Fam174b (family with sequence similarity 174, member B) - Rat Genome Database

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Gene: Fam174b (family with sequence similarity 174, member B) Mus musculus
Analyze
Symbol: Fam174b
Name: family with sequence similarity 174, member B
RGD ID: 1624860
MGI Page MGI
Description: Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus and plasma membrane. Is expressed in Meckel's cartilage; cortical plate; lung; and skeleton. Orthologous to human FAM174B (family with sequence similarity 174 member B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: membrane protein FAM174B; MGC31276
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39773,390,055 - 73,426,667 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl773,390,050 - 73,426,667 (+)EnsemblGRCm39 Ensembl
GRCm38773,740,307 - 73,776,919 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl773,740,302 - 73,776,919 (+)EnsemblGRCm38mm10GRCm38
MGSCv37780,885,193 - 80,921,805 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera771,186,731 - 71,223,572 (+)NCBICelera
Cytogenetic Map7D1NCBI
cM Map742.24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
Golgi organization  (ISO,ISS)

Cellular Component
Golgi apparatus  (ISO,ISS)
plasma membrane  (ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10922068   PMID:12477932   PMID:15782199   PMID:18554416   PMID:21267068   PMID:30728831   PMID:31541165   PMID:34321999  


Genomics

Comparative Map Data
Fam174b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39773,390,055 - 73,426,667 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl773,390,050 - 73,426,667 (+)EnsemblGRCm39 Ensembl
GRCm38773,740,307 - 73,776,919 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl773,740,302 - 73,776,919 (+)EnsemblGRCm38mm10GRCm38
MGSCv37780,885,193 - 80,921,805 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera771,186,731 - 71,223,572 (+)NCBICelera
Cytogenetic Map7D1NCBI
cM Map742.24NCBI
FAM174B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381592,617,448 - 92,655,775 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1592,617,448 - 92,809,884 (-)EnsemblGRCh38hg38GRCh38
GRCh371593,160,678 - 93,199,005 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361590,961,682 - 91,000,035 (-)NCBINCBI36Build 36hg18NCBI36
Celera1569,572,621 - 69,610,827 (-)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1569,297,716 - 69,335,942 (-)NCBIHuRef
CHM1_11593,001,739 - 93,040,012 (-)NCBICHM1_1
T2T-CHM13v2.01590,379,890 - 90,418,117 (-)NCBIT2T-CHM13v2.0
Fam174b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81136,925,162 - 137,006,082 (+)NCBIGRCr8
mRatBN7.21127,515,393 - 127,618,591 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1127,508,068 - 127,516,078 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl1127,514,041 - 127,596,128 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1135,490,081 - 135,535,880 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01142,660,212 - 142,706,008 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01135,501,717 - 135,554,904 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01135,081,596 - 135,180,266 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1135,083,974 - 135,162,685 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01136,107,161 - 136,197,902 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41128,936,112 - 128,989,452 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1119,641,416 - 119,740,642 (+)NCBICelera
Cytogenetic Map1q31NCBI
Fam174b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541620,900,730 - 20,926,529 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541620,899,846 - 20,926,531 (-)NCBIChiLan1.0ChiLan1.0
FAM174B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21682,168,046 - 82,206,687 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11585,862,645 - 85,907,419 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01571,306,617 - 71,345,402 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11590,502,598 - 90,540,788 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1590,502,814 - 90,540,745 (-)Ensemblpanpan1.1panPan2
FAM174B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1347,403,458 - 47,455,199 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha350,114,298 - 50,157,336 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0347,824,209 - 47,867,269 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl347,824,209 - 47,865,552 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1347,340,374 - 47,383,359 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0347,572,416 - 47,615,430 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0347,904,655 - 47,947,656 (+)NCBIUU_Cfam_GSD_1.0
FAM174B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl786,268,959 - 86,304,979 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1786,181,970 - 86,356,953 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2792,211,792 - 92,300,016 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FAM174B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12911,173,622 - 11,227,910 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605935,442,943 - 35,483,725 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fam174b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476811,053,296 - 11,080,732 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476811,053,296 - 11,081,825 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:785
Count of miRNA genes:449
Interacting mature miRNAs:552
Transcripts:ENSMUST00000107456
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
25314305Vmm6_mvariable multisystem mineralization 6, eye (mouse)761849748102749207Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
11252140Fdr1_mfat response to dietary restriction 1 (mouse)74114882075148965Mouse
26884381Bzwq2_mbi-zygomatic width QTL 2, 5 week (mouse)76524974896949207Mouse
1301784Ses2_msalmonella enteritidis susceptibility 2 (mouse)Not determined767290094101290240Mouse
1301663Skull9_mskull morphology 9 (mouse)Not determined75732612191326352Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
1301383Aem2_manti-erythrocyte autoantibody modifier 2 (mouse)Not determined76413542498135653Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73628001592394346Mouse
27095937Ulnl7_mulna length 7, 10 week (mouse)76644974898349207Mouse
11565101Tsve1_mvariable short tail (Tsv) enhancer 1 (mouse)75588950887142720Mouse
1300620Pgia21_mproteoglycan induced arthritis 21 (mouse)Not determined767290094101290240Mouse
13208555Lgth10_mbody length 10 (mouse)751649748125599172Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)761749748121399223Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
10054064Bwq11_mbody weight QTL 11 (mouse)Not determined75112495485125093Mouse
1357752Tabw_mtally ho asscoiated body weight (mouse)Not determined74919327883193390Mouse
10053685Eae43_mexperimental allergic encephalomyelitis susceptibility 43 (mouse)Not determined75112495485125093Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301155Bpq7_mblood pressure QTL 7 (mouse)Not determined770143137104143379Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1300654Bomd1_mbone mineral density 1 (mouse)Not determined768365595102365702Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765249748126499172Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)767849748119499223Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)767849748124199223Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)754819589116822815Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
1301465Egrm3_mearly growth rate (mouse)Not determined75732612191326352Mouse
1300952Hcs1_mhepatocarcinogenesis susceptibility 1 (mouse)Not determined75732612191326352Mouse
4142319Powg_mpost-ovarectomy weight gain (mouse)Not determined7285710592582163Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301826Pgia3_mproteoglycan induced arthritis 3 (mouse)Not determined767290094101290240Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3003248581135653Mouse
4141929Chlq18_mcirculating hormone level QTL 18 (mouse)Not determined74114882075148965Mouse
26884418Bzwq7_mbi-zygomatic width QTL 7, 10 week (mouse)767849748105449207Mouse
10043973Obq29_mobesity QTL 29 (mouse)Not determined772263372106263372Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
12880417V125Dq5_mvitamin D active form serum level QTL 5 (mouse)74524974879249748Mouse
12880418V125Dq6_mvitamin D active form serum level QTL 6 (mouse)75214974886149748Mouse
11532741Tbrs5_mtuberculosis resistance 5 (mouse)74915922783235415Mouse
1302141Fcsa6_mfemoral cross-sectional area 6 (mouse)Not determined74838446182384607Mouse
13506750Tbthq2_mtrabecular bone thickness QTL 2 (mouse)76565974877549748Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)761749748123699223Mouse
12801463Rta1_mretinal aging 1 (mouse)76716802789089989Mouse
11553865Stmm1c_mskin tumor modifier of MSM 1c (mouse)76578898699788986Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)767849748124999172Mouse
11553866Stmm1d_mskin tumor modifier of MSM 1d (mouse)76578898699788986Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773049748125699172Mouse
25314302Vmm2_mvariable multisystem mineralization 2, heart (mouse)74714974874149748Mouse
25314303Vmm4_mvariable multisystem mineralization 4, kidney (mouse)73729942587049208Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)769949748120499223Mouse

