LCMT1 (leucine carboxyl methyltransferase 1)

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Gene: LCMT1 (leucine carboxyl methyltransferase 1) Chlorocebus sabaeus

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Symbol:

LCMT1

Name:

leucine carboxyl methyltransferase 1

RGD ID:

18441938

Description:

ENCODES a protein that exhibits methyltransferase activity (inferred); protein C-terminal carboxyl O-methyltransferase activity (inferred); protein C-terminal leucine carboxyl O-methyltransferase activity (inferred); INVOLVED IN C-terminal protein methylation (ortholog); negative regulation of protein-containing complex assembly (ortholog); protein methylation (ortholog); ASSOCIATED WITH Embryo Loss (ortholog); FOUND IN cytosol (inferred)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	22,830,677 - 22,897,691 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	22,830,549 - 22,897,682 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	6,831,077 - 6,902,187 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Embryo Loss (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

C-terminal protein methylation (ISO)

methylation (IEA)

negative regulation of protein-containing complex assembly (IEA,ISO)

protein methylation (ISO)

regulation of apoptotic process (IEA,ISO)

regulation of glucose metabolic process (IEA,ISO)

regulation of mitotic cell cycle spindle assembly checkpoint (IEA,ISO)

Cellular Component

cytosol (IEA)

Molecular Function

methyltransferase activity (IEA)

protein binding (ISO)

protein C-terminal carboxyl O-methyltransferase activity (IEA)

protein C-terminal leucine carboxyl O-methyltransferase activity (IEA)

protein methyltransferase activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

LCMT1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	22,830,677 - 22,897,691 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	22,830,549 - 22,897,682 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	6,831,077 - 6,902,187 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

LCMT1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	25,111,742 - 25,178,228 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	25,111,731 - 25,178,231 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	25,123,063 - 25,189,549 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	25,030,548 - 25,097,052 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	25,030,675 - 25,097,050	NCBI
Celera	16	23,903,957 - 23,969,431 (+)	NCBI		Celera
Cytogenetic Map	16	p12.1	NCBI
HuRef	16	23,216,333 - 23,282,516 (+)	NCBI		HuRef
CHM1_1	16	26,136,800 - 26,203,307 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	25,391,240 - 25,457,759 (+)	NCBI		T2T-CHM13v2.0

Lcmt1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	122,977,026 - 123,029,581 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	122,969,007 - 123,029,581 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	123,377,803 - 123,430,358 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	123,369,784 - 123,430,358 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	130,521,496 - 130,573,872 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	123,169,130 - 123,221,506 (+)	NCBI		MGSCv36	mm8
Celera	7	123,261,211 - 123,313,647 (+)	NCBI		Celera
Cytogenetic Map	7	F3	NCBI
cM Map	7	67.42	NCBI

Lcmt1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	187,335,173 - 187,391,195 (+)	NCBI		GRCr8
mRatBN7.2	1	177,904,119 - 177,960,111 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	177,904,139 - 177,960,112 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	186,240,042 - 186,296,278 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	193,426,030 - 193,482,279 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	186,103,922 - 186,159,944 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	193,335,629 - 193,391,620 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	193,335,645 - 193,391,638 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	200,394,399 - 200,450,384 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	182,242,293 - 182,298,243 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	182,382,612 - 182,438,493 (+)	NCBI
Celera	1	175,592,825 - 175,648,387 (+)	NCBI		Celera
Cytogenetic Map	1	q36	NCBI

Lcmt1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955493	3,431,578 - 3,502,066 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955493	3,440,832 - 3,499,658 (+)	NCBI	ChiLan1.0	ChiLan1.0

LCMT1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	26,521,239 - 26,587,091 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	31,041,920 - 31,108,409 (+)	NCBI		NHGRI_mPanPan1
PanPan1.1	16	25,352,488 - 25,418,285 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	25,351,814 - 25,418,285 (+)	Ensembl	panpan1.1		panPan2

LCMT1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	21,026,125 - 21,066,884 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	21,026,186 - 21,066,876 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	22,601,655 - 22,642,365 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	21,166,737 - 21,207,683 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	21,166,717 - 21,207,673 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	20,970,135 - 21,010,599 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	20,872,708 - 20,913,635 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	21,267,162 - 21,308,117 (-)	NCBI		UU_Cfam_GSD_1.0

Lcmt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	121,256,737 - 121,299,811 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936501	9,354,565 - 9,397,686 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936501	9,354,607 - 9,397,675 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LCMT1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	3	21,548,349 - 21,593,667 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

