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Gene: SCD5 (stearoyl-CoA desaturase 5) Chlorocebus sabaeus

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Symbol:

SCD5

Name:

stearoyl-CoA desaturase 5

RGD ID:

18459318

Description:

ENCODES a protein that exhibits palmitoyl-CoA 9-desaturase activity (ortholog); stearoyl-CoA 9-desaturase activity (ortholog); INVOLVED IN monounsaturated fatty acid biosynthetic process (ortholog); ASSOCIATED WITH autosomal dominant nonsyndromic deafness 79 (ortholog); chromosome 4q21 deletion syndrome (ortholog); pneumoconiosis (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC103235891

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	31,021,144 - 31,186,564 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	31,019,361 - 31,186,584 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	9,585,887 - 9,755,569 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant nonsyndromic deafness 79 (ISO)

chromosome 4q21 deletion syndrome (ISO)

pneumoconiosis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

fatty acid biosynthetic process (IEA)

lipid metabolic process (IEA)

monounsaturated fatty acid biosynthetic process (ISO)

unsaturated fatty acid biosynthetic process (IEA)

Cellular Component

endoplasmic reticulum membrane (IEA)

membrane (IEA)

Molecular Function

acyl-CoA desaturase activity (IEA)

iron ion binding (IEA)

metal ion binding (IEA)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (IEA)

palmitoyl-CoA 9-desaturase activity (ISO)

protein binding (ISO)

stearoyl-CoA 9-desaturase activity (IEA,ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

SCD5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	31,021,144 - 31,186,564 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	31,019,361 - 31,186,584 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	9,585,887 - 9,755,569 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

SCD5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	82,629,539 - 82,798,796 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	82,629,539 - 82,798,796 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	83,550,692 - 83,719,949 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	83,769,714 - 83,939,034 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	83,938,219 - 84,077,104	NCBI
Celera	4	80,841,716 - 81,011,030 (-)	NCBI		Celera
Cytogenetic Map	4	q21.22	NCBI
HuRef	4	79,291,302 - 79,459,888 (-)	NCBI		HuRef
CHM1_1	4	83,527,197 - 83,696,517 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	85,958,718 - 86,128,016 (-)	NCBI		T2T-CHM13v2.0

Scd3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	44,191,727 - 44,232,455 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	44,191,708 - 44,232,455 (+)	Ensembl		GRCm39 Ensembl
GRCm38	19	44,203,288 - 44,244,016 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	44,203,269 - 44,244,016 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	44,277,778 - 44,318,506 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	44,098,078 - 44,138,928 (+)	NCBI		MGSCv36	mm8
MGSCv36	19	44,256,599 - 44,297,327 (+)	NCBI		MGSCv36	mm8
Celera	19	44,981,578 - 45,013,768 (+)	NCBI		Celera
Cytogenetic Map	19	C3	NCBI
cM Map	19	37.98	NCBI

Scd5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955433	6,700,555 - 6,818,147 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955433	6,700,616 - 6,819,782 (-)	NCBI	ChiLan1.0	ChiLan1.0

SCD5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	47,272,214 - 47,442,325 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	47,461,374 - 47,631,532 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	41,404,736 - 41,574,802 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	47,255,546 - 47,425,894 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	47,255,546 - 47,425,894 (+)	Ensembl	panpan1.1		panPan2

SCD5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	6,594,607 - 6,745,379 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	6,595,424 - 6,745,308 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	35,139,305 - 35,289,125 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	6,615,984 - 6,766,611 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	32	6,615,979 - 6,766,650 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	32	6,687,486 - 6,837,460 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	6,555,633 - 6,706,287 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	33,260,063 - 33,410,889 (+)	NCBI		UU_Cfam_GSD_1.0

Scd5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	5,593,117 - 5,733,450 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936738	1,754,310 - 1,895,303 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936738	1,755,000 - 1,895,292 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SCD5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	135,507,296 - 135,634,021 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	135,507,346 - 135,634,031 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	144,868,201 - 145,004,015 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Scd5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624757	8,132,895 - 8,302,551 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624757	8,133,260 - 8,302,168 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in SCD5
4769 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	18	34	34	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007999057	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007999058	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000002484 ⟹ ENSCSAP00000000792

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	7	31,019,361 - 31,186,584 (-)	Ensembl

RefSeq Acc Id:

XM_007999057 ⟹ XP_007997248

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	7	31,021,144 - 31,186,564 (-)	NCBI
Vero_WHO_p1.0	NW_023666037	9,585,887 - 9,755,569 (-)	NCBI

Sequence:

show sequence

GCACCCCTCCCCGGCCGCGCGCCCTTCCCGCCCCGCGCGCGCCTCCTCTTTCTCGCCGCCGAGT
TCAGCCCGGGCAGCCGTACGGGGGATACGCCAGCAACAGATGCCGGCCGCCAAGATCTGCATTC
CTAGGCCACGCTAAGACCCTGGGGAAGAGTGCAGGAGTCCGGGAGAAGGGCTGGAAGGAGGGGA
CAGGACGTGCGGAGAATTCCCCCCTAAAAGGCAGAAGCCCCCGCCCCCACCCTCGATCTCCGCT
CGGGCCGAGCGCCTGCCTGCCTGCTGCTGCTGCGGGCGCCCACCTCGCCCAGCCATGCCAGGCC
CGGCCACCGACGCGGGGAAGATCCCCTTCTGCGACGCCAAGGAAGAAATCCGTGCCGGGCTCGA
AAGCTCGGAGGGCGGCGGCGGCCGGGAGAGGCCAGGCGCGCGCGGACAGCGGCAGAACATCGTC
TGGAGGAACGTCGTCCTGATGAGCCTGCTCCACTTGGGGGCTGTGTACTCCCTGGTGCTCATCC
CCAAAGCCAAGCCGCTCACTCTGCTCTGGGCCTACTTCTGCTTCCTCCTGGCCGCTCTGGGTGT
GACAGCTGGTGCCCACCGCTTGTGGAGCCACAGGTCCTACAAGGCCAAGCTGCCTCTGAGGATA
TTTCTGGCTGTCGCCAACTCCATGGCTTTCCAGAATGACATCTTCGAGTGGTCCAGGGACCACC
GAGCCCACCACAAGTACTCAGAGACCGATGCTGACCCCCACAATGCCCGCCGGGGCTTCTTCTT
CTCCCATATCGGGTGGCTGTTTGTTCGCAAGCATCCGGATGTTATTGAGAAGGGGAGAAAGCTT
GACGTCACTGACCTGCTTGCTGATCCTGTGGTCCGGATCCAGAGAAAAGAACTTTTTTGGAGTG
GAAGATTGTCTACGTTTTTACCAAGGTACTATAAGATCTCCGTGGTGCTCATGTGCTTCGCGGT
CCCCACACTAGTGCCCTGGTACATCTGGGCAGAGAGCCTGTGGAATTCCTACTTCTTGGCCTCT
ATTCTCCGCTATACCATCTCGCTCAACGTCGCCTGGCTAGTCAACAGCGCCGCCCACATGTATG
GAAACCGGCCCTATGACAAGCACATCAGCCCTCGGCAGAACCCACTCGTCGCTCTGGGTGCTAT
TGGTGAAGGCTTCCATAATTACCATCACACCTTTCCCTTTGACTACTCTGCGAGTGAATTTGGC
TTAAATTTTAACCCAACCACCTGGTTCATTGATCTCATGTGCTGGCTGGGGCTGGCCACTGACC
GCAAACGGGCAACCAAGCCGATGATCGAGGCCCGGAAGGCCAGGACTGGAGACAGCAGTGCTTG
AACCTGGAACAGCCATCCCACATGTCTGCCATTGCACCCTCGGTTCATGGCTTTGGTTAGAATA
GTTCTCTTGTACATTGGATCGTGGGAGGGGCAGAGAGTGGGGAAGGAATGGAATTATGTGGCTT
GGGAATTTTTTTGTTTCTCTCAAAATAATGTTGAAATACAATTATCAATGAAAAAACTTTTTTT
TTTTTTTTTTTTTTTT

hide sequence

RefSeq Acc Id:

XM_007999058 ⟹ XP_007997249

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	7	31,021,144 - 31,186,559 (-)	NCBI
Vero_WHO_p1.0	NW_023666037	9,585,887 - 9,755,569 (-)	NCBI

