DOK2 (docking protein 2) - Rat Genome Database

Name: DOK2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: DOK2 (docking protein 2) Chlorocebus sabaeus

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Symbol:

DOK2

Name:

docking protein 2

RGD ID:

18473998

Description:

ENCODES a protein that exhibits transmembrane receptor protein tyrosine kinase adaptor activity (inferred); INVOLVED IN cell surface receptor protein tyrosine kinase signaling pathway (ortholog); Ras protein signal transduction (ortholog); PARTICIPATES IN interleukin-2 signaling pathway; interleukin-4 signaling pathway; ASSOCIATED WITH Crohn's disease (ortholog); lung adenocarcinoma (ortholog); Lung Neoplasms (ortholog); FOUND IN cytoplasm (inferred)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DOK2 (docking protein 2)	NCBI	Ortholog
Mus musculus (house mouse):	Dok2 (docking protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Dok2 (docking protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dok2 (docking protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DOK2 (docking protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DOK2 (docking protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dok2 (docking protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DOK2 (docking protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dok2 (docking protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	19,979,303 - 19,984,022 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	19,979,298 - 19,984,263 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	22,246,772 - 22,258,430 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Crohn's disease (ISO)

lung adenocarcinoma (ISO)

Lung Neoplasms (ISO)

malignant astrocytoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell surface receptor protein tyrosine kinase signaling pathway (IEA,ISO)

positive regulation of MAPK cascade (IEA)

Ras protein signal transduction (IEA,ISO)

Cellular Component

cytoplasm (IEA)

Molecular Function

protein binding (ISO)

transmembrane receptor protein tyrosine kinase adaptor activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

interleukin-2 signaling pathway (ISO)

interleukin-4 signaling pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

DOK2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	19,979,303 - 19,984,022 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	19,979,298 - 19,984,263 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	22,246,772 - 22,258,430 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

DOK2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	21,908,873 - 21,913,690 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	21,908,873 - 21,913,690 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	21,766,384 - 21,771,201 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	21,822,330 - 21,827,151 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	21,822,330 - 21,827,151	NCBI
Celera	8	20,728,645 - 20,733,466 (-)	NCBI		Celera
Cytogenetic Map	8	p21.3	NCBI
HuRef	8	20,309,352 - 20,314,173 (-)	NCBI		HuRef
CHM1_1	8	21,968,112 - 21,972,933 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	22,182,868 - 22,187,684 (-)	NCBI		T2T-CHM13v2.0

Dok2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	71,003,336 - 71,015,934 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	71,003,476 - 71,015,935 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	70,765,889 - 70,778,494 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	70,766,036 - 70,778,495 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	71,174,188 - 71,178,301 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	69,509,461 - 69,513,574 (+)	NCBI		MGSCv36	mm8
Celera	14	68,310,407 - 68,314,520 (+)	NCBI		Celera
Cytogenetic Map	14	D2	NCBI
cM Map	14	36.71	NCBI

Dok2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	52,237,046 - 52,251,091 (+)	NCBI		GRCr8
mRatBN7.2	15	45,826,984 - 45,841,409 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	45,827,398 - 45,841,402 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	49,945,191 - 49,959,234 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	51,056,723 - 51,070,766 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	47,916,043 - 47,930,081 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	52,449,884 - 52,455,414 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	52,451,161 - 52,456,409 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	56,165,853 - 56,179,111 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	51,171,277 - 51,174,337 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	51,185,960 - 51,190,117 (+)	NCBI
Celera	15	45,514,158 - 45,517,221 (+)	NCBI		Celera
Cytogenetic Map	15	p11	NCBI

Dok2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	45,410,279 - 45,415,067 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	45,410,689 - 45,421,366 (-)	NCBI	ChiLan1.0	ChiLan1.0

DOK2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	40,410,545 - 40,418,165 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	16,135,681 - 16,142,280 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	21,153,653 - 21,159,863 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	18,094,383 - 18,099,225 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	18,094,383 - 18,099,225 (-)	Ensembl	panpan1.1		panPan2

