RTN2 (reticulon 2) - Rat Genome Database

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Gene: RTN2 (reticulon 2) Chlorocebus sabaeus
Analyze
Symbol: RTN2
Name: reticulon 2
RGD ID: 18482781
Description: INVOLVED IN protein transport (ortholog); ASSOCIATED WITH autosomal recessive distal hereditary motor neuronopathy 11 (ortholog); genetic disease (ortholog); hereditary spastic paraplegia (ortholog); FOUND IN cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: reticulon-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1638,931,473 - 38,943,057 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl638,931,348 - 38,942,886 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607318,551,246 - 18,564,389 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
RTN2Green Monkeyautosomal recessive distal hereditary motor neuronopathy 11  ISORTN2 (Homo sapiens)8554872ClinVar Annotator: match by term: Neuronopathy more ...ClinVarPMID:10677333 more ...
RTN2Green Monkeygenetic disease  ISORTN2 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 more ...
RTN2Green Monkeyhereditary spastic paraplegia  ISORTN2 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary spastic paraplegiaClinVarPMID:25741868 more ...
RTN2Green Monkeyhereditary spastic paraplegia 10  ISORTN2 (Homo sapiens)8554872ClinVar Annotator: match by term: Spastic paraplegia and autosomal dominantClinVarPMID:25741868 more ...
RTN2Green Monkeyhereditary spastic paraplegia 12  ISORTN2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10677333 more ...
RTN2Green Monkeyparaplegia  ISORTN2 (Homo sapiens)8554872ClinVar Annotator: match by term: Spastic paraplegiaClinVarPMID:16199547 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
RTN2Green Monkeyautosomal recessive distal hereditary motor neuronopathy 11  ISORTN2 (Homo sapiens)7240710 OMIM 
RTN2Green Monkeyhereditary spastic paraplegia 12  ISORTN2 (Homo sapiens)7240710 OMIM 


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
RTN2Green Monkeybrain development involved_inIEAPANTHER:PTN002910008150520179 TreeGrafterGO_REF:0000118
RTN2Green Monkeyendoplasmic reticulum tubular network formation involved_inIEAPANTHER:PTN002910008150520179 TreeGrafterGO_REF:0000118
RTN2Green Monkeygene expression acts_upstream_of_or_withinIEAUniProtKB:O70622 and ensembl:ENSMUSP00000032559150520179 EnsemblGO_REF:0000107
RTN2Green Monkeyintracellular protein transmembrane transport acts_upstream_of_or_withinIEAUniProtKB:O70622 and ensembl:ENSMUSP00000032559150520179 EnsemblGO_REF:0000107
RTN2Green Monkeynegative regulation of amyloid-beta formation involved_inIEAUniProtKB:O75298 and ensembl:ENSP00000245923150520179 EnsemblGO_REF:0000107
RTN2Green Monkeyneuron differentiation involved_inIEAPANTHER:PTN002910008150520179 TreeGrafterGO_REF:0000118
RTN2Green Monkeyprotein transport acts_upstream_of_or_withinISORtn2 (Rattus norvegicus)9068941PMID:18096700MGIPMID:18096700 and REF_RGD_ID:40902968
RTN2Green Monkeyregulation of D-glucose import acts_upstream_of_or_withinIEAUniProtKB:O70622 and ensembl:ENSMUSP00000032559150520179 EnsemblGO_REF:0000107

Cellular Component
1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
RTN2Green Monkeycell surface located_inISORtn2 (Rattus norvegicus)9068941PMID:18096700UniProtPMID:18096700 and REF_RGD_ID:40902968
RTN2Green Monkeyendoplasmic reticulum located_inIEAUniProtKB:O75298 and ensembl:ENSP00000245923150520179 EnsemblGO_REF:0000107
RTN2Green Monkeyendoplasmic reticulum located_inIEAUniProtKB-KW:KW-0256150520179 UniProtGO_REF:0000043
RTN2Green Monkeyendoplasmic reticulum membrane located_inIEAPANTHER:PTN002910008150520179 TreeGrafterGO_REF:0000118
RTN2Green Monkeyendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-0097150520179 UniProtGO_REF:0000044
RTN2Green Monkeyendoplasmic reticulum membrane located_inIEAUniRule:UR000046420150520179 UniProtGO_REF:0000104
RTN2Green Monkeyintermediate filament located_inIEAUniProtKB:O70622 and ensembl:ENSMUSP00000032559150520179 EnsemblGO_REF:0000107
RTN2Green Monkeymembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
RTN2Green Monkeymembrane located_inIEAUniRule:UR000046420150520179 UniProtGO_REF:0000104
RTN2Green Monkeyneuron projection located_inIEAPANTHER:PTN002910008150520179 TreeGrafterGO_REF:0000118
RTN2Green Monkeypostsynaptic density located_inIEAPANTHER:PTN002910008150520179 TreeGrafterGO_REF:0000118
RTN2Green MonkeyT-tubule located_inIEAUniProtKB:O70622 and ensembl:ENSMUSP00000032559150520179 EnsemblGO_REF:0000107
RTN2Green Monkeyterminal cisterna located_inIEAUniProtKB:O70622 and ensembl:ENSMUSP00000032559150520179 EnsemblGO_REF:0000107
RTN2Green MonkeyZ disc located_inIEAUniProtKB:O70622 and ensembl:ENSMUSP00000032559150520179 EnsemblGO_REF:0000107
1 to 14 of 14 rows

