MTMR14 (myotubularin related protein 14) - Rat Genome Database

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Gene: MTMR14 (myotubularin related protein 14) Chlorocebus sabaeus
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Symbol: MTMR14
Name: myotubularin related protein 14
RGD ID: 18499123
Description: ENCODES a protein that exhibits phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity (inferred); phosphatidylinositol-3-phosphate phosphatase activity (inferred); ASSOCIATED WITH Atrioventricular Septal Defect 2 (ortholog); autosomal dominant centronuclear myopathy (ortholog); centronuclear myopathy 1 (ortholog); FOUND IN perinuclear region of cytoplasm (inferred); ruffle (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: myotubularin-related protein 14
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12245,650,544 - 45,704,237 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2245,650,556 - 45,713,176 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041120,858,495 - 120,912,572 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MTMR14Green MonkeyAtrioventricular Septal Defect 2  ISOMTMR14 (Homo sapiens)8554872ClinVar Annotator: match by term: Atrioventricular septal defect more ...ClinVarPMID:28492532
MTMR14Green Monkeyautosomal dominant centronuclear myopathy  ISOMTMR14 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:17008356 more ...
MTMR14Green Monkeycentronuclear myopathy 1  ISOMTMR14 (Homo sapiens)8554872ClinVar Annotator: match by term: MTMR14-related conditionClinVarPMID:25741868 and PMID:28492532
MTMR14Green Monkeycongenital structural myopathy  ISOMTMR14 (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal dominant centronuclear myopathyClinVarPMID:17008356 more ...
MTMR14Green Monkeylong QT syndrome  ISOMTMR14 (Homo sapiens)8554872ClinVar Annotator: match by term: Long QT syndromeClinVarPMID:28492532
MTMR14Green Monkeymyoclonic-atonic epilepsy  ISOMTMR14 (Homo sapiens)8554872ClinVar Annotator: match by term: Generalized myoclonic-atonic seizureClinVarPMID:25865495 more ...
MTMR14Green MonkeyNeurodevelopmental Disorders  ISOMTMR14 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MTMR14Green Monkeyovarian carcinoma  ISOMTMR14 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:30365097
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MTMR14Green Monkeycentronuclear myopathy 1  ISOMTMR14 (Homo sapiens)7240710 OMIM 


Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MTMR14Green Monkeyperinuclear region of cytoplasm located_inIEAUniProtKB:Q8NCE2 and ensembl:ENSP00000296003150520179 EnsemblGO_REF:0000107
MTMR14Green Monkeyruffle located_inIEAUniProtKB:Q8NCE2 and ensembl:ENSP00000296003150520179 EnsemblGO_REF:0000107

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MTMR14Green Monkeyphosphatidylinositol-3,5-bisphosphate 3-phosphatase activity enablesIEAUniProtKB:Q8NCE2 and ensembl:ENSP00000296003150520179 EnsemblGO_REF:0000107
MTMR14Green Monkeyphosphatidylinositol-3-phosphate phosphatase activity enablesIEAPANTHER:PTN002669614150520179 TreeGrafterGO_REF:0000118
MTMR14Green Monkeyphosphatidylinositol-3-phosphate phosphatase activity enablesIEAUniProtKB:Q8NCE2 and ensembl:ENSP00000296003150520179 EnsemblGO_REF:0000107
MTMR14Green Monkeyphosphatidylinositol-3-phosphate phosphatase activity enablesIEAInterPro:IPR039802150520179 InterProGO_REF:0000002
MTMR14Green Monkeyprotein binding enablesISOUniProtKB:Q05BL19068941 PMID:25910212IntActPMID:25910212
MTMR14Green Monkeyprotein binding enablesISOUniProtKB:Q13625-39068941 PMID:25416956IntActPMID:25416956

