RNASE2 (ribonuclease A family member 2)

Gene: RNASE2 (ribonuclease A family member 2) Chlorocebus sabaeus

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Symbol:

RNASE2

Name:

ribonuclease A family member 2

RGD ID:

18370114

Description:

ENCODES a protein that exhibits lipopolysaccharide binding (ortholog); INVOLVED IN defense response to Gram-negative bacterium (ortholog); defense response to Gram-positive bacterium (ortholog); induction of bacterial agglutination (ortholog); ASSOCIATED WITH Brain-Lung-Thyroid Syndrome (ortholog); COVID-19 (ortholog); genetic disease (ortholog); FOUND IN extracellular space (inferred); lysosome (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

non-secretory ribonuclease

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	29	21,411,633 - 21,412,723 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	29	21,412,062 - 21,412,544 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	25,023,402 - 25,024,342 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Brain-Lung-Thyroid Syndrome (ISO)

COVID-19 (ISO)

genetic disease (ISO)

purine nucleoside phosphorylase deficiency (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chemotaxis (IEA)

defense response to Gram-negative bacterium (ISO)

defense response to Gram-positive bacterium (ISO)

defense response to virus (IEA)

induction of bacterial agglutination (ISO)

innate immune response in mucosa (IEA)

Cellular Component

extracellular space (IEA)

lysosome (IEA)

Molecular Function

endonuclease activity (IEA)

hydrolase activity (IEA)

lipopolysaccharide binding (ISO)

nuclease activity (IEA)

nucleic acid binding (IEA)

protein binding (ISO)

RNA nuclease activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

RNASE2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	29	21,411,633 - 21,412,723 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	29	21,412,062 - 21,412,544 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	25,023,402 - 25,024,342 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

RNASE2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	20,955,487 - 20,956,436 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	20,955,487 - 20,956,436 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	21,423,646 - 21,424,595 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	20,493,470 - 20,494,434 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	20,493,469 - 20,494,434	NCBI
Celera	14	1,284,485 - 1,285,449 (+)	NCBI		Celera
Cytogenetic Map	14	q11.2	NCBI
HuRef	14	1,544,743 - 1,545,707 (+)	NCBI		HuRef
CHM1_1	14	21,425,751 - 21,426,715 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	15,152,872 - 15,153,821 (+)	NCBI		T2T-CHM13v2.0

Ear6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	52,091,225 - 52,092,100 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	52,091,156 - 52,092,100 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	51,853,768 - 51,854,643 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	51,853,699 - 51,854,643 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	52,473,443 - 52,474,318 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	50,775,719 - 50,776,594 (+)	NCBI		MGSCv36	mm8
Celera	14	48,829,263 - 48,842,051 (+)	NCBI		Celera
Cytogenetic Map	14	C2	NCBI
cM Map	14	26.7	NCBI

Rnase2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	26,923,125 - 26,923,934 (-)	NCBI		GRCr8
mRatBN7.2	15	24,449,618 - 24,450,427 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	24,449,611 - 24,450,479 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	27,220,768 - 27,221,577 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	28,182,202 - 28,183,011 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	26,429,330 - 26,430,139 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	28,154,482 - 28,155,291 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	28,154,482 - 28,155,291 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	31,984,003 - 31,984,812 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	27,209,877 - 27,210,686 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	27,225,576 - 27,226,386 (-)	NCBI
Celera	15	24,766,498 - 24,767,307 (-)	NCBI		Celera
Cytogenetic Map	15	p14	NCBI

LOC100981889
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	22,394,999 - 22,396,712 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	21,611,486 - 21,613,199 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	1,759,482 - 1,760,873 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	19,841,044 - 19,842,028 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	19,841,364 - 19,841,849 (+)	Ensembl	panpan1.1		panPan2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium		7
Low	23	13	23
Below cutoff	13		33

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007990692	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000018191 ⟹ ENSCSAP00000017655

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	29	21,412,062 - 21,412,544 (+)	Ensembl

RefSeq Acc Id:

XM_007990692 ⟹ XP_007988883

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	29	21,411,633 - 21,412,723 (+)	NCBI
Vero_WHO_p1.0	NW_023666059	25,023,402 - 25,024,342 (-)	NCBI

Sequence:

show sequence

AAAAAAAAAAAAAAAAGGCTGATTGCACAAGCGGACTATGTACCAATCTGTGGGTTTCTACAAG
ACCAAGAGTCAGACCCTCCCTCCTGGCTCTGCTGGCCCAACCCTCCAAGAGATGCTTTATTTAC
ACAGTTCCAAGTAGGGAAGAACAGTTGCCCCTGAACGCCAGAACAACCAGCTGGATCAGTTCTC
ACAGGAGCCGCAGCGCAGAGACTGGGAAACATGGTTCCAAAACTGTTCACTTCCCCAATTTGTC
TGCTTCTTCTGTTGGGGCTTATGGGTGTGGAGGGCTCACTCCATGCCAAACCCGGACAATTTAC
CTGGGCTCAGTGGTTTGAAATCCAGCATATAAATATGACCTCTGGCCAATGCACCAATGCAATG
CTGGTAATTAACAATTATCAACGGCGATGCAAAAATCAAAATACTTTTCTTCTTACAACTTTTG
CTGATGTAGTTCATGTCTGTGGTAACCCAAGCATGCCCTGCCCTAGCAACACAAGTCTCAACAA
TTGTCATCATAGTGGAGTCCAGGTGCCTTTAATCCACTGTAACCTCACAACTCCAAGTCAAAAT
ATTTCAAATTGCAAGTATACACAGACAACAGCAAACAAGTTCTACATAGTTGCATGTAACAACA
GCGATCCAGTACGGGACCCTCCACAGTATCCAGTGGTTCCAGTTCACCTGGATAGAGTCATCTA
AGCTCCTGTATCAGCACTCCTCATCATCACTCATCTGCCAAGCTCCTCAATCATAGCCAAGATC
CCATCCCTCCATGTACCCTGGGTATCAGCATCTGTCCTCATCAGTATCCATACCCCTTCAGGTT
TCCTGAGCTGAAGTCCCTTGTGAACCCTGCAATAAACTGCTTTGCAAATTCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007988883	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000017655
	ENSCSAP00000017655.1

RefSeq Acc Id:	XP_007988883 ⟸ XM_007990692
- UniProtKB:	A0A0D9S9W6 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000017655 ⟸ ENSCSAT00000018191

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000000344	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000018191.1	UniProtKB/TrEMBL
Gene3D-CATH	3.10.130.10	UniProtKB/TrEMBL
InterPro	RNaseA	UniProtKB/TrEMBL
	RNaseA-like_dom_sf	UniProtKB/TrEMBL
	RNaseA_AS	UniProtKB/TrEMBL
	RNaseA_domain	UniProtKB/TrEMBL
KEGG Report	csab:103231363	UniProtKB/TrEMBL
NCBI Gene	RNASE2	ENTREZGENE
PANTHER	NON-SECRETORY RIBONUCLEASE	UniProtKB/TrEMBL
	PTHR11437	UniProtKB/TrEMBL
Pfam	RnaseA	UniProtKB/TrEMBL
PRINTS	RIBONUCLEASE	UniProtKB/TrEMBL
PROSITE	RNASE_PANCREATIC	UniProtKB/TrEMBL
SMART	RNAse_Pc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54076	UniProtKB/TrEMBL
UniProt	A0A0D9S9W6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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