Psg21 (pregnancy-specific beta-1-glycoprotein 21) - Rat Genome Database

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Gene: Psg21 (pregnancy-specific beta-1-glycoprotein 21) Mus musculus
Analyze
No known orthologs.
Symbol: Psg21
Name: pregnancy-specific beta-1-glycoprotein 21
RGD ID: 1618316
MGI Page MGI
Description: Predicted to be involved in T cell activation and immune response. Predicted to be located in apical plasma membrane and cytosol. Predicted to be active in external side of plasma membrane. Is expressed in labyrinthine zone. Orthologous to human CEACAM4 (CEA cell adhesion molecule 4); CEACAM7 (CEA cell adhesion molecule 7); and PSG5 (pregnancy specific beta-1-glycoprotein 5).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1600019C01Rik; 1600025N01Rik; 1600026N13Rik; cea; cea8; pregnancy-specific glrcoprotein 21; pregnancy-specific glycoprotein 21
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39718,380,579 - 18,390,650 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl718,380,661 - 18,390,650 (-)EnsemblGRCm39 Ensembl
GRCm38718,646,654 - 18,656,725 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl718,646,736 - 18,656,725 (-)EnsemblGRCm38mm10GRCm38
MGSCv37719,232,003 - 19,242,074 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36717,805,375 - 17,815,244 (-)NCBIMGSCv36mm8
Celera716,059,952 - 16,069,924 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14697515   PMID:16141072   PMID:16141073   PMID:16595723   PMID:21119013   PMID:21873635  
PMID:26476147   PMID:27542691   PMID:30158284   PMID:34246625   PMID:36843585  


Genomics

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:600
Count of miRNA genes:409
Interacting mature miRNAs:464
Transcripts:ENSMUST00000094793, ENSMUST00000182128, ENSMUST00000182228, ENSMUST00000182933
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
1301115Lrdm1_mlymphoproliferation (Fas) renal disease modifier 1 (mouse)Not determined7335204824879418Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
12904941Edlmmq6_mextensor digitorum longus muscle mass QTL 6 (mouse)7121821047Mouse
1301177Vent3_mventricular size 3 (mouse)Not determined7120511925Mouse
10054067Sle20_msystematic lupus erythematosus susceptibility 20 (mouse)Not determined7120511925Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
12904948Tammq5_mtibialis anterior muscle mass QTL 5 (mouse)7121821047Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
12904953Gmmq5_mgastrocnemius muscle mass QTL 5 (mouse)7121821047Mouse
1302188Lxw6_mlupus BXSB x NZW 6 (mouse)Not determined7121698146Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000094793   ⟹   ENSMUSP00000092387
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl718,380,661 - 18,390,647 (-)Ensembl
GRCm38.p6 Ensembl718,646,736 - 18,656,722 (-)Ensembl
Ensembl Acc Id: ENSMUST00000182128   ⟹   ENSMUSP00000138173
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl718,383,872 - 18,390,647 (-)Ensembl
GRCm38.p6 Ensembl718,649,947 - 18,656,722 (-)Ensembl
Ensembl Acc Id: ENSMUST00000182228
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl718,385,645 - 18,390,650 (-)Ensembl
GRCm38.p6 Ensembl718,651,720 - 18,656,725 (-)Ensembl
Ensembl Acc Id: ENSMUST00000182933
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl718,386,414 - 18,390,624 (-)Ensembl
GRCm38.p6 Ensembl718,652,489 - 18,656,699 (-)Ensembl
RefSeq Acc Id: NM_027403   ⟹   NP_081679
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39718,380,579 - 18,390,650 (-)NCBI
GRCm38718,646,654 - 18,656,725 (-)ENTREZGENE
MGSCv37719,232,003 - 19,242,074 (-)RGD
Celera716,059,952 - 16,069,924 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_081679   ⟸   NM_027403
- UniProtKB: Q9DAV5 (UniProtKB/TrEMBL),   Q9R1F9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000092387   ⟸   ENSMUST00000094793
Ensembl Acc Id: ENSMUSP00000138173   ⟸   ENSMUST00000182128
Protein Domains
Ig-like   Immunoglobulin subtype

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9DAV5-F1-model_v2 AlphaFold Q9DAV5 1-471 view protein structure

Promoters
RGD ID:6891998
Promoter ID:EPDNEW_M9450
Type:multiple initiation site
Name:Psg21_1
Description:Mus musculus pregnancy-specific glycoprotein 21 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38718,656,722 - 18,656,782EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1891353 AgrOrtholog
Ensembl Genes ENSMUSG00000070796 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000094793 ENTREZGENE
  ENSMUST00000094793.12 UniProtKB/TrEMBL
  ENSMUST00000182128.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro CEA_cell_adhesion UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
KEGG Report mmu:72242 UniProtKB/TrEMBL
MGD MGI:1891353 ENTREZGENE
NCBI Gene Psg21 ENTREZGENE
PANTHER CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19 UniProtKB/TrEMBL
  CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 21 UniProtKB/TrEMBL
  PREGNANCY-SPECIFIC GLYCOPROTEIN 18-RELATED UniProtKB/TrEMBL
  SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE UniProtKB/TrEMBL
Pfam Ig_3 UniProtKB/TrEMBL
  V-set UniProtKB/TrEMBL
PhenoGen Psg21 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
SMART IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt Q9DAT6_MOUSE UniProtKB/TrEMBL
  Q9DAV5 ENTREZGENE, UniProtKB/TrEMBL
  Q9R1F9 ENTREZGENE
  S4R1D2_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-09-25 Psg21  pregnancy-specific beta-1-glycoprotein 21  Psg21  pregnancy-specific glrcoprotein 21  Symbol and/or name change 5135510 APPROVED
2024-08-21 Psg21  pregnancy-specific glrcoprotein 21  Psg21  pregnancy-specific beta-1-glycoprotein 21  Symbol and/or name change 5135510 APPROVED
2022-06-14 Psg21  pregnancy-specific beta-1-glycoprotein 21  Psg21  pregnancy-specific glycoprotein 21  Symbol and/or name change 5135510 APPROVED