophy (ortholog); genetic disease (ortholog); FOUND IN centrosome (inferred); endoplasmic reticulum (inferred); Golgi apparatus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein lifeguard 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4682,835 - 686,116 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14682,823 - 686,144 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:30032202  


Genomics

Comparative Map Data
GRINA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4682,835 - 686,116 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14682,823 - 686,144 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GRINA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388143,990,056 - 143,993,415 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8143,990,056 - 143,993,415 (+)EnsemblGRCh38hg38GRCh38
GRCh378145,064,224 - 145,067,583 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368145,136,214 - 145,139,571 (+)NCBINCBI36Build 36hg18NCBI36
Cytogenetic Map8q24.3NCBI
HuRef8140,305,288 - 140,323,781 (+)NCBIHuRef
CHM1_18145,104,475 - 145,107,832 (+)NCBICHM1_1
T2T-CHM13v2.08145,150,254 - 145,153,613 (+)NCBIT2T-CHM13v2.0
Grina
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391576,130,917 - 76,134,109 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1576,130,964 - 76,134,104 (+)EnsemblGRCm39 Ensembl
GRCm381576,246,717 - 76,249,909 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1576,246,764 - 76,249,904 (+)EnsemblGRCm38mm10GRCm38
MGSCv371576,077,237 - 76,080,334 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361576,074,062 - 76,077,159 (+)NCBIMGSCv36mm8
Celera1577,746,755 - 77,749,852 (+)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1535.59NCBI
Grina
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87109,842,870 - 109,846,048 (+)NCBIGRCr8
mRatBN7.27107,962,194 - 107,965,372 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7107,962,207 - 107,965,366 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7109,705,794 - 109,708,972 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07111,929,476 - 111,932,654 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07111,887,957 - 111,891,135 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07117,304,742 - 117,307,916 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7117,304,742 - 117,307,916 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07117,290,445 - 117,293,621 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47114,277,208 - 114,280,339 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17114,311,439 - 114,314,569 (+)NCBI
Celera7104,314,740 - 104,317,914 (+)NCBICelera
Cytogenetic Map7q34NCBI
Grina
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554542,658,490 - 2,660,021 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554542,657,374 - 2,660,591 (+)NCBIChiLan1.0ChiLan1.0
GRINA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27161,479,190 - 161,483,099 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18137,009,368 - 137,012,765 (+)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl8143,749,331 - 143,752,071 (+)Ensemblpanpan1.1panPan2
GRINA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11337,512,129 - 37,514,303 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1337,512,217 - 37,514,257 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1337,475,101 - 37,478,196 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01337,987,687 - 37,990,781 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11337,659,794 - 37,662,885 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01337,787,997 - 37,791,086 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01338,264,550 - 38,267,645 (+)NCBIUU_Cfam_GSD_1.0
Grina
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303754,364 - 757,621 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364708,180,468 - 8,183,694 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRINA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18138,199,642 - 138,202,989 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8138,200,792 - 138,202,453 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660391,670,935 - 1,674,284 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grina
