Skint3 (selection and upkeep of intraepithelial T cells 3) - Rat Genome Database

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Gene: Skint3 (selection and upkeep of intraepithelial T cells 3) Mus musculus
Analyze
No known orthologs.
Symbol: Skint3
Name: selection and upkeep of intraepithelial T cells 3
RGD ID: 1619888
MGI Page MGI
Description: Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including genitourinary system; gut; integumental system; liver; and thymus.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A430090E18Rik; RP23-29D6.1; selection and upkeep of intraepithelial T-cells protein 3; skint 3; Skint-3
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394112,089,442 - 112,157,665 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4112,089,442 - 112,157,665 (+)EnsemblGRCm39 Ensembl
GRCm384112,232,245 - 112,300,468 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4112,232,245 - 112,300,468 (+)EnsemblGRCm38mm10GRCm38
MGSCv374111,904,850 - 111,973,073 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364111,730,177 - 111,798,400 (+)NCBIMGSCv36mm8
MGSCv364109,986,001 - 110,055,097 (+)NCBIMGSCv36mm8
Cytogenetic Map4D1NCBI
cM Map451.53NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Skint3Mouse1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactionsEXP 6480464[2 more ...CTDPMID:25510870
Skint3Mouse2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsEXP 6480464[2 more ...CTDPMID:25510870
Skint3Mouse2,2',5,5'-tetrachlorobiphenyl multiple interactionsEXP 6480464[2 more ...CTDPMID:25510870
Skint3Mouse2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of SKINT3 mRNACTDPMID:26377647
Skint3Mouse2,4,4'-trichlorobiphenyl multiple interactionsEXP 6480464[2 more ...CTDPMID:25510870
Skint3Mousebenzo[b]fluoranthene decreases expressionEXP 6480464benzo(b)fluoranthene results in decreased expression of SKINT3 mRNACTDPMID:26377693
Skint3Mousebis(2-ethylhexyl) phthalate increases expressionEXP 6480464Diethylhexyl Phthalate results in increased expression of SKINT3 mRNACTDPMID:34319233
Skint3Mousecarbon nanotube decreases expressionEXP 6480464Nanotubes more ...CTDPMID:25554681
Skint3Mousefolic acid increases expressionEXP 6480464Folic Acid results in increased expression of SKINT3 mRNACTDPMID:25629700
Skint3Mouseozone multiple interactionsEXP 6480464[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of SKINT3 mRNACTDPMID:34911549
Skint3MousePCB138 multiple interactionsEXP 6480464[2 more ...CTDPMID:25510870
Skint3Mousetitanium dioxide decreases expressionEXP 6480464titanium dioxide results in decreased expression of SKINT3 mRNACTDPMID:29264374

1 to 12 of 12 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Skint3Mouseregulation of cytokine production involved_inIBAPANTHER:PTN008605761 more ...2290270 GO_CentralGO_REF:0000033
Skint3MouseT cell receptor signaling pathway involved_inIBAPANTHER:PTN008605761 and UniProtKB:O004812290270 GO_CentralGO_REF:0000033

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Skint3Mouseexternal side of plasma membrane is_active_inIBAPANTHER:PTN008605761 more ...2290270 GO_CentralGO_REF:0000033
Skint3Mousemembrane located_inIEAUniProtKB-SubCell:SL-01622290270 UniProtGO_REF:0000044

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Skint3Mousesignaling receptor binding enablesIBAPANTHER:PTN008605761 more ...2290270 GO_CentralGO_REF:0000033


#
Reference Title
Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:16141072   PMID:16141073   PMID:18408721   PMID:21677750   PMID:21873635  



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Variants in Skint3
2743 total Variants

