Cd300ld3 (CD300 molecule like family member D3) - Rat Genome Database

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Gene: Cd300ld3 (CD300 molecule like family member D3) Mus musculus
Analyze
No known orthologs.
Symbol: Cd300ld3
Name: CD300 molecule like family member D3
RGD ID: 1621182
MGI Page MGI
Description: Predicted to enable transmembrane signaling receptor activity. Acts upstream of or within positive regulation of protein ubiquitination and positive regulation of toll-like receptor 9 signaling pathway. Located in endosome and lysosome. Orthologous to human CD300LD (CD300 molecule like family member d).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AY457049; CD300 antigen like family member H; Cd300l; Cd300lh; Clm; clm-3; Clm3; CMRF-35-like molecule 3; CMRF35-like molecule 3; Lm; Lmir7
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911114,932,930 - 114,939,244 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11114,932,957 - 114,939,235 (-)EnsemblGRCm39 Ensembl
GRCm3811115,042,104 - 115,048,419 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11115,042,131 - 115,048,409 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711114,903,445 - 114,909,609 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611114,858,221 - 114,864,385 (-)NCBIMGSCv36mm8
Celera11126,805,888 - 126,808,452 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1180.58NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
early endosome  (IEA)
endosome  (IDA)
lysosome  (IDA)
plasma membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14662855   PMID:20817736   PMID:21873635   PMID:21940676  


Genomics

Variants

.
Variants in Cd300ld3
349 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:63
Count of miRNA genes:58
Interacting mature miRNAs:58
Transcripts:ENSMUST00000092459
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101022590121973369Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
4141612Cia40_mcollagen induced arthritis 40 (mouse)Not determined11103273992115021444Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100254186120887165Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100058103121973369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000092459   ⟹   ENSMUSP00000090116
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11114,932,957 - 114,939,235 (-)Ensembl
GRCm38.p6 Ensembl11115,042,131 - 115,048,409 (-)Ensembl
RefSeq Acc Id: NM_199201   ⟹   NP_954671
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911114,932,930 - 114,939,156 (-)NCBI
GRCm3811115,042,104 - 115,048,330 (-)NCBI
MGSCv3711114,903,445 - 114,909,609 (-)RGD
Celera11126,805,888 - 126,808,452 (-)NCBI
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006533653   ⟹   XP_006533716
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911114,932,945 - 114,939,244 (-)NCBI
GRCm3811115,042,119 - 115,048,419 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_954671 (Get FASTA)   NCBI Sequence Viewer  
  XP_006533716 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI19353 (Get FASTA)   NCBI Sequence Viewer  
  AAI20624 (Get FASTA)   NCBI Sequence Viewer  
  AAR27940 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000090116
  ENSMUSP00000090116.4
GenBank Protein Q6SJQ5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_954671   ⟸   NM_199201
- Peptide Label: precursor
- UniProtKB: Q6SJQ5 (UniProtKB/Swiss-Prot),   A2A7W0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006533716   ⟸   XM_006533653
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000090116   ⟸   ENSMUST00000092459
Protein Domains
Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6SJQ5-F1-model_v2 AlphaFold Q6SJQ5 1-245 view protein structure

Promoters
RGD ID:6820656
Promoter ID:MM_KWN:10498
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:ENSMUST00000106574,   OTTMUST00000007762,   UC007MGI.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611114,909,281 - 114,909,781 (-)MPROMDB
RGD ID:8677304
Promoter ID:EPDNEW_M16683
Type:initiation region
Name:Cd300ld3_1
Description:Mus musculus CD300 molecule like family member D3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811115,048,365 - 115,048,425EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2687214 AgrOrtholog
Ensembl Genes ENSMUSG00000069607 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000092459 ENTREZGENE
  ENSMUST00000092459.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
InterPro CD300_family_receptors UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_V-set UniProtKB/Swiss-Prot
KEGG Report mmu:382551 UniProtKB/Swiss-Prot
MGD MGI:2687214 ENTREZGENE
NCBI Gene 382551 ENTREZGENE
PANTHER CD300 MOLECULE-LIKE FAMILY MEMBER D2-RELATED UniProtKB/Swiss-Prot
  POLYMERIC-IMMUNOGLOBULIN RECEPTOR UniProtKB/Swiss-Prot
Pfam V-set UniProtKB/Swiss-Prot
PhenoGen Cd300ld3 PhenoGen
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt A2A7W0 ENTREZGENE
  CLM3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-17 Cd300ld3  CD300 molecule like family member D3  Cd300lh  CD300 antigen like family member H  Symbol and/or name change 5135510 APPROVED
2011-07-27 Cd300lh  CD300 antigen like family member H  Clm3  CMRF-35-like molecule 3  Symbol and/or name change 5135510 APPROVED