Lcmt1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624782	9,979,433 - 10,043,475 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624782	9,974,415 - 10,043,475 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007988263	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007988272	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007988279	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037989731	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005237694	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_496361	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_496363	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000036	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000004518 ⟹ ENSCSAP00000002770

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	5	22,830,549 - 22,897,682 (+)	Ensembl

RefSeq Acc Id:

XM_007988263 ⟹ XP_007986454

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	5	22,830,680 - 22,897,691 (+)	NCBI
Vero_WHO_p1.0	NW_023666068	6,831,091 - 6,902,186 (-)	NCBI

Sequence:

show sequence

AGGTTGCTGGGGCAGCCGGCGTGGGCGGCGTCACTGAGCCGCGCCAGCTGAGCCAGGTGGAGCC
TTACCGTCTTCTCTTGCTTTCTGCCTGTGACTAGCGCCGTGCCCCACCGCCGGTCGACCCCGCT
TGCATGTCCCTGGCGGACACAGCTCCCCGGAACCTCCACGCCCATGGCCACTAGGCAGAGGGAG
TCCTCTATTACCTCTTGCTCTTCCGCCTCAAGCTGCGACGCGGACGACGAGGGCGTGCGCGGCA
CCTGCGAAGATGCTTCCCTGTGCAAGAGGTTTGCAGTAAGCATTGGCTACTGGCACGACCCTTA
CATCCAGCACTTTGTGAGACTGTCTAAAGAGAGGAAAGCCCCCGAAATCAACAGAGGATATTTT
GCCCGAGTCCATGGTGTCAGTCAGCTTATAAAGGCGTTTCTACGGAAGACAGAATGTCATTGTC
AAATTATCAACCTTGGGGCAGGCATGGATACCACCTTCTGGAGATTAAAGGATGAAGATCTTCT
CCCAAGTAAATATTTTGAGGTTGACTTTCCAATGATCGTCACAAGAAAGCTGCACAGTATCAAA
TGCAAGCCTCCCCTATCCAGCCCCATTCTAGAACTGCATTCAGAGGACACACTTCAGATGGATG
GACACATACTGGATTCAAAGAGATACGCTGTTATTGGAGCCGATCTCCGAGACCTGTCCGAACT
GGAAGAGAAACTAAAGAAATGTAACATGAATACACAATTGCCAACACTCCTGATAGCTGAATGT
GTGCTGGTTTACATGACTCCAGAGCAGTCCGCAAACCTCCTGAAGTGGGCAGCCAACAGTTTTG
AGGCAGCCATGTTCATAAACTACGAACAGGTGAACATGGGTGATCGGTTTGGGCAGATCATGAT
TGAAAACCTACGGAGACGCCAGTGTGACCTGGCGGGAGTGGAGACTTGCAAGTCATTAGAGTCA
CAGAAAGAACGGCTCCTGTCGAATGGGTGGGAAACAGCATCGGCCGTCGACATGATGGAGTTGT
ACAACAGGTTACCTCGAGCTGAAGTGAGCAGGATAGAATCACTTGAATTCCTGGATGAAATGGA
GCTGCTGGAGCAGCTCATGCGGCATTACTGCCTTTGCTGGGCAACCAAAGGAGGAAATGAGCTC
GGGCTGAAGGAGATAACTTATTAATCTGTTGAAGGCTTATGCCGAGCCAGAAGCGGAAGCCACT
CGCCCTCCTGGAGGATACCTGCGAGCTCCCTGAGCAGTGGGCGGGCCTCCTCTGCAGGTCTCAT
CCCACACGCTGAGAAGCCTCGATCACTACAGTGGTCGCCCATGTTCCTCTTCCTGTTCCTGTTG
ACATGTCGGTGTTTAAATAAATCTCACTTGCCACCAGTTTCCTGTGGTTGGAACTC

hide sequence

RefSeq Acc Id:

XM_007988272 ⟹ XP_007986463

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	5	22,830,680 - 22,897,691 (+)	NCBI
Vero_WHO_p1.0	NW_023666068	6,831,077 - 6,902,186 (-)	NCBI