DOK2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	35,328,767 - 35,338,712 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	35,334,176 - 35,339,175 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	35,916,511 - 35,927,422 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	35,538,727 - 35,549,625 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	35,543,219 - 35,549,616 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	35,483,726 - 35,494,648 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	35,338,286 - 35,349,197 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	35,493,865 - 35,504,771 (+)	NCBI		UU_Cfam_GSD_1.0

Dok2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	12,811,663 - 12,820,726 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936555	5,750,270 - 5,753,964 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936555	5,749,787 - 5,754,149 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DOK2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	6,177,009 - 6,188,708 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	6,176,487 - 6,180,895 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	6,617,646 - 6,622,059 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Dok2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624758	17,515,265 - 17,519,657 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624758	17,515,367 - 17,523,817 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
66	36	20	36	36	50	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007961821	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037983732	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037983733	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000014770 ⟹ ENSCSAP00000012731

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	8	19,979,298 - 19,984,263 (-)	Ensembl

RefSeq Acc Id:

XM_007961821 ⟹ XP_007960012

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	8	19,979,303 - 19,984,022 (-)	NCBI
Vero_WHO_p1.0	NW_023666052	22,253,191 - 22,258,430 (+)	NCBI

Sequence:

show sequence

CCTGAACTGTTGCTCACTGAAGAGCTGGCATTTGGCTTTTTGGCAATTGTCTCTAGCTCACTGA
AAATGCAGGAAGCTTGAGTATAAAACTCACTCAGAAAAAAAAAAAAGAACACACACTCAGAAGA
AACCACAGGGCCTATCGGCCTGTCGTCATCGAGCAGACTAGAATAGTGTAGAAAACCCTAGGCA
GAGAGGAAATGAACTTCAGAGAAGGGGAACACACGGCTGAGAAGAGAGAGGCAAGGGCAGGAGA
GAAGGAGATTACTGAAGCCTGGGGCCCGGAGATGGTCAGAGGATGGGAGACGGGGCAGTGAAAC
AAGGCTTCCTGTATCTTCAGCAGCAACAGACGTTTGGAAAGAAATGGCGCCGCTTCGGGGCCTC
ACTGTATGGAGAATCGGACTGCGCCTTGGCCCGGCTGGAGCTGCAGGAGGGCCCGGAGAAGCCA
CGTCGGGGTGAGGCTGCCCGGAAGGTCATCCGCCTCAGTGACTGCCTGCGGGTGGCCGAGGCCG
GCGGAGAGGCCAGCAGCCCCCGGGACACCAGTGCCTTCTTACTGGAGACCAAGGAGCGCCTGTA
CCTGCTGGCGGCCCCTGCTGCAGAGCGCGGCGACTGGGTGCAGGCCATCTGCCTCCTGGCCTTC
CCCGGGCAGAGGAAGGAGCTCTCGGGGCCAGAGGGAAAGCAGAGCCGGCCCTGCATGGAGGAAA
ATGAATTGTACAGCAGCGCGGCCACAGTTGCCCCCCACAAGGAATTTGCTGTGACCATGAGACC
TACAGAAGCCAGCGAGAGGTGCCACCTGCGGGGGTCCTATACCCTCCGGGCTGGGGAGAGCGCC
CTGGAGCTGTGGGGTGGGCCCGAGCCAGGGACCCAGCTGTACAACTGGCCCTACAGGTTTCTGC
GGCGCTTTGGGCGGGACAAGGTAACCTTTTCCTTTGAGGCAGGCCGGCGCTGCATTTCTGGAGA
GGGCAACTTTGAGTTCGAAACCCGGCAAGGCAATGAGATCTTTTTGGCCCTGGAAGAGGCCATC
TCTGCCCAGAAGAATGCTGCACCCCCTACACTGCAACCCCAGCCAGCCACAATCCCCGCCTCGC
TGCCCCGGCCTGAGAGCCCCTACTCCCGGCCCCATGACTCACTGCCACCGCCTTCACCCACCAC
ACCGGTGCCTGCTCCACGGCCTCGGGGCCCGGAGGGGGAGTATGCCATGCCCTTCGATGCGGTG
GCCCGTTCCTTGGGGAAGAACTACAGGGGCATCTTGGCAGTCCCTCCTCAGCTCCTGGCTGACC
CTCTGTACGACAGCATTGAGGAGCCCCCTCCTCCTCGACACGACCACATATACGATGAGCCCGA
AGGAGTGGCTGCCCTGTCCCTGTATGACAGCCTGCAGGAGCCCCGGGGTGAGGCATGGAGGAGG
CAGGCAACCGCTGACAGGGACCCTGGTGGCCTCCAGCGTGTCCACCCAGCCGGGCAGGATTTCT
CTGCCTCTGGCTGGCAGCCAGGAACTGAGTATGACAATGTTGTACTTAAGAAAGGCCCGAAGTA
ACAGAGGCAGCAGAGGGATGGTCCACCGCCCCCTGGCTTCTGCTGGTGACTCCTCCTGACCACT
GCATCAGAAGAACCTCCTCTGCCCCTTCTGGAGCCCGAGGCCTAGCCTGCCTTCGTTGGGGCTG
ATAAATTGCCTCTCCCAGGGCCTGCTGGGTGAGTCACCATCCCAAAGCAGGAAGGGTGCCCTGG
AGAGAACCACCCTCCTCCTACTCTTTTTCCACTTCCTCCTCTTTCTTTCCCCAGCTGAGGGGGA
ACCTGGGGCATTTAGGGCAGAGGGCAAAGGATGTCAGCAATTGCCTGGGCTGCTTGGCTATGCA
AGCCTCCTGCCTGCTCATGGCCACTTCAGGGACAGCCTGGGCCCAGGCACCCAGGTGGATGGTG
GCAGCTTCCTGCACCTTTCAGATTTCTCGGTGGCATTAAAGCATTTTTGGAATGTTT