Predicted Target Of
Summary Value
Count of predictions:1052
Count of miRNA genes:384
Interacting mature miRNAs:432
Transcripts:ENSMUST00000038455, ENSMUST00000170945
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 66 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
13824982Svwq1_mseminal vesicle weight QTL 1 (mouse)489888237118857197Mouse
11532714Sluc43_msusceptibility to lung cancer 43 (mouse)446642108123127211Mouse
12904002Opfaq9_mopen field activity QTL 9 (mouse)492975790126975790Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined88982069140468203Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105835310141433838Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
1357726Lnopy1_mlens opacity 1 (mouse)Not determined485428838119429037Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105835310141433838Mouse
14696689Gdq2_mgrooming duration QTL 2, females (mouse)4100857197124893793Mouse
1300743Skull6_mskull morphology 6 (mouse)Not determined4111009051145009280Mouse

1 to 10 of 66 rows






Ensembl Acc Id: ENSMUST00000038455   ⟹   ENSMUSP00000042662
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4112,089,442 - 112,157,665 (+)Ensembl
GRCm38.p6 Ensembl4112,232,245 - 112,300,468 (+)Ensembl
Ensembl Acc Id: ENSMUST00000170945   ⟹   ENSMUSP00000131300
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4112,089,442 - 112,157,665 (+)Ensembl
GRCm38.p6 Ensembl4112,232,245 - 112,300,468 (+)Ensembl
RefSeq Acc Id: NM_001102474   ⟹   NP_001095944
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394112,089,442 - 112,157,665 (+)NCBI
GRCm384112,232,245 - 112,300,468 (+)NCBI
MGSCv374111,904,850 - 111,973,073 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001348354   ⟹   NP_001335283
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394112,089,442 - 112,157,665 (+)NCBI
GRCm384112,232,245 - 112,300,468 (+)NCBI
Sequence:
RefSeq Acc Id: NM_177578   ⟹   NP_808246
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394112,089,442 - 112,157,665 (+)NCBI
GRCm384112,232,245 - 112,300,468 (+)ENTREZGENE
MGSCv374111,904,850 - 111,973,073 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_808246   ⟸   NM_177578
- Peptide Label: isoform b precursor
- UniProtKB: A7TZF0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001095944   ⟸   NM_001102474
- Peptide Label: isoform a precursor
- UniProtKB: A7TZF2 (UniProtKB/Swiss-Prot),   Q8BIN0 (UniProtKB/Swiss-Prot),   A7TZF0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001335283   ⟸   NM_001348354
- Peptide Label: isoform c precursor
- UniProtKB: A7TZF0 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSMUSP00000131300   ⟸   ENSMUST00000170945
Ensembl Acc Id: ENSMUSP00000042662   ⟸   ENSMUST00000038455
Ig-like C1-type   Ig-like V-type

Name Modeler Protein Id AA Range Protein Structure
AF-A7TZF0-F1-model_v2 AlphaFold A7TZF0 1-458 view protein structure



1 to 31 of 31 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000070868 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000038455 ENTREZGENE
  ENSMUST00000038455.12 UniProtKB/Swiss-Prot
  ENSMUST00000170945 ENTREZGENE
  ENSMUST00000170945.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
InterPro BTN3A2-like_Ig-C UniProtKB/Swiss-Prot
  Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_V-set UniProtKB/Swiss-Prot
  IgSF_BTN/MOG UniProtKB/Swiss-Prot
KEGG Report mmu:195564 UniProtKB/Swiss-Prot
MGD MGI:3045331 ENTREZGENE
NCBI Gene 195564 ENTREZGENE
PANTHER BUTYROPHILIN UniProtKB/Swiss-Prot
  SELECTION AND UPKEEP OF INTRAEPITHELIAL T-CELLS PROTEIN 2-RELATED UniProtKB/Swiss-Prot
Pfam C2-set_3 UniProtKB/Swiss-Prot
  V-set UniProtKB/Swiss-Prot
PhenoGen Skint3 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot
SMART IGv UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt A7TZF0 ENTREZGENE
  A7TZF2 ENTREZGENE
  Q8BIN0 ENTREZGENE
  SKIT3_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary A7TZF2 UniProtKB/Swiss-Prot
  Q8BIN0 UniProtKB/Swiss-Prot
1 to 31 of 31 rows