Sequence:

show sequence

AGGTTGCTGGGGCAGCCGGCGTGGGCGGCGTCACTGAGCCGCGCCAGCTGAGCCAGGTGGAGCC
TTACCGTCTTCTCTTGCTTTCTGCCTGTGACTAGCGCCGTGCCCCACCGCCGGTCGACCCCGCT
TGCATGTCCCTGGCGGACACAGCTCCCCGGAACCTCCACGCCCATGGCCACTAGGCAGAGGGAG
TCCTCTATTACCTCTTGCTCTTCCGCCTCAAGCTGCGACGCGGACGACGAGGGCGTGCGCGGCA
CCTGCGAAGATGCTTCCCTGTGCAAGAGGTTTGCAGTAAGCATTGGCTACTGGCACGACCCTTA
CATCCAGCACTTTGTGAGACTGTCTAAAGAGAGGAAAGCCCCCGAAATCAACAGAGGATATTTT
GCCCGAGTCCATGGTGTCAGTCAGCTTATAAAGGCGTTTCTACGGAAGACAGAATGTCATTGTC
AAATTATCAACCTTGGGGCAGGCATGGATACCACCTTCTGGAGATTAAAGGATGAAGATCTTCT
CCCAAGTAAATATTTTGAGGTTGACTTTCCAATGATCGTCACAAGAAAGCTGCACAGTATCAAA
TGCAAGCCTCCCCTATCCAGCCCCATTCTAGAACTGCATTCAGAGGACACACTTCAGATGGATG
GACACATACTGGATTCAAAGAGATACGCTGTTATTGGAGCCGATCTCCGAGACCTGTCCGAACT
GGAAGAGAAACTAAAGAAATGTAACATGAATACACAATTGCCAACACTCCTGATAGCTGAATGT
GTGCTGGTTTACATGACTCCAGAGCAGTCCGCAAACCTCCTGAAGTGGGCAGCCAACAGTTTTG
AGGCAGCCATGTTCATAAACTACGAACAGGTGAACATGGGTGATCGGTTTGGGCAGATCATGAT
TGAAAACCTACGGAGACGCCAGTGTGACCTGGCGGGAGTGGAGACTTGCAAGTCATTAGAGTCA
CAGAAAGAACGGCTCCTGTCGAATGGGTGGGAAACAGCATCGGCCGTCGACATGATGGAGTTGT
ACAACAGGTTACCTCGAGCTGAAGTGAGCAGGGCTGAAGGAGATAACTTATTAATCTGTTGAAG
GCTTATGCCGAGCCAGAAGCGGAAGCCACTCGCCCTCCTGGAGGATACCTGCGAGCTCCCTGAG
CAGTGGGCGGGCCTCCTCTGCAGGTCTCATCCCACACGCTGAGAAGCCTCGATCACTACAGTGG
TCGCCCATGTTCCTCTTCCTGTTCCTGTTGACATGTCGGTGTTTAAATAAATCTCACTTGCCAC
CAGTTTCCTGTGGTTGGAACTC

hide sequence

RefSeq Acc Id:

XM_037989731 ⟹ XP_037845659

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666068	6,831,080 - 6,902,187 (-)	NCBI

RefSeq Acc Id:

XR_005237694

Type:

NON-CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666068	6,831,077 - 6,902,186 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_007986454	(Get FASTA)	NCBI Sequence Viewer
	XP_007986463	(Get FASTA)	NCBI Sequence Viewer
	XP_037845659	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000002770
	ENSCSAP00000002770.1

RefSeq Acc Id:	XP_007986454 ⟸ XM_007988263
- Peptide Label:	isoform X1
- UniProtKB:	A0A0D9R2D1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_007986463 ⟸ XM_007988272
- Peptide Label:	isoform X3

Ensembl Acc Id:

ENSCSAP00000002770 ⟸ ENSCSAT00000004518

RefSeq Acc Id:	XP_037845659 ⟸ XM_037989731
- Peptide Label:	isoform X2

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000006481	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000004518.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.150	UniProtKB/TrEMBL
InterPro	PPM1	UniProtKB/TrEMBL
	Ppm1/Ppm2/Tcmp	UniProtKB/TrEMBL
	SAM-dependent_MTases	UniProtKB/TrEMBL
KEGG Report	csab:103229986	UniProtKB/TrEMBL
NCBI Gene	LCMT1	ENTREZGENE
PANTHER	LEUCINE CARBOXYL METHYLTRANSFERASE 1	UniProtKB/TrEMBL
	PTHR13600	UniProtKB/TrEMBL
Pfam	LCM	UniProtKB/TrEMBL
PIRSF	LCM_mtfrase	UniProtKB/TrEMBL
PROSITE	PROKAR_LIPOPROTEIN	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53335	UniProtKB/TrEMBL
UniProt	A0A0D9R2D1	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD