SLC5A4 (solute carrier family 5 member 4) - Rat Genome Database

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Gene: SLC5A4 (solute carrier family 5 member 4) Chlorocebus sabaeus
Analyze
Symbol: SLC5A4
Name: solute carrier family 5 member 4
RGD ID: 18363867
Description: ENCODES a protein that exhibits glucose:sodium symporter activity (ortholog); low-affinity glucose:sodium symporter activity (ortholog); proton transmembrane transporter activity (ortholog); INVOLVED IN proton transmembrane transport (ortholog); ASSOCIATED WITH genetic disease (ortholog); Glucose-Galactose Malabsorption (ortholog); muscular dystrophy-dystroglycanopathy type B6 (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: low affinity sodium-glucose cotransporter
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11915,043,810 - 15,080,535 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1915,044,069 - 15,079,766 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045110,907,424 - 110,949,182 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SLC5A4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11915,043,810 - 15,080,535 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1915,044,069 - 15,079,766 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045110,907,424 - 110,949,182 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SLC5A4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382232,218,464 - 32,355,063 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2232,218,464 - 32,255,347 (-)EnsemblGRCh38hg38GRCh38
GRCh372232,614,451 - 32,651,334 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362230,944,463 - 30,981,318 (-)NCBINCBI36Build 36hg18NCBI36
Build 342230,939,018 - 30,975,873NCBI
Celera2216,416,726 - 16,453,537 (-)NCBICelera
Cytogenetic Map22q12.3NCBI
HuRef2215,572,136 - 15,608,952 (-)NCBIHuRef
CHM1_12232,573,814 - 32,610,685 (-)NCBICHM1_1
T2T-CHM13v2.02232,682,547 - 32,819,011 (-)NCBIT2T-CHM13v2.0
Slc5a4a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,983,285 - 76,025,099 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1075,983,285 - 76,025,099 (+)EnsemblGRCm39 Ensembl
GRCm381076,147,451 - 76,189,265 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1076,147,451 - 76,189,265 (+)EnsemblGRCm38mm10GRCm38
MGSCv371075,610,196 - 75,652,010 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361075,591,167 - 75,632,981 (+)NCBIMGSCv36mm8
Celera1077,191,382 - 77,233,195 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.71NCBI
Slc5a4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,475,096 - 12,518,186 (-)NCBIGRCr8
mRatBN7.22012,475,644 - 12,518,738 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,475,644 - 12,518,738 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2013,174,399 - 13,217,606 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,535,325 - 12,578,533 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,007,106 - 13,050,314 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02013,415,039 - 13,458,110 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,415,039 - 13,458,110 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02015,500,218 - 15,529,128 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42012,876,032 - 12,919,116 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12012,876,263 - 12,919,254 (-)NCBI
Celera2013,968,710 - 14,011,331 (-)NCBICelera
Cytogenetic Map20p12NCBI
SLC5A4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22342,149,974 - 42,203,754 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12244,850,803 - 44,904,590 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02213,229,789 - 13,267,477 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12231,084,256 - 31,120,946 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2231,084,256 - 31,120,946 (-)Ensemblpanpan1.1panPan2
SLC5A4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12624,966,469 - 25,026,600 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2624,966,989 - 25,026,867 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2624,835,603 - 24,893,297 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02625,353,171 - 25,413,321 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2625,353,660 - 25,413,330 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12625,052,077 - 25,112,170 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02625,314,968 - 25,375,049 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02625,376,375 - 25,424,932 (-)NCBIUU_Cfam_GSD_1.0
SLC5A4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1448,708,047 - 48,741,440 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11448,708,047 - 48,741,440 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21452,153,405 - 52,322,914 (-)NCBISscrofa10.2Sscrofa10.2susScr3


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 16
Below cutoff 1 3 2

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007975555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000006411   ⟹   ENSCSAP00000004615
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1915,044,069 - 15,079,766 (-)Ensembl
RefSeq Acc Id: XM_007975555   ⟹   XP_007973746
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11915,043,810 - 15,080,535 (-)NCBI
Vero_WHO_p1.0NW_023666045110,907,424 - 110,949,182 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007973746 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000004615.1
Reference Protein Sequences
RefSeq Acc Id: XP_007973746   ⟸   XM_007975555
- UniProtKB: A0A0D9R7M6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000004615   ⟸   ENSCSAT00000006411


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000008464 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000006411.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1730.10 UniProtKB/TrEMBL
InterPro Na/Glc_symporter_sf UniProtKB/TrEMBL
  Na/solute_symporter UniProtKB/TrEMBL
  Na/solute_symporter_CS UniProtKB/TrEMBL
NCBI Gene SLC5A4 ENTREZGENE
PANTHER SOLUTE CARRIER FAMILY 5 UniProtKB/TrEMBL
  SOLUTE CARRIER FAMILY 5 MEMBER 4 UniProtKB/TrEMBL
Pfam SSF UniProtKB/TrEMBL
PROSITE NA_SOLUT_SYMP_2 UniProtKB/TrEMBL
  NA_SOLUT_SYMP_3 UniProtKB/TrEMBL
UniProt A0A0D9R7M6 ENTREZGENE, UniProtKB/TrEMBL