Izumo3 (IZUMO family member 3) - Rat Genome Database

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Gene: Izumo3 (IZUMO family member 3) Mus musculus
Analyze
Symbol: Izumo3
Name: IZUMO family member 3
RGD ID: 1620817
MGI Page MGI
Description: Enables protein homodimerization activity. Predicted to be located in plasma membrane. Orthologous to human IZUMO3 (IZUMO family member 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1700011H22Rik; hypothetical protein LOC69314; izumo sperm-egg fusion protein 3; RP23-434B7.1; transmembrane protein C9orf134
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39492,032,555 - 92,035,462 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl492,032,566 - 92,035,471 (-)EnsemblGRCm39 Ensembl
GRCm38492,144,318 - 92,147,225 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl492,144,329 - 92,147,234 (-)EnsemblGRCm38mm10GRCm38
MGSCv37491,811,009 - 91,813,912 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36491,636,336 - 91,639,239 (-)NCBIMGSCv36mm8
Celera490,583,099 - 90,586,002 (-)NCBICelera
Cytogenetic Map4C5NCBI
cM Map443.16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:19658160   PMID:34114279  


Genomics

Comparative Map Data
Izumo3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39492,032,555 - 92,035,462 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl492,032,566 - 92,035,471 (-)EnsemblGRCm39 Ensembl
GRCm38492,144,318 - 92,147,225 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl492,144,329 - 92,147,234 (-)EnsemblGRCm38mm10GRCm38
MGSCv37491,811,009 - 91,813,912 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36491,636,336 - 91,639,239 (-)NCBIMGSCv36mm8
Celera490,583,099 - 90,586,002 (-)NCBICelera
Cytogenetic Map4C5NCBI
cM Map443.16NCBI
IZUMO3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38924,542,952 - 24,545,897 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl924,542,952 - 24,545,946 (-)EnsemblGRCh38hg38GRCh38
GRCh37924,542,950 - 24,545,895 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36924,533,227 - 24,536,004 (-)NCBINCBI36Build 36hg18NCBI36
Celera924,465,817 - 24,468,595 (-)NCBICelera
Cytogenetic Map9p21.3NCBI
HuRef924,491,693 - 24,494,156 (-)NCBIHuRef
CHM1_1924,543,260 - 24,545,693 (-)NCBICHM1_1
T2T-CHM13v2.0924,548,941 - 24,551,927 (-)NCBIT2T-CHM13v2.0
Izumo3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85111,990,148 - 111,992,826 (-)NCBIGRCr8
mRatBN7.25106,874,321 - 106,876,978 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5106,874,351 - 106,877,004 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.05110,703,837 - 110,706,655 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5110,703,960 - 110,706,656 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05114,650,553 - 114,653,261 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45112,112,365 - 112,114,591 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5105,539,355 - 105,542,173 (-)NCBICelera
Cytogenetic Map5q32NCBI
Izumo3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554729,923,831 - 9,958,452 (+)NCBIChiLan1.0ChiLan1.0
IZUMO3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21199,998,807 - 100,002,144 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19100,004,752 - 100,008,089 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0924,390,621 - 24,394,391 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1925,002,186 - 25,004,778 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl925,002,131 - 25,004,778 (-)Ensemblpanpan1.1panPan2
IZUMO3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11143,191,033 - 43,195,120 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1143,191,033 - 43,194,893 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1141,869,239 - 41,873,340 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01144,132,733 - 44,136,834 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1144,132,730 - 44,137,106 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11142,802,500 - 42,806,606 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01142,692,806 - 42,696,914 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01143,438,130 - 43,442,237 (-)NCBIUU_Cfam_GSD_1.0
