Cmtm2b (CKLF-like MARVEL transmembrane domain containing 2B) - Rat Genome Database

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Gene: Cmtm2b (CKLF-like MARVEL transmembrane domain containing 2B) Mus musculus
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Symbol: Cmtm2b
Name: CKLF-like MARVEL transmembrane domain containing 2B
RGD ID: 1623142
MGI Page MGI
Description: Predicted to enable cytokine activity. Predicted to be involved in chemotaxis and signal transduction. Predicted to be located in extracellular space. Predicted to be active in membrane. Orthologous to human CMTM2 (CKLF like MARVEL transmembrane domain containing 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1700013O04Rik; chemokine-like factor super family 2B; chemokine-like factor superfamily member 2B; chemokine-like factor superfamily protein 2-2; CKLF-like MARVEL transmembrane domain-containing protein 2B; Cklfsf; Cklfsf22; Cklfsf2b
RGD Orthologs
Human
Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398105,048,838 - 105,057,396 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8105,048,862 - 105,057,396 (+)EnsemblGRCm39 Ensembl
GRCm388104,322,206 - 104,330,764 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8104,322,230 - 104,330,764 (+)EnsemblGRCm38mm10GRCm38
MGSCv378106,846,137 - 106,854,656 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368107,211,366 - 107,219,885 (+)NCBIMGSCv36mm8
Celera8108,553,629 - 108,562,034 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.04NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cmtm2bMouseCOVID-19  ISOCMTM2 (Homo sapiens)9068941mRNA:decreased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cmtm2bMouseautosomal dominant dyskeratosis congenita 6  ISOCMTM2 (Homo sapiens)8554872ClinVar Annotator: match by term: Dyskeratosis congenita and autosomal dominant 6ClinVarPMID:28492532
Cmtm2bMousecataract 5 multiple types  ISOCMTM2 (Homo sapiens)8554872ClinVar Annotator: match by term: Cataract 5 multiple typesClinVarPMID:15959809 more ...
Cmtm2bMouseChromosome 16q12 Duplication Syndrome  ISOCMTM2 (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 16q12 duplication syndromeClinVarPMID:25741868
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cmtm2bMousejuvenile rheumatoid arthritis  ISOCMTM2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19565504

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cmtm2bMouse17alpha-ethynylestradiol affects expressionEXP 6480464Ethinyl Estradiol affects the expression of CMTM2B mRNACTDPMID:17555576
Cmtm2bMouseantirheumatic drug decreases expressionISOCMTM2 (Homo sapiens)6480464Antirheumatic Agents results in decreased expression of CMTM2 mRNACTDPMID:24449571
Cmtm2bMousearistolochic acid A increases expressionISOCMTM2 (Homo sapiens)6480464aristolochic acid I results in increased expression of CMTM2 mRNACTDPMID:33212167
Cmtm2bMousebenzo[a]pyrene increases methylationISOCMTM2 (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of CMTM2 promoterCTDPMID:27901495
Cmtm2bMousebisphenol A decreases methylationEXP 6480464bisphenol A results in decreased methylation of CMTM2B promoterCTDPMID:27312807
Cmtm2bMousebisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of CMTM2B mRNACTDPMID:32156529
Cmtm2bMousecadmium dichloride decreases expressionISOCMTM2 (Homo sapiens)6480464Cadmium Chloride results in decreased expression of CMTM2 mRNACTDPMID:38382870
Cmtm2bMouseCGP 52608 multiple interactionsISOCMTM2 (Homo sapiens)6480464CGP 52608 promotes the reaction [RORA protein binds to CMTM2 gene]CTDPMID:28238834
Cmtm2bMouseDibutyl phosphate affects expressionISOCMTM2 (Homo sapiens)6480464di-n-butylphosphoric acid affects the expression of CMTM2 mRNACTDPMID:37042841
Cmtm2bMousemono(2-ethylhexyl) phthalate decreases expressionEXP 6480464mono-(2-ethylhexyl)phthalate results in decreased expression of CMTM2B mRNACTDPMID:22401849
Cmtm2bMouseozone multiple interactionsISOCMTM2 (Homo sapiens)6480464[Air Pollutants results in increased abundance of Ozone] which affects the expression of CMTM2 mRNACTDPMID:35430440
Cmtm2bMouseparacetamol decreases expressionISOCMTM2 (Homo sapiens)6480464Acetaminophen results in decreased expression of CMTM2 mRNACTDPMID:22230336
Cmtm2bMousesodium arsenite increases expressionISOCMTM2 (Homo sapiens)6480464sodium arsenite results in increased expression of CMTM2 mRNACTDPMID:38568856
Cmtm2bMousesodium fluoride increases expressionEXP 6480464Sodium Fluoride results in increased expression of CMTM2B proteinCTDPMID:28918527
Cmtm2bMousetamoxifen affects expressionEXP 6480464Tamoxifen affects the expression of CMTM2B mRNACTDPMID:17555576
Cmtm2bMouseTheaflavin 3,3'-digallate affects expressionISOCMTM2 (Homo sapiens)6480464theaflavin-3 and 3'-digallate affects the expression of CMTM2 mRNACTDPMID:34925699
Cmtm2bMousetriphenyl phosphate affects expressionISOCMTM2 (Homo sapiens)6480464triphenyl phosphate affects the expression of CMTM2 mRNACTDPMID:37042841

