Nxf2 (nuclear RNA export factor 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Nxf2 (nuclear RNA export factor 2) Mus musculus
Analyze
Symbol: Nxf2
Name: nuclear RNA export factor 2
RGD ID: 1622191
MGI Page MGI
Description: Enables mRNA binding activity. Acts upstream of or within poly(A)+ mRNA export from nucleus. Located in nuclear envelope. Is expressed in central nervous system; sensory organ; and testis. Orthologous to several human genes including NXF2 (nuclear RNA export factor 2) and NXF2B (nuclear RNA export factor 2B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4930455N06Rik; nuclear RNA export factor 5; Nxf-; Nxf-b
RGD Orthologs
Human
Rat
Bonobo
Squirrel
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X133,845,275 - 133,865,503 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX133,845,275 - 133,865,503 (-)EnsemblGRCm39 Ensembl
GRCm38X134,944,526 - 134,964,754 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX134,944,526 - 134,964,754 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X131,479,070 - 131,499,293 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X130,290,895 - 130,311,118 (-)NCBIMGSCv36mm8
CeleraX117,831,175 - 117,848,668 (-)NCBICelera
Cytogenetic MapXF1NCBI
cM MapX56.31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11279525   PMID:11566096   PMID:12466851   PMID:12477932   PMID:15820316   PMID:16014633   PMID:16027110  
PMID:16033648   PMID:16141072   PMID:16141073   PMID:17403691   PMID:17548835   PMID:19345203   PMID:21308854   PMID:21677750   PMID:21873635   PMID:23675524   PMID:23677977  


Genomics

Comparative Map Data
Nxf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X133,845,275 - 133,865,503 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX133,845,275 - 133,865,503 (-)EnsemblGRCm39 Ensembl
GRCm38X134,944,526 - 134,964,754 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX134,944,526 - 134,964,754 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X131,479,070 - 131,499,293 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X130,290,895 - 130,311,118 (-)NCBIMGSCv36mm8
CeleraX117,831,175 - 117,848,668 (-)NCBICelera
Cytogenetic MapXF1NCBI
cM MapX56.31NCBI
NXF5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X101,832,112 - 101,857,577 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX101,832,537 - 101,843,278 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p14 EnsemblX101,832,112 - 101,857,577 (-)EnsemblGRCh38hg38GRCh38
GRCh37X101,087,085 - 101,112,549 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X100,973,741 - 100,999,205 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X100,893,229 - 100,918,694NCBI
CeleraX101,607,687 - 101,633,150 (-)NCBICelera
Cytogenetic MapXq22.1NCBI
HuRefX90,894,346 - 90,920,212 (-)NCBIHuRef
CHM1_1X100,981,153 - 101,006,521 (-)NCBICHM1_1
T2T-CHM13v2.0X100,276,716 - 100,302,189 (-)NCBIT2T-CHM13v2.0
Nxf7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X102,828,592 - 102,845,799 (-)NCBIGRCr8
mRatBN7.2X98,535,374 - 98,552,562 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX98,535,375 - 98,552,526 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX100,196,722 - 100,213,805 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X103,712,746 - 103,729,829 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X101,222,664 - 101,239,768 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X106,049,075 - 106,066,334 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX106,049,075 - 106,066,227 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X105,934,946 - 105,952,143 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X122,897,820 - 122,914,925 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX99,552,583 - 99,569,687 (-)NCBICelera
Cytogenetic MapXq32NCBI
LOC100978865
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X101,850,372 - 101,931,250 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X101,853,974 - 101,934,854 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X91,029,232 - 91,040,710 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X101,162,023 - 101,168,749 (-)NCBIpanpan1.1PanPan1.1panPan2
Nxf5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X62,598,818 - 62,741,717 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936813733,393 - 874,254 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100153087
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X83,338,757 - 83,361,973 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X97,200,538 - 97,224,518 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Nxf2
468 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:481
Count of miRNA genes:218
Interacting mature miRNAs:237
Transcripts:ENSMUST00000010085, ENSMUST00000113187, ENSMUST00000113189, ENSMUST00000143059
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208552Wght12_mweight 12 (mouse)X94043606149782996Mouse
1558900Bw3_mbody weight QTL 3 (mouse)Not determinedX133540040165298595Mouse
13208556Lgth14_mbody length 14 (mouse)X94043606149782996Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X54045360148782996Mouse
25314309Syncl5_msynaptonemal complex length 5 (mouse)X121909697152582996Mouse
13824981Svwq2_mseminal vesicle weight QTL 2 (mouse)X128900749153782996Mouse
1301209Cia19_mcollagen induced arthritis 19 (mouse)Not determinedX120993165160213038Mouse
10412164Cmv2_mcytomegalovirus resistance 2 (mouse)Not determinedX125685149159685269Mouse
1357823Spha3_msperm head anomaly 3 (mouse)Not determinedX102055848162758941Mouse
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
4141665Mhysq2_mmale hybrid sterility QTL 2 (mouse)Not determined71453852139203212Mouse

