NHLH1 (nescient helix-loop-helix 1) - Rat Genome Database

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Gene: NHLH1 (nescient helix-loop-helix 1) Chlorocebus sabaeus
Analyze
Symbol: NHLH1
Name: nescient helix-loop-helix 1
RGD ID: 18359503
Description: ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); protein dimerization activity (inferred); INVOLVED IN positive regulation of transcription by RNA polymerase II (inferred); regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH autoimmune interstitial lung, joint, and kidney disease (ortholog); gastrointestinal stromal tumor (ortholog); genetic disease (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: helix-loop-helix protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1203,576,519 - 3,582,427 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl203,578,227 - 3,578,628 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660382,634,274 - 2,637,372 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NHLH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1203,576,519 - 3,582,427 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl203,578,227 - 3,578,628 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660382,634,274 - 2,637,372 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
NHLH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381160,367,071 - 160,372,846 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1160,367,071 - 160,372,846 (+)EnsemblGRCh38hg38GRCh38
GRCh371160,336,861 - 160,342,636 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361158,603,498 - 158,609,229 (+)NCBINCBI36Build 36hg18NCBI36
Build 341157,149,946 - 157,155,673NCBI
Celera1133,405,619 - 133,411,396 (+)NCBICelera
Cytogenetic Map1q23.2NCBI
HuRef1131,693,002 - 131,698,779 (+)NCBIHuRef
CHM1_11161,732,200 - 161,737,981 (+)NCBICHM1_1
T2T-CHM13v2.01159,504,143 - 159,509,918 (+)NCBIT2T-CHM13v2.0
Nhlh1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391171,879,859 - 171,885,163 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1171,879,859 - 171,885,140 (-)EnsemblGRCm39 Ensembl
GRCm381172,052,292 - 172,057,596 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,052,292 - 172,057,573 (-)EnsemblGRCm38mm10GRCm38
MGSCv371173,982,423 - 173,987,727 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361173,888,967 - 173,894,238 (-)NCBIMGSCv36mm8
Celera1174,906,526 - 174,911,828 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.54NCBI
Nhlh1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81387,049,733 - 87,054,934 (-)NCBIGRCr8
mRatBN7.21384,517,347 - 84,522,548 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1384,517,289 - 84,525,094 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1387,020,685 - 87,025,886 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01388,420,948 - 88,426,149 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01385,605,569 - 85,610,770 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01390,437,956 - 90,443,157 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1390,437,956 - 90,443,157 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,960,920 - 94,966,121 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41388,047,392 - 88,052,593 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11388,237,802 - 88,241,396 (-)NCBI
Celera1384,129,141 - 84,134,342 (-)NCBICelera
Cytogenetic Map13q24NCBI
Nhlh1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546812,133,717 - 12,137,700 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546812,133,717 - 12,137,700 (+)NCBIChiLan1.0ChiLan1.0
NHLH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2189,477,228 - 89,484,708 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1189,217,185 - 89,224,677 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01135,721,367 - 135,727,206 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11139,642,016 - 139,647,802 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1139,645,680 - 139,646,081 (+)Ensemblpanpan1.1panPan2
NHLH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,867,603 - 21,868,942 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3821,941,576 - 21,942,304 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03821,984,336 - 21,985,064 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3821,984,366 - 21,984,761 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13821,889,193 - 21,889,921 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03822,285,703 - 22,286,431 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03822,695,487 - 22,696,215 (-)NCBIUU_Cfam_GSD_1.0
Nhlh1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050586,475,928 - 6,481,294 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936740274,395 - 278,419 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936740273,294 - 278,419 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NHLH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl490,109,057 - 90,109,458 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1490,107,243 - 90,116,068 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2497,999,109 - 98,011,523 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Nhlh1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624794896,557 - 896,958 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624794896,416 - 900,669 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 3 11 41
Below cutoff 20 7 17

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007976490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000018448   ⟹   ENSCSAP00000017904
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl203,578,227 - 3,578,628 (-)Ensembl
RefSeq Acc Id: XM_007976490   ⟹   XP_007974681
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1203,576,519 - 3,582,427 (-)NCBI
Vero_WHO_p1.0NW_0236660382,634,274 - 2,637,372 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007974681 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000017904
  ENSCSAP00000017904.1
Reference Protein Sequences
RefSeq Acc Id: XP_007974681   ⟸   XM_007976490
- UniProtKB: A0A0D9SAL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000017904   ⟸   ENSCSAT00000018448


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000000087 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000018448.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  TAL-like UniProtKB/TrEMBL
KEGG Report csab:103223721 UniProtKB/TrEMBL
NCBI Gene NHLH1 ENTREZGENE
PANTHER HELIX-LOOP-HELIX PROTEIN 1 UniProtKB/TrEMBL
  PTHR13864 UniProtKB/TrEMBL
Pfam HLH UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/TrEMBL
UniProt A0A0D9SAL5 ENTREZGENE, UniProtKB/TrEMBL