Izumo3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947158,067,396 - 158,070,251 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366114,598,133 - 4,600,728 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366114,598,387 - 4,600,728 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IZUMO3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1198,356,839 - 198,360,395 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11198,357,091 - 198,360,043 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21221,066,634 - 221,070,033 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Izumo3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473628,595,870 - 28,598,233 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:114
Count of miRNA genes:58
Interacting mature miRNAs:58
Transcripts:ENSMUST00000107108, ENSMUST00000143542
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824979Epid1_mepididymis and vas deferens weight 1 (mouse)48988823799857197Mouse
27226782Tibl2_mtibia length 2, 5 week (mouse)490888237111257197Mouse
13824982Svwq1_mseminal vesicle weight QTL 1 (mouse)489888237118857197Mouse
11532714Sluc43_msusceptibility to lung cancer 43 (mouse)446642108123127211Mouse
13506251Cytrq1_mcytokine response QTL 1 (mouse)46571808699718086Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined88982069140468203Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
1357726Lnopy1_mlens opacity 1 (mouse)Not determined485428838119429037Mouse
11532708Sluc43i_msusceptibility to lung cancer 43i (mouse)474444699108444983Mouse
11532707Sluc43h_msusceptibility to lung cancer 43h (mouse)474444699108444983Mouse
11532706Sluc43c_msusceptibility to lung cancer 43c (mouse)474444699108444983Mouse
27226770Tibl11_mtibia length 11, 10 week (mouse)488518237108357197Mouse
11532705Sluc43b_msusceptibility to lung cancer 43b (mouse)474444699108444983Mouse
10412176Habiir3_mhyperoxic acute lung injury imprinted region 3 (mouse)Not determined48375713094293740Mouse
1302044Nss1_mNOD Sjogren's syndrome 1 (mouse)Not determined471982069105982216Mouse
11532704Sluc43a_msusceptibility to lung cancer 43a (mouse)474444699108444983Mouse
27226766Tibl17_mtibia length 17, 16 week (mouse)488518237108457197Mouse
27226760Feml19_mfemur length 19, 16 week (mouse)490888237108457197Mouse
4141093W3q17_mweight 3 weeks QTL 17 (mouse)Not determined88982069140468203Mouse
1302031Bulb1_mbulb size 1 (mouse)Not determined474033887108034029Mouse
27095939Ulnl9_mulna length 9, 16 week (mouse)465318237118857197Mouse
27095938Ulnl6_mulna length 6, 10 week (mouse)46671823798588237Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
12904933Edlmmq3_mextensor digitorum longus muscle mass QTL 3 (mouse)481213991115213991Mouse
10043964Obq26_mobesity QTL 26 (mouse)Not determined45904725193047251Mouse
1300918Stheal4_msoft tissue heal 4 (mouse)Not determined489969627123969747Mouse
1301556Cd4vts1_mCD4 virgin T cell subset 1 (mouse)Not determined485428838119429037Mouse
26884406Huml3_mhumerus length 3, 10 week (mouse)475618237100157197Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
27226801Feml6_mfemur length 6, 5 week (mouse)487518237103257197Mouse
1302204Spm1_msplenomegaly modifier (mouse)Not determined482244395116244582Mouse
11532703Sluc43g_msusceptibility to lung cancer 43g (mouse)474444699108444983Mouse
11532702Sluc43f_msusceptibility to lung cancer 43f (mouse)474444699108444983Mouse
11532701Sluc43e_msusceptibility to lung cancer 43e (mouse)474444699108444983Mouse
1558948Ath8_matherosclerosis 8 (mouse)Not determined445658442105156995Mouse
