Tcap (titin-cap) - Rat Genome Database

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Gene: Tcap (titin-cap) Mus musculus
Analyze
Symbol: Tcap
Name: titin-cap
RGD ID: 1620095
MGI Page MGI
Description: Predicted to have several functions, including BMP binding activity; cytoskeletal protein binding activity; and ion channel binding activity. Predicted to be a structural constituent of muscle. Involved in adult heart development; otic vesicle formation; and somitogenesis. Localizes to Z disc. Is expressed in heart; otocyst; tail somite; and trunk somite. Used to study autosomal recessive limb-girdle muscular dystrophy type 2G. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2G and hypertrophic cardiomyopathy 25. Orthologous to human TCAP (titin-cap); INTERACTS WITH 2,3-dimethoxynaphthalene-1,4-dione; benzo[a]pyrene; Benzo[k]fluoranthene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI503981; AJ223855; Telet; telethonin; titin cap protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,274,637 - 98,275,779 (+)NCBIGRCm39mm39
GRCm39 Ensembl1198,274,637 - 98,275,779 (+)Ensembl
GRCm381198,383,811 - 98,384,953 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,383,811 - 98,384,953 (+)EnsemblGRCm38mm10GRCm38
MGSCv371198,245,125 - 98,246,267 (+)NCBIGRCm37mm9NCBIm37
MGSCv361198,199,901 - 98,201,302 (+)NCBImm8
Celera11108,038,035 - 108,039,177 (+)NCBICelera
Cytogenetic Map11DNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
I band  (IDA)
Z disc  (IBA,IDA,ISO)

Molecular Function

References

Additional References at PubMed
PMID:9350988   PMID:9817758   PMID:10208846   PMID:10349636   PMID:10655062   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11842093   PMID:12466851   PMID:12477932   PMID:12507422  
PMID:15489334   PMID:16141072   PMID:16141073   PMID:16702235   PMID:18440815   PMID:20233748   PMID:21267068   PMID:21305318   PMID:21799151   PMID:21873635   PMID:21884692   PMID:23100327  
PMID:24280220   PMID:25121604   PMID:32937135  


Genomics

Comparative Map Data
Tcap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,274,637 - 98,275,779 (+)NCBIGRCm39mm39
GRCm39 Ensembl1198,274,637 - 98,275,779 (+)Ensembl
GRCm381198,383,811 - 98,384,953 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,383,811 - 98,384,953 (+)EnsemblGRCm38mm10GRCm38
MGSCv371198,245,125 - 98,246,267 (+)NCBIGRCm37mm9NCBIm37
MGSCv361198,199,901 - 98,201,302 (+)NCBImm8
Celera11108,038,035 - 108,039,177 (+)NCBICelera
Cytogenetic Map11DNCBI
TCAP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1739,664,187 - 39,666,555 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1739,665,349 - 39,666,554 (+)EnsemblGRCh38hg38GRCh38
GRCh381739,665,349 - 39,666,554 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371737,821,602 - 37,822,807 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,075,125 - 35,076,333 (+)NCBINCBI36hg18NCBI36
Build 341735,075,124 - 35,076,333NCBI
Celera1734,481,328 - 34,482,536 (+)NCBI
Cytogenetic Map17q12NCBI
HuRef1733,615,530 - 33,616,738 (+)NCBIHuRef
CHM1_11738,057,420 - 38,058,628 (+)NCBICHM1_1
Tcap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21083,381,719 - 83,382,887 (+)NCBI
Rnor_6.0 Ensembl1086,337,728 - 86,338,411 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01086,337,705 - 86,338,414 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Celera1082,128,978 - 82,130,146 (+)NCBICelera
Cytogenetic Map10q31NCBI
Tcap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,413,657 - 14,414,735 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,413,657 - 14,414,735 (+)NCBIChiLan1.0ChiLan1.0
TCAP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11717,839,139 - 17,841,500 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1717,839,139 - 17,842,727 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01717,622,318 - 17,625,252 (-)NCBIMhudiblu_PPA_v0panPan3
TCAP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,811,792 - 22,812,980 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,794,177 - 22,813,012 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha922,284,243 - 22,285,432 (-)NCBI
ROS_Cfam_1.0923,605,436 - 23,606,624 (-)NCBI
UMICH_Zoey_3.1922,378,080 - 22,379,268 (-)NCBI
UNSW_CanFamBas_1.0922,639,078 - 22,640,266 (-)NCBI
UU_Cfam_GSD_1.0922,764,185 - 22,765,373 (-)NCBI
LOC101966001
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560222,217,447 - 22,220,249 (-)NCBI
SpeTri2.0NW_00493649014,856,433 - 14,857,692 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TCAP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,651,666 - 22,653,453 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,651,666 - 22,652,904 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21223,107,378 - 23,108,618 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103243538
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11666,500,535 - 66,503,455 (-)NCBI
ChlSab1.1 Ensembl1666,500,949 - 66,501,703 (-)Ensembl
Tcap
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247953,411,744 - 3,414,229 (-)NCBI