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473512,821,243 - 12,822,787 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473512,820,678 - 12,823,920 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GRINA
21 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 17
Low 10 2 3 5 2 6 2 3 3
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000057965   ⟹   ENSSSCP00000044928
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4682,835 - 686,114 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000061501   ⟹   ENSSSCP00000032665
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4682,835 - 686,116 (-)Ensembl
RefSeq Acc Id: XM_021090537   ⟹   XP_020946196
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14682,823 - 686,144 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021090538   ⟹   XP_020946197
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14682,823 - 685,228 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021090540   ⟹   XP_020946199
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14682,823 - 685,346 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020946196   ⟸   XM_021090537
- UniProtKB: A0A8D1NBR3 (UniProtKB/TrEMBL),   A0A8D0T111 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020946199   ⟸   XM_021090540
- UniProtKB: A0A8D1NBR3 (UniProtKB/TrEMBL),   A0A8D0T111 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020946197   ⟸   XM_021090538
- UniProtKB: A0A8D1NBR3 (UniProtKB/TrEMBL),   A0A8D0T111 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000032665   ⟸   ENSSSCT00000061501
RefSeq Acc Id: ENSSSCP00000044928   ⟸   ENSSSCT00000057965
Protein Domains
Speriolin C-terminal   Speriolin N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000032796 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025065380 UniProtKB/TrEMBL
  ENSSSCG00030004641 UniProtKB/TrEMBL
  ENSSSCG00035068677 UniProtKB/TrEMBL
  ENSSSCG00040056179 UniProtKB/TrEMBL
  ENSSSCG00045007387 UniProtKB/TrEMBL
  ENSSSCG00050064548 UniProtKB/TrEMBL
  ENSSSCG00055013602 UniProtKB/TrEMBL
  ENSSSCG00060021754 UniProtKB/TrEMBL
  ENSSSCG00065012427 UniProtKB/TrEMBL
  ENSSSCG00070019232 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000061501 ENTREZGENE
  ENSSSCT00000061501.3 UniProtKB/TrEMBL
  ENSSSCT00025089705.1 UniProtKB/TrEMBL
  ENSSSCT00025089817.1 UniProtKB/TrEMBL
  ENSSSCT00030006216.1 UniProtKB/TrEMBL
  ENSSSCT00030006225.1 UniProtKB/TrEMBL
  ENSSSCT00035092703.1 UniProtKB/TrEMBL
  ENSSSCT00035092749.1 UniProtKB/TrEMBL
  ENSSSCT00035092793.1 UniProtKB/TrEMBL
  ENSSSCT00035092859.1 UniProtKB/TrEMBL
  ENSSSCT00035092895.1 UniProtKB/TrEMBL
  ENSSSCT00040076137.1 UniProtKB/TrEMBL
  ENSSSCT00040076176.1 UniProtKB/TrEMBL
  ENSSSCT00040076227.1 UniProtKB/TrEMBL
  ENSSSCT00045012271.1 UniProtKB/TrEMBL
  ENSSSCT00045012309.1 UniProtKB/TrEMBL
  ENSSSCT00045012335.1 UniProtKB/TrEMBL
  ENSSSCT00050087891.1 UniProtKB/TrEMBL
  ENSSSCT00050087895.1 UniProtKB/TrEMBL
  ENSSSCT00055026778.1 UniProtKB/TrEMBL
  ENSSSCT00055026839.1 UniProtKB/TrEMBL
  ENSSSCT00055026881.1 UniProtKB/TrEMBL
  ENSSSCT00060029477.1 UniProtKB/TrEMBL
  ENSSSCT00060029486.1 UniProtKB/TrEMBL
  ENSSSCT00060029491.1 UniProtKB/TrEMBL
  ENSSSCT00065016542.1 UniProtKB/TrEMBL
  ENSSSCT00065016555.1 UniProtKB/TrEMBL
  ENSSSCT00065016561.1 UniProtKB/TrEMBL
  ENSSSCT00070037986.1 UniProtKB/TrEMBL
  ENSSSCT00070037994.1 UniProtKB/TrEMBL
InterPro Bax_inhibitor_1-related UniProtKB/TrEMBL
  SPATC1 UniProtKB/TrEMBL
  Speriolin_C UniProtKB/TrEMBL
  Speriolin_N UniProtKB/TrEMBL
NCBI Gene GRINA ENTREZGENE
PANTHER PROTEIN LIFEGUARD 1 UniProtKB/TrEMBL
  PTHR22192 UniProtKB/TrEMBL
  PTHR23291 UniProtKB/TrEMBL
  SPERIOLIN UniProtKB/TrEMBL
Pfam Bax1-I UniProtKB/TrEMBL
  Speriolin_C UniProtKB/TrEMBL
  Speriolin_N UniProtKB/TrEMBL
UniProt A0A286ZMH1_PIG UniProtKB/TrEMBL
  A0A4X1UT26_PIG UniProtKB/TrEMBL
  A0A8D0T111 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0V9I9_PIG UniProtKB/TrEMBL
  A0A8D1AWB2_PIG UniProtKB/TrEMBL
  A0A8D1D2E2_PIG UniProtKB/TrEMBL
  A0A8D1F4Y5_PIG UniProtKB/TrEMBL
  A0A8D1NBR3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:88689 ENTREZGENE