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Gene: PROZ (protein Z, vitamin K dependent plasma glycoprotein) Chlorocebus sabaeus

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Symbol:

PROZ

Name:

protein Z, vitamin K dependent plasma glycoprotein

RGD ID:

18397519

Description:

ENCODES a protein that exhibits calcium ion binding (inferred); serine-type endopeptidase activity (inferred); INVOLVED IN blood coagulation (ortholog); PARTICIPATES IN coagulation cascade pathway; ASSOCIATED WITH Behcet's disease (ortholog); blood coagulation disease (ortholog); brain ischemia (ortholog); FOUND IN endoplasmic reticulum lumen (inferred); extracellular region (inferred); extracellular space (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

vitamin K-dependent protein Z

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	91,156,880 - 91,171,333 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	3	91,157,307 - 91,171,042 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666046	48,193,308 - 48,207,312 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Behcet's disease (ISO)

blood coagulation disease (ISO)

brain ischemia (ISO)

factor X deficiency (ISO)

hemorrhagic disease (ISO)

Stroke (ISO)

Thromboembolism (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blood coagulation (IEA,ISO)

proteolysis (IEA)

Cellular Component

endoplasmic reticulum lumen (IEA)

extracellular region (IEA)

extracellular space (IEA)

Golgi lumen (IEA)

Molecular Function

calcium ion binding (IEA)

protein binding (ISO)

serine-type endopeptidase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

coagulation cascade pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

PROZ
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	91,156,880 - 91,171,333 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	3	91,157,307 - 91,171,042 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666046	48,193,308 - 48,207,312 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

PROZ
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	13	113,158,648 - 113,172,386 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	13	113,158,648 - 113,172,386 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	13	113,812,962 - 113,826,700 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	13	112,860,969 - 112,874,695 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	13	112,860,968 - 112,874,695	NCBI
Celera	13	94,638,628 - 94,652,355 (+)	NCBI		Celera
Cytogenetic Map	13	q34	NCBI
HuRef	13	94,251,393 - 94,264,909 (+)	NCBI		HuRef
CHM1_1	13	113,781,985 - 113,795,462 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	13	112,406,247 - 112,424,058 (+)	NCBI		T2T-CHM13v2.0

Proz
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	13,110,583 - 13,126,026 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	13,110,914 - 13,126,026 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	13,060,584 - 13,076,026 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	13,060,914 - 13,076,026 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	13,060,908 - 13,075,006 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	13,060,885 - 13,074,983 (+)	NCBI		MGSCv36	mm8
Celera	8	13,228,680 - 13,241,944 (+)	NCBI		Celera
Cytogenetic Map	8	A1.1	NCBI
cM Map	8	5.73	NCBI

Proz
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	83,150,104 - 83,165,688 (-)	NCBI		GRCr8
mRatBN7.2	16	76,450,013 - 76,463,558 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	76,450,013 - 76,463,480 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	81,730,561 - 81,744,028 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	85,183,138 - 85,196,605 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	80,432,639 - 80,445,876 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	81,784,348 - 81,797,889 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	81,784,348 - 81,797,815 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	81,269,715 - 81,283,268 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	81,311,405 - 81,321,986 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	81,311,007 - 81,322,132 (-)	NCBI
Celera	16	74,256,045 - 74,269,512 (-)	NCBI		Celera
Cytogenetic Map	16	q12.5	NCBI

Proz
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955404	646,841 - 657,262 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955404	647,217 - 657,256 (-)	NCBI	ChiLan1.0	ChiLan1.0

PROZ
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	14	114,660,438 - 114,676,729 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	13	113,345,218 - 113,363,802 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	13	94,294,846 - 94,314,458 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	13	113,363,530 - 113,383,010 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	13	113,364,280 - 113,383,010 (+)	Ensembl	panpan1.1		panPan2

Proz
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624793	745,579 - 755,059 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624793	745,490 - 757,886 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007960988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000015538 ⟹ ENSCSAP00000013476

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	3	91,157,307 - 91,171,042 (+)	Ensembl

RefSeq Acc Id:

XM_007960988 ⟹ XP_007959179

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	3	91,156,880 - 91,171,333 (+)	NCBI
Vero_WHO_p1.0	NW_023666046	48,193,308 - 48,207,312 (+)	NCBI

Sequence:

show sequence

TCCTTTTCTCCCCTTCCTTCCATCCTCCATCCTTCTCTCCCTCACTCCCTCCTTTTTCTTTCCC
TCGTTCCTTCCTGTGTATTCCACGTACACTTAGAACATAAGCTGCATTGTGACTTTGTCCTGCC
CACTGCTGTGTCCCCAGGCTGGGGCTGTGCCTGTCTCACCTCCAACTCACTACACACGGCATGG
GTGTCACCTTCCACCTTGCACCTGCTGCCTTTACCCTCCATTCTCTGTCTCCCTAAATATCTCC
CAGGGCCCTCTGAGCCTTCACTGTTCATTTCTCTGCCTGGCCTCAAACAGAAAACGTCAGGAGG
GAAGCACACAGCTGCGCAGGTCATGCCCCAAGGCTCCTGCTGCCAGCACCTCCCCCAGCCTGGA
CTTTGGCTGTGTTTGCAGCCCTGTCCCAGTGCTGTGGGTGGGAATGGCAGGCTGCATCCCGCTG
CTCCGGGGCCTGGTCCTGGTCCTCGCCCTCCAGCGTGCGGAGCCCTCAGTGCTCAGTCTTGAGA
ACAGACACGGACTCCATCCTGACTCTGCCTGCACAGATGTCCAGGAAAGCTAGAAGTCAAACAC
CCAGCTATTTCTCCCGGCCTCCAAAGCAAACAACGTTCTCGTGAGGTGGAAGCGTGCGGGCTCC
TATCTCCTGGAAGAACTCTTCGAGGGAAACTTGGAAAAAGAATGTTACGAAGAAATCTGTACCT
ATGAAGAAGCAAGAGAAGTGTTCGAAAATGAAGTAGTCACTGATGAATTCTGGAGACGATATAA
GGGTGGCTCCCCGTGCATCTCCCAGCCCTGCCTCCACAACGGATCTTGTCAGGACAGCATCTGG
GGCTACACCTGCACCTGCTCCCCCGGCTATGAGGGCAGCAACTGCGAGCTGGCTAAAAATGAAT
GTCACCTGGAGCGGACTGATGGGTGTCAACACTTCTGCCTCCCAGGACAGGAATCCTACACGTG
CAGCTGTGCTCAAGGCTACAGGCTTGGTGAGGACCGCAAACAGTGCATTCCCCACGACCAGTGT
GCCTGTGGGGTGCTGACCTCCGAGAAGCGTGCACTGGATCTACAGGATCTCCCGTGGCAGGTAA
AGTTAACAAATGCCGAAGGAAAAGACTTCTGTGGTGGTGTTATAATACAGGAAAACTTTGTACT
GACAACAGCAAGATGCTCACTGTTACACAGGAATATTAGTGTAAAAACATATTTTAACAGAACG
AGCCAAGACCCACTGATGATCAAGATAATGCGTGCCCATGTGCACATGTGGTATGACGCGGACA
CGGGGGAGAATGACCTGTCACTGCTGGAGCTGGAGTGGCCCATCCAGTGCCCAGATGCGGGGCT
CCCCGTGTGCACCCCTGAGAACGACTTCGCTGAGCACCTCCTCATCCCACGCACTGGGGGCCTC
CTCAGTGGCTGGGCACGCAATGGCACTGACCTGGGCAACTCGCTGACCACGCTGCCTGTCACAC
TTGTGGAGGGGGAGGAGTGCGGGCAGGTCCTGAATGTGACCGTTACCACCAGGACCTATTGTGA
GAGAAGCAGTGTGGCGGCCGTGCACTGGATGGAGGGAAGTGTGGTCACCAGAGAGCACAGAGGC
TCCTGGTTCCTCACAGGGGTCCTGAGCTCGCAGCCAGCAGGAGGGCAGGCTCGCATGGTCCTTG
TCACCAAGGTCTCCAGGTACTCACTCTGGTTTAAACGGATCATGAACTAACTGAAACCCAGCCA
GAAAGAACACAACCTGAAGTGGGATTCCAAGCTTGCACTGCCACCATGGAGAGCACTGAAACTT
CACCACACGCTTAGAGGCCGTCACAGTCCCGGGCCACCGCTCAGCCCCAGGCCACCTGCTCAGC
CCACGGAGCAGCAGAGCCGCCCTTGCTGGGCCATTTACCGAGCACTGTGACTTTTCTTTCCCTG
GATCTCCTTCTCTCAATAGAGACCTTCAGAAAAAACATGAGATGCATTAAATAATAAAATAAGA
TAATCTGTCAGTCATAAAACA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007959179	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000013476
	ENSCSAP00000013476.1

RefSeq Acc Id:	XP_007959179 ⟸ XM_007960988
- UniProtKB:	A0A0D9RXY7 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000013476 ⟸ ENSCSAT00000015538

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000017442	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000015538.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.10.10	UniProtKB/TrEMBL
	4.10.740.10	UniProtKB/TrEMBL
	Laminin	UniProtKB/TrEMBL
InterPro	Coagulation_fac-like_Gla_dom	UniProtKB/TrEMBL
	EGF-like_Ca-bd_dom	UniProtKB/TrEMBL
	EGF-like_dom	UniProtKB/TrEMBL
	EGF-type_Asp/Asn_hydroxyl_site	UniProtKB/TrEMBL
	GLA-like_dom_SF	UniProtKB/TrEMBL
	GLA_domain	UniProtKB/TrEMBL
	Pept_S1A_FX	UniProtKB/TrEMBL
	Peptidase_S1_coag_factors	UniProtKB/TrEMBL
	Peptidase_S1_PA	UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/TrEMBL
	Trypsin_dom	UniProtKB/TrEMBL
NCBI Gene	PROZ	ENTREZGENE
PANTHER	COAGULATION FACTOR	UniProtKB/TrEMBL
	VITAMIN K-DEPENDENT PROTEIN Z	UniProtKB/TrEMBL
Pfam	EGF	UniProtKB/TrEMBL
	FXa_inhibition	UniProtKB/TrEMBL
	Gla	UniProtKB/TrEMBL
	Trypsin	UniProtKB/TrEMBL
PIRSF	Factor_X	UniProtKB/TrEMBL
PRINTS	GLABLOOD	UniProtKB/TrEMBL
PROSITE	ASX_HYDROXYL	UniProtKB/TrEMBL
	EGF_1	UniProtKB/TrEMBL
	EGF_2	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
	GLA_1	UniProtKB/TrEMBL
	GLA_2	UniProtKB/TrEMBL
	TRYPSIN_DOM	UniProtKB/TrEMBL
SMART	EGF	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	GLA	UniProtKB/TrEMBL
	Tryp_SPc	UniProtKB/TrEMBL
Superfamily-SCOP	EGF/Laminin	UniProtKB/TrEMBL
	SSF50494	UniProtKB/TrEMBL
	SSF57630	UniProtKB/TrEMBL
UniProt	A0A0D9RXY7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

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Imported Disease Annotations - ClinVar

RGD Manual Annotations