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Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cmtm2bMousechemotaxis involved_inIEAUniProtKB-KW:KW-01452290270 UniProtGO_REF:0000043
Cmtm2bMousesignal transduction involved_inIEAGO:00051252290270 GOCGO_REF:0000108

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cmtm2bMouseextracellular space located_inIEAUniProtKB-KW:KW-02022290270 UniProtGO_REF:0000043
Cmtm2bMousemembrane located_inIEAUniProtKB-SubCell:SL-01622290270 UniProtGO_REF:0000044
Cmtm2bMousemembrane is_active_inIBAPANTHER:PTN001103553 more ...2290270 GO_CentralGO_REF:0000033

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cmtm2bMousecytokine activity enablesIEAUniProtKB-KW:KW-02022290270 UniProtGO_REF:0000043
Cmtm2bMouseprotein binding enablesISOUniProtKB:P0DN84 more ...9068941 PMID:32296183IntActPMID:32296183


#
Reference Title
Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12782130   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16343975   PMID:21873635  
PMID:30209135   PMID:30321752   PMID:31455729  



Cmtm2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398105,048,838 - 105,057,396 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8105,048,862 - 105,057,396 (+)EnsemblGRCm39 Ensembl
GRCm388104,322,206 - 104,330,764 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8104,322,230 - 104,330,764 (+)EnsemblGRCm38mm10GRCm38
MGSCv378106,846,137 - 106,854,656 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368107,211,366 - 107,219,885 (+)NCBIMGSCv36mm8
Celera8108,553,629 - 108,562,034 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.04NCBI
CMTM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381666,579,463 - 66,588,275 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1666,579,448 - 66,588,275 (+)EnsemblGRCh38hg38GRCh38
GRCh371666,613,366 - 66,622,178 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361665,170,852 - 65,179,679 (+)NCBINCBI36Build 36hg18NCBI36
Build 341665,170,851 - 65,179,676NCBI
Celera1651,119,925 - 51,128,752 (+)NCBICelera
Cytogenetic Map16q21NCBI
HuRef1652,489,275 - 52,498,102 (+)NCBIHuRef
CHM1_11668,020,529 - 68,029,356 (+)NCBICHM1_1
T2T-CHM13v2.01672,373,758 - 72,382,570 (+)NCBIT2T-CHM13v2.0
Cmtm2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr819647,273 - 667,683 (-)NCBIGRCr8
mRatBN7.219640,838 - 651,872 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl19640,824 - 651,939 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.019849,308 - 860,032 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl19848,311 - 860,493 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.019846,972 - 848,043 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Cytogenetic Map19p14NCBI

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Variants in Cmtm2b
705 total Variants