Sequence:

show sequence

CCTCCCCGGCCGCGCGCCCTTCCCGCCCCGCGCGCGCCTCCTCTTTCTCGCCGCCGAGTTCAGC
CCGGGCAGCCGTACGGGGGATACGCCAGCAACAGATGCCGGCCGCCAAGATCTGCATTCCTAGG
CCACGCTAAGACCCTGGGGAAGAGTGCAGGAGTCCGGGAGAAGGGCTGGAAGGAGGGGACAGGA
CGTGCGGAGAATTCCCCCCTAAAAGGCAGAAGCCCCCGCCCCCACCCTCGATCTCCGCTCGGGC
CGAGCGCCTGCCTGCCTGCTGCTGCTGCGGGCGCCCACCTCGCCCAGCCATGCCAGGCCCGGCC
ACCGACGCGGGGAAGATCCCCTTCTGCGACGCCAAGGAAGAAATCCGTGCCGGGCTCGAAAGCT
CGGAGGGCGGCGGCGGCCGGGAGAGGCCAGGCGCGCGCGGACAGCGGCAGAACATCGTCTGGAG
GAACGTCGTCCTGATGAGCCTGCTCCACTTGGGGGCTGTGTACTCCCTGGTGCTCATCCCCAAA
GCCAAGCCGCTCACTCTGCTCTGGGCCTACTTCTGCTTCCTCCTGGCCGCTCTGGGTGTGACAG
CTGGTGCCCACCGCTTGTGGAGCCACAGGTCCTACAAGGCCAAGCTGCCTCTGAGGATATTTCT
GGCTGTCGCCAACTCCATGGCTTTCCAGAATGACATCTTCGAGTGGTCCAGGGACCACCGAGCC
CACCACAAGTACTCAGAGACCGATGCTGACCCCCACAATGCCCGCCGGGGCTTCTTCTTCTCCC
ATATCGGGTGGCTGTTTGTTCGCAAGCATCCGGATGTTATTGAGAAGGGGAGAAAGCTTGACGT
CACTGACCTGCTTGCTGATCCTGTGGTCCGGATCCAGAGAAAGTACTATAAGATCTCCGTGGTG
CTCATGTGCTTCGCGGTCCCCACACTAGTGCCCTGGTACATCTGGGCAGAGAGCCTGTGGAATT
CCTACTTCTTGGCCTCTATTCTCCGCTATACCATCTCGCTCAACGTCGCCTGGCTAGTCAACAG
CGCCGCCCACATGTATGGAAACCGGCCCTATGACAAGCACATCAGCCCTCGGCAGAACCCACTC
GTCGCTCTGGGTGCTATTGGTGAAGGCTTCCATAATTACCATCACACCTTTCCCTTTGACTACT
CTGCGAGTGAATTTGGCTTAAATTTTAACCCAACCACCTGGTTCATTGATCTCATGTGCTGGCT
GGGGCTGGCCACTGACCGCAAACGGGCAACCAAGCCGATGATCGAGGCCCGGAAGGCCAGGACT
GGAGACAGCAGTGCTTGAACCTGGAACAGCCATCCCACATGTCTGCCATTGCACCCTCGGTTCA
TGGCTTTGGTTAGAATAGTTCTCTTGTACATTGGATCGTGGGAGGGGCAGAGAGTGGGGAAGGA
ATGGAATTATGTGGCTTGGGAATTTTTTTGTTTCTCTCAAAATAATGTTGAAATACAATTATCA
ATGAAAAAACTTTTTTTTTTTTTTTTTTTTTTT

hide sequence

Protein Sequences


Protein RefSeqs	XP_007997248	(Get FASTA)	NCBI Sequence Viewer
	XP_007997249	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000000792.1

RefSeq Acc Id:	XP_007997248 ⟸ XM_007999057
- Peptide Label:	isoform X1
- UniProtKB:	A0A0D9QWQ3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_007997249 ⟸ XM_007999058
- Peptide Label:	isoform X2
- UniProtKB:	A0A0D9QWQ3 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000000792 ⟸ ENSCSAT00000002484

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000004452	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000002484.1	UniProtKB/TrEMBL
InterPro	Acyl-CoA_DS	UniProtKB/TrEMBL
	FA_desaturase_dom	UniProtKB/TrEMBL
	FADS-1_CS	UniProtKB/TrEMBL
KEGG Report	csab:103235891	UniProtKB/TrEMBL
NCBI Gene	LOC103235891	ENTREZGENE
PANTHER	PTHR11351	UniProtKB/TrEMBL
	STEAROYL-COA DESATURASE 5	UniProtKB/TrEMBL
Pfam	FA_desaturase	UniProtKB/TrEMBL
PRINTS	FACDDSATRASE	UniProtKB/TrEMBL
PROSITE	FATTY_ACID_DESATUR_1	UniProtKB/TrEMBL
UniProt	A0A0D9QWQ3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-12-08	SCD5	stearoyl-CoA desaturase 5	LOC103235891	stearoyl-CoA desaturase 5	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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