Molecular Function

  



RTN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1638,931,473 - 38,943,057 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl638,931,348 - 38,942,886 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607318,551,246 - 18,564,389 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
RTN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381945,485,294 - 45,497,047 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1945,485,294 - 45,497,055 (-)EnsemblGRCh38hg38GRCh38
GRCh371945,988,552 - 46,000,305 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,680,390 - 50,692,153 (-)NCBINCBI36Build 36hg18NCBI36
Build 341950,680,389 - 50,692,153NCBI
Celera1942,794,649 - 42,806,419 (-)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1942,418,168 - 42,429,756 (-)NCBIHuRef
CHM1_11945,991,794 - 46,003,559 (-)NCBICHM1_1
T2T-CHM13v2.01948,312,543 - 48,326,854 (-)NCBIT2T-CHM13v2.0
Rtn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39719,016,549 - 19,030,089 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl719,016,549 - 19,030,085 (+)EnsemblGRCm39 Ensembl
GRCm38719,282,624 - 19,296,164 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,282,624 - 19,296,160 (+)EnsemblGRCm38mm10GRCm38
MGSCv37719,868,016 - 19,881,509 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36718,441,189 - 18,454,682 (+)NCBIMGSCv36mm8
Celera716,679,800 - 16,713,582 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.54NCBI
Rtn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,063,124 - 88,076,082 (+)NCBIGRCr8
mRatBN7.2178,935,056 - 78,948,069 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,935,104 - 78,948,069 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,324,335 - 84,337,063 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0192,881,890 - 92,894,670 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,079,422 - 86,092,150 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,195,594 - 80,208,449 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,195,532 - 80,208,448 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,462,077 - 81,474,932 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4178,647,099 - 78,660,389 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1178,725,036 - 78,738,491 (+)NCBI
Celera173,397,564 - 73,410,355 (+)NCBICelera
Cytogenetic Map1q21NCBI
Rtn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555741,071 - 21,117 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555741,543 - 11,476 (-)NCBIChiLan1.0ChiLan1.0
RTN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22051,645,690 - 51,658,924 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11953,517,190 - 53,530,413 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01942,434,085 - 42,446,862 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11951,030,708 - 51,043,404 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1951,030,708 - 51,043,404 (-)Ensemblpanpan1.1panPan2
RTN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11109,976,820 - 110,080,252 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1109,976,930 - 110,048,532 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,070,607 - 110,079,992 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1109,555,949 - 109,564,507 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01110,604,326 - 110,612,895 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1110,604,196 - 110,612,536 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,280,107 - 110,288,666 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01109,914,219 - 109,922,802 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01110,783,582 - 110,792,149 (+)NCBIUU_Cfam_GSD_1.0
Rtn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,567,224 - 17,575,639 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367061,913,842 - 1,922,772 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367061,913,852 - 1,922,982 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RTN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl651,854,998 - 51,875,169 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1651,855,844 - 51,864,753 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Rtn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249072,344,134 - 2,352,199 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249072,345,223 - 2,350,844 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in RTN2
319 total Variants



ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20


RefSeq Transcripts XM_007997232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007997233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCSAT00000001207   ⟹   ENSCSAP00000014868
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl638,931,348 - 38,942,886 (-)Ensembl
RefSeq Acc Id: XM_007997232   ⟹   XP_007995423
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1638,931,473 - 38,943,057 (-)NCBI
Vero_WHO_p1.0NW_02366607318,551,246 - 18,564,389 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007997233   ⟹   XP_007995424
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1638,931,473 - 38,943,015 (-)NCBI
Vero_WHO_p1.0NW_02366607318,551,246 - 18,564,389 (-)NCBI
Sequence:
Protein RefSeqs XP_007995423 (Get FASTA)   NCBI Sequence Viewer  
  XP_007995424 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000014868
  ENSCSAP00000014868.1
RefSeq Acc Id: XP_007995423   ⟸   XM_007997232
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S1X9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007995424   ⟸   XM_007997233
- Peptide Label: isoform X2
Ensembl Acc Id: ENSCSAP00000014868   ⟸   ENSCSAT00000001207



1 to 12 of 12 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCSAG00000003175 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000001207.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.2480 UniProtKB/TrEMBL
InterPro Reticulon UniProtKB/TrEMBL
  RTN1-4 UniProtKB/TrEMBL
KEGG Report csab:103234870 UniProtKB/TrEMBL
NCBI Gene RTN2 ENTREZGENE
PANTHER RETICULON-2 UniProtKB/TrEMBL
  RETICULON-LIKE PROTEIN UniProtKB/TrEMBL
Pfam Reticulon UniProtKB/TrEMBL
PROSITE RETICULON UniProtKB/TrEMBL
UniProt A0A0D9S1X9 ENTREZGENE, UniProtKB/TrEMBL
1 to 12 of 12 rows