hide sequence

RefSeq Acc Id:

XM_037983732 ⟹ XP_037839660

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666052	22,246,772 - 22,258,430 (+)	NCBI

RefSeq Acc Id:

XM_037983733 ⟹ XP_037839661

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666052	22,253,192 - 22,258,430 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_007960012	(Get FASTA)	NCBI Sequence Viewer
	XP_037839660	(Get FASTA)	NCBI Sequence Viewer
	XP_037839661	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000012731.1

RefSeq Acc Id:	XP_007960012 ⟸ XM_007961821
- Peptide Label:	isoform X1
- UniProtKB:	A0A0D9RVU2 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000012731 ⟸ ENSCSAT00000014770

RefSeq Acc Id:	XP_037839660 ⟸ XM_037983732
- Peptide Label:	isoform X2
- UniProtKB:	A0A0D9RVU2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_037839661 ⟸ XM_037983733
- Peptide Label:	isoform X3

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000016676	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000014770.1	UniProtKB/TrEMBL
Gene3D-CATH	2.30.29.30	UniProtKB/TrEMBL
InterPro	Docking_Protein_DOK	UniProtKB/TrEMBL
	Dok1/2/3_PTB	UniProtKB/TrEMBL
	IRS_PTB	UniProtKB/TrEMBL
	PH-like_dom_sf	UniProtKB/TrEMBL
	PH_domain	UniProtKB/TrEMBL
KEGG Report	csab:103215430	UniProtKB/TrEMBL
NCBI Gene	DOK2	ENTREZGENE
PANTHER	DOCKING PROTEIN 2	UniProtKB/TrEMBL
	DOCKING PROTEIN RELATED	UniProtKB/TrEMBL
Pfam	IRS	UniProtKB/TrEMBL
PROSITE	IRS_PTB	UniProtKB/TrEMBL
	PH_DOMAIN	UniProtKB/TrEMBL
SMART	IRS	UniProtKB/TrEMBL
	PTBI	UniProtKB/TrEMBL
	SM00233	UniProtKB/TrEMBL
Superfamily-SCOP	PH domain-like	UniProtKB/TrEMBL
UniProt	A0A0D9RVU2	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)

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Imported Disease Annotations - CTD

Imported Annotations - PID (archival)