PMID:22301074   PMID:30032202  



MTMR14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12245,650,544 - 45,704,237 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2245,650,556 - 45,713,176 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041120,858,495 - 120,912,572 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
MTMR14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3839,649,505 - 9,702,393 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl39,649,433 - 9,702,393 (+)EnsemblGRCh38hg38GRCh38
GRCh3739,691,189 - 9,744,077 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3639,666,144 - 9,719,077 (+)NCBINCBI36Build 36hg18NCBI36
Celera39,625,828 - 9,678,788 (+)NCBICelera
Cytogenetic Map3p25.3NCBI
HuRef39,627,478 - 9,680,438 (+)NCBIHuRef
CHM1_139,641,322 - 9,694,282 (+)NCBICHM1_1
T2T-CHM13v2.039,641,462 - 9,694,348 (+)NCBIT2T-CHM13v2.0
Mtmr14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396113,214,596 - 113,258,353 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6113,214,804 - 113,258,353 (+)EnsemblGRCm39 Ensembl
GRCm386113,237,635 - 113,281,392 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6113,237,843 - 113,281,392 (+)EnsemblGRCm38mm10GRCm38
MGSCv376113,187,837 - 113,231,386 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366113,203,670 - 113,246,979 (+)NCBIMGSCv36mm8
Celera6115,064,752 - 115,108,357 (+)NCBICelera
Cytogenetic Map6E3NCBI
cM Map652.74NCBI
Mtmr14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84147,942,604 - 147,985,649 (+)NCBIGRCr8
mRatBN7.24146,386,949 - 146,429,990 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4146,386,956 - 146,429,990 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4151,771,236 - 151,814,238 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04147,552,076 - 147,595,078 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04146,173,614 - 146,216,640 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04145,195,046 - 145,238,097 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4145,195,070 - 145,238,097 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04208,492,228 - 208,535,256 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44149,121,980 - 149,165,007 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14149,366,863 - 149,409,781 (+)NCBI
Celera4134,944,291 - 134,987,313 (+)NCBICelera
Cytogenetic Map4q42NCBI
Mtmr14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555611,195,650 - 1,237,997 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555611,195,689 - 1,237,852 (+)NCBIChiLan1.0ChiLan1.0
MTMR14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v229,660,342 - 9,713,316 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan139,665,092 - 9,718,074 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v039,600,866 - 9,653,860 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.139,839,821 - 9,892,055 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl39,839,821 - 9,892,055 (+)Ensemblpanpan1.1panPan2
MTMR14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1208,530,682 - 8,576,911 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl208,530,711 - 8,576,913 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha208,563,755 - 8,609,973 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0208,559,972 - 8,606,437 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl208,559,972 - 8,606,458 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1208,282,438 - 8,328,672 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0208,626,952 - 8,673,385 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0208,600,596 - 8,647,110 (-)NCBIUU_Cfam_GSD_1.0
Mtmr14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494215,396,074 - 15,443,162 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366023,466,549 - 3,513,628 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366023,466,547 - 3,513,628 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTMR14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1365,948,544 - 65,994,820 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11365,948,520 - 65,994,231 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21373,030,575 - 73,069,921 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Mtmr14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247314,289,938 - 4,340,980 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247314,290,107 - 4,340,978 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in MTMR14
858 total Variants



ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20



Ensembl Acc Id: ENSCSAT00000008794   ⟹   ENSCSAP00000006929
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2245,650,556 - 45,713,176 (+)Ensembl
RefSeq Acc Id: XM_007985131   ⟹   XP_007983322
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12245,650,544 - 45,704,237 (+)NCBI
Vero_WHO_p1.0NW_023666041120,858,495 - 120,912,572 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007985132   ⟹   XP_007983323
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12245,650,544 - 45,704,237 (+)NCBI
Vero_WHO_p1.0NW_023666041120,858,495 - 120,912,572 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007985134   ⟹   XP_007983325
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12245,650,544 - 45,704,237 (+)NCBI
Vero_WHO_p1.0NW_023666041120,858,495 - 120,912,572 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038003626   ⟹   XP_037859554
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666041120,858,495 - 120,912,572 (-)NCBI
Protein RefSeqs XP_007983322 (Get FASTA)   NCBI Sequence Viewer  
  XP_007983323 (Get FASTA)   NCBI Sequence Viewer  
  XP_007983325 (Get FASTA)   NCBI Sequence Viewer  
  XP_037859554 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000006929
  ENSCSAP00000006929.1
RefSeq Acc Id: XP_007983322   ⟸   XM_007985131
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RE90 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007983323   ⟸   XM_007985132
- Peptide Label: isoform X2
RefSeq Acc Id: XP_007983325   ⟸   XM_007985134
- Peptide Label: isoform X4
Ensembl Acc Id: ENSCSAP00000006929   ⟸   ENSCSAT00000008794
RefSeq Acc Id: XP_037859554   ⟸   XM_038003626
- Peptide Label: isoform X3



1 to 14 of 14 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCSAG00000010706 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000008794.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.190.10 UniProtKB/TrEMBL
InterPro MTMR14 UniProtKB/TrEMBL
  MTMR14_PH-GRAM UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
KEGG Report csab:103227971 UniProtKB/TrEMBL
NCBI Gene MTMR14 ENTREZGENE
PANTHER MYOTUBULARIN-RELATED PROTEIN 14 UniProtKB/TrEMBL
  PTHR13524 UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/TrEMBL
UniProt A0A0D9RE90 ENTREZGENE, UniProtKB/TrEMBL
1 to 14 of 14 rows