Predicted Target Of
Summary Value
Count of predictions:156
Count of miRNA genes:148
Interacting mature miRNAs:154
Transcripts:ENSMUST00000041973
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 34 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300560Tgl1_mtriglyceride level 1 (mouse)Not determined8102486208111650036Mouse
4141435Fbtq3_mfemoral bone trait QTL 3 (mouse)Not determined8100965309130127694Mouse
11252141Fdr2_mfat response to dietary restriction 2 (mouse)898390634130127694Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined876411976110412125Mouse
1302105Im1_mImmunoregulatory 1 (mouse)Not determined899828531130127694Mouse
1301080Sluc9_msusceptibility to lung cancer 9 (mouse)Not determined899828531130127694Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined876411976110412125Mouse
1301766Desp1_mdespair 1 (mouse)Not determined885486208119486373Mouse
1301253Skmw2_mskeletal muscle weight 2 (mouse)Not determined886443553120443701Mouse

1 to 10 of 34 rows






Ensembl Acc Id: ENSMUST00000041973   ⟹   ENSMUSP00000043127
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8105,048,862 - 105,057,396 (+)Ensembl
GRCm38.p6 Ensembl8104,322,230 - 104,330,764 (+)Ensembl
Ensembl Acc Id: ENSMUST00000212912   ⟹   ENSMUSP00000148496
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8105,049,247 - 105,057,394 (+)Ensembl
GRCm38.p6 Ensembl8104,322,615 - 104,330,762 (+)Ensembl
RefSeq Acc Id: NM_028524   ⟹   NP_082800
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398105,048,859 - 105,057,396 (+)NCBI
GRCm388104,322,227 - 104,330,764 (+)NCBI
MGSCv378106,846,137 - 106,854,656 (+)RGD
Celera8108,553,619 - 108,562,042 (+)NCBI
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006531455   ⟹   XP_006531518
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398105,048,838 - 105,057,396 (+)NCBI
GRCm388104,322,206 - 104,330,764 (+)NCBI
Sequence:
1 to 11 of 11 rows
Protein RefSeqs NP_082800 (Get FASTA)   NCBI Sequence Viewer  
  XP_006531518 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH60997 (Get FASTA)   NCBI Sequence Viewer  
  AAO34103 (Get FASTA)   NCBI Sequence Viewer  
  AAP33494 (Get FASTA)   NCBI Sequence Viewer  
  BAB24346 (Get FASTA)   NCBI Sequence Viewer  
  EDL11209 (Get FASTA)   NCBI Sequence Viewer  
  EDL11210 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000043127
  ENSMUSP00000043127.6
GenBank Protein Q9DAC0 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_082800   ⟸   NM_028524
- UniProtKB: Q9DAC0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006531518   ⟸   XM_006531455
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000148496   ⟸   ENSMUST00000212912
Ensembl Acc Id: ENSMUSP00000043127   ⟸   ENSMUST00000041973
MARVEL

Name Modeler Protein Id AA Range Protein Structure
AF-Q9DAC0-F1-model_v2 AlphaFold Q9DAC0 1-210 view protein structure

RGD ID:8668007
Promoter ID:EPDNEW_M12034
Type:initiation region
Name:Cmtm2b_1
Description:Mus musculus CKLF-like MARVEL transmembrane domain containing2B , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm388104,322,237 - 104,322,297EPDNEW


1 to 11 of 11 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000035785 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000041973 ENTREZGENE
  ENSMUST00000041973.7 UniProtKB/Swiss-Prot
InterPro Marvel UniProtKB/Swiss-Prot
KEGG Report mmu:75502 UniProtKB/Swiss-Prot
MGD MGI:2447311 ENTREZGENE
NCBI Gene 75502 ENTREZGENE
PhenoGen Cmtm2b PhenoGen
PROSITE MARVEL UniProtKB/Swiss-Prot
UniProt A0A1D5RLT3_MOUSE UniProtKB/TrEMBL
  CLF2B_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
1 to 11 of 11 rows