Markers in Region
AW549803  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38773,776,410 - 73,776,529UniSTSGRCm38
MGSCv37780,921,296 - 80,921,415UniSTSGRCm37
Celera771,223,063 - 71,223,182UniSTS
Whitehead/MRC_RH7824.87UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000107456   ⟹   ENSMUSP00000103080
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl773,390,050 - 73,426,667 (+)Ensembl
GRCm38.p6 Ensembl773,740,302 - 73,776,919 (+)Ensembl
Ensembl Acc Id: ENSMUST00000205946   ⟹   ENSMUSP00000145753
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl773,415,620 - 73,424,905 (+)Ensembl
GRCm38.p6 Ensembl773,765,872 - 73,775,157 (+)Ensembl
Ensembl Acc Id: ENSMUST00000206337
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl773,415,684 - 73,425,766 (+)Ensembl
GRCm38.p6 Ensembl773,765,936 - 73,776,018 (+)Ensembl
RefSeq Acc Id: NM_001162532   ⟹   NP_001156004
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39773,390,055 - 73,426,667 (+)NCBI
GRCm38773,740,307 - 73,776,919 (+)ENTREZGENE
MGSCv37780,885,193 - 80,921,805 (+)RGD
Celera771,186,731 - 71,223,572 (+)RGD
cM Map7 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001156004 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000103080
  ENSMUSP00000103080.3
  ENSMUSP00000145753.2
GenBank Protein Q8K064 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001156004   ⟸   NM_001162532
- Peptide Label: precursor
- UniProtKB: Q2NLC2 (UniProtKB/Swiss-Prot),   Q8K064 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000145753   ⟸   ENSMUST00000205946
Ensembl Acc Id: ENSMUSP00000103080   ⟸   ENSMUST00000107456

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K064-F1-model_v2 AlphaFold Q8K064 1-153 view protein structure

Promoters
RGD ID:8664437
Promoter ID:EPDNEW_M10249
Type:initiation region
Name:Fam174b_1
Description:Mus musculus family with sequence similarity 174, member B ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38773,740,344 - 73,740,404EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3698178 AgrOrtholog
Ensembl Genes ENSMUSG00000078670 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000107456 ENTREZGENE
  ENSMUST00000107456.4 UniProtKB/Swiss-Prot
  ENSMUST00000205946.2 UniProtKB/TrEMBL
InterPro DUF1180 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:100038347 UniProtKB/Swiss-Prot
MGD MGI:3698178 ENTREZGENE
NCBI Gene 100038347 ENTREZGENE
PANTHER MEMBRANE PROTEIN FAM174B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR28607 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF1180 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fam174b PhenoGen
UniProt A0A0U1RNY8_MOUSE UniProtKB/TrEMBL
  F174B_MOUSE UniProtKB/Swiss-Prot
  Q2NLC2 ENTREZGENE
  Q8K064 ENTREZGENE
UniProt Secondary Q2NLC2 UniProtKB/Swiss-Prot