Ear6 (eosinophil-associated, ribonuclease A family, member 6) - Rat Genome Database

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Gene: Ear6 (eosinophil-associated, ribonuclease A family, member 6) Mus musculus
Analyze
Symbol: Ear6
Name: eosinophil-associated, ribonuclease A family, member 6
RGD ID: 1623072
MGI Page MGI
Description: Enables RNA nuclease activity. Predicted to be involved in chemotaxis; defense response to Gram-positive bacterium; and innate immune response in mucosa. Predicted to be active in extracellular space. Orthologous to human RNASE2 (ribonuclease A family member 2) and RNASE3 (ribonuclease A family member 3).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: eosinophil-associated ribonuclease 6; non-secretory ribonuclease
RGD Orthologs
Human
Bonobo
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391452,091,225 - 52,092,100 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1452,091,156 - 52,092,100 (+)EnsemblGRCm39 Ensembl
GRCm381451,853,768 - 51,854,643 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1451,853,699 - 51,854,643 (+)EnsemblGRCm38mm10GRCm38
MGSCv371452,473,443 - 52,474,318 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361450,775,719 - 50,776,594 (+)NCBIMGSCv36mm8
Celera1448,829,263 - 48,842,051 (+)NCBICelera
Cytogenetic Map14C2NCBI
cM Map1426.7NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11331942   PMID:12466851   PMID:12477932   PMID:15058383   PMID:15526002   PMID:15676279   PMID:16141072   PMID:16141073  
PMID:21267068   PMID:21873635   PMID:26147683   PMID:27480124   PMID:28378742  


Genomics

Comparative Map Data
Ear6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391452,091,225 - 52,092,100 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1452,091,156 - 52,092,100 (+)EnsemblGRCm39 Ensembl
GRCm381451,853,768 - 51,854,643 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1451,853,699 - 51,854,643 (+)EnsemblGRCm38mm10GRCm38
MGSCv371452,473,443 - 52,474,318 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361450,775,719 - 50,776,594 (+)NCBIMGSCv36mm8
Celera1448,829,263 - 48,842,051 (+)NCBICelera
Cytogenetic Map14C2NCBI
cM Map1426.7NCBI
RNASE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381420,955,487 - 20,956,436 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1420,955,487 - 20,956,436 (+)EnsemblGRCh38hg38GRCh38
GRCh371421,423,646 - 21,424,595 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361420,493,470 - 20,494,434 (+)NCBINCBI36Build 36hg18NCBI36
Build 341420,493,469 - 20,494,434NCBI
Celera141,284,485 - 1,285,449 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef141,544,743 - 1,545,707 (+)NCBIHuRef
CHM1_11421,425,751 - 21,426,715 (+)NCBICHM1_1
T2T-CHM13v2.01415,152,872 - 15,153,821 (+)NCBIT2T-CHM13v2.0
LOC100981889
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21522,394,999 - 22,396,712 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11421,611,486 - 21,613,199 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0141,759,482 - 1,760,873 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11419,841,044 - 19,842,028 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1419,841,364 - 19,841,849 (+)Ensemblpanpan1.1panPan2
RNASE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12921,411,633 - 21,412,723 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2921,412,062 - 21,412,544 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605925,023,402 - 25,024,342 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ear6
23 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:243
Count of miRNA genes:144
Interacting mature miRNAs:147
Transcripts:ENSMUST00000074477, ENSMUST00000169070
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
27226744Metcl6_mmetatarsal-calcaneal length 6, 5 week (mouse)143032195752937457Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492624858179769Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
27226737Metcl12_mmetatarsal-calcaneal length 12, 10 week (mouse)143322195759437449Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse
1301372Sluc13_msusceptibility to lung cancer 13 (mouse)Not determined141882760452827726Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141484Hcbip1_mhexachlorobenzene induced porphyria 1 (mouse)Not determined4733525059962593Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143033525064335381Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142999699463997133Mouse
27226727Tibl21_mtibia length 21, 16 week (mouse)143412195752937457Mouse
4142310Carg1_mCandida albicans resistance gene 1 (mouse)Not determined5138245954461655Mouse
14746973Manh76_mmandible shape 76 (mouse)142228721756287217Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143033525064335381Mouse
13506929Recrq10_mrecombination rate in male meiosis QTL 10 (mouse)142792195761137449Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000074477   ⟹   ENSMUSP00000074075
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1452,091,225 - 52,092,100 (+)Ensembl
GRCm38.p6 Ensembl1451,853,768 - 51,854,643 (+)Ensembl
Ensembl Acc Id: ENSMUST00000169070   ⟹   ENSMUSP00000127152
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1452,091,156 - 52,092,048 (+)Ensembl
GRCm38.p6 Ensembl1451,853,699 - 51,854,591 (+)Ensembl
RefSeq Acc Id: NM_053111   ⟹   NP_444341
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391452,091,225 - 52,092,100 (+)NCBI
GRCm381451,853,768 - 51,854,643 (+)ENTREZGENE
MGSCv371452,473,443 - 52,474,318 (+)RGD
Celera1448,829,263 - 48,842,051 (+)ENTREZGENE
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_444341   ⟸   NM_053111
- Peptide Label: precursor
- UniProtKB: Q923L7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000074075   ⟸   ENSMUST00000074477
Ensembl Acc Id: ENSMUSP00000127152   ⟸   ENSMUST00000169070
Protein Domains
Ribonuclease A-domain

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q923L7-F1-model_v2 AlphaFold Q923L7 1-155 view protein structure

Promoters
RGD ID:8682166
Promoter ID:EPDNEW_M19114
Type:single initiation site
Name:Ear6_1
Description:Mus musculus eosinophil-associated, ribonuclease A family, member6 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381451,853,772 - 51,853,832EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1890463 AgrOrtholog
Ensembl Genes ENSMUSG00000062148 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000074477 ENTREZGENE
  ENSMUST00000074477.7 UniProtKB/TrEMBL
  ENSMUST00000169070.2 UniProtKB/TrEMBL
Gene3D-CATH 3.10.130.10 UniProtKB/TrEMBL
InterPro RNaseA UniProtKB/TrEMBL
  RNaseA-like_dom_sf UniProtKB/TrEMBL
  RNaseA_AS UniProtKB/TrEMBL
  RNaseA_domain UniProtKB/TrEMBL
KEGG Report mmu:93719 UniProtKB/TrEMBL
MGD MGI:1890463 ENTREZGENE
NCBI Gene 93719 ENTREZGENE
PANTHER EOSINOPHIL CATIONIC PROTEIN UniProtKB/TrEMBL
  RNaseA UniProtKB/TrEMBL
Pfam RnaseA UniProtKB/TrEMBL
PhenoGen Ear6 PhenoGen
PRINTS RIBONUCLEASE UniProtKB/TrEMBL
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  RNASE_PANCREATIC UniProtKB/TrEMBL
SMART RNAse_Pc UniProtKB/TrEMBL
Superfamily-SCOP RNaseA UniProtKB/TrEMBL
UniProt Q923L7 ENTREZGENE, UniProtKB/TrEMBL