Position Markers
AI503981  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381198,384,769 - 98,384,863UniSTSGRCm38
MGSCv371198,246,083 - 98,246,177UniSTSGRCm37
Celera11108,038,993 - 108,039,087UniSTS
Cytogenetic Map11DUniSTS
Whitehead/MRC_RH111308.14UniSTS
Whitehead/MRC_RH111306.72UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162700000109500000Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116493951098939647Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116493951098939647Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116493951098939647Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166842594100842826Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166842594100842826Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66842594100842826Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166842594100842826Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166842594100842826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166842594100842826Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168300000102000000Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170800372104800540Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170800372104800540Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170800372104800540Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170800372104800540Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172128823106128908Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172835299106835463Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172927789106927907Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172927789106927907Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177172953111173092Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177546357111546496Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177546357111546496Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117768304799486994Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177880152111880273Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179265183107725646Mouse
14746970Manh71_mmandible shape 71 (mouse)1179525431113525431Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179922933104611872Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1181000000102000000Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181683655115683810Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181683655115683810Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181919441115919441Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182486872116486994Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185954085119954085Mouse
15039374Adip29_madiposity 29 (mouse)1186717494120717494Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186717494120717494Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186717494120717494Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187600000126900000Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187611774121611872Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187800372103383289Mouse
1301491Abbp4_mA/J and C57BL/6 blood pressure 4 (mouse)Not determined118880876299190771Mouse
1301313Pas5a_mpulmonary adenoma susceptibility 5a (mouse)Not determined118907597898974942Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189978425122082543Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191713782122082543Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191713782122082543Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1193048547112653728Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193338357122082543Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194172953118131898Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194300000119000000Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94546357118131898Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195513139122082543Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195513139122082543Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196246848122082543Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196285639108915558Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196919310122082543Mouse
1301153Estq3_mestradiol regulated response QTL 3 (mouse)Not determined119700686799436202Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1197006867110713165Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:315
Count of miRNA genes:254
Interacting mature miRNAs:266
Transcripts:ENSMUST00000008021
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000008021   ⟹   ENSMUSP00000008021
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1198,383,811 - 98,384,953 (+)Ensembl
RefSeq Acc Id: NM_011540   ⟹   NP_035670
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391198,274,637 - 98,275,779 (+)NCBI
GRCm381198,383,811 - 98,384,953 (+)ENTREZGENE
MGSCv371198,245,125 - 98,246,267 (+)RGD
Celera11108,038,035 - 108,039,177 (+)RGD
cM Map11 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035670   ⟸   NM_011540
- UniProtKB: O70548 (UniProtKB/Swiss-Prot),   Q545G3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000008021   ⟸   ENSMUST00000008021

Promoters
RGD ID:6822296
Promoter ID:MM_KWN:9567
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:NM_011540
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361198,244,756 - 98,245,602 (+)MPROMDB
RGD ID:8676482
Promoter ID:EPDNEW_M16272
Type:multiple initiation site
Name:Tcap_1
Description:Mus musculus titin-cap , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381198,383,824 - 98,383,884EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1330233 AgrOrtholog
Ensembl Genes ENSMUSG00000007877 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000008021 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000008021 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.20.160.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Telethonin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Titin-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21393 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1330233 ENTREZGENE
NCBI Gene 21393 ENTREZGENE
PANTHER PTHR15143 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Telethonin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tcap PhenoGen
UniProt O70548 ENTREZGENE
  Q545G3 ENTREZGENE, UniProtKB/TrEMBL
  TELT_MOUSE UniProtKB/Swiss-Prot