FFAR1 (free fatty acid receptor 1)

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Gene: FFAR1 (free fatty acid receptor 1) Chlorocebus sabaeus

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Symbol:

FFAR1

Name:

free fatty acid receptor 1

RGD ID:

18339707

Description:

ENCODES a protein that exhibits fatty acid binding (ortholog); INVOLVED IN G protein-coupled receptor signaling pathway (ortholog); glucose homeostasis (ortholog); insulin secretion (ortholog); ASSOCIATED WITH Brugada syndrome 5 (ortholog); dystonia (ortholog); hereditary spastic paraplegia 75 (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	30,289,268 - 30,290,838 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	30,289,285 - 30,290,187 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	8,078,579 - 8,080,768 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Brugada syndrome 5 (ISO)

dystonia (ISO)

hereditary spastic paraplegia 75 (ISO)

type 2 diabetes mellitus (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

G protein-coupled receptor signaling pathway (IEA,ISO)

glucose homeostasis (IEA,ISO)

insulin secretion (IEA,ISO)

ion channel modulating, G protein-coupled receptor signaling pathway (IEA)

ligand-gated ion channel signaling pathway (IEA)

negative regulation of interleukin-1 beta production (IEA)

phospholipase C-activating G protein-coupled receptor signaling pathway (IEA)

positive regulation of calcium ion transport (IEA)

positive regulation of calcium ion transport into cytosol (ISO)

positive regulation of cytosolic calcium ion concentration (IEA)

positive regulation of insulin secretion (IEA,ISO)

response to fatty acid (IEA)

Cellular Component

membrane (IEA)

plasma membrane (IEA)

Molecular Function

bioactive lipid receptor activity (IEA)

fatty acid binding (ISO)

G protein-coupled receptor activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

FFAR1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	30,289,268 - 30,290,838 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	30,289,285 - 30,290,187 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	8,078,579 - 8,080,768 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

FFAR1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	35,347,902 - 35,353,864 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	35,347,902 - 35,353,864 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	35,838,805 - 35,844,766 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	40,534,295 - 40,535,197 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	40,534,294 - 40,535,197	NCBI
Celera	19	32,555,895 - 32,556,817 (+)	NCBI		Celera
Cytogenetic Map	19	q13.12	NCBI
HuRef	19	32,350,940 - 32,351,862 (+)	NCBI		HuRef
CHM1_1	19	35,844,054 - 35,844,976 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	37,892,634 - 37,898,598 (+)	NCBI		T2T-CHM13v2.0

Ffar1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	30,559,993 - 30,560,895 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	30,556,815 - 30,560,989 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	30,860,568 - 30,861,470 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	30,857,390 - 30,861,564 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	31,645,587 - 31,646,489 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	30,569,328 - 30,570,230 (-)	NCBI		MGSCv36	mm8
Celera	7	25,444,014 - 25,444,916 (-)	NCBI		Celera
Cytogenetic Map	7	B1	NCBI
cM Map	7	19.25	NCBI

Ffar1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	95,238,785 - 95,239,689 (-)	NCBI		GRCr8
mRatBN7.2	1	86,111,368 - 86,112,272 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	86,111,368 - 86,112,272 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	91,526,041 - 91,526,945 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	99,992,210 - 99,993,114 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	93,284,340 - 93,285,244 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	89,308,475 - 89,309,379 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	89,308,475 - 89,309,379 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	90,463,925 - 90,464,829 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	85,917,624 - 85,918,528	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	85,995,734 - 85,996,639	NCBI
Cytogenetic Map	1	q21	NCBI

Ffar1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955468	4,626,748 - 4,627,650 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955468	4,626,567 - 4,627,683 (+)	NCBI	ChiLan1.0	ChiLan1.0

FFAR1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	41,364,498 - 41,368,103 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	43,345,490 - 43,351,174 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	32,298,259 - 32,300,601 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	41,034,901 - 41,037,219 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	41,034,905 - 41,035,807 (+)	Ensembl	panpan1.1		panPan2

FFAR1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	117,257,005 - 117,258,799 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	116,659,986 - 116,661,656 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	117,856,745 - 117,858,415 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	117,856,767 - 117,857,666 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	117,416,141 - 117,421,463 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	117,045,554 - 117,047,224 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	118,101,028 - 118,102,774 (-)	NCBI		UU_Cfam_GSD_1.0

Ffar1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	10,688,445 - 10,690,821 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936570	955,102 - 957,437 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

Ffar1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624794	8,206,491 - 8,207,393 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624794	8,206,491 - 8,207,393 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
42	15	18	28	28	32	5

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007996357	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000041	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000018613 ⟹ ENSCSAP00000018062

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	6	30,289,285 - 30,290,187 (+)	Ensembl

RefSeq Acc Id:

