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Gene: CRBN (cereblon) Chlorocebus sabaeus

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Symbol:

CRBN

Name:

cereblon

RGD ID:

18343426

Description:

ENCODES a protein that exhibits transmembrane transporter binding (ortholog); INVOLVED IN negative regulation of large conductance calcium-activated potassium channel activity (ortholog); negative regulation of monoatomic ion transmembrane transport (ortholog); negative regulation of protein-containing complex assembly (ortholog); ASSOCIATED WITH Abnormalities, Drug-Induced (ortholog); autosomal recessive intellectual developmental disorder (ortholog); autosomal recessive intellectual developmental disorder 2 (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

protein cereblon

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CRBN (cereblon)	NCBI	Ortholog
Mus musculus (house mouse):	Crbn (cereblon)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Crbn (cereblon)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Crbn (cereblon)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CRBN (cereblon)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CRBN (cereblon)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Crbn (cereblon)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CRBN (cereblon)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Crbn (cereblon)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	39,248,087 - 39,277,778 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	39,248,905 - 39,277,749 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	127,426,181 - 127,455,892 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Abnormalities, Drug-Induced (ISO)

autosomal recessive intellectual developmental disorder (ISO)

autosomal recessive intellectual developmental disorder 2 (ISO)

genetic disease (ISO)

intellectual disability (ISO)

multiple myeloma (ISO)

Nervous System Malformations (ISO)

Neurodevelopmental Disorders (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

locomotory exploration behavior (IEA)

negative regulation of large conductance calcium-activated potassium channel activity (ISO)

negative regulation of monoatomic ion transmembrane transport (ISO)

negative regulation of protein-containing complex assembly (ISO)

positive regulation of protein-containing complex assembly (ISO)

positive regulation of Wnt signaling pathway (IEA)

proteasome-mediated ubiquitin-dependent protein catabolic process (IEA)

protein ubiquitination (IEA)

Cellular Component

Cul4A-RING E3 ubiquitin ligase complex (IEA)

cytoplasm (IEA)

nucleus (IEA)

perinuclear region of cytoplasm (ISO)

Molecular Function

protein binding (ISO)

transmembrane transporter binding (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

CRBN
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	39,248,087 - 39,277,778 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	39,248,905 - 39,277,749 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	127,426,181 - 127,455,892 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

CRBN
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	3,149,633 - 3,179,717 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	3,144,628 - 3,179,727 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	3,191,317 - 3,221,401 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	3,166,695 - 3,196,390 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	3,166,697 - 3,196,390	NCBI
Celera	3	3,130,511 - 3,160,615 (-)	NCBI		Celera
Cytogenetic Map	3	p26.2	NCBI
HuRef	3	3,125,335 - 3,155,445 (-)	NCBI		HuRef
CHM1_1	3	3,141,344 - 3,171,426 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	3,143,956 - 3,174,065 (-)	NCBI		T2T-CHM13v2.0

Crbn
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	106,755,205 - 106,777,060 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	106,757,162 - 106,777,038 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	106,778,244 - 106,800,099 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	106,780,201 - 106,800,077 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	106,728,238 - 106,750,068 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	106,744,026 - 106,765,846 (-)	NCBI		MGSCv36	mm8
Celera	6	108,595,522 - 108,617,352 (-)	NCBI		Celera
Cytogenetic Map	6	E1	NCBI
cM Map	6	49.24	NCBI

Crbn
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	141,255,400 - 141,276,722 (-)	NCBI		GRCr8
mRatBN7.2	4	139,701,154 - 139,719,949 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	139,701,094 - 139,719,938 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	145,131,740 - 145,150,553 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	140,912,428 - 140,931,241 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	139,556,365 - 139,575,178 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	138,864,910 - 138,885,786 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	138,866,761 - 138,885,556 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	203,337,149 - 203,355,944 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	142,135,935 - 142,154,730 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	142,381,683 - 142,399,558 (-)	NCBI
Celera	4	128,413,500 - 128,432,250 (-)	NCBI		Celera
Cytogenetic Map	4	q41	NCBI