Markers in Region
Nxf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X134,951,119 - 134,952,104UniSTSGRCm38
MGSCv37X131,485,658 - 131,486,643UniSTSGRCm37
CeleraX117,837,763 - 117,838,748UniSTS
Cytogenetic MapXE3UniSTS
cM MapX53.1UniSTS
G65204  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X134,957,111 - 134,957,545UniSTSGRCm38
MGSCv37X131,491,650 - 131,492,084UniSTSGRCm37
CeleraX117,843,756 - 117,844,190UniSTS
Cytogenetic MapXE3UniSTS
cM MapX UniSTS
G65780  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXE3UniSTS
cM MapX53.1UniSTS
px-31c10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X134,958,490 - 134,958,597UniSTSGRCm38
MGSCv37X131,493,029 - 131,493,136UniSTSGRCm37
CeleraX117,845,135 - 117,845,242UniSTS
Cytogenetic MapXE3UniSTS
cM MapX53.1UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001289735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001289736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011247765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB178900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF285575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF490577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ305319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK015471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL672063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY017476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC137928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC137929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  G65204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  G65780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000010085   ⟹   ENSMUSP00000010085
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX133,845,277 - 133,865,503 (-)Ensembl
GRCm38.p6 EnsemblX134,944,528 - 134,964,754 (-)Ensembl
Ensembl Acc Id: ENSMUST00000113187   ⟹   ENSMUSP00000108812
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX133,845,277 - 133,864,645 (-)Ensembl
GRCm38.p6 EnsemblX134,944,528 - 134,963,896 (-)Ensembl
Ensembl Acc Id: ENSMUST00000113189   ⟹   ENSMUSP00000108814
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX133,845,277 - 133,865,503 (-)Ensembl
GRCm38.p6 EnsemblX134,944,528 - 134,964,754 (-)Ensembl
Ensembl Acc Id: ENSMUST00000143059
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX133,845,275 - 133,857,099 (-)Ensembl
GRCm38.p6 EnsemblX134,944,526 - 134,956,350 (-)Ensembl
RefSeq Acc Id: NM_001289735   ⟹   NP_001276664
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X133,845,275 - 133,865,503 (-)NCBI
GRCm38X134,944,526 - 134,964,754 (-)NCBI
CeleraX117,831,170 - 117,850,514 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001289736   ⟹   NP_001276665
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X133,845,275 - 133,864,646 (-)NCBI
GRCm38X134,944,526 - 134,963,897 (-)NCBI
CeleraX117,831,170 - 117,850,514 (-)NCBI
Sequence:
RefSeq Acc Id: NM_031259   ⟹   NP_112549
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X133,845,275 - 133,865,503 (-)NCBI
GRCm38X134,944,526 - 134,964,754 (-)NCBI
MGSCv37X131,479,070 - 131,499,293 (-)RGD
CeleraX117,831,170 - 117,850,514 (-)NCBI
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011247765   ⟹   XP_011246067
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X133,845,276 - 133,857,196 (-)NCBI
GRCm38X134,944,527 - 134,956,447 (-)NCBI
Sequence:
RefSeq Acc Id: NP_112549   ⟸   NM_031259
- Peptide Label: isoform 2
- UniProtKB: Q99MW6 (UniProtKB/TrEMBL),   Q99NI0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001276665   ⟸   NM_001289736
- Peptide Label: isoform 3
- UniProtKB: Q8R499 (UniProtKB/TrEMBL),   Q99NI0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001276664   ⟸   NM_001289735
- Peptide Label: isoform 1
- UniProtKB: Q4ZGD8 (UniProtKB/TrEMBL),   Q99NI0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011246067   ⟸   XM_011247765
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000108814   ⟸   ENSMUST00000113189
Ensembl Acc Id: ENSMUSP00000108812   ⟸   ENSMUST00000113187
Ensembl Acc Id: ENSMUSP00000010085   ⟸   ENSMUST00000010085
Protein Domains
NTF2   TAP-C

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4ZGD8-F1-model_v2 AlphaFold Q4ZGD8 1-691 view protein structure

Promoters
RGD ID:13681378
Promoter ID:EPDNEW_M24838
Type:initiation region
Name:Nxf2_1
Description:Mus musculus nuclear RNA export factor 2 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X134,964,701 - 134,964,761EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1933192 AgrOrtholog
Ensembl Genes ENSMUSG00000009941 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000010085 ENTREZGENE
  ENSMUST00000010085.4 UniProtKB/TrEMBL
  ENSMUST00000113187 ENTREZGENE
  ENSMUST00000113187.8 UniProtKB/TrEMBL
  ENSMUST00000113189 ENTREZGENE
  ENSMUST00000113189.8 UniProtKB/TrEMBL
  ENSMUST00000143059 ENTREZGENE
Gene3D-CATH 3.10.450.50 UniProtKB/TrEMBL
  3.30.70.330 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
InterPro L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  NTF2-like_dom UniProtKB/TrEMBL
  NTF2_dom UniProtKB/TrEMBL
  Nuclear_transport_factor_2_euk UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  NXF_fam UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  TAP_C UniProtKB/TrEMBL
  Tap_RNA-bd UniProtKB/TrEMBL
  UBA-like UniProtKB/TrEMBL
KEGG Report mmu:83454 UniProtKB/TrEMBL
MGD MGI:1933192 ENTREZGENE
NCBI Gene 83454 ENTREZGENE
PANTHER NUCLEAR RNA EXPORT FACTOR 2 UniProtKB/TrEMBL
  PTHR10662 UniProtKB/TrEMBL
Pfam NXF_NTF2 UniProtKB/TrEMBL
  Tap-RNA_bind UniProtKB/TrEMBL
  TAP_C UniProtKB/TrEMBL
PhenoGen Nxf2 PhenoGen
PROSITE LRR UniProtKB/TrEMBL
  NTF2_DOMAIN UniProtKB/TrEMBL
  TAP_C UniProtKB/TrEMBL
SMART TAP_C UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  SSF54427 UniProtKB/TrEMBL
  SSF54928 UniProtKB/TrEMBL
  UBA_like UniProtKB/TrEMBL
UniProt Q4ZGD8 ENTREZGENE, UniProtKB/TrEMBL
  Q8R499 ENTREZGENE, UniProtKB/TrEMBL
  Q99JG4_MOUSE UniProtKB/TrEMBL
  Q99MW6 ENTREZGENE, UniProtKB/TrEMBL
  Q99NI0 ENTREZGENE, UniProtKB/TrEMBL