11532700Sluc43d_msusceptibility to lung cancer 43d (mouse)474444699108444983Mouse
11039517Ltpr4_mLeishmania tropica response 4 (mouse)479365751113365867Mouse
11039504Ltpr4a_mLeishmania tropica response 4a (mouse)479365751113365867Mouse
11039505Ltpr4c_mLeishmania tropica response 4c (mouse)479365751113365867Mouse
1301930Papg1_mpulmonary adenoma progression 1 (mouse)Not determined485781167119781279Mouse
1301033Abbp2_mA/J and C57BL/6 blood pressure 2 (mouse)Not determined45355083993763305Mouse
1357870Pfat1_mpredicted fat percentage 1 (mouse)Not determined46361952697619685Mouse
1302057Pgia27_mproteoglycan induced arthritis 27 (mouse)Not determined470067227104067464Mouse
1301545Gauc_mglucose area under curve (mouse)Not determined476763107110763305Mouse
11039506Ltpr4b_mLeishmania tropica response 4b (mouse)479365751113365867Mouse
13208562Wght7_mweight 7 (mouse)490888237148084457Mouse
27226787Feml14_mfemur length 14, 10 week (mouse)484918237107157197Mouse
10412193Plep_mplasma lepin levels (mouse)Not determined474444699108444983Mouse
27095900Scvln9_msacral vertebrae length 2, 10 week (mouse)468018237107157197Mouse
39128212Lwq21_mliver weight QTL 21 (mouse)488982069140468203Mouse
27226716Metcl2_mmetatarsal-calcaneal length 2, 5 week (mouse)488118237118557197Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
26884434Zlq1_mzygomatic length QTL 1, 5 week (mouse)453700000103257197Mouse
26884435Zlq4_mzygomatic length QTL 4, 10 week (mouse)485118237104957197Mouse
1300697Sle2_msystemic lupus erythmatosus susceptibility 2 (mouse)Not determined477957579111957775Mouse
1301597Anxty_manxiety (mouse)Not determined474137574128009280Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
12880404Embq1_memotional behavior QTL 1 (mouse)46575720395921546Mouse
4141549W10q10_mweight 10 weeks QTL 10 (mouse)Not determined88982069140468203Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
1301190Cd4ts2_mCD4 T cell subset 2 (mouse)Not determined46014527794145424Mouse
26884431Zlq8_mzygomatic length QTL 8, 16 week (mouse)474718237108357197Mouse
1357507Synch2_msynechia 2 (mouse)Not determined46014527794145424Mouse
12879903Berr8_mberghei resistance locus 8 (mouse)46422246098222460Mouse
12879897Berr4_mberghei resistance locus 4 (mouse)471982069105982216Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
27095934Ulnl2_mulna length 2, 5 week (mouse)45770000094788237Mouse
27226746Metcl8_mmetatarsal-calcaneal length 8, 10 week (mouse)487518237107157197Mouse
12904738Idohtq_miris defect with ocular hypertension QTL (mouse)48075246793112991Mouse
27095924Pglq2_mpelvic girdle length QTL 2, 5 week (mouse)469118237130727311Mouse
27095927Pglq7_mpelvic girdle length QTL 7, 10 week (mouse)488118237108357197Mouse
1300601Tlsr1_mthymic lymphoma suppressor region 1 (mouse)Not determined48860115894957775Mouse
27095921Pglq12_mpelvic girdle length QTL 12, 16 week (mouse)483118237108357197Mouse
27226739Metcl14_mmetatarsal-calcaneal length 14, 16 week (mouse)487518237108357197Mouse
1357561Mbsyd_mmetabolic syndrome (mouse)Not determined466888445100888588Mouse
1301118Bbaa23_mB.burgdorferi-associated arthritis 23 (mouse)Not determined485781167119781279Mouse
11532738Abd1_mautoimmune biliary disease 1 (mouse)488982069116271120Mouse
15039368Nmrs19_mNAFLD-associated magnetic resonance shift 19 (mouse)490882780124882780Mouse
1301757Tlsr4_mthymic lymphoma suppressor region 4 (mouse)Not determined466757130100757258Mouse
27095917Scvln14_msacral vertebrae length 2, 16 week (mouse)468018237130277062Mouse
4141900Skts-fp1_mskin tumor susceptibility in FVB and PWK 1 (mouse)Not determined453550839124055180Mouse
1300966Pabr2_mplasma apolipoprotein B (human) regulator 2 (mouse)Not determined446332646105801860Mouse
1301739Pitm2_mprion incubation time 2 (mouse)Not determined471982069105982216Mouse
1301867Idd11_minsulin dependent diabetes susceptibility 11 (mouse)Not determined483604870117605006Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000128993793Mouse