Crbn
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955421	10,166,962 - 10,189,916 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955421	10,166,927 - 10,190,470 (+)	NCBI	ChiLan1.0	ChiLan1.0

CRBN
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	3,149,228 - 3,178,994 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	3,153,928 - 3,183,753 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	3,091,328 - 3,121,364 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	3,195,361 - 3,225,345 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	3,190,979 - 3,225,345 (-)	Ensembl	panpan1.1		panPan2

CRBN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	14,240,723 - 14,275,617 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	14,240,804 - 14,274,940 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	14,207,100 - 14,239,868 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	14,273,589 - 14,306,602 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	14,273,658 - 14,307,077 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	13,975,281 - 14,008,269 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	14,309,697 - 14,342,500 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	14,300,743 - 14,333,740 (+)	NCBI		UU_Cfam_GSD_1.0

Crbn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404942	9,878,746 - 9,904,708 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936577	2,833,972 - 2,851,174 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936577	2,834,134 - 2,854,116 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CRBN
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	59,730,639 - 59,757,860 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	59,733,503 - 59,757,776 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	66,166,373 - 66,187,211 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Crbn
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624773	13,384,383 - 13,407,191 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624773	13,383,697 - 13,406,892 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in CRBN
464 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007985049	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000009138 ⟹ ENSCSAP00000007265

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	22	39,248,905 - 39,277,749 (-)	Ensembl

RefSeq Acc Id:

XM_007985049 ⟹ XP_007983240

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	22	39,248,087 - 39,277,778 (-)	NCBI
Vero_WHO_p1.0	NW_023666041	127,426,181 - 127,455,892 (+)	NCBI

Sequence:

show sequence

CGGCACCGCCCTGTCCCAGCCTCCTTTGCGGGTAAACAGACATGGCCGGCGAAGGAGATCAGCA
GGACGCTGCGCACAACATGGGCAATCACCTGCCGCTCTTGCCTGCAGAGAGTGAGGAAGAAGAT
GAAATGGAAGTTGAAGACCAGGATAGTAAAGAAGCCAAAAAACCAAACATCATAAATTTTGACA
CCAGTCTGCCAACATCACATACATATCTAGGCGCTGATATGGAAGAATTTCATGGCAGGACTTT
GCACGATGACGACAGCTGTCAGGTGATTCCAGTTCTGCCACAGGTGATGATGATCCTGATTCCC
GGACAGACATTGCCTCTTCAGCTTTTTCACCCTCAAGAAGTCAGTATGGTGCGGAATTTAATTC
AGAAAGATAGAACCTTTGCTGTTCTTGCATACAGCAATATACAGGAAAGGGAAGCACAGTTTGG
AACAACAGCAGAGATATATGCCTATCGAGAAGAACAGGATTTTGGAATTGAGATAGTGAAAGTG
AAAGCAATTGGAAGACAAAGGTTCAAAGTCCTTGAGCTAAGAACACAGTCAGATGGAATCCAGC
AAGCTAAAGTGCAAATTCTTCCTGAATGTGTGTTGCCTTCAACCATGTCTGCAGTTCAGTTAGA
ATCCCTCAATAAGTGCCAGATATTTCCTTCAAAACCTGTCTCAAGGGAAGACCAGTGTTCATAT
AAATGGTGGCAGAAATACCAGAAGAGAAAGTTTCATTGTGCAAATCTAACTTCATGGCCTCGCT
GGCTATATTCCTTATATGATGCTGAAACCTTAATGGACAGAATCAAGAAACAGCTACGTGAATG
GGATGAAAATCTAAAAGATGATTCTCTTCCTTCAAATCCAATAGATTTTTCTTACAGAGTAGCT
GCTTGTCTTCCTATTGACGATGTATTGAGAATTCAGCTCCTTAAAATTGGCAGTGCTATCCAAC
GACTTCGCTGTGAATTAGACATTATGAATAAATGTACTTCCCTTTGCTGTAAACAATGTCAAGA
AACAGAAATAACAACCAAAAATGAAATATTCAGTTTATCCTTATGTGGGCCGATGGCAGCTTAT
GTGAATCCTCATGGATATGTGCATGAGACACTTACTGTGTATAAAGCTTGCAACTTGAATCTGA
TAGGCCGGCCTTCTACGGAACACAGCTGGTTTCCTGGGTATGCCTGGACTGTTGCCCAGTGTAA
GATCTGTGCAAGCCATATTGGATGGAAGTTTACGGCCACCAAAAAAGACATGTCACCTCAAAAA
TTTTGGGGCTTAACGCGATCTGCTCTGTTGCCCACGATCCCAGACACTGAAGATGAAATAAGTC
CAGACAAAGTAATACTTTGCTTGTAAACAGATGTGGTAGAGATAAAGTTATCTAACAAACTGGT
TATATTCTAAAATCAGATCTGCTTTGGAAATTATTGCGTCTGATACATACCTAAGTAAACACAA
CATTACTTGGAGGGTTGCAGTTTCTAAGTATACTTTTGGAGAGCATGAACAGCAGTCTAGAATA
CTAGAAACATCTATTTGGGTAGCTTGGTACCATTATCCTGTGGAATCTGATATGTCTGGCAGCA
TGTCATTGATGGGACATGTTTGGAAATGAGATTATTTCCTGCGTAAAAAAAAATCTTAAATTCC
TACAATGTGAAACGAATTATTTGATCCTGATGTATGGGACAGCATATCTGTACCAGTGCTCTAA
ATGACAAAAGCTAGGGTGACAAGTACATGTTCCTTTTTGAAAGAAGCAAGGCAATGTATAATTC
TAAAAGGGCTTTGTTCCTTTCCATTTTCTTTAGCTTCTCTGAGATACTGATTTGTAAATTTTGA
AAATTAGTTAAAATATGCAGTTTTTTGAGCCCACGAATAGTTGTCATTTCCTTTATGTGCCTGT
TAGTAAAAAATAGTATTGTGTATTTGCTCAGTATTTGAACTGTAAGCCCATTTATACTGTTCCA
TACAAAAGCTATTTTTCAAAAATTAATTTGAACCAAAACTACTATTATAGGGAAAATTTGCCAA
AACATGTCCCCTCACACAGGCTACACGTGATACTGTATTTTGTTCAATGTAAATTGAAGAAAAT
CTGTAAGTAAACCTTAAATGTGAAACTAAACATGTTCTTTGTTCAAATAATATAAAATATCACT
TATAATTTTAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007983240	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000007265
	ENSCSAP00000007265.1

RefSeq Acc Id:	XP_007983240 ⟸ XM_007985049
- UniProtKB:	A0A0D9RF76 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000007265 ⟸ ENSCSAT00000009138

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000011049	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000009138.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.58.1480	UniProtKB/TrEMBL
	2.30.130.40	UniProtKB/TrEMBL
	Peptide methionine sulfoxide reductase	UniProtKB/TrEMBL
InterPro	CULT	UniProtKB/TrEMBL
	Lon_prtase_N_sf	UniProtKB/TrEMBL
	Lon_substr-bd	UniProtKB/TrEMBL
	PUA-like_sf	UniProtKB/TrEMBL
	Yippee/Mis18/Cereblon	UniProtKB/TrEMBL
KEGG Report	csab:103227931	UniProtKB/TrEMBL
NCBI Gene	CRBN	ENTREZGENE
PANTHER	CEREBLON	UniProtKB/TrEMBL
	PROTEIN CEREBLON	UniProtKB/TrEMBL
Pfam	LON_substr_bdg	UniProtKB/TrEMBL
	Yippee-Mis18	UniProtKB/TrEMBL
PROSITE	CULT	UniProtKB/TrEMBL
	LON_N	UniProtKB/TrEMBL
SMART	LON	UniProtKB/TrEMBL
Superfamily-SCOP	SSF88697	UniProtKB/TrEMBL
UniProt	A0A0D9RF76	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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