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Gene: SHD (Src homology 2 domain containing transforming protein D) Chlorocebus sabaeus

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Symbol:

SHD

Name:

Src homology 2 domain containing transforming protein D

RGD ID:

18337682

Description:

ENCODES a protein that exhibits phosphotyrosine residue binding (inferred); ASSOCIATED WITH amenorrhea (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

SH2 domain-containing adapter protein D

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	4,021,013 - 4,030,904 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	4,022,494 - 4,030,812 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666081	4,182,012 - 4,193,091 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amenorrhea (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Molecular Function

phosphotyrosine residue binding (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

SHD
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	4,021,013 - 4,030,904 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	4,022,494 - 4,030,812 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666081	4,182,012 - 4,193,091 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

SHD
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	4,279,069 - 4,290,722 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	4,279,266 - 4,290,722 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	4,279,066 - 4,290,719 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	4,230,659 - 4,241,720 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	19	4,217,984 - 4,230,101 (+)	NCBI		Celera
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	4,041,763 - 4,053,879 (+)	NCBI		HuRef
CHM1_1	19	4,278,213 - 4,290,327 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	4,262,345 - 4,273,993 (+)	NCBI		T2T-CHM13v2.0

Shd
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	56,276,828 - 56,283,624 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	56,277,467 - 56,283,625 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	55,969,828 - 55,976,620 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	55,970,467 - 55,976,625 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	56,109,905 - 56,116,043 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	55,563,776 - 55,569,910 (+)	NCBI		MGSCv36	mm8
Celera	17	59,389,009 - 59,395,147 (+)	NCBI		Celera
Cytogenetic Map	17	D	NCBI
cM Map	17	29.09	NCBI

Shd
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	888,865 - 895,557 (+)	NCBI		GRCr8
mRatBN7.2	9	799,652 - 809,769 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	795,674 - 808,371 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	1,248,790 - 1,255,476 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	6,595,976 - 6,602,670 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	5,553,828 - 5,560,514 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	11,090,048 - 11,098,813 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	11,089,106 - 11,096,704 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	10,075,316 - 10,083,990 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	9	7,698,081 - 7,704,778 (-)	NCBI		Celera
Cytogenetic Map	9	q11	NCBI

Shd
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	4,577,178 - 4,586,955 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	4,579,252 - 4,587,192 (-)	NCBI	ChiLan1.0	ChiLan1.0

SHD
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	8,676,614 - 8,687,690 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	7,906,663 - 7,917,916 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	3,301,944 - 3,313,769 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	4,250,630 - 4,261,038 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	4,250,630 - 4,261,038 (+)	Ensembl	panpan1.1		panPan2

SHD
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	55,356,407 - 55,361,675 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	55,356,169 - 55,361,681 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	55,084,340 - 55,089,970 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	56,015,524 - 56,021,165 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	56,015,513 - 56,020,937 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	55,075,479 - 55,081,100 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	55,556,686 - 55,562,330 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	55,755,327 - 55,760,970 (-)	NCBI		UU_Cfam_GSD_1.0

Shd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	215,380,272 - 215,388,721 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936588	2,447,947 - 2,454,591 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936588	2,447,133 - 2,454,511 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SHD
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	74,497,351 - 74,504,659 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	74,496,771 - 74,506,855 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	74,990,300 - 74,997,236 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Shd
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	5,368,029 - 5,375,702 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624828	5,368,153 - 5,376,086 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in SHD
292 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	18	34	34	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007994845	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007994846	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000049	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000008722 ⟹ ENSCSAP00000006860

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	6	4,022,494 - 4,030,812 (+)	Ensembl

RefSeq Acc Id:

XM_007994845 ⟹ XP_007993036

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	6	4,021,013 - 4,030,904 (+)	NCBI
Vero_WHO_p1.0	NW_023666081	4,182,012 - 4,193,091 (-)	NCBI

Sequence:

show sequence

GGACAGATGCAGAGGACAGGCGCCAGGCTCAGATACCATCTCCCTTCCCCAGGCCAGCTGCCCC
CAACCCTCCCCCTGCCCGCAATTAGTCCCCTGGGAAGGGAGCGGGGAACAGAGCAGAGCCCTCT
TGGGGGAGGGGAAGCCTGATCCCCACCGTCCCTTCCTTTGCCCCCCTCTTCCTTCTGCTGCGTC
AATATCAATTTCAACCAGTGACCTCTCCACCAATTTCCACACCCCCACTCTGCCGGTCCGTTTC
ACCGCCAGACATCGGTTCCATTTCGACCCTCAGTGGCGGTCATTCCCACCCCCTCTGCTGGTCA
ATTTCACCCCTTCTGGCGGTCAAGTCCAGTCCCCCATTTCCCGGGCAATTTCCCCCTCCCTTCC
TTCTCCCCCTCCCCTCTCCTCCCTCTCTCCCTCCCCAGCAGTGTCACTCCCAGCCGGTCCCCAC
CTCCCGCGCTCCGCGCTCGCTGCGGCCAGTCTCGGGCGTCCGGGTCAGTGTCCAGCTGCCGCGG
CCTCGGCCCCGGCGACTCCCGCCCCCAGCCCCCCCTTCCCTCCGCGGGCAGCGGCTCCCTCCCT
CCCCAGAACAGCTGAAGGTCTCAGTCACCTCCGAGGGGAGCGCAGGGGGAGGGGAGGGGCGGGG
GACGCGGCCGAGGGGAGGCGGGGGAGCCTTGACGCTGCTGCCCGGGACGCGGCCCGGGGCTGGT
GGGAACCGGGGCGTCCTCCCGCGCTCCCCCCTCCCCAGCGTCCCACCTCCCGGCGGCGGCGGGG
AAAGTGTCTCCGAAAGCGTGAAGAGGGATTGGAGGAGGTTTTTATTTCCCTTTGTGCGGGTGGC
TGGGGCCGGATCGAGGCGGCCCGGCCGGGGACCGCGGGATTGGGGGCTCCCCGCTGAGCCGAGA
GGAGCGCGACAAAGGATGCGTCCCGCCGGGGTCACTGGCTCCGCGGCCCAACTTTGCGCGCGGC
GCCCGCGCTCCTGGGGAGCCCGCCCGCTGCGCTGAGAACCCAGGCGTCCGGACTGGGCGAGGGG
CCGGGAGCGTCCGCAGGTGGCGCTGGCCCCGATCTCCCGACCCCAGGAAGGGATCCCGGAGCTT
CCCGGAGGCGGCGGGCGGCCGAGTTGCTCCAGGGAACCGCGCTGCCCGCGGAAACTCCGCGCGC
CTCCGCGGATGCCCCTCGCCCTAGCCCCTAGCGCGCGGCACTCAGGGCCCTGCGGGACGCCCCC
TTCCCCTGCGGTGCTTCCCAAACCCGGCTAAAGCGGGCTTGTCCTCCCTCCCTCCTCTGTCGCC
TCCTTTTCCTCCCCCTCGTTCACCTTTTCCTTGCCTCTATCCATCCAGAACCCCGCCAAAGGGC
GCACCTGATCTTTCTCCTCCTTCCCTGCTCTTCCCTTCCTCTCCTCCTCCTCCTCCTCCTCCCT
GAGAAAAGGGGCCTGGAGAAGGGCATGTGGGGGCCCCTCTGACAGTGGCCCGATTGGGGTGACA
GGCGCCCAAATGGCCAAGTGGCTACGGGACTACCTGAGCTTTGGCGGTCGGAGGCCCCCTCCGC
AGCCGCCCACCCCGGACTACACCGAGAGCGACATCCTGAGGGCCTACCGCGCGCAGAAGAACCT
GGACTTCGAAGACCCCTATGAGGACGCGGAGAGCCGCTTGGAGCCGGACCCCGCGGGCCCTGGG
GACTCCAAGAACCCCGGAGATGCCAAGTACGGCTCTCCCAAGCACCGGCTCATCAAGGTGGAGG
CTGCGGATATGGCCAGAGCCAAGGCCCTTCTGGGCGGCCCCGGGGAGGAGCTGGAAGCCGACAC
TGAGTATTCAGACCCCTTTGATGCTCAGCCTCATCCTGCACCCCCGGATGATGGGTACATGGAG
CCCTACGACGCCCAACGGGTCATGAGTGAACTGCCCGGCAGAGGGGTGCAACTCTATGACACCC
CTTATGAGGAACAGGACCCAGAGACAGCAGATGGACCCCCTTCTGGGCAGAAGCCTCGGCAGAG
CCGGATGCCCCAGGAGGATGAACGGCCAGCAGATGAGTATGATCAGCCCTGGGAGTGGAAGAAA
GACCACATCTCCAGGGCGTTTGCAGTGCAGTTTGACAGTCCAGAGTGGGAGAGGACTCCAGGCT
CAGCCAAGGAGCTCCGGAGACCCCCACCCAGAAGCCCCCAGCCTGCGGAGCGTGTGGACCCAGC
CCTGCCCCTGGAGAAACAGCCGTGGTTTCATGGCCCCCTGAACAGGGCGGATGCCGAGAGCCTC
CTGTCCCTCTGCAAGGAAGGCAGCTACCTAGTGCGGCTCAGCGAGACCAGCCCCCAGGACTGCT
CCTTGTCTCTCAGGAGCAGCCAGGGCTTCCTGCATCTGAAGTTCGCACGGACCCGAGAGAACCA
GGTGGTGCTGGGCCAACACAGTGGGCCCTTCCCCAGCGTGCCCGAGCTCGTCCTCCACTACAGT
TCACGCCCACTGCCGGTGCAAGGCGCCGAGCATCTGGCTCTGCTGTACCCCGTGGTCACGCAGA
CCCCCTGACAGTGACCCTCGGCCCCCTTTTGAGTCCTCGGGCCCAGCATTGTATCCCAAAGCCG
TCCCATGGCCTAGAAAATAAATAAGTTATTGTTTGT

hide sequence

Protein Sequences


Protein RefSeqs	XP_007993036	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000006860
	ENSCSAP00000006860.1

RefSeq Acc Id:	XP_007993036 ⟸ XM_007994845
- UniProtKB:	A0A0D9RE21 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000006860 ⟸ ENSCSAT00000008722

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000010649	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000008722.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.505.10	UniProtKB/TrEMBL
InterPro	SH2	UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/TrEMBL
	SH2_domain_adapters	UniProtKB/TrEMBL
	SHD_SH2	UniProtKB/TrEMBL
KEGG Report	csab:103233711	UniProtKB/TrEMBL
NCBI Gene	SHD	ENTREZGENE
PANTHER	HEAVYWEIGHT, ISOFORM A	UniProtKB/TrEMBL
	PTHR15127:SF33	UniProtKB/TrEMBL
Pfam	SH2	UniProtKB/TrEMBL
PRINTS	SH2DOMAIN	UniProtKB/TrEMBL
PROSITE	SH2	UniProtKB/TrEMBL
SMART	SH2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF55550	UniProtKB/TrEMBL
UniProt	A0A0D9RE21	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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