XM_007996357 ⟹ XP_007994548

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	6	30,289,268 - 30,290,838 (+)	NCBI
Vero_WHO_p1.0	NW_023666073	8,078,579 - 8,080,768 (+)	NCBI

Sequence:

show sequence

GCCAGGACAGTGGCCCCATGGACCTGCCCCGGCAGCTCTCCTTCGCCCTCTATGTGGCGGCCTT
TGCGCTGGGCTTCCCGCTCAACGTCCTGGCCATCCGAGGCGCGACAGCCCACGCCCGGCTGCGT
CTCACCCCCAGCCTGGTCTACGCCCTGAACCTGGGCTGCTCCGACCTGTTGCTGACAGTCTCCC
TGCCCCTGAAGGCGGTGGAGGCGCTGGCCTCCGGGGCCTGGCCTCTGCCGGCCTCGCTGTGCCC
CGTCTTCGGGGTGGCCCACTTTGCTCCACTCTATGCCGGCGGGGGCTTCCTGGCCGCCCTGAGT
GCAGGCCGCTACCTGGGAGCGGCCTTCCCCTTGGGCTACCAAGCCTTCCGGAGGCCGTGCTATT
CCTGGGGGGTGTGTGCGGCCATCTGGGCCCTCGTCCTGTGTCACCTGGGTCTGGTCTTGGTGTT
GGAGGCTCCGGGAGGCTGGCTGGACCACAGCAACACCTCCCTGGGCATCAACACACCGGTCAAC
GGCTCTCCTGTCTGCCTGGAGGCCTGGGACCCGGCCTCTGCCGGCCCGGCCCGCTTCAGCCTCT
CTCTCCTGCTTTTTTTCCTGCCCTTGGCCATCACAGCCTTCTGCTACGTGGGCTGCCTCCGGGC
ACTGGCCCACTCCGGCCTGACGCACAGGCGGAAGCTGAGGGCCGCCTGGGTAGCCGGCGGGGCC
CTCCTCACGCTGCTGCTCTGCGTAGGACCCTACAACGCCTCCAACGTAGCCAACTTCCTGAACC
CCAATCTGGGAGGCTCCTGGCGGAAGCTGGGGCTCATCACGGGTGCCTGGAGTGTGGTGCTCAA
CCCGCTGGTGACCGGTTACTTGGGAAGGGGTCCTGGCCTGAAGACAGTGTGTGCGGCAAGAACG
CAAGGGAGCACGTCCCAGAAGTAACGCCACCGCTCGGGGGAAGGAGCATGAGGCAGGAGGGCCC
GGCTGCGTCTCCAGGCCCCTGCGGAGGGCTGCTTCGGAGGAACTGCAGGGCAGCCTGGCCCGGA
GGCCTCCCTGGAGCCACTCAAGCGGAGAGCGGCGCCTGCTGAGGGCAGCACCCCAGTCAAGAGA
GGAGCACGGAGCCAAAGCAAGGCGGCAGGGGGAGGTAAGCTTGCCCCTGCACACATAGGCCCCT
TTCCTCGTCTGTCTGTCTCTGCCCTCTGCACGTCCTCACCTGCCTGTCTTCAGTGGGCCGCGAG
CAGAGGCCTTGTACTTACGGGAAGGAGGAGACAATCTGTTTCTGACCCACACGAACGGTCACTC
CGGTGATGCACTTGAGGACACGCTACGCTGAAATCAGTTCCCAGGTGAGAACATTTGATTTCGG
AGTAGGAGAGGAGGCAGGAGGCAGGATAATGACACTGTTATACCATGCGAAACTCACAAGGGGG
CAGCCTTGGAGCTGGGAACGGAGGCTGGCGGGAAAAGATGTTTCAGCCAGGGAGGGAAAATGCA
AGGTCCCGCAGTGATGGGCAGCGGCCACGCAGTTGACTCTTGAACAACGTGGGGATGGGGTGCC
GAACCCCCACGCAGTGGAAAATCTGTGCATAACTT

hide sequence

Protein Sequences


Protein RefSeqs	XP_007994548	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000018062
	ENSCSAP00000018062.1

RefSeq Acc Id:	XP_007994548 ⟸ XM_007996357
- UniProtKB:	A0A0D9SB23 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000018062 ⟸ ENSCSAT00000018613

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000018523	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000018613.1	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
	GPR40-rel_orph	UniProtKB/TrEMBL
	GPR40_recept_FA	UniProtKB/TrEMBL
KEGG Report	csab:103234507	UniProtKB/TrEMBL
NCBI Gene	FFAR1	ENTREZGENE
PANTHER	FREE FATTY ACID RECEPTOR 1	UniProtKB/TrEMBL
	FREE FATTY ACID RECEPTOR 2-RELATED	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PRINTS	FATTYACIDR	UniProtKB/TrEMBL
	GPCRRHODOPSN	UniProtKB/TrEMBL
	GPR40FAMILY	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	A0A0D9SB23	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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