27226724Tibw2_mtibia width 2, proximal, 10 week (mouse)443000000108357197Mouse
27095905Scvln3_msacral vertebrae length 2, 5 week (mouse)455600000128993793Mouse
11553870Cmmm_mcarcinoma modifier of MSM (mouse)490590668124590781Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000107108   ⟹   ENSMUSP00000102725
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl492,032,566 - 92,035,458 (-)Ensembl
GRCm38.p6 Ensembl492,144,329 - 92,147,221 (-)Ensembl
Ensembl Acc Id: ENSMUST00000143542   ⟹   ENSMUSP00000121187
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl492,032,575 - 92,035,471 (-)Ensembl
GRCm38.p6 Ensembl492,144,338 - 92,147,234 (-)Ensembl
RefSeq Acc Id: NM_027034   ⟹   NP_081310
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39492,032,555 - 92,035,458 (-)NCBI
GRCm38492,144,318 - 92,147,221 (-)ENTREZGENE
MGSCv37491,811,009 - 91,813,912 (-)RGD
Celera490,583,099 - 90,586,002 (-)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017320383   ⟹   XP_017175872
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39492,032,570 - 92,035,462 (-)NCBI
GRCm38492,144,333 - 92,147,225 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003955008
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39492,032,570 - 92,035,462 (-)NCBI
GRCm38492,144,333 - 92,147,225 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003955009
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39492,032,570 - 92,035,462 (-)NCBI
GRCm38492,144,333 - 92,147,225 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003955010
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39492,032,570 - 92,035,462 (-)NCBI
GRCm38492,144,333 - 92,147,225 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004941954
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39492,032,570 - 92,035,462 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_081310 (Get FASTA)   NCBI Sequence Viewer  
  XP_017175872 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A6PWV3 (Get FASTA)   NCBI Sequence Viewer  
  BAB24287 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000102725
  ENSMUSP00000102725.2
  ENSMUSP00000121187.2
RefSeq Acc Id: NP_081310   ⟸   NM_027034
- Peptide Label: precursor
- UniProtKB: Q9DAG1 (UniProtKB/Swiss-Prot),   A6PWV3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017175872   ⟸   XM_017320383
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000121187   ⟸   ENSMUST00000143542
Ensembl Acc Id: ENSMUSP00000102725   ⟸   ENSMUST00000107108

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A6PWV3-F1-model_v2 AlphaFold A6PWV3 1-263 view protein structure

Promoters
RGD ID:6883844
Promoter ID:EPDNEW_M5373
Type:initiation region
Name:Izumo3_1
Description:Mus musculus IZUMO family member 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38492,147,221 - 92,147,281EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1916564 AgrOrtholog
Ensembl Genes ENSMUSG00000028533 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000107108 ENTREZGENE
  ENSMUST00000107108.8 UniProtKB/Swiss-Prot
  ENSMUST00000143542.2 UniProtKB/TrEMBL
InterPro IZUMO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:69314 UniProtKB/Swiss-Prot
MGD MGI:1916564 ENTREZGENE
NCBI Gene 69314 ENTREZGENE
PANTHER IZUMO SPERM-EGG FUSION PROTEIN 3 UniProtKB/Swiss-Prot
  IZUMO SPERM-EGG FUSION PROTEIN 3 UniProtKB/Swiss-Prot
  IZUMO SPERM-EGG FUSION PROTEIN 3 UniProtKB/TrEMBL
  IZUMO SPERM-EGG FUSION PROTEIN 3 UniProtKB/TrEMBL
Pfam IZUMO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Izumo3 PhenoGen
UniProt A6PWV3 ENTREZGENE
  F6T8K1_MOUSE UniProtKB/TrEMBL
  IZUM3_MOUSE UniProtKB/Swiss-Prot
  Q9DAG1 ENTREZGENE
UniProt Secondary Q9DAG1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Izumo3  IZUMO family member 3  1700011H22Rik  RIKEN cDNA 1700011H22 gene  Symbol and/or name change 5135510 APPROVED